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M. Schilham, Anne Wilson, P. Moerer, Barry Benaissa-Trouw, A. Cumano, H. Clevers (1998)
Critical involvement of Tcf-1 in expansion of thymocytes.Journal of immunology, 161 8
R. Medzhitov, C. Janeway (1998)
Innate immune recognition and control of adaptive immune responses.Seminars in immunology, 10 5
M. Merchant, R. Swart, R. Katzman, M. Ikeda, A. Ikeda, R. Longnecker, Michelle Dykstra, S. Pierce (2001)
The Effects of the Epstein-Barr Virus Latent Membrane Protein 2a on B Cell FunctionInternational Reviews of Immunology, 20
T. Nishida, H. Yasuda (2002)
PIAS1 and PIASxα Function as SUMO-E3 Ligases toward Androgen Receptor and Repress Androgen Receptor-dependent Transcription*The Journal of Biological Chemistry, 277
A. Capili, D. Schultz, F. Rauscher, K. Borden (2001)
Solution structure of the PHD domain from the KAP‐1 corepressor: structural determinants for PHD, RING and LIM zinc‐binding domainsThe EMBO Journal, 20
Lynn Verplank, F. Bouamr, Tracy LaGrassa, B. Agresta, A. Kikonyogo, J. Leis, C. Carter (2001)
Tsg101, a homologue of ubiquitin-conjugating (E2) enzymes, binds the L domain in HIV type 1 Pr55GagProceedings of the National Academy of Sciences of the United States of America, 98
Erica Johnson, Aseem Gupta (2001)
An E3-like Factor that Promotes SUMO Conjugation to the Yeast SeptinsCell, 106
Y. Liu, A. Altman (1998)
Cbl: complex formation and functional implications.Cellular signalling, 10 6
J. Yewdell, L. Antón, J. Bennink (1996)
Defective ribosomal products (DRiPs): a major source of antigenic peptides for MHC class I molecules?Journal of immunology, 157 5
M. Wetering, W. Lau, H. Clevers (2002)
WNT Signaling and Lymphocyte DevelopmentCell, 109
Jidong Liu, M. Furukawa, Tomohiro Matsumoto, Y. Xiong (2002)
NEDD8 modification of CUL1 dissociates p120(CAND1), an inhibitor of CUL1-SKP1 binding and SCF ligases.Molecular cell, 10 6
A. Moustakas, S. Souchelnytskyi, C. Heldin (2001)
Smad regulation in TGF-beta signal transduction.Journal of cell science, 114 Pt 24
K. Rock, A. Goldberg (1999)
Degradation of cell proteins and the generation of MHC class I-presented peptides.Annual review of immunology, 17
Shengyun Fang, J. Jensen, R. Ludwig, K. Vousden, A. Weissman (2000)
Mdm2 Is a RING Finger-dependent Ubiquitin Protein Ligase for Itself and p53*The Journal of Biological Chemistry, 275
Yili Yang, Shengyun Fang, J. Jensen, A. Weissman, J. Ashwell (2000)
Ubiquitin protein ligase activity of IAPs and their degradation in proteasomes in response to apoptotic stimuli.Science, 288 5467
Gang Hu, E. Fearon (1999)
Siah-1 N-Terminal RING Domain Is Required for Proteolysis Function, and C-Terminal Sequences Regulate Oligomerization and Binding to Target ProteinsMolecular and Cellular Biology, 19
Tomoaki Kahyo, T. Nishida, Hideyo Yasuda (2001)
Involvement of PIAS1 in the sumoylation of tumor suppressor p53.Molecular cell, 8 3
O. Staub, S. Dho, Pauline Henry, Judy Correa, T. Ishikawa, J. Mcglade, D. Rotin (1996)
WW domains of Nedd4 bind to the proline‐rich PY motifs in the epithelial Na+ channel deleted in Liddle's syndrome.The EMBO Journal, 15
E. Spencer, Jin-qi Jiang, Zhijian Chen (1999)
Signal-induced ubiquitination of IκBα by the F-box protein Slimb/β-TrCPGenes & Development, 13
D. Hou, C. Cenciarelli, J. Jensen, H. Nguygen, A. Weissman (1994)
Activation-dependent ubiquitination of a T cell antigen receptor subunit on multiple intracellular lysines.The Journal of biological chemistry, 269 19
Neetu Gupta-Rossi, O. Bail, H. Gonen, C. Brou, F. Logeat, E. Six, A. Ciechanover, A. Israël (2001)
Functional Interaction between SEL-10, an F-box Protein, and the Nuclear Form of Activated Notch1 Receptor*The Journal of Biological Chemistry, 276
M. Lohrum, D. Woods, R. Ludwig, E. Balint, K. Vousden (2001)
C-Terminal Ubiquitination of p53 Contributes to Nuclear ExportMolecular and Cellular Biology, 21
J. Disanto, Werner Müller, D. Guy‐grand, A. Fischer, K. Rajewsky (1995)
Lymphoid development in mice with a targeted deletion of the interleukin 2 receptor gamma chain.Proceedings of the National Academy of Sciences of the United States of America, 92
Limin Li, Stanley Cohen (1996)
tsg101: A Novel Tumor Susceptibility Gene Isolated by Controlled Homozygous Functional Knockout of Allelic Loci in Mammalian CellsCell, 85
E. Pamer, P. Cresswell (1998)
Mechanisms of MHC class I--restricted antigen processing.Annual review of immunology, 16
N. Rao, I. Dodge, H. Band (2002)
The Cbl family of ubiquitin ligases: critical negative regulators of tyrosine kinase signaling in the immune systemJournal of Leukocyte Biology, 71
R. Tiedt, Boris Bartholdy, G. Matthias, J. Newell, P. Matthias (2001)
The RING finger protein Siah‐1 regulates the level of the transcriptional coactivator OBF‐1The EMBO Journal, 20
J. Mcgrath, S. Jentsch, A. Varshavsky (1991)
UBA 1: an essential yeast gene encoding ubiquitin‐activating enzyme.The EMBO Journal, 10
R. Schwartz (2003)
T cell anergy.Annual review of immunology, 21
Y. Ben-Neriah (2002)
Regulatory functions of ubiquitination in the immune systemNature Immunology, 3
M. Gaczynska, K. Rock, A. Goldberg (1993)
