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Chest X-ray Image Analysis and Penehyclidine Hydrochloride Postconditioning Influence of Lung Ischemia Reperfusion Injury

Chest X-ray Image Analysis and Penehyclidine Hydrochloride Postconditioning Influence of Lung... <jats:p><jats:italic>Purpose</jats:italic>: We analyze chest X-ray diagnosis results of patients undergoing cardiopulmonary bypass heart surgery in intensive care unit (ICU). In our previous study, we found that penehyclidine hydrochloride (PHC) preconditioning pretects lung function and reduced the apoptosis. Although preconditioning is effective, this clinical treatment is often given only when symptoms appear, when postconditioning is easier to administer. In this study, after confirming the lung condition via medical image analysis, we aimed to look the effect of high-dose penehyclidine hydrochloride postconditioning in lung after I/R in rats, and the apoptosis mechanisms involved. <jats:italic>Methods</jats:italic>: Chest X-ray was taken in 256 adult patients under cardiopulmonary bypass with heart syurery. Medical image analysis was preliminarily performed, the diagnostic results were analyzed. Rats were subjected to ischemia in left lung 45 min, and then 2 h reperfusion, and treated with PHC. We then observed the effects of PHC on the following: lung function, lung injury, oxidative stress, rate of apoptosis of lung cells, apoptosis-related proteins, and the p38 MAPK pathway.<jats:italic> Results</jats:italic>: Analysis results of chest X-ray suggest multiple pulmonary complications after cardiopulmonary bypass heart surgery. The laboratory results showed that high-dose penehyclidine hydrochloride postconditioning significantly protected lung function, reduced oxidative stress and apoptosis of the lungs caused by reperfusion, and inhibited activation of the p38 MAPK pathway.<jats:italic> Conclusion</jats:italic>: Analysis results of chest X-ray show multiple pulmonary complications after cardiopulmonary bypass heart surgery. This study suggests that high-dose penehyclidine hydrochloride can treat lung I/R injury.</jats:p> http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Journal of Medical Imaging and Health Informatics CrossRef

Chest X-ray Image Analysis and Penehyclidine Hydrochloride Postconditioning Influence of Lung Ischemia Reperfusion Injury

Journal of Medical Imaging and Health Informatics , Volume 10 (12): 2834-2841 – Dec 1, 2020

Chest X-ray Image Analysis and Penehyclidine Hydrochloride Postconditioning Influence of Lung Ischemia Reperfusion Injury


Abstract

<jats:p><jats:italic>Purpose</jats:italic>: We analyze chest X-ray diagnosis results of patients undergoing cardiopulmonary bypass heart surgery in intensive care unit (ICU). In our previous study, we found that penehyclidine hydrochloride (PHC) preconditioning pretects lung function and reduced the apoptosis.
Although preconditioning is effective, this clinical treatment is often given only when symptoms appear, when postconditioning is easier to administer. In this study, after confirming the lung condition via medical image analysis, we aimed to look the effect of high-dose penehyclidine hydrochloride
postconditioning in lung after I/R in rats, and the apoptosis mechanisms involved. <jats:italic>Methods</jats:italic>: Chest X-ray was taken in 256 adult patients under cardiopulmonary bypass with heart syurery. Medical image analysis was preliminarily performed, the diagnostic results were analyzed. Rats were
subjected to ischemia in left lung 45 min, and then 2 h reperfusion, and treated with PHC. We then observed the effects of PHC on the following: lung function, lung injury, oxidative stress, rate of apoptosis of lung cells, apoptosis-related proteins, and the p38 MAPK pathway.<jats:italic> Results</jats:italic>:
Analysis results of chest X-ray suggest multiple pulmonary complications after cardiopulmonary bypass heart surgery. The laboratory results showed that high-dose penehyclidine hydrochloride postconditioning significantly protected lung function, reduced oxidative stress and apoptosis of the
lungs caused by reperfusion, and inhibited activation of the p38 MAPK pathway.<jats:italic> Conclusion</jats:italic>: Analysis results of chest X-ray show multiple pulmonary complications after cardiopulmonary bypass heart surgery. This study suggests that high-dose penehyclidine hydrochloride can treat lung
I/R injury.</jats:p>

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Publisher
CrossRef
ISSN
2156-7018
DOI
10.1166/jmihi.2020.3249
Publisher site
See Article on Publisher Site

Abstract

<jats:p><jats:italic>Purpose</jats:italic>: We analyze chest X-ray diagnosis results of patients undergoing cardiopulmonary bypass heart surgery in intensive care unit (ICU). In our previous study, we found that penehyclidine hydrochloride (PHC) preconditioning pretects lung function and reduced the apoptosis. Although preconditioning is effective, this clinical treatment is often given only when symptoms appear, when postconditioning is easier to administer. In this study, after confirming the lung condition via medical image analysis, we aimed to look the effect of high-dose penehyclidine hydrochloride postconditioning in lung after I/R in rats, and the apoptosis mechanisms involved. <jats:italic>Methods</jats:italic>: Chest X-ray was taken in 256 adult patients under cardiopulmonary bypass with heart syurery. Medical image analysis was preliminarily performed, the diagnostic results were analyzed. Rats were subjected to ischemia in left lung 45 min, and then 2 h reperfusion, and treated with PHC. We then observed the effects of PHC on the following: lung function, lung injury, oxidative stress, rate of apoptosis of lung cells, apoptosis-related proteins, and the p38 MAPK pathway.<jats:italic> Results</jats:italic>: Analysis results of chest X-ray suggest multiple pulmonary complications after cardiopulmonary bypass heart surgery. The laboratory results showed that high-dose penehyclidine hydrochloride postconditioning significantly protected lung function, reduced oxidative stress and apoptosis of the lungs caused by reperfusion, and inhibited activation of the p38 MAPK pathway.<jats:italic> Conclusion</jats:italic>: Analysis results of chest X-ray show multiple pulmonary complications after cardiopulmonary bypass heart surgery. This study suggests that high-dose penehyclidine hydrochloride can treat lung I/R injury.</jats:p>

Journal

Journal of Medical Imaging and Health InformaticsCrossRef

Published: Dec 1, 2020

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