Access the full text.
Sign up today, get DeepDyve free for 14 days.
Soheil Talemi, Therese Jacobson, Vijay Garla, Clara Navarrete, A. Wagner, Markus Tamás, J. Schaber (2014)
Mathematical modelling of arsenic transport, distribution and detoxification processes in yeastMolecular Microbiology, 92
Sara Beese, Takahiro Negishi, D. Levin (2009)
Identification of Positive Regulators of the Yeast Fps1 Glycerol ChannelPLoS Genetics, 5
R. Wysocki, Pierre-Karl Fortier, E. Maciaszczyk, Michael Thorsen, A. Leduc, Asa Odhagen, G. Owsianik, S. Ułaszewski, D. Ramotar, Markus Tamás (2004)
Transcriptional activation of metalloid tolerance genes in Saccharomyces cerevisiae requires the AP-1-like proteins Yap1p and Yap8p.Molecular biology of the cell, 15 5
A. Pierart, M. Shahid, N. Séjalon‐Delmas, C. Dumat (2015)
Antimony bioavailability: knowledge and research perspectives for sustainable agricultures.Journal of hazardous materials, 289
D. Beyersmann, A. Hartwig (2008)
Carcinogenic metal compounds: recent insight into molecular and cellular mechanismsArchives of Toxicology, 82
Ewa Maciaszczyk-Dziubinska, D. Wawrzycka, R. Wysocki (2012)
Arsenic and Antimony Transporters in EukaryotesInternational Journal of Molecular Sciences, 13
A. Hirner, A. Rettenmeier (2010)
14 Methylated Metal(loid) Species in HumansMetal ions in life sciences, 7
C. Cobbett, P. Goldsbrough (2002)
Phytochelatins and metallothioneins: roles in heavy metal detoxification and homeostasis.Annual review of plant biology, 53
Sebastian Ibstedt, Theodora Sideri, C. Grant, Markus Tamás (2014)
Global analysis of protein aggregation in yeast during physiological conditions and arsenite stressBiology Open, 3
Carina Schlebusch, Lucie Gattepaille, Karin Engström, M. Vahter, M. Jakobsson, K. Broberg (2015)
Human adaptation to arsenic-rich environments.Molecular biology and evolution, 32 6
A. Coelho, E. Yamashiro-Kanashiro, Sueli Bastos, R. Mortara, P. Cotrim (2006)
Intracellular location of the ABC transporter PRP1 related to pentamidine resistance in Leishmania major.Molecular and biochemical parasitology, 150 2
Therese Jacobson, Clara Navarrete, Sandeep Sharma, Theodora Sideri, Sebastian Ibstedt, S. Priya, C. Grant, P. Christen, P. Goloubinoff, Markus Tamás (2012)
Arsenite interferes with protein folding and triggers formation of protein aggregates in yeastJournal of Cell Science, 125
J. Carbrey, Linhua Song, Yao Zhou, Masafumi Yoshinaga, A. Rojek, Yiding Wang, Yangjian Liu, H. Lujan, S. DiCarlo, S. Nielsen, B. Rosen, P. Agre, R. Mukhopadhyay (2009)
Reduced arsenic clearance and increased toxicity in aquaglyceroporin-9-null miceProceedings of the National Academy of Sciences, 106
S. Detke, K. Katakura, K. Chang (1989)
DNA amplification in arsenite-resistant Leishmania.Experimental cell research, 180 1
Barbara Papadopoulou, G. Roy, S. Dey, Barry Rosen, Martin Olivier, Marc Ouellette (1996)
Gene disruption of the P-glycoprotein related gene pgpa of Leishmania tarentolae.Biochemical and biophysical research communications, 224 3
N. Kumar, Jianbo Yang, J. Pillai, S. Rawat, Carlos Solano, Abhay Kumar, M. Grøtli, Timothy Stemmler, B. Rosen, Markus Tamás (2015)
Arsenic Directly Binds to and Activates the Yeast AP-1-Like Transcription Factor Yap8Molecular and Cellular Biology, 36
H. Bhattacharjee, J. Carbrey, B. Rosen, R. Mukhopadhyay (2004)
Drug uptake and pharmacological modulation of drug sensitivity in leukemia by AQP9.Biochemical and biophysical research communications, 322 3
L. Ma, K. Komar, C. Tu, Weihua Zhang, Yong Cai, E. Kennelley (2001)
A fern that hyperaccumulates arsenicNature, 409
Ze-Sheng Li, Yu-ping Lu, R. Zhen, M. Szczypka, Dennis Thiele, P. Rea (1997)