Gamma-interferon and expression of MHC genes regulate peptide hydrolysis by proteasomes.Nature, 365 6443
J. Schmitt, P. Stork (2002)
PKA phosphorylation of Src mediates cAMP's inhibition of cell growth via Rap1.Molecular cell, 9 1
Jihong Jiang, C. Ballinger, Yaxu Wu, Q. Dai, D. Cyr, J. Höhfeld, C. Patterson (2001)
CHIP Is a U-box-dependent E3 Ubiquitin LigaseThe Journal of Biological Chemistry, 276
R. Paolini, R. Molfetta, L. Beitz, Juan Zhang, A. Scharenberg, M. Piccoli, L. Frati, R. Siraganian, A. Santoni (2002)
Activation of Syk Tyrosine Kinase Is Required for c-Cbl-mediated Ubiquitination of FcεRI and Syk in RBL Cells*The Journal of Biological Chemistry, 277
Zhiqun Wu, J. Earle, Shinichi Saito, C. Anderson, E. Appella, Yang Xu (2002)
Mutation of Mouse p53 Ser23 and the Response to DNA DamageMolecular and Cellular Biology, 22
S. Chiang, C. Baumann, M. Kanzaki, D. Thurmond, R. Watson, C. Neudauer, I. Macara, J. Pessin, A. Saltiel (2001)
Insulin-stimulated GLUT4 translocation requires the CAP-dependent activation of TC10Nature, 410
E. José, A. Borroto, F. Niedergang, A. Alcover, B. Alarcón (2000)
Triggering the TCR complex causes the downregulation of nonengaged receptors by a signal transduction-dependent mechanism.Immunity, 12 2
R. Glynne, S. Powis, S. Beck, A. Kelly, L. Kerr, J. Trowsdale (1991)
A proteasome-related gene between the two ABC transporter loci in the class II region of the human MHCNature, 353
A. Nakao, M. Afrakhte, A. Morn, T. Nakayama, J. Christian, R. Heuchel, S. Itoh, M. Kawabata, N. Heldin, C. Heldin, P. Dijke (1997)
Identification of Smad7, a TGFβ-inducible antagonist of TGF-β signallingNature, 389
G. Goldstein, M. Scheid, U. Hämmerling, D. Schlesinger, H. Niall, E. Boyse (1975)
Isolation of a polypeptide that has lymphocyte-differentiating properties and is probably represented universally in living cells.Proceedings of the National Academy of Sciences of the United States of America, 72 1
M. Murphy, Ralf Schnall, D. Venter, L. Barnett, I. Bertoncello, C. Thien, W. Langdon, D. Bowtell (1998)
Tissue Hyperplasia and Enhanced T-Cell Signalling via ZAP-70 in c-Cbl-Deficient MiceMolecular and Cellular Biology, 18
A. Wolfer, T. Bakker, Anne Wilson, M. Nicolas, V. Ioannidis, D. Littman, Christopher Wilson, W. Held, H. MacDonald, F. Radtke (2001)
Inactivation of Notch1 in immature thymocytes does not perturb CD4 or CD8 T cell developmentNature Immunology, 2
J. Guérin, J. Gelfi, S. Boullier, M. Delverdier, Frederique-Anne Bellanger, S. Bertagnoli, I. Drexler, G. Sutter, F. Messud-Petit (2002)
Myxoma Virus Leukemia-Associated Protein Is Responsible for Major Histocompatibility Complex Class I and Fas-CD95 Down-Regulation and Defines Scrapins, a New Group of Surface Cellular Receptor Abductor ProteinsJournal of Virology, 76
M. Hochstrasser (2001)
SP-RING for SUMO New Functions Bloom for a Ubiquitin-like ProteinCell, 107
V. Cerundolo, A. Benham, V. Braud, S. Mukherjee, K. Gould, B. Macino, J. Neefjes, Alain Townsend (1997)
The proteasome‐specific inhibitor lactacystin blocks presentation of cytotoxic T lymphocyte epitopes in human and murine cellsEuropean Journal of Immunology, 27
Peter Kavsak, R. Rasmussen, Carrie Causing, S. Bonni, Hai-qing Zhu, G. Thomsen, J. Wrana (2000)
Smad7 binds to Smurf2 to form an E3 ubiquitin ligase that targets the TGF beta receptor for degradation.Molecular cell, 6 6
A. Schmidt, Michael Wolde, C. Thiele, W. Fest, H. Kratzin, A. Podtelejnikov, W. Witke, W. Huttner, H. Söling (1999)
Endophilin I mediates synaptic vesicle formation by transfer of arachidonate to lysophosphatidic acidNature, 401
J. Yasuda, E. Hunter, M. Nakao, H. Shida (2002)
Functional involvement of a novel Nedd4‐like ubiquitin ligase on retrovirus buddingEMBO reports, 3
F. Radtke, Anne Wilson, G. Stark, Michelle Bauer, J. Meerwijk, H. Macdonald, M. Aguet (1999)
Deficient T cell fate specification in mice with an induced inactivation of Notch1.Immunity, 10 5
A. Viola, A. Lanzavecchia (1996)
T Cell Activation Determined by T Cell Receptor Number and Tunable ThresholdsScience, 273
A. Nikolaev, Muyang Li, N. Puskas, J. Qin, W. Gu (2003)
Parc A Cytoplasmic Anchor for p53Cell, 112
Baiyong Li, C. Tournier, R. Davis, R. Flavell (1999)
Regulation of IL‐4 expression by the transcription factor JunB during T helper cell differentiationThe EMBO Journal, 18
Yoshimitsu Takahashi, T. Kahyo, A. Toh-e, H. Yasuda, Y. Kikuchi (2001)
Yeast Ull1/Siz1 Is a Novel SUMO1/Smt3 Ligase for Septin Components and Functions as an Adaptor between Conjugating Enzyme and Substrates*The Journal of Biological Chemistry, 276
Hong-ying Wang, Yoav Altman, Deyu Fang, C. Elly, Yang Dai, Y. Shao, Yun-Cai Liu (2001)
Cbl Promotes Ubiquitination of the T Cell Receptor ζ through an Adaptor Function of Zap-70*The Journal of Biological Chemistry, 276
L. Walker, A. Abbas (2002)
The enemy within: keeping self-reactive T cells at bay in the peripheryNature Reviews Immunology, 2
C. Chambers, J. Allison (1999)
Costimulatory regulation of T cell function.Current opinion in cell biology, 11 2
W. Hon, Michael Wilson, K. Harlos, T. Claridge, C. Schofield, C. Pugh, P. Maxwell, P. Ratcliffe, D. Stuart, E. Jones (2002)
