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Serum α-fetoprotein level as a biomarker for early recurrence after R0 resection in primary hepatocellular carcinoma

Serum α-fetoprotein level as a biomarker for early recurrence after R0 resection in primary... ObjectivesTo investigate the impact of serum α-fetoprotein (AFP) levels on survival and early recurrence after R0 resection in primary hepatocellular carcinoma (HCC).MethodsWe retrospectively analyzed clinical data of 582 patients with primary HCC (male: 488, female: 94; mean age: 51 years [age range, 31-73 years]) who underwent R0 resection between January 1997 and December 2009. The 1-, 3-, and 5-year overall survival (OS) rates and the clinico-pathological factors between the AFP-negative and AFP-positive groups were compared. Risk factors of early recurrence in the AFP-positive group were further analyzed.ResultsAge and histological differentiation were significantly lower in the AFP-positive group than in AFP-negative group (χ2=1 1.004, 32.293; P=0.000). In the AFP-positive group, serum γ-glutamyl transferase levels, tumor diameters, TNM stage, and early recurrence rate were higher (χ2=9.814 to 14.009, P<0.05), whereas the proportion of solitary HCC was lower (χ2=8.509, P=0.004). The 1-, 3-, and 5-year OS rates in the AFP-positive group were 80.5%, 66.9%, and 40.2%, respectively, and those in the AFP-negative group were 89.2%, 79.9%, and 50.3%, respectively (χ2=11.884, P=0.001). The 1-, 3-, and 5-year disease-free survival rates were 65.6%, 48.5%, 29.6% in the AFP-positive group and 81.7%, 63.9%, 42.1% in the AFP-negative group respectively (χ2=15.574, P=0.000). The median OS times of early recurrence and non-early recurrence were 10 and 62 months, respectively (χ2=45.013, P=0.000), and their median survival times from recurrence to death were 6 and 14 months, respectively (χ2=40.581, P=0.000). Multiple-factor analysis suggested non-solitary HCC and low histological differentiation are independent risk factors influencing early recurrence of HCC.ConclusionElevated preoperative serum AFP levels were indicative of early HCC recurrence. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Family Medicine and Community Health British Medical Journal

Serum α-fetoprotein level as a biomarker for early recurrence after R0 resection in primary hepatocellular carcinoma

Serum α-fetoprotein level as a biomarker for early recurrence after R0 resection in primary hepatocellular carcinoma

Family Medicine and Community Health , Volume 1 (2) – Jun 1, 2013

Abstract

ObjectivesTo investigate the impact of serum α-fetoprotein (AFP) levels on survival and early recurrence after R0 resection in primary hepatocellular carcinoma (HCC).MethodsWe retrospectively analyzed clinical data of 582 patients with primary HCC (male: 488, female: 94; mean age: 51 years [age range, 31-73 years]) who underwent R0 resection between January 1997 and December 2009. The 1-, 3-, and 5-year overall survival (OS) rates and the clinico-pathological factors between the AFP-negative and AFP-positive groups were compared. Risk factors of early recurrence in the AFP-positive group were further analyzed.ResultsAge and histological differentiation were significantly lower in the AFP-positive group than in AFP-negative group (χ2=1 1.004, 32.293; P=0.000). In the AFP-positive group, serum γ-glutamyl transferase levels, tumor diameters, TNM stage, and early recurrence rate were higher (χ2=9.814 to 14.009, P<0.05), whereas the proportion of solitary HCC was lower (χ2=8.509, P=0.004). The 1-, 3-, and 5-year OS rates in the AFP-positive group were 80.5%, 66.9%, and 40.2%, respectively, and those in the AFP-negative group were 89.2%, 79.9%, and 50.3%, respectively (χ2=11.884, P=0.001). The 1-, 3-, and 5-year disease-free survival rates were 65.6%, 48.5%, 29.6% in the AFP-positive group and 81.7%, 63.9%, 42.1% in the AFP-negative group respectively (χ2=15.574, P=0.000). The median OS times of early recurrence and non-early recurrence were 10 and 62 months, respectively (χ2=45.013, P=0.000), and their median survival times from recurrence to death were 6 and 14 months, respectively (χ2=40.581, P=0.000). Multiple-factor analysis suggested non-solitary HCC and low histological differentiation are independent risk factors influencing early recurrence of HCC.ConclusionElevated preoperative serum AFP levels were indicative of early HCC recurrence.

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References (9)

Publisher
British Medical Journal
Copyright
© 2013 Family Medicine and Community Health
ISSN
2305-6983
eISSN
2009-8774
DOI
10.15212/FMCH.2013.0202
Publisher site
See Article on Publisher Site

Abstract

ObjectivesTo investigate the impact of serum α-fetoprotein (AFP) levels on survival and early recurrence after R0 resection in primary hepatocellular carcinoma (HCC).MethodsWe retrospectively analyzed clinical data of 582 patients with primary HCC (male: 488, female: 94; mean age: 51 years [age range, 31-73 years]) who underwent R0 resection between January 1997 and December 2009. The 1-, 3-, and 5-year overall survival (OS) rates and the clinico-pathological factors between the AFP-negative and AFP-positive groups were compared. Risk factors of early recurrence in the AFP-positive group were further analyzed.ResultsAge and histological differentiation were significantly lower in the AFP-positive group than in AFP-negative group (χ2=1 1.004, 32.293; P=0.000). In the AFP-positive group, serum γ-glutamyl transferase levels, tumor diameters, TNM stage, and early recurrence rate were higher (χ2=9.814 to 14.009, P<0.05), whereas the proportion of solitary HCC was lower (χ2=8.509, P=0.004). The 1-, 3-, and 5-year OS rates in the AFP-positive group were 80.5%, 66.9%, and 40.2%, respectively, and those in the AFP-negative group were 89.2%, 79.9%, and 50.3%, respectively (χ2=11.884, P=0.001). The 1-, 3-, and 5-year disease-free survival rates were 65.6%, 48.5%, 29.6% in the AFP-positive group and 81.7%, 63.9%, 42.1% in the AFP-negative group respectively (χ2=15.574, P=0.000). The median OS times of early recurrence and non-early recurrence were 10 and 62 months, respectively (χ2=45.013, P=0.000), and their median survival times from recurrence to death were 6 and 14 months, respectively (χ2=40.581, P=0.000). Multiple-factor analysis suggested non-solitary HCC and low histological differentiation are independent risk factors influencing early recurrence of HCC.ConclusionElevated preoperative serum AFP levels were indicative of early HCC recurrence.

Journal

Family Medicine and Community HealthBritish Medical Journal

Published: Jun 1, 2013

Keywords: CarcinomaHepatocellularAlpha-FetoproteinsHepatectomyLocal neoplasm recurrence

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