Get 20M+ Full-Text Papers For Less Than $1.50/day. Start a 14-Day Trial for You or Your Team.

Learn More →

Vascular stiffness and aging in HIV

Vascular stiffness and aging in HIV Large artery stiffening is a biological index of vascular aging. Vascular aging and atherosclerosis are two closely linked processes that develop in parallel and in synergy, sharing common aetiological determinants. Vascular stiffening increases left ventricular work and can lead to diminished coronary perfusion, and may therefore contribute to the development of cardiovascular disease. There is emerging evidence that large artery stiffness and vascular aging are accelerated in HIV infection because of the high prevalence of cardiovascular risk factors among HIV-infected patients. Moreover, the biological effects of HIV and the metabolic perturbations associated with antiretroviral therapies appear to accelerate vascular stiffening in HIV-infected patients. Further studies evaluating the effects of general and targeted therapies and various combinations of antiretroviral therapies on measures of large artery stiffness are urgently needed. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Sexual Health CSIRO Publishing

Vascular stiffness and aging in HIV

Chan William; Dart Anthony M.
Sexual Health , Volume 8 (4) – Jul 29, 2011
Download PDF
11 pages

Loading next page...
 
/lp/csiro-publishing/vascular-stiffness-and-aging-in-hiv-0xPb6ybhBD

References

References for this paper are not available at this time. We will be adding them shortly, thank you for your patience.

Publisher
CSIRO Publishing
Copyright
CSIRO
ISSN
1448-5028
eISSN
1449-8987
DOI
10.1071/SH10160
pmid
22127032
Publisher site
See Article on Publisher Site

Abstract

Large artery stiffening is a biological index of vascular aging. Vascular aging and atherosclerosis are two closely linked processes that develop in parallel and in synergy, sharing common aetiological determinants. Vascular stiffening increases left ventricular work and can lead to diminished coronary perfusion, and may therefore contribute to the development of cardiovascular disease. There is emerging evidence that large artery stiffness and vascular aging are accelerated in HIV infection because of the high prevalence of cardiovascular risk factors among HIV-infected patients. Moreover, the biological effects of HIV and the metabolic perturbations associated with antiretroviral therapies appear to accelerate vascular stiffening in HIV-infected patients. Further studies evaluating the effects of general and targeted therapies and various combinations of antiretroviral therapies on measures of large artery stiffness are urgently needed.

Journal

Sexual Health – CSIRO Publishing

Published: Jul 29, 2011

Keywords: AIDS, antiretroviral, carotid intima–media thickness, large artery stiffness, pulse wave velocity, vascular aging.