Structural basis for the recognition of hydroxyproline in HIF-1α by pVHLNature, 417
M. Michalek, E. Grant, C. Gramm, A. Goldberg, K. Rock (1993)
A role for the ubiquitin-dependent proteolytic pathway in MHC class l-restricted antigen presentationNature, 363
M. Treier, L. Staszewski, D. Bohmann (1994)
Ubiquitin-dependent c-Jun degradation in vivo is mediated by the δ domainCell, 78
R. Locksley, N. Killeen, M. Lenardo (2001)
The TNF and TNF Receptor Superfamilies Integrating Mammalian BiologyCell, 104
J. Boname, P. Stevenson (2001)
MHC class I ubiquitination by a viral PHD/LAP finger protein.Immunity, 15 4
A. Ito, Y. Kawaguchi, Chun‐Hsiang Lai, Jeffrey Kovacs, Y. Higashimoto, E. Appella, T. Yao (2002)
MDM2–HDAC1‐mediated deacetylation of p53 is required for its degradationThe EMBO Journal, 21
C. Joazeiro, S. Wing, Han-kuei Huang, J. Leverson, T. Hunter, Yun-Cai Liu (1999)
The tyrosine kinase negative regulator c-Cbl as a RING-type, E2-dependent ubiquitin-protein ligase.Science, 286 5438
M. Ivan, K. Kondo, H. Yang, W. Kim, J. Valiando, M. Ohh, A. Salic, J. Asara, William Lane, W. Kaelin (2001)
HIFα Targeted for VHL-Mediated Destruction by Proline Hydroxylation: Implications for O2 SensingScience, 292
M. Deftos, You-Wen He, E. Ojala, M. Bevan (1998)
Correlating notch signaling with thymocyte maturation.Immunity, 9 6
U. Schubert, L. Antón, I. Bačík, J. Cox, S. Bour, J. Bennink, M. Orłowski, K. Strebel, J. Yewdell (1998)
CD4 Glycoprotein Degradation Induced by Human Immunodeficiency Virus Type 1 Vpu Protein Requires the Function of Proteasomes and the Ubiquitin-Conjugating PathwayJournal of Virology, 72
V. Vogt (2000)
Ubiquitin in retrovirus assembly: actor or bystander?Proceedings of the National Academy of Sciences of the United States of America, 97 24
R. Conaway, C. Brower, J. Conaway (2002)
Emerging Roles of Ubiquitin in Transcription RegulationScience, 296
P. Jackson (2001)
A new RING for SUMO: wrestling transcriptional responses into nuclear bodies with PIAS family E3 SUMO ligases.Genes & development, 15 23
Zhimin Lu, Shuichan Xu, C. Joazeiro, M. Cobb, T. Hunter (2002)
The PHD domain of MEKK1 acts as an E3 ubiquitin ligase and mediates ubiquitination and degradation of ERK1/2.Molecular cell, 9 5
Guangyu Wu, S. Lyapina, I. Das, Jinhe Li, M. Gurney, A. Pauley, Inca Chui, R. Deshaies, J. Kitajewski (2001)
SEL-10 Is an Inhibitor of Notch Signaling That Targets Notch for Ubiquitin-Mediated Protein DegradationMolecular and Cellular Biology, 21
C. Pickart (2001)
Mechanisms underlying ubiquitination.Annual review of biochemistry, 70
R. Amson, M. Nemani, J. Roperch, D. Israeli, L. Bougueleret, I. Gall, M. Medhioub, G. Linares‐Cruz, F. Lethrosne, P. Pasturaud, L. Piouffre, S. Prieur, Laurent Susini, V. Alvaro, P. Millasseau, C. Guidicelli, H. Bui, C. Massart, L. Cazes, F. Dufour, H. Bruzzoni-Giovanelli, H. Owadi, C. Hennion, G. Charpak, A. Telerman (1996)
Isolation of 10 differentially expressed cDNAs in p53-induced apoptosis: activation of the vertebrate homologue of the drosophila seven in absentia gene.Proceedings of the National Academy of Sciences of the United States of America, 93 9
Joanna Timmins, G. Schoehn, S. Ricard-Blum, S. Scianimanico, T. Vernet, R. Ruigrok, W. Weissenhorn (2003)
Ebola virus matrix protein VP40 interaction with human cellular factors Tsg101 and Nedd4.Journal of molecular biology, 326 2
J. Martin-Serrano, Trinity Zang, P. Bieniasz (2001)
HIV-1 and Ebola virus encode small peptide motifs that recruit Tsg101 to sites of particle assembly to facilitate egressNature Medicine, 7
J. Letterio, A. Roberts (1998)
REGULATION OF IMMUNE RESPONSES BY TGF-β*Annual Review of Immunology, 16
S. Ghosh, M. Karin (2002)
Missing Pieces in the NF-κB PuzzleCell, 109
G. Levkowitz, H. Waterman, S. Ettenberg, M. Katz, A. Tsygankov, I. Alroy, S. Lavi, K. Iwai, Y. Reiss, A. Ciechanover, S. Lipkowitz, Y. Yarden (1999)
Ubiquitin ligase activity and tyrosine phosphorylation underlie suppression of growth factor signaling by c-Cbl/Sli-1.Molecular cell, 4 6
D. Demirov, Akira Ono, J. Orenstein, E. Freed (2002)
Overexpression of the N-terminal domain of TSG101 inhibits HIV-1 budding by blocking late domain functionProceedings of the National Academy of Sciences of the United States of America, 99
E. Claudio, K. Brown, S. Park, Hong-shan Wang, U. Siebenlist (2002)
BAFF-induced NEMO-independent processing of NF-κB2 in maturing B cellsNature Immunology, 3
Seiichi Nakamura, J. Roth, T. Mukhopadhyay (2000)
Multiple Lysine Mutations in the C-Terminal Domain of p53 Interfere with MDM2-Dependent Protein Degradation and UbiquitinationMolecular and Cellular Biology, 20
A. Deleo (1998)
p53-based immunotherapy of cancer.Critical reviews in immunology, 18 1-2
M. Naramura, I. Jang, H. Kole, Fang Huang, D. Haines, Hua Gu (2002)
c-Cbl and Cbl-b regulate T cell responsiveness by promoting ligand-induced TCR down-modulationNature Immunology, 3
V. Ioannidis, F. Beermann, H. Clevers, W. Held (2001)
The β-catenin–TCF-1 pathway ensures CD4+CD8+ thymocyte survivalNature Immunology, 2
Dominique Thomas, M. Tyers (2000)
Transcriptional regulation: Kamikaze activatorsCurrent Biology, 10
