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Abstracts: Seventeenth International Winter-Workshop on Biochemical J.nd Clin ical Aspects of Pteridines Pteridines Vol. 9, 1998, pp. 145 - 173 Abstracts Seventeenth International Winter-Workshop on Biochemical and Clinical Aspects of Pteridines Held in St. Christoph, Arlberg, Austria, February 14th-21st, 1998 Organized by J.A. Blair (Birmingham), D. Fuchs (Innsbruck), W. Pfleiderer (Konstanz ), G . Reibnegger (Graz), and H. Wachter (Innsbruck) Redox-Sensitive Intracellular Signal Transduction Pathways Baier-Bitterlich G, Wrrleimer B, Widner B, Fuchs D Instirute of Medical Chemistry and Biochemistry, University of Innsbruck; Ludwig Boltzmann Institute of AIDS Research, Innsbruck, Austria Free radical species are constantly produced in vivo. Biological sources of free radicals are respiratory burst, ischemia-reperfusion and mitochondria . Recent data in the literature indicate that free radical species are required for many extracellular ligands to successfully transmit their signals to the nucleus, whereby the diversity of cellular events that utilize free radicals is striking. In some cases, free radical production is required for ligandstimulated gene expression, whereas in others, free radicals themselves initiate a cellular response . The majority of free radical action is affiliated with the following categories: 1 ) cytokine, growth factor, hormone action and secretion, 2 ) ion transport, 3) transcription, 4 )
Pteridines – de Gruyter
Published: Aug 1, 1998
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