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/lp/de-gruyter/6-acetonylisoxanthopterin-a-potent-inhibitor-of-sepiapterin-reductase-kvVpJC0Llr
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- Publisher
- de Gruyter
- Copyright
- Copyright © 1991 by the
- ISSN
- 0933-4807
- eISSN
- 2195-4720
- DOI
- 10.1515/pteridines.1991.3.3.165
- Publisher site
- See Article on Publisher Site
Abstract
The inhibitory effect of 6-/7-substituted (2'-oxo) pteridines and ichthyopterin was examined for sepiapterin reductase. 6-Acetonylisoxanthopterin and 6-acetonyl-2,4-diamino-7-hydroxypteridine showed pronounced competitive inhibitory effects to sepiapterin reductase and Ki values were 0.38 μM and 90 μM, respectively. Ichthyopterin and 6-acetonyl-7-hydroxylumazine showed weak noncompetitive inhibitory effects and Ki values were 2.4 mM and 1.1 mM, respectively. 7-Acetonylxanthopterin exhibited no inhibition to sepiapterin reductase.
Journal
Pteridines – de Gruyter
Published: Sep 1, 1991