P. Polakis (2000)
Wnt signaling and cancer.Genes & development, 14 15
R. Dickins, I. Frew, C. House, M. O’Bryan, A. Holloway, I. Haviv, N. Traficante, D. Kretser, D. Bowtell (2002)
The Ubiquitin Ligase Component Siah1a Is Required for Completion of Meiosis I in Male MiceMolecular and Cellular Biology, 22
K. Lorick, J. Jensen, Shengyun Fang, A. Ong, S. Hatakeyama, A. Weissman (1999)
RING fingers mediate ubiquitin-conjugating enzyme (E2)-dependent ubiquitination.Proceedings of the National Academy of Sciences of the United States of America, 96 20
L. Donehower, M. Harvey, B. Slagle, M. McArthur, C. Montgomery, J. Butel, A. Bradley (1992)
Mice deficient for p53 are developmentally normal but susceptible to spontaneous tumoursNature, 356
A. Musti, M. Treier, D. Bohmann (1997)
Reduced Ubiquitin-Dependent Degradation of c-Jun After Phosphorylation by MAP KinasesScience, 275
Li Lin, G. Demartino, W. Greene (2000)
Cotranslational dimerization of the Rel homology domain of NF‐κB1 generates p50–p105 heterodimers and is required for effective p50 productionThe EMBO Journal, 19
Erica Johnson, G. Blobel (1997)
Ubc9p Is the Conjugating Enzyme for the Ubiquitin-like Protein Smt3p*The Journal of Biological Chemistry, 272
L. Lybarger, Xiaoli Wang, M. Harris, H. Virgin, T. Hansen (2003)
Virus subversion of the MHC class I peptide-loading complex.Immunity, 18 1
David Izon, Jennifer Punt, Lanwei Xu, F. Karnell, David Allman, Peggy Myung, N. Boerth, John Pui, G. Koretzky, Warren Pear (2001)
Notch1 regulates maturation of CD4+ and CD8+ thymocytes by modulating TCR signal strength.Immunity, 14 3
L. Gorelik, R. Flavell (2002)
Transforming growth factor-β in T-cell biologyNature Reviews Immunology, 2
Marjolein Kikkert, Gerco Hassink, M. Barel, Christian Hirsch, Fimme Wal, Emmanuel Wiertz (2001)
Ubiquitination is essential for human cytomegalovirus US11-mediated dislocation of MHC class I molecules from the endoplasmic reticulum to the cytosol.The Biochemical journal, 358 Pt 2
Mircea Ivan, W. Kaelin (2001)
The von Hippel-Lindau tumor suppressor protein.Current opinion in genetics & development, 11 1
G. Schönrich, U. Kalinke, F. Momburg, M. Malissen, A. Schmitt-Verhulst, B. Malissen, G. Hämmerling, B. Arnold (1991)
Down-regulation of T cell receptors on self-reactive T cells as a novel mechanism for extrathymic tolerance inductionCell, 65
T. Kamradt, N. Mitchison (2001)
Tolerance and autoimmunity.The New England journal of medicine, 344 9
S. Grossman, M. Deato, C. Brignone, H. Chan, A. Kung, H. Tagami, Y. Nakatani, D. Livingston (2003)
Polyubiquitination of p53 by a Ubiquitin Ligase Activity of p300Science, 300
Haitao Zhu, Peter Kavsak, S. Abdollah, J. Wrana, G. Thomsen (1999)
A SMAD ubiquitin ligase targets the BMP pathway and affects embryonic pattern formationNature, 400
Wenying Zhang, Y. Shao, Deyu Fang, Jianyong Huang, Myung-Shin Jeon, Yun-Cai Liu (2003)
Negative Regulation of T Cell Antigen Receptor-mediated Crk-L-C3G Signaling and Cell Adhesion by Cbl-b*Journal of Biological Chemistry, 278
S. Valitutti, S. Müller, M. Salio, A. Lanzavecchia (1997)
Degradation of T Cell Receptor (TCR)–CD3-ζ Complexes after Antigenic StimulationThe Journal of Experimental Medicine, 185
A. Kikonyogo, F. Bouamr, Marcy Vana, Yan Xiang, A. Aiyar, C. Carter, J. Leis (2001)
Proteins related to the Nedd4 family of ubiquitin protein ligases interact with the L domain of Rous sarcoma virus and are required for gag budding from cellsProceedings of the National Academy of Sciences of the United States of America, 98
M. Ikeda, A. Ikeda, R. Longnecker (2001)
PY Motifs of Epstein-Barr Virus LMP2A Regulate Protein Stability and Phosphorylation of LMP2A-Associated ProteinsJournal of Virology, 75
K. Yasutomo, C. Doyle, L. Miele, R. Germain (2000)
The duration of antigen receptor signalling determines CD4+ versus CD8+ T-cell lineage fateNature, 404
C. Janeway, R. Medzhitov (2002)
Innate immune recognition.Annual review of immunology, 20
G. Cope, Greg Suh, L. Aravind, Sylvia Schwarz, S. Zipursky, E. Koonin, R. Deshaies (2002)
Role of Predicted Metalloprotease Motif of Jab1/Csn5 in Cleavage of Nedd8 from Cul1Science, 298
M. Panigada, S. Porcellini, E. Barbier, Sonja Hoeflinger, P. Cazenave, Hua Gu, H. Band, H. Boehmer, F. Grassi (2002)
Constitutive Endocytosis and Degradation of the Pre-T Cell ReceptorThe Journal of Experimental Medicine, 195
S. Mandriota, K. Turner, D. Davies, P. Murray, N. Morgan, H. Sowter, C. Wykoff, E. Maher, A. Harris, P. Ratcliffe, P. Maxwell (2002)
HIF activation identifies early lesions in VHL kidneys: evidence for site-specific tumor suppressor function in the nephron.Cancer cell, 1 5
G. Winberg, L. Matskova, Fu Chen, P. Plant, D. Rotin, G. Gish, R. Ingham, I. Ernberg, T. Pawson (2000)
Latent Membrane Protein 2A of Epstein-Barr Virus Binds WW Domain E3 Protein-Ubiquitin Ligases That Ubiquitinate B-Cell Tyrosine KinasesMolecular and Cellular Biology, 20
P. Maxwell, M. Wiesener, G. Chang, S. Clifford, E. Vaux, M. Cockman, C. Wykoff, C. Pugh, E. Maher, P. Ratcliffe (1999)
The tumour suppressor protein VHL targets hypoxia-inducible factors for oxygen-dependent proteolysisNature, 399