References

  • Non-AIDS-defining deaths and immunodeficiency in the era of combination antiretroviral therapy.
    Marin B Thiebaut R Bucher HC Rondeau V Costagliola D Dorrucci M et al
  • Cardiovascular risk and body-fat abnormalities in HIV-infected adults.
    Grinspoon S Carr A
  • Severe premature coronary artery disease with protease inhibitors.
    Henry K Melroe H Huebsch J Hermundson J Levine C Swensen L et al
  • The Data Collection on Adverse Events of Anti-HIV
  • Atherosclerosis – an immune disease: the Anitschkov Lecture 2007.
    Hansson GK
  • The DAD Study Group. Class of antiretroviral drugs and the risk of myocardial infarction.
  • Risk factors for coronary heart disease in patients treated for human immunodeficiency virus infection compared with the general population.
    Saves M Chene G Ducimetiere P Leport C Le Moal G Amouyel P et al
  • HIV, atherosclerosis and inflammation: implications for treatment.
    Chan W Sviridov D Dart AM
  • Determinants of arterial stiffness in Chinese migrants to Australia.
    Dart AM Qi XL
  • Relation between coronary artery disease, aortic stiffness, and left ventricular structure in a population sample.
    Gatzka CD Cameron JD Kingwell BA Dart AM
  • The arterial pulse in health and disease.
    O’Rourke MF
  • Arterial stiffness and prediction of cardiovascular risk.
    Kingwell BA Gatzka CD
  • Large artery stiffness predicts ischemic threshold in patients with coronary artery disease.
    Kingwell BA Waddell TK Medley TL Cameron JD Dart AM
  • Carotid intima–media thickness, arterial stiffness and risk of cardiovascular disease: current evidence.
    Bots ML Dijk JM Oren A Grobbee DE
  • Implications of early structural-functional changes in the endothelium for vascular disease.
    Simionescu M
  • Current perspectives on arterial stiffness and pulse pressure in hypertension and cardiovascular diseases.
    Safar ME Levy BI Struijker-Boudier H
  • Age related changes in the tunica media of the vertebral artery: implications for the assessment of vessels injured by trauma.
    Johnson CP Baugh R Wilson CA Burns J
  • Mechanisms, pathophysiology, and therapy of arterial stiffness.
    Zieman SJ Melenovsky V Kass DA
  • Arterial alterations with aging and high blood pressure. A noninvasive study of carotid and femoral arteries.
    Benetos A Laurent S Hoeks AP Boutouyrie PH Safar ME
  • Pulse pressure – a review of mechanisms and clinical relevance.
    Dart AM Kingwell BA
  • Comparative effects of aging in men and women on the properties of the arterial tree.
    Smulyan H Asmar RG Rudnicki A London GM Safar ME
  • Dietary sodium restriction rapidly improves large elastic artery compliance in older adults with systolic hypertension.
    Gates PE Tanaka H Hiatt WR Seals DR
  • The dietary sodium-blood pressure plot “stiffens”.
    Bagrov AY Lakatta EG
  • Effects of blood pressure, smoking, and their interaction on carotid artery structure and function.
    Liang YL Shiel LM Teede H Kotsopoulos D McNeil J Cameron JD et al
  • Hypercholesterolemia superimposed by experimental hypertension induces differential distribution of collagen and elastin.
    Xu C Zarins CK Pannaraj PS Bassiouny HS Glagov S
  • Structural and functional modifications of peripheral large arteries in hypertensive patients.
    Safar ME Laurent S Pannier BM London GM
  • Interactions of elastin and aorta with sugars in vitro and their effects on biochemical and physical properties.
    Winlove CP Parker KH Avery NC Bailey AJ
  • Structural alterations in subcutaneous small arteries of normotensive and hypertensive patients with non-insulin-dependent diabetes mellitus.
    Rizzoni D Porteri E Guelfi D Muiesan ML Valentini U Cimino A et al
  • Impaired radial artery compliance in normotensive subjects with familial hypercholesterolemia.
    Giannattasio C Mangoni AA Failla M Carugo S Stella ML Stefanoni P et al
