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Assessment of C-Reactive Protein, Neutrophil-to-Lymphocyte Ratio and Platelet-to-Lymphocyte Ratio in Patients at Different Stages of Chronic Kidney Disease

Assessment of C-Reactive Protein, Neutrophil-to-Lymphocyte Ratio and Platelet-to-Lymphocyte Ratio... AbstractBackground: Low-grade chronic inflammation is an important feature of chronic kidney disease (CKD).Aim: To determine the values of C-reactive protein (CRP), neutrophil-to-lymphocyte ratio (NLR) and platelet-to-lymphocyte ratio (PLR) in patients with different stages of CKD and to examine how they change depending on the progression of renal damage.Materials and methods: A cross-sectional descriptive comparative study included 157 subjects at different stages of CKD which was assessed based on glomerular filtration rate (GFR) calculated according to the MDRD equation. CRP was analyzed by an immunoturbidimetric method. NLR and PLR were calculated by a mathematical calculation after a blood count was performed.Results: The present study showed an increase in serum creatinine, CRP, and NLR values with progression of renal failure. There was a statistically significant difference in the creatinine and CRP concentrations between groups with different stages of CKD (p <0.001 for all comparisons). A significant positive correlation was found between NLR and CRP, while negative, significant correlations were observed between NLR and eGFR as well as between PLR and eGFR. There was a slight increase in PLR value with the progression of renal impairment, but the correlation between PLR and CRP was not significant.Conclusion: These results suggest that NLR, together with CRP, may serve as an indicator of systemic low-grade inflammation progression in patients with CKD. Larger prospective studies are required to observe the possibility of using NLR as a surrogate marker for CRP in patients with CKD. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Journal of Interdisciplinary Medicine de Gruyter

Assessment of C-Reactive Protein, Neutrophil-to-Lymphocyte Ratio and Platelet-to-Lymphocyte Ratio in Patients at Different Stages of Chronic Kidney Disease

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Publisher
de Gruyter
Copyright
© 2022 Nermina Klapuh-Bukvić et al., published by Sciendo
ISSN
2501-5974
eISSN
2501-8132
DOI
10.2478/jim-2022-0019
Publisher site
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Abstract

AbstractBackground: Low-grade chronic inflammation is an important feature of chronic kidney disease (CKD).Aim: To determine the values of C-reactive protein (CRP), neutrophil-to-lymphocyte ratio (NLR) and platelet-to-lymphocyte ratio (PLR) in patients with different stages of CKD and to examine how they change depending on the progression of renal damage.Materials and methods: A cross-sectional descriptive comparative study included 157 subjects at different stages of CKD which was assessed based on glomerular filtration rate (GFR) calculated according to the MDRD equation. CRP was analyzed by an immunoturbidimetric method. NLR and PLR were calculated by a mathematical calculation after a blood count was performed.Results: The present study showed an increase in serum creatinine, CRP, and NLR values with progression of renal failure. There was a statistically significant difference in the creatinine and CRP concentrations between groups with different stages of CKD (p <0.001 for all comparisons). A significant positive correlation was found between NLR and CRP, while negative, significant correlations were observed between NLR and eGFR as well as between PLR and eGFR. There was a slight increase in PLR value with the progression of renal impairment, but the correlation between PLR and CRP was not significant.Conclusion: These results suggest that NLR, together with CRP, may serve as an indicator of systemic low-grade inflammation progression in patients with CKD. Larger prospective studies are required to observe the possibility of using NLR as a surrogate marker for CRP in patients with CKD.

Journal

Journal of Interdisciplinary Medicine – de Gruyter

Published: Dec 1, 2022

Keywords: C-reactive protein; neutrophil-to-lymphocyte ratio; platelet-to-lymphocyte ratio; chronic kidney disease

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