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Additional neopterin screening to improve safety of blood donations

Additional neopterin screening to improve safety of blood donations Fuchs et at.: Additional neoptcrin screening to improve safety of blood donations Pteridines Vol. 11 , 2000, pp. 76 - 80 Additional neopterin screening to impr~ve safety of blood donations Presented at: 3 rd Neopterin-Day, October 1.+to 2000, Bratislava Harald Schennach, Peter Meyersb?.-:h, Diether Schonitzer, Dietrnar Fuchs* Central Institute of Blood T ransfusion and Department of Immunology, University Hospital Innsbruck, and *Institute of Medical Ch emistry and Biochemistry, University of Innsbruck, and Ludwig Boltzmann Institute of AIDS Research, A-60:L0 Innsbruck, Austria Increased amouncs of neopterin are produced from human monocy'..es/macrophages when stimulated with the T-cell-derived cytokine interferon-g. Therefore, measuremen'. of neopterin concentrations in patients allows to detect and monitor activation of celImedia ted '- = Th 1-type) immune response (I). In the course of uirus infections, the virus enters a target cell and manipulates it to metabolic activity in a way that virus is reproduced. Virus-producing cells exposing virus antigenic ::;tnu:tures at their surface in the presence of HLA-antigens are an optimal target for the human immune system evoking cell-mediated (= Th I-type) immune response. In agreement, increased n eopterin concentrations can be seen in various acute infections with viruses, e.g ., hepatitis A, Band C , as http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Pteridines de Gruyter

Additional neopterin screening to improve safety of blood donations

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References (19)

Publisher
de Gruyter
Copyright
Copyright © 2000 by the
ISSN
0933-4807
eISSN
2195-4720
DOI
10.1515/pteridines.2000.11.3.76
Publisher site
See Article on Publisher Site

Abstract

Fuchs et at.: Additional neoptcrin screening to improve safety of blood donations Pteridines Vol. 11 , 2000, pp. 76 - 80 Additional neopterin screening to impr~ve safety of blood donations Presented at: 3 rd Neopterin-Day, October 1.+to 2000, Bratislava Harald Schennach, Peter Meyersb?.-:h, Diether Schonitzer, Dietrnar Fuchs* Central Institute of Blood T ransfusion and Department of Immunology, University Hospital Innsbruck, and *Institute of Medical Ch emistry and Biochemistry, University of Innsbruck, and Ludwig Boltzmann Institute of AIDS Research, A-60:L0 Innsbruck, Austria Increased amouncs of neopterin are produced from human monocy'..es/macrophages when stimulated with the T-cell-derived cytokine interferon-g. Therefore, measuremen'. of neopterin concentrations in patients allows to detect and monitor activation of celImedia ted '- = Th 1-type) immune response (I). In the course of uirus infections, the virus enters a target cell and manipulates it to metabolic activity in a way that virus is reproduced. Virus-producing cells exposing virus antigenic ::;tnu:tures at their surface in the presence of HLA-antigens are an optimal target for the human immune system evoking cell-mediated (= Th I-type) immune response. In agreement, increased n eopterin concentrations can be seen in various acute infections with viruses, e.g ., hepatitis A, Band C , as

Journal

Pteridinesde Gruyter

Published: Aug 1, 2000

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