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Role of fractional flow reserve in guiding intervention for borderline coronary lesions

Role of fractional flow reserve in guiding intervention for borderline coronary lesions ObjectiveThis study investigated the clinical efficacy and value of fractional flow reserve (FFR) in guiding the treatment of borderline coronary lesions.MethodsForty-three patients with borderline coronary lesions, as demonstrated by coronary angiography, and who had FFR measurements were selected. The patients were grouped according to FFR values. All patients were evaluated 6 months after surgery to record major adverse cardiac events (MACE [sudden cardiac death, non-fatal myocardial infarction, or revascularization]) and recurrence of angina pectoris.ResultsAfter the 6-month follow-up, no sudden cardiac deaths or myocardial infarctions occurred in either group, and there were no statistically significant differences (P>0.05). Inter-group comparisons showed that in the groups with a FFR<0.75, the recurrence rate of angina pectoris in the PCI group was significantly lower than the drug therapy group (0.08% vs. 0.27%, P<0.05). In contrast, the recurrence rate of angina pectoris in the PCI group among the groups with a FFR<0.75 revealed no statistical significance when compared to the groups with a FFR≥0.75 (0.08% vs. 0.05%, P>0.05). The recurrence rate of angina pectoris in the simple drug therapy group among the groups with a FFR<0.75 was higher than the same groups with a FFR≥0.75 (0.27% vs. 0.05%, P<0.05).ConclusionWhen coronary intervention is used to treat borderline lesions, guiding interventional therapy with measurement of FFR does not increase the incidence of adverse cardiovascular events in the short term and can better guide PCI therapy. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Family Medicine and Community Health British Medical Journal

Role of fractional flow reserve in guiding intervention for borderline coronary lesions

Role of fractional flow reserve in guiding intervention for borderline coronary lesions

Family Medicine and Community Health , Volume 2 (3) – Sep 1, 2014

Abstract

ObjectiveThis study investigated the clinical efficacy and value of fractional flow reserve (FFR) in guiding the treatment of borderline coronary lesions.MethodsForty-three patients with borderline coronary lesions, as demonstrated by coronary angiography, and who had FFR measurements were selected. The patients were grouped according to FFR values. All patients were evaluated 6 months after surgery to record major adverse cardiac events (MACE [sudden cardiac death, non-fatal myocardial infarction, or revascularization]) and recurrence of angina pectoris.ResultsAfter the 6-month follow-up, no sudden cardiac deaths or myocardial infarctions occurred in either group, and there were no statistically significant differences (P>0.05). Inter-group comparisons showed that in the groups with a FFR<0.75, the recurrence rate of angina pectoris in the PCI group was significantly lower than the drug therapy group (0.08% vs. 0.27%, P<0.05). In contrast, the recurrence rate of angina pectoris in the PCI group among the groups with a FFR<0.75 revealed no statistical significance when compared to the groups with a FFR≥0.75 (0.08% vs. 0.05%, P>0.05). The recurrence rate of angina pectoris in the simple drug therapy group among the groups with a FFR<0.75 was higher than the same groups with a FFR≥0.75 (0.27% vs. 0.05%, P<0.05).ConclusionWhen coronary intervention is used to treat borderline lesions, guiding interventional therapy with measurement of FFR does not increase the incidence of adverse cardiovascular events in the short term and can better guide PCI therapy.

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Publisher
British Medical Journal
Copyright
© 2014 Family Medicine and Community Health
ISSN
2305-6983
eISSN
2009-8774
DOI
10.15212/FMCH.2014.0117
Publisher site
See Article on Publisher Site

Abstract

ObjectiveThis study investigated the clinical efficacy and value of fractional flow reserve (FFR) in guiding the treatment of borderline coronary lesions.MethodsForty-three patients with borderline coronary lesions, as demonstrated by coronary angiography, and who had FFR measurements were selected. The patients were grouped according to FFR values. All patients were evaluated 6 months after surgery to record major adverse cardiac events (MACE [sudden cardiac death, non-fatal myocardial infarction, or revascularization]) and recurrence of angina pectoris.ResultsAfter the 6-month follow-up, no sudden cardiac deaths or myocardial infarctions occurred in either group, and there were no statistically significant differences (P>0.05). Inter-group comparisons showed that in the groups with a FFR<0.75, the recurrence rate of angina pectoris in the PCI group was significantly lower than the drug therapy group (0.08% vs. 0.27%, P<0.05). In contrast, the recurrence rate of angina pectoris in the PCI group among the groups with a FFR<0.75 revealed no statistical significance when compared to the groups with a FFR≥0.75 (0.08% vs. 0.05%, P>0.05). The recurrence rate of angina pectoris in the simple drug therapy group among the groups with a FFR<0.75 was higher than the same groups with a FFR≥0.75 (0.27% vs. 0.05%, P<0.05).ConclusionWhen coronary intervention is used to treat borderline lesions, guiding interventional therapy with measurement of FFR does not increase the incidence of adverse cardiovascular events in the short term and can better guide PCI therapy.

Journal

Family Medicine and Community HealthBritish Medical Journal

Published: Sep 1, 2014

Keywords: Coronary interventionBorderline lesionFractional flow reserve

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