  • Presence of increased stiffness of the common carotid artery and endothelial dysfunction in severely obese children: a prospective study.
    Tounian P Aggoun Y Dubern B Varille V Guy-Grand B Sidi D et al
  • Stiffness of systemic arteries in patients with myocardial infarction. A noninvasive method to predict severity of coronary atherosclerosis.
    Hirai T Sasayama S Kawasaki T Yagi S
  • Association between arterial stiffness and atherosclerosis: the Rotterdam study.
    van Popele NM Grobbee DE Bots ML Asmar R Topouchian J Reneman RS et al
  • Do arterial endothelin 1 levels affect local arterial stiffness?
    Heintz B Dorr R Gillessen T Walkenhorst F Krebs W Hanrath P et al
  • Increased carotid artery intimal–medial thickness in asymptomatic older subjects with exercise-induced myocardial ischemia.
    Nagai Y Metter EJ Earley CJ Kemper MK Becker LC Lakatta EG et al
  • Carotid-artery intima and media thickness as a risk factor for myocardial infarction and stroke in older adults. Cardiovascular Health Study Collaborative Research Group.
    O’Leary DH Polak JF Kronmal RA Manolio TA Burke GL Wolfson SK Jr
  • Effect of aging on aortic morphology in populations with high and low prevalence of hypertension and atherosclerosis. Comparison between occidental and Chinese communities.
    Virmani R Avolio AP Mergner WJ Robinowitz M Herderick EE Cornhill JF et al
  • Effect of reduced aortic compliance on cardiac efficiency and contractile function of in situ canine left ventricle.
    Kelly RP Tunin R Kass DA
  • Cardiac consequences of prolonged exposure to an isolated increase in aortic stiffness.
    Lartaud-Idjouadiene I Lompre AM Kieffer P Colas T Atkinson J
  • Coronary circulation in dogs with an experimental decrease in aortic compliance.
    Watanabe H Ohtsuka S Kakihana M Sugishita Y
  • Adverse influence of systemic vascular stiffening on cardiac dysfunction and adaptation to acute coronary occlusion.
    Kass DA Saeki A Tunin RS Recchia FA
  • Aortic distensibility and left ventricular structure and function in isolated systolic hypertension.
    Dart A Silagy C Dewar E Jennings G McNeil J
  • Aortic stiffness is an independent predictor of progression to hypertension in nonhypertensive subjects.
    Dernellis J Panaretou M
  • Sphygmomanometrically determined pulse pressure is a powerful independent predictor of recurrent events after myocardial infarction in patients with impaired left ventricular function. SAVE investigators. Survival and Ventricular Enlargement.
    Mitchell GF Moye LA Braunwald E Rouleau JL Bernstein V Geltman EM et al
  • Increased pulse pressure and risk of heart failure in the elderly.
    Chae CU Pfeffer MA Glynn RJ Mitchell GF Taylor JO Hennekens CH
  • Pulse pressure and risk of cardiovascular events in the systolic hypertension in the elderly program.
    Vaccarino V Berger AK Abramson J Black HR Setaro JF Davey JA et al
  • Association of increased pulse pressure with the development of heart failure in SHEP. Systolic Hypertension in the
    Kostis JB Lawrence-Nelson J Ranjan R Wilson AC Kostis WJ Lacy CR
  • Pulse pressure: a predictor of long-term cardiovascular mortality in a French male population.
    Benetos A Safar M Rudnichi A Smulyan H Richard JL Ducimetieere P et al
  • Is pulse pressure useful in predicting risk for coronary heart disease? The Framingham heart study.
    Franklin SS Khan SA Wong ND Larson MG Levy D
  • Hypertension and borderline isolated systolic hypertension increase risks of cardiovascular disease and mortality in male physicians.
    O’Donnell CJ Ridker PM Glynn RJ Berger K Ajani U Manson JE et al
  • Aortic pulse wave velocity predicts cardiovascular mortality in subjects >70 years of age.
    Meaume S Benetos A Henry OF Rudnichi A Safar ME
  • Guidelines for the management of arterial hypertension: The Task Force for the Management of Arterial Hypertension of the European Society of
    Mancia G De Backer G Dominiczak A Cifkova R Fagard R Germano G et al