Matthew Hart, J. Concordet, I. Lassot, I. Albert, R. Santos, Hervé Durand, C. Perret, B. Rubinfeld, F. Margottin, Richard Benarous, P. Polakis (1999)
The F-box protein β-TrCP associates with phosphorylated β-catenin and regulates its activity in the cellCurrent Biology, 9
Roseanne Hofmann, C. Pickart (1999)
Noncanonical MMS2-Encoded Ubiquitin-Conjugating Enzyme Functions in Assembly of Novel Polyubiquitin Chains for DNA RepairCell, 96
J. Huibregtse, M. Scheffner, S. Beaudenon, P. Howley (1995)
A family of proteins structurally and functionally related to the E6-AP ubiquitin-protein ligase.Proceedings of the National Academy of Sciences of the United States of America, 92
A. Hershko, A. Ciechanover, A. Varshavsky (2000)
The ubiquitin systemNature Medicine, 6
R. Honda, Hirofumi Tanaka, H. Yasuda (1997)
Oncoprotein MDM2 is a ubiquitin ligase E3 for tumor suppressor p53FEBS Letters, 420
A. Talis, J. Huibregtse, P. Howley (1998)
The Role of E6AP in the Regulation of p53 Protein Levels in Human Papillomavirus (HPV)-positive and HPV-negative Cells*The Journal of Biological Chemistry, 273
K. Reedquist, J. Bos (1998)
Costimulation through CD28 Suppresses T Cell Receptor-dependent Activation of the Ras-like Small GTPase Rap1 in Human T Lymphocytes*The Journal of Biological Chemistry, 273
Michelle Dykstra, R. Longnecker, S. Pierce (2001)
Epstein-Barr virus coopts lipid rafts to block the signaling and antigen transport functions of the BCR.Immunity, 14 1
R. Harty, Melissa Brown, Guangli Wang, J. Huibregtse, Felicia Hayes (2000)
A PPxY motif within the VP40 protein of Ebola virus interacts physically and functionally with a ubiquitin ligase: implications for filovirus budding.Proceedings of the National Academy of Sciences of the United States of America, 97 25
K. Harris, I. Shoji, E. Cooper, Santhosh Kumar, H. Oda, P. Howley (1999)
Ubiquitin-mediated degradation of active Src tyrosine kinase.Proceedings of the National Academy of Sciences of the United States of America, 96 24
M. Tyers, A. Willems (1999)
One Ring to Rule a Superfamily of E3 Ubiquitin LigasesScience, 284
M. Ohh, Cheol Park, Cheol Park, M. Ivan, M. Hoffman, Tae-You Kim, Tae-You Kim, L. Huang, N. Pavletich, N. Pavletich, V. Chau, W. Kaelin, W. Kaelin (2000)
Ubiquitination of hypoxia-inducible factor requires direct binding to the β-domain of the von Hippel–Lindau proteinNature Cell Biology, 2
Yetao Jin, Shelya Zeng, M. Dai, Xiang-Jiao Yang, Hua Lu (2002)
MDM2 Inhibits PCAF (p300/CREB-binding Protein-associated Factor)-mediated p53 Acetylation*The Journal of Biological Chemistry, 277
N. Rao, A. Ghosh, S. Ota, P. Zhou, A. Reddi, Kaoru Hakezi, B. Druker, Jiong Wu, H. Band (2001)
The non‐receptor tyrosine kinase Syk is a target of Cbl‐mediated ubiquitylation upon B‐cell receptor stimulationThe EMBO Journal, 20
J. Martin-Serrano, Trinity Zang, P. Bieniasz (2003)
Role of ESCRT-I in Retroviral BuddingJournal of Virology, 77
J. Massagué (1998)
TGF-beta signal transduction.Annual review of biochemistry, 67
B. Osborne, L. Miele (1999)
Notch and the immune system.Immunity, 11 6
N. Chehab, A. Malikzay, E. Stavridi, T. Halazonetis (1999)
Phosphorylation of Ser-20 mediates stabilization of human p53 in response to DNA damage.Proceedings of the National Academy of Sciences of the United States of America, 96 24
W. Paul, R. Seder (1994)
Lymphocyte responses and cytokinesCell, 76
A. Hirao, Y. Kong, S. Matsuoka, A. Wakeham, J. Ruland, Hiroki Yoshida, Dou Liu, S. Elledge, T. Mak (2000)
DNA damage-induced activation of p53 by the checkpoint kinase Chk2.Science, 287 5459
S. Boyd, K. Tsai, T. Jacks (2000)
An intact HDM2 RING-finger domain is required for nuclear exclusion of p53Nature Cell Biology, 2
H. Hayashi, S. Abdollah, Yubin Qiu, Jie Cai, Yong-Yao Xu, B. Grinnell, M. Richardson, J. Topper, M. Gimbrone, J. Wrana, D. Falb (1997)
The MAD-Related Protein Smad7 Associates with the TGFβ Receptor and Functions as an Antagonist of TGFβ SignalingCell, 89
Xiaoming Li, Yili Yang, J. Ashwell (2002)
TNF-RII and c-IAP1 mediate ubiquitination and degradation of TRAF2Nature, 416
Mingjun Huang, J. Orenstein, Malcolma Martin, E. Freed (1995)
p6Gag is required for particle production from full-length human immunodeficiency virus type 1 molecular clones expressing proteaseJournal of Virology, 69
N. Zheng, B. Schulman, B. Schulman, Langzhou Song, Julie Miller, Philip Jeffrey, Ping Wang, C. Chu, Deanna Koepp, Stephen Elledge, Stephen Elledge, M. Pagano, R. Conaway, J. Conaway, J. Harper, N. Pavletich (2002)
Structure of the Cul1–Rbx1–Skp1–F boxSkp2 SCF ubiquitin ligase complexNature, 416
V. Lang, J. Janzen, Gregory Fischer, Y. Soneji, S. Beinke, A. Salmeron, H. Allen, R. Hay, Y. Ben-Neriah, S. Ley (2003)
βTrCP-Mediated Proteolysis of NF-κB1 p105 Requires Phosphorylation of p105 Serines 927 and 932Molecular and Cellular Biology, 23
M. Koegl, T. Hoppe, S. Schlenker, H. Ulrich, T. Mayer, S. Jentsch (1999)
A Novel Ubiquitination Factor, E4, Is Involved in Multiubiquitin Chain AssemblyCell, 96
Muyang Li, Jianyuan Luo, C. Brooks, W. Gu (2002)
Acetylation of p53 Inhibits Its Ubiquitination by Mdm2*The Journal of Biological Chemistry, 277
