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W. Bonadio, Deborah Smith, J. Carmody (1992)
Correlating CBC Profile and Infectious OutcomeClinical Pediatrics, 31
Nebojsa Radunovic, E. Kuczynski, Andrei Rebarber, D. Nastic, Charles Lockwood (1999)
Neopterin concentrations in fetal and maternal blood: a marker of cell-mediated immune activation.American journal of obstetrics and gynecology, 181 1
M. Ip, T. Rainer, N. Lee, C. Chan, S. Chau, Wingman Leung, M. Leung, T. Tam, G. Antonio, G. Lui, T. Lau, D. Hui, D. Fuchs, R. Renneberg, P. Chan (2007)
Value of serum procalcitonin, neopterin, and C-reactive protein in differentiating bacterial from viral etiologies in patients presenting with lower respiratory tract infections.Diagnostic microbiology and infectious disease, 59 2
A. Berdowska, K. Żwirska-Korczala (2001)
Neopterin measurement in clinical diagnosisJournal of Clinical Pharmacy and Therapeutics, 26
G. Shah, S. Budhathoki, B. Das, R. Mandal (2006)
Risk factors in early neonatal sepsis.Kathmandu University medical journal, 4 2
C. Murr, B. Widner, B. Wirleitner, Dietmar Fuchs (2002)
Neopterin as a marker for immune system activation.Current drug metabolism, 3 2
K. Plata-Nazar, A. Jankowska (2011)
Clinical Usefulness of Determining the Concentration of Neopterin, 22
Utomo (2010)
Risk factors of neonatal sepsis : a preliminary study in Dr HospitalInfect Dis, 23
(2003)
Role of cytokines (interleukin-1β, 6, 8, TNF-α, and soluble receptor of interleukin-1) and C-reactive protein in the diagnosis of neonatal sepsis
Arch Dis Child Fetal
L. Carthagena, A. Bergamaschi, Joseph Luna, A. David, P. Uchil, F. Margottin-Goguet, W. Mothes, U. Hazan, C. Transy, G. Pancino, S. Nisole (2009)
Human TRIM Gene Expression in Response to InterferonsPLoS ONE, 4
Bufford (2005)
Gern JE The hygiene hypothesis revisitedClin Am, 25
Gerdes (2004)
Diagnosis and management of bacterial infections in the neonateClin Am
R. Polin (2012)
Management of Neonates With Suspected or Proven Early-Onset Bacterial SepsisPediatrics, 129
R. Zuczek (1976)
A new approach to parallel computingActa Informatica, 7
J. Lawn, M. Gravett, Toni Nunes, C. Rubens, C. Stanton (2010)
Global report on preterm birth and stillbirth (1 of 7): definitions, description of the burden and opportunities to improve dataBMC Pregnancy and Childbirth, 10
Fathia Nemer, D. Midan, A. Mohamed (2015)
Serum Neopterin Level in Early Onset Neonatal SepsisAmerican Journal of BioScience, 3
H. Bomela, D. Ballot, B. Cory, P. Cooper (2000)
Use of C‐reactive protein to guide duration of empiric antibiotic therapy in suspected early neonatal sepsisThe Pediatric Infectious Disease Journal, 19
J. Gerdes (2004)
Diagnosis and management of bacterial infections in the neonate.Pediatric clinics of North America, 51 4
Shah (2006)
Risk factors in early neonatal sepsis KathmanduMed
K. Greksová, V. Parrák, D. Chovancová, P. Štencl, J. Oravec, L. Maršík, R. Sysák, D. Fuchs, Z. Peskova, M. Borovský (2009)
Procalcitonin, neopterin and C-reactive protein in diagnostics of intrauterine infection and preterm delivery.Bratislavske lekarske listy, 110 10
U. Töllner (1982)
Early diagnosis of septicemia in the newbornEuropean Journal of Pediatrics, 138
M. Wakeel, Ghada El-Kassas, Gihan Fathy, A. Wakkad, R. HebaM., Sebaii, S. Zayat, S. Mohamed (2012)
Diagnostic and prognostic values of high sensitive C-Reactive Protein , Tumor Necrosis Factor and Interleukin-1 β in Neonatal Sepsis
R. Huttunen, J. Aittoniemi (2011)
New concepts in the pathogenesis, diagnosis and treatment of bacteremia and sepsis.The Journal of infection, 63 6
M. Utomo (2010)
Risk Factors of Neonatal Sepsis: A Preliminary Study in Dr. Soetomo HospitalIndonesian Journal of Tropical and Infectious Disease, 1
J. Bufford, J. Gern (2005)
The hygiene hypothesis revisited.Immunology and allergy clinics of North America, 25 2
B. Chacko, I. Sohi (2005)
Early onset neonatal sepsisThe Indian Journal of Pediatrics, 72
Gavett (2010)
Lawn Global report on preterm birth and stillbirth of definitions description of the burden and opportunities to improve data BMC Pregnancy Childbirth, 10
Rainer (2007)
Ip Value of serum procalcitonin neopterin reactive protein in differentiating bacterial from viral etiologies in patients presenting with lower respiratory tract infectionsMicrobiol Infect Dis
Greksova (2009)
neopterin reactive protein in diagnostics of intrauterine infection and preterm delivery
Abstract Neonatal sepsis in premature infants is difficult to diagnose, and available markers are still varied. Neopterin is a derivative of pyrazino-pyrimidine produced by macrophages when stimulated by interferon γ. This study aimed to measure and compare the concentration of serum neopterin between groups of neonates with and without sepsis, and its correlation with Töllner’s sepsis score (TSS). This analytic observational study with a cross-sectional design included 46 premature infants with (n=23) and without neonatal sepsis (n=23). Data analysis using the Mann-Whitney U-test was performed to compare the levels of neopterin in premature infants with and without neonatal sepsis, and the Spearman rank correlation test to determine the correlation between neopterin levels and TSS. Neopterin levels in the sepsis group were higher than in the non-sepsis group (116 vs. 41.1 nmol/L; p<0.001). This study also showed a positive correlation between neopterin levels in premature infants with neonatal sepsis and TSS (r=0.776, p<0.001). Neopterin levels were higher in premature infants with neonatal sepsis than in those without it and positively correlated with TSS.
Pteridines – de Gruyter
Published: Jul 1, 2014
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