  • Noninvasive assessment of arterial stiffness and risk of atherosclerotic events.
    Oliver JJ Webb DJ
  • Non-invasive measurements of arterial structure and function: repeatability, interrelationships and trial sample size.
    Liang YL Teede H Kotsopoulos D Shiel L Cameron JD Dart AM et al
  • Terminology for the definition of arterial elastic properties.
    Lehmann ED
  • Intimal plus medial thickness of the arterial wall: a direct measurement with ultrasound imaging.
    Pignoli P Tremoli E Poli A Oreste P Paoletti R
  • Exercise training increases total systemic arterial compliance in humans.
    Cameron JD Dart AM
  • Physiology of cardiovascular aging.
    Folkow B Svanborg A
  • Oxidized LDL and thickness of carotid intima–media are associated with coronary atherosclerosis in middle-aged men: lower levels of oxidized LDL with statin therapy.
    Vasankari T Ahotupa M Toikka J Mikkola J Irjala K Pasanen P et al
  • Correlations between measures of atherosclerosis change using carotid ultrasonography and coronary angiography.
    Mack WJ LaBree L Liu C Selzer RH Hodis HN
  • Atherosclerotic changes of extracoronary arteries are associated with the extent of coronary atherosclerosis.
    Lekakis JP Papamichael CM Cimponeriu AT Stamatelopoulos KS Papaioannou TG Kanakakis J et al
  • Carotid intima–media wall thickness in elderly women with and without atherosclerosis of the abdominal aorta.
    Bots ML Witteman JC Grobbee DE
  • Common carotid intima–media thickness and lower extremity arterial atherosclerosis. The Rotterdam Study.
    Bots ML Hofman A Grobbee DE
  • Ultrasonographic manifestations of common carotid atherosclerosis in elderly eastern Finnish men. Prevalence and associations with cardiovascular diseases and risk factors.
    Salonen R Tervahauta M Salonen JT Pekkanen J Nissinen A Karvonen MJ
  • Association of coronary heart disease incidence with carotid arterial wall thickness and major risk factors: the Atherosclerosis Risk in
    Chambless LE Heiss G Folsom AR Rosamond W Szklo M Sharrett AR et al
  • Common carotid intima–media thickness and risk of stroke and myocardial infarction: the Rotterdam Study.
    Bots ML Hoes AW Koudstaal PJ Hofman A Grobbee DE
  • The role of carotid arterial intima–media thickness in predicting clinical coronary events.
    Hodis HN Mack WJ LaBree L Selzer RH Liu CR Liu CH et al
  • Aortic stiffness is an independent predictor of all-cause and cardiovascular mortality in hypertensive patients.
    Laurent S Boutouyrie P Asmar R Gautier I Laloux B Guize L et al
  • Aortic stiffness is an independent predictor of primary coronary events in hypertensive patients: a longitudinal study.
    Boutouyrie P Tropeano AI Asmar R Gautier I Benetos A Lacolley P et al
  • Impact of aortic stiffness attenuation on survival of patients in end-stage renal failure.
    Guerin AP Blacher J Pannier B Marchais SJ Safar ME London GM
  • Impact of aortic stiffness on survival in end-stage renal disease.
    Blacher J Guerin AP Pannier B Marchais SJ Safar ME London GM
  • Carotid arterial stiffness as a predictor of cardiovascular and all-cause mortality in end-stage renal disease.
    Blacher J Pannier B Guerin AP Marchais SJ Safar ME London GM
  • Reduced arterial distensibility is a predictor of cardiovascular disease in patients after renal transplantation.
    Barenbrock M Kosch M Joster E Kisters K Rahn KH Hausberg M
  • Brachial artery pulse pressure and common carotid artery diameter: mutually independent associations with mortality in subjects with a recent history of impaired glucose tolerance.
    van Dijk RA Dekker JM Nijpels G Heine RJ Bouter LM Stehouwer CD
  • Aortic pulse-wave velocity and its relationship to mortality in diabetes and glucose intolerance: an integrated index of vascular function?
    Cruickshank K Riste L Anderson SG Wright JS Dunn G Gosling RG
  • Arterial stiffness and risk of coronary heart disease and stroke: the Rotterdam Study.
