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Assessment of Vitamin D Levels in Relation to Statin Therapy in Elderly Hypertensive Patients with Comorbidities

Assessment of Vitamin D Levels in Relation to Statin Therapy in Elderly Hypertensive Patients... AbstractBackground: Statin therapy is commonly used on the long term in hypertensive patients with dyslipidemia and can interfere with vitamin D metabolism. Overweight/obesity and type 2 diabetes mellitus (DM) are frequently associated with hypertension.The aim of the study was the assessment of vitamin D status in elderly hypertensive patients with metabolic comorbidities with/without statin therapy, in relation to body mass index (BMI) and lipid profile parameters.Material and methods: The study group included 89 hypertensive patients (61 statin-treated) admitted to the Cardiovascular Rehabilitation Clinical Hospital in Târgu Mureș between 2019 and 2021. Vitamin D levels were measured by ELISA method, lipid profile parameters by photometric procedures. Calculated values were LDL-cholesterol and BMI.Results: Obesity and DM were present in association with hypertension in 51% of the subjects. A total of 89% of the enrolled hypertensive patients had hypovitaminosis D. Average serum vitamin D of the studied subjects was 14.27 ± 11.96 ng/mL. No significant difference was obtained in vitamin D levels depending on gender, the presence/absence of statin therapy, and DM as a comorbidity. A negative correlation was seen between serum HDL-cholesterol and triglyceride concentrations (r = –0.3988, p = 0.0008) and between HDL levels and BMI (r = –0.3114, p = 0.0475).Conclusions: Suboptimal vitamin D levels were present in the majority of the studied hypertensive patients regardless of the statin therapy, which reveals the importance of concomitant assessment of vitamin D levels, especially in elderly subjects presenting chronic metabolic comorbidities. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Journal of Interdisciplinary Medicine de Gruyter

Assessment of Vitamin D Levels in Relation to Statin Therapy in Elderly Hypertensive Patients with Comorbidities

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Publisher
de Gruyter
Copyright
© 2022 Kinga-Ilona Nyulas et al., published by Sciendo
ISSN
2501-5974
eISSN
2501-8132
DOI
10.2478/jim-2022-0021
Publisher site
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Abstract

AbstractBackground: Statin therapy is commonly used on the long term in hypertensive patients with dyslipidemia and can interfere with vitamin D metabolism. Overweight/obesity and type 2 diabetes mellitus (DM) are frequently associated with hypertension.The aim of the study was the assessment of vitamin D status in elderly hypertensive patients with metabolic comorbidities with/without statin therapy, in relation to body mass index (BMI) and lipid profile parameters.Material and methods: The study group included 89 hypertensive patients (61 statin-treated) admitted to the Cardiovascular Rehabilitation Clinical Hospital in Târgu Mureș between 2019 and 2021. Vitamin D levels were measured by ELISA method, lipid profile parameters by photometric procedures. Calculated values were LDL-cholesterol and BMI.Results: Obesity and DM were present in association with hypertension in 51% of the subjects. A total of 89% of the enrolled hypertensive patients had hypovitaminosis D. Average serum vitamin D of the studied subjects was 14.27 ± 11.96 ng/mL. No significant difference was obtained in vitamin D levels depending on gender, the presence/absence of statin therapy, and DM as a comorbidity. A negative correlation was seen between serum HDL-cholesterol and triglyceride concentrations (r = –0.3988, p = 0.0008) and between HDL levels and BMI (r = –0.3114, p = 0.0475).Conclusions: Suboptimal vitamin D levels were present in the majority of the studied hypertensive patients regardless of the statin therapy, which reveals the importance of concomitant assessment of vitamin D levels, especially in elderly subjects presenting chronic metabolic comorbidities.

Journal

Journal of Interdisciplinary Medicine – de Gruyter

Published: Dec 1, 2022

Keywords: statins; vitamin D; hypertension; dyslipidemia; type 2 diabetes mellitus; obesity

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