D. Katzmann, M. Babst, S. Emr (2001)
Ubiquitin-Dependent Sorting into the Multivesicular Body Pathway Requires the Function of a Conserved Endosomal Protein Sorting Complex, ESCRT-ICell, 106
Jillian Licata, M. Simpson-Holley, N. Wright, Ziying Han, J. Paragas, R. Harty (2003)
Overlapping Motifs (PTAP and PPEY) within the Ebola Virus VP40 Protein Function Independently as Late Budding Domains: Involvement of Host Proteins TSG101 and VPS-4Journal of Virology, 77
A. Weissman (2001)
Ubiquitin and proteasomes: Themes and variations on ubiquitylationNature Reviews Molecular Cell Biology, 2
E. Robey, David Chang, A. Itano, D. Cado, Heather Alexander, D. Lans, G. Weinmaster, P. Salmon (1996)
An Activated Form of Notch Influences the Choice between CD4 and CD8 T Cell LineagesCell, 87
R. Aasland, T. Gibson, A. Stewart (1995)
The PHD finger: implications for chromatin-mediated transcriptional regulation.Trends in biochemical sciences, 20 2
R. Okamura, Mikael Sigvardsson, Juan Galceran, Sjef Verbeek, Hans Clevers, R. Grosschedl (1998)
Redundant regulation of T cell differentiation and TCRalpha gene expression by the transcription factors LEF-1 and TCF-1.Immunity, 8 1
F. Yu, S. White, Quan Zhao, F. Lee (2001)
HIF-1α binding to VHL is regulated by stimulus-sensitive proline hydroxylationProceedings of the National Academy of Sciences of the United States of America, 98
S. Murata, Y. Minami, M. Minami, T. Chiba, Keiji Tanaka (2001)
CHIP is a chaperone‐dependent E3 ligase that ubiquitylates unfolded proteinEMBO reports, 2
C. Cenciarelli, D. Hou, K. Hsu, B. Rellahan, D. Wiest, H. Smith, V. Fried, A. Weissman (1992)
Activation-induced ubiquitination of the T cell antigen receptor.Science, 257 5071
C. Prives, J. Manley (2001)
Why Is p53 Acetylated?Cell, 107
C. Elly, S. Witte, Zhihong Zhang, O. Rosnet, S. Lipkowitz, A. Altman, Yun-Cai Liu (1999)
Tyrosine phosphorylation and complex formation of Cbl-b upon T cell receptor stimulationOncogene, 18
Yasuyuki Suzuki, Yui Nakabayashi, R. Takahashi (2001)
Ubiquitin-protein ligase activity of X-linked inhibitor of apoptosis protein promotes proteasomal degradation of caspase-3 and enhances its anti-apoptotic effect in Fas-induced cell deathProceedings of the National Academy of Sciences of the United States of America, 98
M. Ikeda, A. Ikeda, Luz Longan, R. Longnecker (2000)
The Epstein-Barr virus latent membrane protein 2A PY motif recruits WW domain-containing ubiquitin-protein ligases.Virology, 268 1
Deyu Fang, Hong-ying Wang, N. Fang, Yoav Altman, C. Elly, Yun-Cai Liu (2001)
Cbl-b, a RING-type E3 Ubiquitin Ligase, Targets Phosphatidylinositol 3-Kinase for Ubiquitination in T Cells*The Journal of Biological Chemistry, 276
P. Costello, S. Cleverley, R. Galandrini, S. Henning, D. Cantrell (2000)
The Gtpase Rho Controls a P53-Dependent Survival Checkpoint during ThymopoiesisThe Journal of Experimental Medicine, 192
M. Naramura, H. Kole, Ren-Ju Hu, Hua Gu (1998)
Altered thymic positive selection and intracellular signals in Cbl-deficient mice.Proceedings of the National Academy of Sciences of the United States of America, 95 26
Manuel Rodríguez, J. Desterro, S. Laín, D. Lane, R. Hay (2000)
Multiple C-Terminal Lysine Residues Target p53 for Ubiquitin-Proteasome-Mediated DegradationMolecular and Cellular Biology, 20
G. Pirozzi, S. McConnell, A. Uveges, J. Carter, A. Sparks, B. Kay, D. Fowlkes (1997)
Identification of Novel Human WW Domain-containing Proteins by Cloning of Ligand Targets*The Journal of Biological Chemistry, 272
G. Xiao, E. Harhaj, Shao-Cong Sun (2001)
NF-κB-Inducing Kinase Regulates the Processing of NF-κB2 p100Molecular Cell, 7
Amy Hall, N. Jura, J. DaSilva, Y. Jang, Delquin Gong, D. Bar-Sagi (2003)
hSpry2 Is Targeted to the Ubiquitin-Dependent Proteasome Pathway by c-CblCurrent Biology, 13
Xi-liang Cao, E. Shores, J. Hu‐Li, M. Anver, Brian Kelsail, S. Russell, J. Drago, M. Noguchi, A. Grinberg, E. Bloom, W. Paul, S. Katz, P. Love, W. Leonard (1995)
Defective lymphoid development in mice lacking expression of the common cytokine receptor gamma chain.Immunity, 2 3
J. Gu, L. Nie, D. Wiederschain, Zhi-Min Yuan (2001)
Identification of p53 Sequence Elements That Are Required for MDM2-Mediated Nuclear ExportMolecular and Cellular Biology, 21
Deyu Fang, Yun-Cai Liu (2001)
Proteolysis-independent regulation of PI3K by Cbl-b–mediated ubiquitination in T cellsNature Immunology, 2
C. Thien, W. Langdon (2001)
Cbl: many adaptations to regulate protein tyrosine kinasesNature Reviews Molecular Cell Biology, 2
Protein Kinase C (cid:2) Controls Nuclear Factor (cid:3) B Activation in B Cells Through Selective Regulation of the I (cid:3) B Kinase (cid:4)
Roger Leng, Yunping Lin, Weili Ma, Hong Wu, B. Lemmers, S. Chung, J. Parant, G. Lozano, R. Hakem, S. Benchimol (2003)
Pirh2, a p53-Induced Ubiquitin-Protein Ligase, Promotes p53 DegradationCell, 112
O. Pornillos, S. Alam, D. Davis, W. Sundquist (2002)
Structure of the Tsg101 UEV domain in complex with the PTAP motif of the HIV-1 p6 proteinNature Structural Biology, 9
A. Fong, Minying Zhang, John Neely, Shao-Cong Sun (2002)