    Mattace-Raso FU van der Cammen TJ Hofman A van Popele NM Bos ML Schalekamp MA et al
  • Elevated aortic pulse wave velocity, a marker of arterial stiffness, predicts cardiovascular events in well-functioning older adults.
    Sutton-Tyrrell K Najjar SS Boudreau RM Venkitachalam L Kupelian V Simonsick EM et al
  • Prognostic value of aortic pulse wave velocity as index of arterial stiffness in the general population.
    Willum-Hansen T Staessen JA Torp-Pedersen C Rasmussen S Thijs L Ibsen H et al
  • Prediction of cardiovascular events and all-cause mortality with arterial stiffness: a systematic review and meta-analysis.
    Vlachopoulos C Aznaouridis K Stefanadis C
  • Wave travel and reflection in the arterial system.
    O’Rourke MF
  • Inhibition of basal nitric oxide synthesis increases aortic augmentation index and pulse wave velocity in vivo .
    Wilkinson IB MacCallum H Cockcroft JR Webb DJ
  • Arterial stiffness and endothelial dysfunction in HIV-infected children.
    Bonnet D Aggoun Y Szezepanski I Bellal N Blanche S
  • Increased arterial stiffness in HIV-infected children: risk factors and antiretroviral therapy.
    Charakida M Loukogeorgakis SP Okorie MI Masi S Halcox JP Deanfield JE et al
  • Early structural and functional changes of the vasculature in HIV-infected children: impact of disease and antiretroviral therapy.
    Charakida M Donald AE Green H Storry C Clapson M Caslake M et al
  • Increased carotid intima media thickness and cardiac biomarkers in HIV infected children.
    McComsey GA O’Riordan M Hazen SL El-Bejjani D Bhatt S Brennan ML et al
  • Impact of treatment with protease inhibitors on aortic stiffness in adult patients with human immunodeficiency virus infection.
    Schillaci G De Socio GV Pirro M Savarese G Mannarino MR Baldelli F et al
  • Arterial stiffness in HIV-infected patients receiving highly active antiretroviral therapy.
    Sevastianova K Sutinen J Westerbacka J Ristola M Yki-Jarvinen H
  • Influence of pravastatin on carotid artery structure and function in dyslipidemic HIV-infected patients receiving antiretroviral therapy.
    Boccara F Simon T Lacombe K Cohen A Laloux B Bozec E et al
  • Aortic stiffness in untreated adult patients with human immunodeficiency virus infection.
    Schillaci G De Socio GV Pucci G Mannarino MR Helou J Pirro M et al
  • Carotid intima–media thickness and arterial stiffness in HIV-infected patients: the role of HIV, antiretroviral therapy, and lipodystrophy.
    van Vonderen MG Smulders YM Stehouwer CD Danner SA Gundy CM Vos F et al
  • Association of highly active antiretroviral therapy with increased arterial stiffness in patients infected with human immunodeficiency virus.
    Lekakis J Ikonomidis I Palios J Tsiodras S Karatzis E Poulakou G et al
  • Association between human immunodeficiency virus infection and stiffness of the common carotid artery.
    Seaberg EC Benning L Sharrett AR Lazar JM Hodis HN Mack WJ et al
  • Premature lesions of the carotid vessels in HIV-1-infected patients treated with protease inhibitors.
    Maggi P Serio G Epifani G Fiorentino G Saracino A Fico C et al
  • Premature atherosclerosis in HIV-infected individuals – focus on protease inhibitor therapy.
    Depairon M Chessex S Sudre P Rodondi N Doser N Chave JP et al
  • Assessment of atherosclerosis using carotid ultrasonography in a cohort of HIV-positive patients treated with protease inhibitors.
    Seminari E Pan A Voltini G Carnevale G Maserati R Minoli L et al
  • Evaluation of cardiovascular risk factors in HIV-1 infected patients using carotid intima–media thickness measurement.
    Mercie P Thiebaut R Lavignolle V Pellegrin JL Yvorra-Vives MC Morlat P et al
  • Brief report: carotid intima–media thickness in heavily pretreated HIV-infected patients.
    Chironi G Escaut L Gariepy J Cogny A Teicher E Monsuez JJ et al
  • Colour-Doppler ultrasonography of carotid vessels in patients treated with antiretroviral therapy: a comparative study.