A new pathway for vacuolar cadmium sequestration in Saccharomyces cerevisiae: YCF1-catalyzed transport of bis(glutathionato)cadmium.Proceedings of the National Academy of Sciences of the United States of America, 94 1
Charles Hachez, F. Chaumont (2010)
Aquaporins: a family of highly regulated multifunctional channels.Advances in experimental medicine and biology, 679
D. Légaré, D. Richard, R. Mukhopadhyay, Y. Stierhof, B. Rosen, Anass Haimeur, B. Papadopoulou, M. Ouellette (2001)
The Leishmania ATP-binding Cassette Protein PGPA Is an Intracellular Metal-Thiol Transporter ATPase*The Journal of Biological Chemistry, 276
R. Mukhopadhyay, S. Dey, N. Xu, D. Gage, J. Lightbody, M. Ouellette, B. Rosen (1996)
Trypanothione overproduction and resistance to antimonials and arsenicals in Leishmania.Proceedings of the National Academy of Sciences of the United States of America, 93 19
Benjamin Pommerrenig, T. Diehn, G. Bienert (2015)
Metalloido-porins: Essentiality of Nodulin 26-like intrinsic proteins in metalloid transport.Plant science : an international journal of experimental plant biology, 238
J. Lemire, J. Harrison, R. Turner (2013)
Antimicrobial activity of metals: mechanisms, molecular targets and applicationsNature Reviews Microbiology, 11
T. Zhou, S. Radaev, B. Rosen, D. Gatti (2000)
Structure of the ArsA ATPase: the catalytic subunit of a heavy metal resistance pumpThe EMBO Journal, 19
Hongzhe Sun, Siucheong Yan, W. Cheng (2000)
Interaction of antimony tartrate with the tripeptide glutathione implication for its mode of action.European journal of biochemistry, 267 17
Légaré D. Richard D. Mukhopadhyay R. Stierhof Y. D. Rosen B. P. Haimeur A. Papadopoulou B. Ouellette M.
The Leishmania ABC protein PGPA is an intracellular metal-thiol transporter ATPase.
L. Tisa, B. Rosen (1990)
Molecular characterization of an anion pump. The ArsB protein is the membrane anchor for the ArsA protein.The Journal of biological chemistry, 265 1
Yao Zhou, Nadine Messier, M. Ouellette, B. Rosen, R. Mukhopadhyay (2004)
Leishmania major LmACR2 Is a Pentavalent Antimony Reductase That Confers Sensitivity to the Drug Pentostam*Journal of Biological Chemistry, 279
C. Brochu, Anass Haimeur, M. Ouellette (2004)
The heat shock protein HSP70 and heat shock cognate protein HSC70 contribute to antimony tolerance in the protozoan parasite Leishmania, 9
R. Wysocki, S. Clemens, Daria Augustyniak, P. Golik, E. Maciaszczyk, Markus Tamás, D. Dziadkowiec (2003)
Metalloid tolerance based on phytochelatins is not functionally equivalent to the arsenite transporter Acr3p.Biochemical and biophysical research communications, 304 2
N. Verbruggen, C. Hermans, H. Schat (2009)
Mechanisms to cope with arsenic or cadmium excess in plants.Current opinion in plant biology, 12 3
F. Frézard, C. Demicheli, C. Ferreira, M. Costa (2001)
Glutathione-Induced Conversion of Pentavalent Antimony to Trivalent Antimony in Meglumine AntimoniateAntimicrobial Agents and Chemotherapy, 45
G. Rappa, A. Lorico, R. Flavell, A. Sartorelli (1997)
Evidence that the multidrug resistance protein (MRP) functions as a co-transporter of glutathione and natural product toxins.Cancer research, 57 23
C. Demicheli, F. Frézard, J. Mangrum, N. Farrell (2008)
Interaction of trivalent antimony with a CCHC zinc finger domain: potential relevance to the mechanism of action of antimonial drugs.Chemical communications, 39
N. Marquis, B. Gourbal, B. Rosen, R. Mukhopadhyay, M. Ouellette (2005)
Modulation in aquaglyceroporin AQP1 gene transcript levels in drug‐resistant LeishmaniaMolecular Microbiology, 57
P. Bobrowicz, S. Ułaszewski (1998)
