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E. Sheen, G. Triadafilopoulos (2011)
Adverse Effects of Long-Term Proton Pump Inhibitor TherapyDigestive Diseases and Sciences, 56
Vivek Sharma, Mark Brannon, E. Carloss (2004)
Effect of Omeprazole on Oral Iron Replacement in Patients with Iron Deficiency AnemiaSouthern Medical Journal, 97
Marina Maes, Danielle Fixen, S. Linnebur (2017)
Adverse effects of proton-pump inhibitor use in older adults: a review of the evidenceTherapeutic Advances in Drug Safety, 8
Wai-Kit Lo, Walter Chan (2013)
Proton pump inhibitor use and the risk of small intestinal bacterial overgrowth: a meta-analysis.Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association, 11 5
M. Tempel, A. Chawla, C. Messina, M. Celiker (2013)
Effects of omeprazole on iron absorption: preliminary study.Turkish journal of haematology : official journal of Turkish Society of Haematology, 30 3
B. Schenk, H. Festen, E. Kuipers, E. Klinkenberg‐Knol, S. Meuwissen (1996)
Effect of short‐ and long‐term treatment with omeprazole on the absorption and serum levels of cobalaminAlimentary Pharmacology & Therapeutics, 10
H. Koop (1992)
Review article: metabolic consequences of long‐term inhibition of acid secretion by omeprazoleAlimentary Pharmacology & Therapeutics, 6
R. Jensen (2006)
Consequences of long-term proton pump blockade: insights from studies of patients with gastrinomas.Basic & clinical pharmacology & toxicology, 98 1
H. Festen (1991)
Intrinsic factor secretion and cobalamin absorption. Physiology and pathophysiology in the gastrointestinal tract.Scandinavian journal of gastroenterology. Supplement, 188
S. Fujimori (2015)
What are the effects of proton pump inhibitors on the small intestine?World journal of gastroenterology, 21 22
R. Hashimoto, T. Matsuda, A. Chonan (2014)
Iron-deficiency anemia caused by a proton pump inhibitor.Internal medicine, 53 20
H. Koop, M. Bachem (1992)
Serum Iron, Ferritin, and Vitamin B12 During Prolonged Omeprazole TherapyJournal of Clinical Gastroenterology, 14
Jameson Lam, J. Schneider, Wei Zhao, D. Corley (2013)
Proton pump inhibitor and histamine 2 receptor antagonist use and vitamin B12 deficiency.JAMA, 310 22
E. Sarzynski, C. Puttarajappa, Yan Xie, M. Grover, H. Laird-Fick (2011)
Association Between Proton Pump Inhibitor Use and Anemia: A Retrospective Cohort StudyDigestive Diseases and Sciences, 56
S. Miret, R. Simpson, A. Mckie (2003)
Physiology and molecular biology of dietary iron absorption.Annual review of nutrition, 23
An Tran-Duy, An Tran-Duy, Niels Connell, F. Vanmolkot, P. Souverein, N. Wit, Coen Stehouwer, Arno Hoes, F. Vries, A. Boer (2018)
Use of proton pump inhibitors and risk of iron deficiency: a population‐based case–control studyJournal of Internal Medicine, 285
R. Valuck, J. Ruscin (2004)
A case-control study on adverse effects: H2 blocker or proton pump inhibitor use and risk of vitamin B12 deficiency in older adults.Journal of clinical epidemiology, 57 4
D. Johnson, E. Oldfield (2013)
PERSPECTIVES IN CLINICAL GASTROENTEROLOGY AND HEPATOLOGY Reported Side Effects and Complications of Long-term Proton Pump Inhibitor Use: Dissecting the Evidence
M. Khatib, O. Rahim, R. Kania, P. Molloy (2002)
CASE REPORT: Iron Deficiency Anemia: Induced by Long-Term Ingestion of OmeprazoleDigestive Diseases and Sciences, 47
S. Wilhelm, Ryan Rjater, P. Kale-Pradhan (2013)
Perils and pitfalls of long-term effects of proton pump inhibitorsExpert Review of Clinical Pharmacology, 6
R. Force, Angela Meeker, P. Cady, V. Culbertson, Wendy Force, Craig Kelley (2003)
Increased Vitamin B12 Requirement Associated with Chronic Acid Suppression TherapyAnnals of Pharmacotherapy, 37
R. Sandler, J. Everhart, M. Donowitz, Elizabeth Adams, K. Cronin, C. Goodman, E. Gemmen, Shefali Shah, Aida Avdić, R. Rubin (2002)
The burden of selected digestive diseases in the United States.Gastroenterology, 122 5
Tetsuhide Ito, R. Jensen (2010)
Association of Long-Term Proton Pump Inhibitor Therapy with Bone Fractures and Effects on Absorption of Calcium, Vitamin B12, Iron, and MagnesiumCurrent Gastroenterology Reports, 12
AbstractProton pump inhibitors (PPIs) are drugs commonly used for many diseases of the gastrointestinal tract, such as gastroesophageal reflux disease, erosive esophagitis, and peptic ulcers of the stomach and duodenum. Used for about 30 years, they are currently the most effective drugs that reduce the gastric secretion of hydrochloric acid. However, a dramatic increase in their consumption has been recently observed. Very often, they are used not in accordance with the guidelines. The consequences of the long-term use of PPIs may be various, with the most common side effects being bone fractures, cardiovascular events, recurrent infections, and vitamin and mineral deficiencies. Case report: An 82-year-old and a 58-year-old patients who had been taking omeprazole, a PPI for several years, developed vitamin B12 and iron deficiency anemia. Both patients were administered PPI orally for nonspecific dyspeptic symptoms. An evaluation of the gastrointestinal tract did not reveal the evident causes of gastrointestinal blood loss. They were also screened negative for Helicobacter pylori infection. Conclusions: There are no definitive pieces of evidence that the long-term use of PPIs can induce anemia, but our cases strongly suggest this thesis. Physicians should be aware of this potential side effect and consider monitoring in high-risk patients.
Acta Haematologica Polonica – de Gruyter
Published: Jun 1, 2020
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