    Maggi P Lillo A Perilli F Maserati R Chirianni A
  • Carotid artery intima-media thickness and HIV infection: traditional risk factors overshadow impact of protease inhibitor exposure.
    Currier JS Kendall MA Zackin R Henry WK Alston-Smith B Torriani FJ et al
  • Risk of cardiovascular disease in a cohort of HIV-infected adults: a study using carotid intima–media thickness and coronary artery calcium score.
    Mangili A Gerrior J Tang AM O’Leary DH Polak JK Schaefer EJ et al
  • Increased carotid intima–media thickness in HIV patients is associated with increased cytomegalovirus-specific T-cell responses.
    Hsue PY Hunt PW Sinclair E Bredt B Franklin A Killian M et al
  • Functional and structural markers of atherosclerosis in human immunodeficiency virus-infected patients.
    van Wijk JP de Koning EJ Cabezas MC Joven J Op’t Roodt J Rabelink TJ et al
  • Both long-term HIV infection and highly active antiretroviral therapy are independent risk factors for early carotid atherosclerosis.
    Lorenz MW Stephan C Harmjanz A Staszewski S Buehler A Bickel M et al
  • Relationship between inflammatory markers, endothelial activation markers, and carotid intima–media thickness in HIV-infected patients receiving antiretroviral therapy.
    Ross AC Rizk N O’Riordan MA Dogra V El-Bejjani D Storer N et al
  • Smoking status and common carotid artery intima–medial thickness among middle-aged men and women based on ultrasound measurement: a cohort study.
    Fan AZ Paul-Labrador M Merz CN Iribarren C Dwyer JH
  • Association of obesity and visceral fat distribution with intima–media thickness of carotid arteries in middle-aged and older persons.
    Kawamoto R Ohtsuka N Ninomiya D Nakamura S
  • Increase in carotid artery intima–media thickness and arterial stiffness but improvement in several markers of endothelial function after initiation of antiretroviral therapy.
    van Vonderen MG Hassink EA van Agtmael MA Stehouwer CD Danner SA Reiss P et al
  • Clinical features of acute coronary syndromes in patients with human immunodeficiency virus infection.
    Hsue PY Giri K Erickson S MacGregor JS Younes N Shergill A et al
  • Carotid intima–media thickness is slightly increased over time in HIV-1-infected patients.
    Mercie P Thiebaut R Aurillac-Lavignolle V Pellegrin JL Yvorra-Vives MC Cipriano C et al
  • Change in atherosclerosis progression in HIV-infected patients: ANRS Aquitaine Cohort, 1999–2004.
    Thiebaut R Aurillac-Lavignolle V Bonnet F Ibrahim N Cipriano C Neau D et al
  • Metabolic abnormalities and cardiovascular disease risk factors in adults with human immunodeficiency virus infection and lipodystrophy.
    Hadigan C Meigs JB Corcoran C Rietschel P Piecuch S Basgoz N et al
  • HIV-1 envelope glycoprotein 120 increases intercellular adhesion molecule-1 expression by human endothelial cells.
    Ren Z Yao Q Chen C
  • HIV-1 Tat protein and endothelium: from protein/cell interaction to AIDS-associated pathologies.
    Rusnati M Presta M
  • HIV Tat protein causes endothelial dysfunction in porcine coronary arteries.
    Paladugu R Fu W Conklin BS Lin PH Lumsden AB Yao Q et al
  • Shed membrane particles from T lymphocytes impair endothelial function and regulate endothelial protein expression.
    Martin S Tesse A Hugel B Martinez MC Morel O Freyssinet JM et al
  • Indinavir impairs endothelial function in healthy HIV-negative men.
    Shankar SS Dube MP Gorski JC Klaunig JE Steinberg HO
  • Vascular endothelial toxicity induced by HIV protease inhibitor: evidence of oxidant-related dysfunction and apoptosis.
    Baliga RS Liu C Hoyt DG Chaves AA Bauer JA
  • Nucleoside reverse transcriptase inhibitors impair endothelium-dependent relaxation by increasing superoxide.
    Sutliff RL Dikalov S Weiss D Parker J Raidel S Racine AK et al
  • Molecular mechanisms of HIV protease inhibitor-induced endothelial dysfunction.
    Wang X Chai H Yao Q Chen C