Arsenical - induced transcriptional activation of the yeast Saccharomyces cerevisiae ACR2 and ACR3 genes requires the presence of the ACR1 gene productCellular & Molecular Biology Letters, 03
H. Denton, Joanne Mcgregor, G. Coombs (2004)
Reduction of anti-leishmanial pentavalent antimonial drugs by a parasite-specific thiol-dependent reductase, TDR1.The Biochemical journal, 381 Pt 2
A. Coelho, S. Beverley, P. Cotrim (2003)
Functional genetic identification of PRP1, an ABC transporter superfamily member conferring pentamidine resistance in Leishmania major.Molecular and biochemical parasitology, 130 2
Arnulfo Albores, James Koropatnick, M. Cherian, A. Żelazowski (1992)
Arsenic induces and enhances rat hepatic metallothionein production in vivo.Chemico-biological interactions, 85 2-3
G. Bienert, Michael Thorsen, M. Schüssler, Henrik Nilsson, A. Wagner, Markus Tamás, T. Jahn (2008)
A subgroup of plant aquaporins facilitate the bi-directional diffusion of As(OH)3 and Sb(OH)3 across membranesBMC Biology, 6
R. Feng, Chaoyang Wei, S. Tu, Yongzhen Ding, Rui-gang Wang, Junkang Guo (2013)
The uptake and detoxification of antimony by plants: A reviewEnvironmental and Experimental Botany, 96
Zijuan Liu, M. Sánchez, Xuan Jiang, E. Boles, S. Landfear, B. Rosen (2006)
Mammalian glucose permease GLUT1 facilitates transport of arsenic trioxide and methylarsonous acid.Biochemical and biophysical research communications, 351 2
Zijuan Liu, Jian Shen, J. Carbrey, R. Mukhopadhyay, P. Agre, B. Rosen (2002)
Arsenite transport by mammalian aquaglyceroporins AQP7 and AQP9Proceedings of the National Academy of Sciences of the United States of America, 99
Jeremy Allen, J. Carey, A. Walsh, D. Scanlon, G. Watson (2013)
Electronic Structures of Antimony OxidesJournal of Physical Chemistry C, 117
S. Cole, K. Sparks, K. Fraser, D. Loe, C. Grant, G. Wilson, R. Deeley (1994)
Pharmacological characterization of multidrug resistant MRP-transfected human tumor cells.Cancer research, 54 22
Michael Thorsen, Y. Di, Carolina Tängemo, Montse Morillas, Doryaneh Ahmadpour, Charlotte Does, A. Wagner, Erik Johansson, J. Boman, F. Posas, R. Wysocki, Markus Tamás (2006)
The MAPK Hog1p modulates Fps1p-dependent arsenite uptake and tolerance in yeast.Molecular biology of the cell, 17 10
G. Mandal, Mansi Sharma, M. Kruse, Claudia Sander-Juelch, L. Munro, Yong Wang, Jenny Vilg, Markus Tamás, H. Bhattacharjee, M. Wiese, R. Mukhopadhyay (2012)
Modulation of Leishmania major aquaglyceroporin activity by a mitogen‐activated protein kinaseMolecular Microbiology, 85
Hung-chi Yang, Jiujun Cheng, T. Finan, B. Rosen, H. Bhattacharjee (2005)
Novel Pathway for Arsenic Detoxification in the Legume Symbiont Sinorhizobium melilotiJournal of Bacteriology, 187
R. Mukhopadhyay, H. Bhattacharjee, B. Rosen (2014)
Aquaglyceroporins: generalized metalloid channels.Biochimica et biophysica acta, 1840 5
Thanh Ngu, M. Stillman (2006)
Arsenic binding to human metallothionein.Journal of the American Chemical Society, 128 38
Siucheong Yan, K. Ding, Li Zhang, Hongzhe Sun (2000)
Complexation of Antimony(III) by Trypanothione.Angewandte Chemie, 39 23
Omar Sanders, C. Rensing, M. Kuroda, B. Mitra, B. Rosen (1997)
Antimonite is accumulated by the glycerol facilitator GlpF in Escherichia coliJournal of Bacteriology, 179
Zesheng Li, M. Szczypka, Yu-ping Lu, D. Thiele, P. Rea (1996)
The Yeast Cadmium Factor Protein (YCF1) Is a Vacuolar Glutathione S-Conjugate Pump (*)The Journal of Biological Chemistry, 271
M. Ouellette, F. Fase-Fowler, Piet Borst (1990)
The amplified H circle of methotrexate‐resistant leishmania tarentolae contains a novel P‐glycoprotein gene.The EMBO Journal, 9
Rappa G. Lorico A. Flavell R. A. Sartorelli A. C.
