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G. Wells, D. Wilkes, J. Schneiderman‐Walker, M. Elmi, E. Tullis, L. Lands, F. Ratjen, A. Coates (2008)
Reliability and validity of the habitual activity estimation scale (HAES) in patients with cystic fibrosisPediatric Pulmonology, 43
A. Tlacuilo-Parra, Ramsés Morales-Zambrano, Nadia Tostado-Rabago, M. Esparza‐Flores, B. López‐Guido, J. Orozco‐Alcala (2008)
Inactivity is a risk factor for low bone mineral density among haemophilic childrenBritish Journal of Haematology, 140
N. Crabtree, A. Arabi, L. Bachrach, M. Fewtrell, G. Fuleihan, H. Kecskemethy, M. Jaworski, C. Gordon (2014)
Dual-energy X-ray absorptiometry interpretation and reporting in children and adolescents: the revised 2013 ISCD Pediatric Official Positions.Journal of clinical densitometry : the official journal of the International Society for Clinical Densitometry, 17 2
An open-access journal for sharing experience in the care of people with bleeding disorders
A. Iorio, G. Fabbriciani, M. Marcucci, M. Brozzetti, P. Filipponi (2010)
Bone mineral density in haemophilia patientsThrombosis and Haemostasis, 103
C. Webber, L. Beaumont, J. Morrison, A. Sala, R. Barr (2007)
Age-predicted values for lumbar spine, proximal femur, and whole-body bone mineral density: results from a population of normal children aged 3 to 18 years.Canadian Association of Radiologists journal = Journal l'Association canadienne des radiologistes, 58 1
G. Saggese, F. Vierucci, A. Boot, J. Czech-Kowalska, G. Weber, C. Camargo, E. Mallet, M. Fanos, N. Shaw, M. Holick (2015)
Vitamin D in childhood and adolescence: an expert position statementEuropean Journal of Pediatrics, 174
C. Albayrak, D. Albayrak (2015)
Vitamin D levels in children with severe hemophilia A: an underappreciated deficiencyBlood Coagulation & Fibrinolysis, 26
S. Paschou, P. Anagnostis, S. Karras, C. Annweiler, S. Vakalopoulou, V. Garipidou, D. Goulis (2014)
Bone mineral density in men and children with haemophilia A and B: a systematic review and meta-analysisOsteoporosis International, 25
B. Alioglu, Beray Selver, H. Ozsoy, G. Koca, M. Ozdemir, Y. Dallar (2012)
Evaluation of bone mineral density in Turkish children with severe haemophilia A: Ankara hospital experienceHaemophilia, 18
T. Wallny, D. Scholz, J. Oldenburg, C. Nicolay, S. Ezziddin, P. Pennekamp, B. Stoffel‐Wagner, C. Kraft (2007)
Osteoporosis in haemophilia – an underestimated comorbidity?Haemophilia, 13
A. Christoforidis, M. Economou, E. Papadopoulou, E. Kazantzidou, N. Gompakis, M. Athanassiou-metaxa (2010)
Bone Status of Children With Hemophilia A Assessed With Quantitative Ultrasound Sonography (QUS) and Dual Energy X-ray Absorptiometry (DXA)Journal of Pediatric Hematology/Oncology, 32
Colin Webber, Colin Webber, Alessandra Sala, Alessandra Sala, Ronald Barr, Ronald Barr (2008)
Accounting for body size deviations when reporting bone mineral density variables in childrenOsteoporosis International, 20
B. Feldman, S. Funk, B. Bergstrom, N. Zourikian, P. Hilliard, J. Net, R. Engelbert, P. Petrini, H. Berg, M. Manco‐Johnson, G. Rivard, A. Abad, V. Blanchette (2011)
Validation of a new pediatric joint scoring system from the International Hemophilia Prophylaxis Study Group: Validity of the hemophilia joint health scoreArthritis Care & Research, 63
J. Pritchard, Tinasha Seechurn, S. Atkinson (2010)
A Food Frequency Questionnaire for the Assessment of Calcium, Vitamin D and Vitamin K: A Pilot Validation StudyNutrients, 2
O. Souček, V. Komrska, Z. Hlávka, O. Cinek, M. Roček, D. Zemková, J. Lebl, Z. Šumník (2012)
Boys with haemophilia have low trabecular bone mineral density and sarcopenia, but normal bone strength at the radiusHaemophilia, 18
C. Barnes, P. Wong, B. Egan, Tessa Speller, F. Cameron, G. Jones, H. Ekert, P. Monagle (2004)
Reduced bone density among children with severe hemophilia.Pediatrics, 114 2
N. Abdelrazik, M. Reda, M. El-Ziny, H. Rabea (2007)
Evaluation of bone mineral density in children with hemophilia: Mansoura University children hospital (MUCH) experience, Mansoura, EgyptHematology, 12
AbstractBackgroundPrevious research has shown that bone mineral density (BMD), a measure of bone strength, may be lower among people with haemophilia. However, the majority of this research has been done in adults and in countries where the treatment for haemophilia differs from the standard of care in Canada, and there is a lack of paediatric data.AimsThe primary objective of this study was to determine whether Canadian children and youth with severe haemophilia A and B have BMD similar to healthy controls matched for height, age and weight (HAW-score). Secondary objectives included the exploration of any association between BMD and the following variables: factor replacement regimen, Hemophilia Joint Health Score (HJHS), bleeding history, physical activity level, and dietary intake of calcium, vitamin D, vitamin K and protein.MethodsA cross-sectional observational study was designed to determine the BMD of children with severe haemophilia A and B in Canada. Ethical approvals were obtained from participating institutions. Thirty-eight participants aged 3–18 with severe haemophilia A and B were recruited from two treatment centres in Canada. Subjects underwent dual-energy X-ray absorptiometry (DXA) scan, and data was collected from regular clinic visit to identify factor replacement regimen, HJHS, and number of joint bleeds over the lifespan. Physical activity level and dietary intake of calcium, vitamin D, vitamin K and protein were identified using self-report questionnaires.ResultsParticipants showed a mean spine BMD Z-score and HAW-score higher than controls, with no participants showing a spine Z-score or HAW-score of <0. Hip BMD score was within normal range, and 2 participants had a Z-score and HAW-score of <−2. Total body BMD score was lower than controls, with 6 participants having a Z-score of <−2.0, and 3 participants having a HAW-score of <−2.0. Factor replacement regimen, HJHS, calcium intake, and physical activity level had no relationship to BMD Z-score or HAW-score. Low intake of vitamin D was associated with a low hip and spine BMD Z-score and HAW-score. Participants with a HJHS joint score greater than 0 had a higher total body HAW-score than those who had a joint score of 0.ConclusionCanadian children with severe haemophilia A and B demonstrate differences in spine and total body BMD from height-, age-, and weight-matched controls, where spine BMD is higher than controls and total body BMD is lower than controls. Studies with a larger sample size are needed to clarify the status of BMD in children with haemophilia treated with primary prophylaxis.
The Journal of Haemophilia Practice – de Gruyter
Published: Jan 1, 2021
Keywords: Bone density; paediatrics; haemophilia; physical activity; vitamin D; height-age-weight-adjusted score
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