S9, a 19 S Proteasome Subunit Interacting with Ubiquitinated NF-κB2/p100*The Journal of Biological Chemistry, 277
S. Boehme, M. Lenardo (1996)
TCR-mediated death of mature T lymphocytes occurs in the absence of p53.Journal of immunology, 156 11
L. Coscoy, D. Ganem (2000)
Kaposi's sarcoma-associated herpesvirus encodes two proteins that block cell surface display of MHC class I chains by enhancing their endocytosis.Proceedings of the National Academy of Sciences of the United States of America, 97 14
K. Haglund, N. Shimokawa, I. Szymkiewicz, I. Dikič (2002)
Cbl-directed monoubiquitination of CIN85 is involved in regulation of ligand-induced degradation of EGF receptorsProceedings of the National Academy of Sciences of the United States of America, 99
James Witowsky, G. Johnson (2003)
Ubiquitylation of MEKK1 Inhibits Its Phosphorylation of MKK1 and MKK4 and Activation of the ERK1/2 and JNK Pathways*The Journal of Biological Chemistry, 278
N. Rao, M. Lupher, S. Ota, K. Reedquist, B. Druker, H. Band (2000)
The Linker Phosphorylation Site Tyr292 Mediates the Negative Regulatory Effect of Cbl on ZAP-70 in T Cells1The Journal of Immunology, 164
N. Zheng, Ping Wang, P. Jeffrey, N. Pavletich (2000)
Structure of a c-Cbl–UbcH7 Complex RING Domain Function in Ubiquitin-Protein LigasesCell, 102
Michael Cornell, Dana Evans, Robert Mann, M. Fostier, M. Flasza, M. Monthatong, S. Artavanis-Tsakonas, Martin Baron (1999)
The Drosophila melanogaster Suppressor of deltex gene, a regulator of the Notch receptor signaling pathway, is an E3 class ubiquitin ligase.Genetics, 152 2
S. Müller, C. Hoege, George Pyrowolakis, S. Jentsch (2001)
Ubiquitin and proteasomes: Sumo, ubiquitin's mysterious cousinNature Reviews Molecular Cell Biology, 2
A. Orian, H. Gonen, B. Bercovich, I. Fajerman, E. Eytan, A. Israël, F. Mercurio, K. Iwai, A. Schwartz, A. Ciechanover (2000)
SCFβ‐TrCP ubiquitin ligase‐mediated processing of NF‐κB p 105 requires phosphorylation of its C‐terminus by IκB kinaseThe EMBO Journal, 19
E. Reits, J. Vos, M. Grommé, J. Neefjes (2000)
The major substrates for TAP in vivo are derived from newly synthesized proteinsNature, 404
N. Rao, S. Miyake, A. Reddi, P. Douillard, A. Ghosh, I. Dodge, P. Zhou, N. Fernandes, H. Band (2002)
Negative regulation of Lck by Cbl ubiquitin ligaseProceedings of the National Academy of Sciences of the United States of America, 99
B. Strack, A. Calistri, M. Accola, G. Palù, H. Göttlinger (2000)
A role for ubiquitin ligase recruitment in retrovirus release.Proceedings of the National Academy of Sciences of the United States of America, 97 24
P. Soubeyran, Katarzyna Kowanetz, I. Szymkiewicz, W. Langdon, I. Dikič (2002)
Cbl–CIN85–endophilin complex mediates ligand-induced downregulation of EGF receptorsNature, 416
S. Holland, X. Liao, M. Mendenhall, Xiulan Zhou, Jorge Pardo, Peter Chu, Collin Spencer, Alan Fu, N. Sheng, P. Yu, E. Pali, Anup Nagin, M. Shen, Simon Yu, E. Chan, Xian Wu, Connie Li, M. Woisetschlager, G. Aversa, F. Kolbinger, M. Bennett, S. Molineaux, Ying Luo, D. Payan, H. Mancebo, Jun Wu (2001)
Functional Cloning of Src-like Adapter Protein-2 (SLAP-2), a Novel Inhibitor of Antigen Receptor SignalingThe Journal of Experimental Medicine, 194
J. Garrus, U. Schwedler, O. Pornillos, S. Morham, K. Zavitz, Hubert Wang, D. Wettstein, Kirsten Stray, M. Côté, R. Rich, D. Myszka, W. Sundquist (2001)
Tsg101 and the Vacuolar Protein Sorting Pathway Are Essential for HIV-1 BuddingCell, 107
Ling Qiu, C. Joazeiro, N. Fang, Hong-ying Wang, C. Elly, Yoav Altman, Deyu Fang, T. Hunter, Yun-Cai Liu (2000)
Recognition and Ubiquitination of Notch by Itch, a Hect-type E3 Ubiquitin Ligase*The Journal of Biological Chemistry, 275
H. Liou, William Sha, M. Scott, David Baltimore (1994)
Sequential induction of NF-kappa B/Rel family proteins during B-cell terminal differentiation.Molecular and cellular biology, 14 8
A. Kulkarni, C. Huh, D. Becker, A. Geiser, Marion Lyght, K. Flanders, A. Roberts, M. Sporn, Jerrold Ward, S. Karlsson (1993)
Transforming growth factor beta 1 null mutation in mice causes excessive inflammatory response and early death.Proceedings of the National Academy of Sciences of the United States of America, 90
K. Brown, B. Hostager, G. Bishop (2002)
Regulation of TRAF2 Signaling by Self-induced Degradation*The Journal of Biological Chemistry, 277
M. Keane, S. Ettenberg, M. Nau, P. Banerjee, M. Cuello, J. Penninger, S. Lipkowitz (1999)
cbl-3: a new mammalian cbl family proteinOncogene, 18
Philip Morrissey, K. Grabstein, Fred Ramsde, Eugene Maraskovsky, Brian Gliniak, Linda Park, Steven Ziegler, Doughs Williams, Carol Ware, Jeff Meyer, Barry Davison (1994)
Early lymphocyte expansion is severely impaired in interleukin 7 receptor-deficient miceThe Journal of Experimental Medicine, 180
C. Shamu, Dennis Flierman, H. Ploegh, Tom Rapoport, Vincent Chau (2001)
Polyubiquitination is required for US11-dependent movement of MHC class I heavy chain from endoplasmic reticulum into cytosol.Molecular biology of the cell, 12 8
N. Silverman, T. Maniatis (2001)
NF-(cid:1) B signaling pathways in mammalian and insect innate immunity
M. Kitagawa, S. Hatakeyama, M. Shirane, M. Matsumoto, N. Ishida, K. Hattori, Ikuo Nakamichi, A. Kikuchi, Kei-ichi Nakayama, Kei-ichi Nakayama (1999)
