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Antimycobacterial cycloartane derivatives from the roots of Trichilia welwistchii C. DC (Meliaceae)

Antimycobacterial cycloartane derivatives from the roots of Trichilia welwistchii C. DC (Meliaceae) AbstractChemical investigation of the roots of Trichilia welwitschii yielded a cycloartane type terpenoid 28,29-bis-norcycloart-24-en-3β,4α,6α-triol (1), isolated as pure compound for the first time, three coumarins and three sterols. New cycloartane derivatives (1a) and (1b+1c) were obtained by hemi-synthetic reaction of compound 1. The structures of 1a–c were established by spectroscopic methods including 1D and 2D-NMR analysis, HR-EIMS, chemical transformations and by comparison of these data with those of related compounds. Evaluated for their antimycobacterial potential, compound 1 and 1b+1c were determined to show significant activities against Mycobacterium tuberculosis MIC values of 6.25 μg mL−1 while compound 1a displayed weak activity showing MIC > 100 μg mL−1. Compounds 2–4 displayed moderate activity with MIC values range from 12.5 to 50 μg mL−1. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Zeitschrift für Naturforschung B de Gruyter

Antimycobacterial cycloartane derivatives from the roots of Trichilia welwistchii C. DC (Meliaceae)

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Publisher
de Gruyter
Copyright
© 2021 Walter de Gruyter GmbH, Berlin/Boston
ISSN
0932-0776
eISSN
1865-7117
DOI
10.1515/znb-2021-0060
Publisher site
See Article on Publisher Site

Abstract

AbstractChemical investigation of the roots of Trichilia welwitschii yielded a cycloartane type terpenoid 28,29-bis-norcycloart-24-en-3β,4α,6α-triol (1), isolated as pure compound for the first time, three coumarins and three sterols. New cycloartane derivatives (1a) and (1b+1c) were obtained by hemi-synthetic reaction of compound 1. The structures of 1a–c were established by spectroscopic methods including 1D and 2D-NMR analysis, HR-EIMS, chemical transformations and by comparison of these data with those of related compounds. Evaluated for their antimycobacterial potential, compound 1 and 1b+1c were determined to show significant activities against Mycobacterium tuberculosis MIC values of 6.25 μg mL−1 while compound 1a displayed weak activity showing MIC > 100 μg mL−1. Compounds 2–4 displayed moderate activity with MIC values range from 12.5 to 50 μg mL−1.

Journal

Zeitschrift für Naturforschung B – de Gruyter

Published: Oct 26, 2021

Keywords: antimycobacterial activity; cycloartanes; hemi-synthetic derivatives; Meliaceae; Trichilia welwitschii

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