Evidence that the multidrug resistance
A. Ramírez‐Solís, Rita Mukopadhyay, B. Rosen, Timothy Stemmler (2004)
Experimental and theoretical characterization of arsenite in water: insights into the coordination environment of As-O.Inorganic chemistry, 43 9
Markus Tamás, Sandeep Sharma, Sebastian Ibstedt, Therese Jacobson, P. Christen (2014)
Heavy Metals and Metalloids As a Cause for Protein Misfolding and AggregationBiomolecules, 4
E. Lombi, P. Holm (2010)
Metalloids, soil chemistry and the environment.Advances in experimental medicine and biology, 679
L. Vernhet, A. Courtois, N. Allain, L. Payen, J. Anger, A. Guillouzo, O. Fardel (1999)
Overexpression of the multidrug resistance‐associated protein (MRP1) in human heavy metal‐selected tumor cellsFEBS Letters, 443
R. Zangi, Montserrat Filella (2012)
Transport routes of metalloids into and out of the cell: a review of the current knowledge.Chemico-biological interactions, 197 1
Jie Liu, Yaping Liu, R. Goyer, W. Achanzar, M. Waalkes (2000)
Metallothionein-I/II null mice are more sensitive than wild-type mice to the hepatotoxic and nephrotoxic effects of chronic oral or injected inorganic arsenicals.Toxicological sciences : an official journal of the Society of Toxicology, 55 2
Won-Yong Song, Jiyoung Park, D. Mendoza-Cózatl, Marianne Suter-Grotemeyer, Donghwan Shim, S. Hörtensteiner, Markus Geisler, Barbara Weder, P. Rea, D. Rentsch, J. Schroeder, Youngsook Lee, E. Martinoia (2010)
Arsenic tolerance in Arabidopsis is mediated by two ABCC-type phytochelatin transportersProceedings of the National Academy of Sciences, 107
R. Wysocki, Markus Tamás (2010)
How Saccharomyces cerevisiae copes with toxic metals and metalloids.FEMS microbiology reviews, 34 6
Takehiro Kamiya, T. Fujiwara (2009)
Arabidopsis NIP1;1 transports antimonite and determines antimonite sensitivity.Plant & cell physiology, 50 11
J. Ma, N. Yamaji, Namiki Mitani, Xiao-Yan Xu, Yu-hong Su, S. McGrath, F. Zhao (2008)
Transporters of arsenite in rice and their role in arsenic accumulation in rice grainProceedings of the National Academy of Sciences, 105
J Wu, B. Rosen (1993)
Metalloregulated expression of the ars operon.The Journal of biological chemistry, 268 1
M. Mollapour, P. Piper (2007)
Hog1 Mitogen-Activated Protein Kinase Phosphorylation Targets the Yeast Fps1 Aquaglyceroporin for Endocytosis, Thereby Rendering Cells Resistant to Acetic AcidMolecular and Cellular Biology, 27
M. Ghosh, Jian Shen, Barry Rosen (1999)
Pathways of As(III) detoxification in Saccharomyces cerevisiae.Proceedings of the National Academy of Sciences of the United States of America, 96 9
M. Naujokas, B. Anderson, H. Ahsan, H. Aposhian, J. Graziano, C. Thompson, W. Suk (2013)
The Broad Scope of Health Effects from Chronic Arsenic Exposure: Update on a Worldwide Public Health ProblemEnvironmental Health Perspectives, 121
Y. Di, Markus Tamás (2007)
Regulation of the arsenic-responsive transcription factor Yap8p involves the ubiquitin-proteasome pathwayJournal of Cell Science, 120
Zijuan Liu, J. Carbrey, P. Agre, B. Rosen (2004)