  • HIV protease inhibitors promote atherosclerotic lesion formation independent of dyslipidemia by increasing CD36-dependent cholesteryl ester accumulation in macrophages.
    Dressman J Kincer J Matveev SV Guo L Greenberg RN Guerin T et al
  • Low-grade systemic inflammation impairs arterial stiffness in newly diagnosed hypercholesterolaemia.
    Pirro M Schillaci G Savarese G Gemelli F Vaudo G Siepi D et al
  • Relations of inflammatory biomarkers and common genetic variants with arterial stiffness and wave reflection.
    Schnabel R Larson MG Dupuis J Lunetta KL Lipinska I Meigs JB et al
  • Association of multiple inflammatory markers with carotid intimal medial thickness and stenosis (from the Framingham Heart Study).
    Thakore AH Guo CY Larson MG Corey D Wang TJ Vasan RS et al
  • Large artery stiffness and inflammation.
    McEniery CM Wilkinson IB
  • Metabolic syndrome is associated with aortic stiffness in untreated essential hypertension.
    Schillaci G Pirro M Vaudo G Mannarino MR Savarese G Pucci G et al
  • Arteriopathy in children with acquired immune deficiency syndrome.
    Joshi VV Pawel B Connor E Sharer L Oleske JM Morrison S et al
  • Alcohol consumption and arterial stiffness in men.
    Sierksma A Muller M van der Schouw YT Grobbee DE Hendriks HF Bots ML
  • Does fish oil lower blood pressure? A meta-analysis of controlled trials.
    Morris MC Sacks F Rosner B
  • The antihypertensive effects of fish oil. A controlled study of polyunsaturated fatty acid supplements in essential hypertension.
    Knapp HR FitzGerald GA
  • The effects of changes in physical activity on major cardiovascular risk factors, hemodynamics, sympathetic function, and glucose utilization in man: a controlled study of four levels of activity.
    Jennings G Nelson L Nestel P Esler M Korner P Burton D et al
  • Cardiovascular effects of exercise training: molecular mechanisms.
    Gielen S Schuler G Adams V
  • Arterial compliance increases after moderate-intensity cycling.
    Kingwell BA Berry KL Cameron JD Jennings GL Dart AM
  • Spontaneous running increases aortic compliance in Wistar–Kyoto rats.
    Kingwell BA Arnold PJ Jennings GL Dart AM
  • Four weeks of cycle training increases basal production of nitric oxide from the forearm.
    Kingwell BA Sherrard B Jennings GL Dart AM
  • Exercise training increases basal nitric oxide production from the forearm in hypercholesterolemic patients.
    Lewis TV Dart AM Chin-Dusting JP Kingwell BA
  • The N-3 fatty acids eicosapentaenoic acid and docosahexaenoic acid increase systemic arterial compliance in humans.
    Nestel P Shige H Pomeroy S Cehun M Abbey M Raederstorff D
  • Marine oils dose-dependently inhibit vasoconstriction of forearm resistance vessels in humans.
    Chin JP Gust AP Nestel PJ Dart AM
  • Effects on blood pressure of reduced dietary sodium and the Dietary Approaches to Stop
    Sacks FM Svetkey LP Vollmer WM Appel LJ Bray GA Harsha D et al
  • Improved arterial distensibility in normotensive subjects on a low salt diet.
    Avolio AP Clyde KM Beard TC Cooke HM Ho KK O’Rourke MF
  • Effects of aging on arterial distensibility in populations with high and low prevalence of hypertension: comparison between urban and rural communities in China.
    Avolio AP Deng FQ Li WQ Luo YF Huang ZD Xing LF et al
  • The effect of cholesterol lowering on carotid and femoral artery wall stiffness and thickness in patients with familial hypercholesterolaemia.
    Smilde TJ van den Berkmortel FW Wollersheim H van Langen H Kastelein JJ Stalenhoef AF
  • Simvastatin improves arterial compliance in the lower limb but not in the aorta.
    Shige H Dart A Nestel P
  • Advanced glycation end-product cross-link breakers. A novel approach to cardiovascular pathologies related to the aging process.
    Bakris GL Bank AJ Kass DA Neutel JM Preston RA Oparil S
  • Relaxin therapy reverses large artery remodeling and improves arterial compliance in senescent spontaneously hypertensive rats.
    Xu Q Chakravorty A Bathgate RA Dart AM Du XJ