Arsenic trioxide uptake by human and rat aquaglyceroporins.Biochemical and biophysical research communications, 316 4
G. Bienert, M. Schüssler, T. Jahn (2008)
Metalloids: essential, beneficial or toxic? Major intrinsic proteins sort it out.Trends in biochemical sciences, 33 1
Y. Ilina, E. Sloma, Ewa Maciaszczyk-Dziubinska, M. Novotný, Michael Thorsen, R. Wysocki, Markus Tamás (2008)
Characterization of the DNA-binding motif of the arsenic-responsive transcription factor Yap8p.The Biochemical journal, 415 3
Zijuan Liu, E. Boles, B. Rosen (2004)
Arsenic Trioxide Uptake by Hexose Permeases in Saccharomyces cerevisiae*Journal of Biological Chemistry, 279
Xuan Jiang, Joseph Mcdermott, A. Ajees, Barry Rosen, Barry Rosen, Zijuan Liu (2010)
Trivalent arsenicals and glucose use different translocation pathways in mammalian GLUT1.Metallomics : integrated biometal science, 2 3
E. Leslie (2012)
Arsenic-glutathione conjugate transport by the human multidrug resistance proteins (MRPs/ABCCs).Journal of inorganic biochemistry, 108
D. Légaré, Barbara Papadopoulou, G. Roy, R. Mukhopadhyay, Anass Haimeur, S. Dey, Katherine Grondin, Christian Brochu, Barry Rosen, Marc Ouellette (1997)
Efflux systems and increased trypanothione levels in arsenite-resistant Leishmania.Experimental parasitology, 87 3
R. Ge, Hongzhe Sun (2007)
Bioinorganic chemistry of bismuth and antimony: target sites of metallodrugs.Accounts of chemical research, 40 4
Ewa Maciaszczyk-Dziubinska, I. Migdal, M. Migocka, Tomasz Bocer, R. Wysocki (2010)
The yeast aquaglyceroporin Fps1p is a bidirectional arsenite channelFEBS Letters, 584
Michael Thorsen, Gilles Lagniel, E. Kristiansson, C. Junot, O. Nerman, J. Labarre, Markus Tamás (2007)
Quantitative transcriptome, proteome, and sulfur metabolite profiling of the Saccharomyces cerevisiae response to arsenite.Physiological genomics, 30 1
S. Wyllie, M. Cunningham, A. Fairlamb (2004)
Dual Action of Antimonial Drugs on Thiol Redox Metabolism in the Human Pathogen Leishmania donovani*Journal of Biological Chemistry, 279
Ewa Maciaszczyk-Dziubinska, D. Wawrzycka, E. Sloma, M. Migocka, R. Wysocki (2010)
The yeast permease Acr3p is a dual arsenite and antimonite plasma membrane transporter.Biochimica et biophysica acta, 1798 11
Ewa Maciaszczyk-Dziubinska, M. Migocka, R. Wysocki (2011)
Acr3p is a plasma membrane antiporter that catalyzes As(III)/H(+) and Sb(III)/H(+) exchange in Saccharomyces cerevisiae.Biochimica et biophysica acta, 1808 7
Siucheong Yan, Fei Li, K. Ding, Hongzhe Sun (2003)
Reduction of pentavalent antimony by trypanothione and formation of a binary and ternary complex of antimony(III) and trypanothioneJBIC Journal of Biological Inorganic Chemistry, 8
Siucheong Yan, I. Wong, L. Chow, Hongzhe Sun (2003)
Rapid reduction of pentavalent antimony by trypanothione: potential relevance to antimonial activation.Chemical communications, 2
Emily Indriolo, Gunnam Na, D. Ellis, D. Salt, J. Banks (2010)
A Vacuolar Arsenite Transporter Necessary for Arsenic Tolerance in the Arsenic Hyperaccumulating Fern Pteris vittata Is Missing in Flowering Plants[W][OA]Plant Cell, 22
Maharjan M. Singh S. Chatterjee M. Madhubala R.
Role of
F. Frézard, C. Demicheli, R. Ribeiro (2009)
Pentavalent Antimonials: New Perspectives for Old DrugsMolecules, 14
Jongmin Lee, W. Reiter, I. Dohnal, Christa Gregori, Sara Beese-Sims, K. Kuchler, G. Ammerer, D. Levin (2013)
MAPK Hog1 closes the S. cerevisiae glycerol channel Fps1 by phosphorylating and displacing its positive regulatorsGenes & Development, 27
A. Porquet, Montserrat Filella (2007)
Structural evidence of the similarity of Sb(OH)3 and As(OH)3 with glycerol: implications for their uptake.Chemical research in toxicology, 20 9
P. Baiocco, G. Colotti, S. Franceschini, A. Ilari (2009)
Molecular basis of antimony treatment in leishmaniasis.Journal of medicinal chemistry, 52 8
B. Gourbal, Nil Sonuç, H. Bhattacharjee, D. Légaré, S. Sundar, M. Ouellette, B. Rosen, R. Mukhopadhyay (2004)
Drug Uptake and Modulation of Drug Resistance in Leishmania by an Aquaglyceroporin*Journal of Biological Chemistry, 279
Yuling Meng, Zijuan Liu, B. Rosen (2004)
As(III) and Sb(III) Uptake by GlpF and Efflux by ArsB in Escherichia coli*Journal of Biological Chemistry, 279
B. Rosen, Markus Tamás (2010)
Arsenic transport in prokaryotes and eukaryotic microbes.Advances in experimental medicine and biology, 679
R. Wysocki, C. Chery, D. Wawrzycka, M. Hulle, R. Cornelis, J. Thevelein, Markus Tamás (2001)
The glycerol channel Fps1p mediates the uptake of arsenite and antimonite in Saccharomyces cerevisiaeMolecular Microbiology, 40
M. Maharjan, Sushma Singh, M. Chatterjee, R. Madhubala (2008)
Role of aquaglyceroporin (AQP1) gene and drug uptake in antimony-resistant clinical isolates of Leishmania donovani.The American journal of tropical medicine and hygiene, 79 1
R. Wysocki, P. Bobrowicz, S. Ułaszewski (1997)
The Saccharomyces cerevisiae ACR3 Gene Encodes a Putative Membrane Protein Involved in Arsenite Transport*The Journal of Biological Chemistry, 272
Sundar S. Chakravarty J.
Antimony toxicity.
Vernhet L. Courtois A. Allain N. Payen L. Anger J. P. Guillouzo A. Fardel O.
Overexpression of the multidrug resistance-associated
Environmental contextAntimony is a toxic metalloid that is used in a wide range of modern technology applications and in medical treatments. The accelerating needs for antimony in various industrial applications has led to concerns about increased human and environmental exposure. This review provides a brief summary of the biological properties of antimony and its mechanisms of actions in cells.AbstractAntimony is a toxic metalloid that is naturally present in low amounts in the environment, but can locally reach high concentrations at mining and processing sites. Today, antimony is used in a wide range of modern technology applications and is also an important constituent of pharmacological drugs. The increasing use of antimony has led to concerns about human and environmental exposure. Yet little is known about the biological properties of antimony and its mechanisms of actions in cells. This review will provide a brief summary of how antimony enters and affects cells, and how cells deal with the presence of this metalloid to acquire resistance.
Environmental Chemistry – CSIRO Publishing
Published: Jan 1, 2016
Read and print from thousands of top scholarly journals.
Already have an account? Log in
Bookmark this article. You can see your Bookmarks on your DeepDyve Library.
To save an article, log in first, or sign up for a DeepDyve account if you don’t already have one.
Copy and paste the desired citation format or use the link below to download a file formatted for EndNote
Access the full text.
Sign up today, get DeepDyve free for 14 days.
All DeepDyve websites use cookies to improve your online experience. They were placed on your computer when you launched this website. You can change your cookie settings through your browser.