An F‐box protein, FWD1, mediates ubiquitin‐dependent proteolysis of β‐cateninThe EMBO Journal, 18
Hiroshi Hisamatsu, N. Shimbara, yutaka Saitofl, Poul Kristensen, K. Hendil, Tsutomu Fujiwara, Ei-ichi Takahashi, N. Tanahashi, Tomohiro Tamura, Akira Ichihara, Keiji Tanaka (1996)
Newly identified pair of proteasomal subunits regulated reciprocally by interferon gammaThe Journal of Experimental Medicine, 183
A. Wolfer, Anne Wilson, M. Nemir, H. Macdonald, F. Radtke (2002)
Inactivation of Notch1 impairs VDJbeta rearrangement and allows pre-TCR-independent survival of early alpha beta Lineage Thymocytes.Immunity, 16 6
Mandana Mansouri, E. Bartee, Kristine Gouveia, Bianca Nerenberg, J. Barrett, L. Thomas, G. Thomas, G. McFadden, K. Früh (2003)
The PHD/LAP-Domain Protein M153R of Myxomavirus Is a Ubiquitin Ligase That Induces the Rapid Internalization and Lysosomal Destruction of CD4Journal of Virology, 77
G. Deblandre, E. Lai, C. Kintner (2001)
Xenopus neuralized is a ubiquitin ligase that interacts with XDelta1 and regulates Notch signaling.Developmental cell, 1 6
L. O’Neill, C. Dinarello (2000)
The IL-1 receptor/toll-like receptor superfamily: crucial receptors for inflammation and host defense.Immunology today, 21 5
Akash Patnaik, V. Chau, J. Wills (2000)
Ubiquitin is part of the retrovirus budding machinery.Proceedings of the National Academy of Sciences of the United States of America, 97 24
Annalisa Petrelli, Giorgio Gilestro, S. Lanzardo, P. Comoglio, N. Migone, S. Giordano (2002)
The endophilin–CIN85–Cbl complex mediates ligand-dependent downregulation of c-MetNature, 416
Yun-Cai Liu, Hua Gu (2002)
Cbl and Cbl-b in T-cell regulation.Trends in immunology, 23 3
T. Kamura, D. Koepp, M. Conrad, D. Skowyra, R. Moreland, O. Iliopoulos, William Lane, W. Kaelin, S. Elledge, R. Conaway, J. Harper, J. Conaway (1999)
Rbx1, a component of the VHL tumor suppressor complex and SCF ubiquitin ligase.Science, 284 5414
Ying Zhang, Chenbei Chang, Daniel Gehling, A. Hemmati‐Brivanlou, R. Derynck (2001)
Regulation of Smad degradation and activity by Smurf2, an E3 ubiquitin ligase.Proceedings of the National Academy of Sciences of the United States of America, 98 3
Z. Nawaz, D. Lonard, Carolyn Smith, E. Lev-Lehman, S. Tsai, M. Tsai, Bert O’Malley (1999)
The Angelman Syndrome-Associated Protein, E6-AP, Is a Coactivator for the Nuclear Hormone Receptor SuperfamilyMolecular and Cellular Biology, 19
Takanori Ebisawa, Minoru Fukuchi, Gyo Murakami, T. Chiba, Keiji Tanaka, T. Imamura, K. Miyazono (2001)
Smurf1 Interacts with Transforming Growth Factor-β Type I Receptor through Smad7 and Induces Receptor Degradation*The Journal of Biological Chemistry, 276
F. Mack, W. Rathmell, A. Arsham, J. Gnarra, B. Keith, M. Simon (2003)
Loss of pVHL is sufficient to cause HIF dysregulation in primary cells but does not promote tumor growth.Cancer cell, 3 1
U. Senftleben, Yixue Cao, G. Xiao, F. Greten, G. Krähn, G. Bonizzi, Yi Chen, Yinling Hu, A. Fong, Shao-Cong Sun, M. Karin (2001)
Activation by IKKα of a Second, Evolutionary Conserved, NF-κB Signaling PathwayScience, 293
F. Gounari, I. Aifantis, K. Khazaie, Sonja Hoeflinger, N. Harada, M. Taketo, H. Boehmer (2001)
Somatic activation of β-catenin bypasses pre-TCR signaling and TCR selection in thymocyte developmentNature Immunology, 2
L. Hicke (1999)
Gettin' down with ubiquitin: turning off cell-surface receptors, transporters and channels.Trends in cell biology, 9 3
Xia Lin, M. Liang, Xin-Hua Feng (2000)
Smurf2 Is a Ubiquitin E3 Ligase Mediating Proteasome-dependent Degradation of Smad2 in Transforming Growth Factor-β Signaling* 210The Journal of Biological Chemistry, 275
U. Albrecht, J. Sutcliffe, B. Cattanach, C. Beechey, D. Armstrong, G. Eichele, A. Beaudet (1997)
Imprinted expression of the murine Angelman syndrome gene, Ube3a, in hippocampal and Purkinje neuronsNature Genetics, 17
A. Schwartz, A. Ciechanover (1999)
The ubiquitin-proteasome pathway and pathogenesis of human diseases.Annual review of medicine, 50
M. Lupher, N. Rao, M. Eck, H. Band (1999)
The Cbl protooncoprotein: a negative regulator of immune receptor signal transduction.Immunology today, 20 8
E. Lai, G. Deblandre, C. Kintner, Gerald Rubin (2001)
Drosophila neuralized is a ubiquitin ligase that promotes the internalization and degradation of delta.Developmental cell, 1 6
E. Wagner (2001)
AP-1 – Introductory remarksOncogene, 20
Li Lin, G. Demartino, W. Greene (1998)
Cotranslational Biogenesis of NF-κB p50 by the 26S ProteasomeCell, 92
M. Yokouchi, T. Kondo, A. Houghton, M. Bartkiewicz, W. Horne, Hui Zhang, A. Yoshimura, R. Baron (1999)
Ligand-induced Ubiquitination of the Epidermal Growth Factor Receptor Involves the Interaction of the c-Cbl RING Finger and UbcH7*The Journal of Biological Chemistry, 274
M. Sudol (1996)
The WW module competes with the SH3 domain?Trends in biochemical sciences, 21 5
D. Schmidt, S. Müller (2002)
Members of the PIAS family act as SUMO ligases for c-Jun and p53 and repress p53 activityProceedings of the National Academy of Sciences of the United States of America, 99
P. Angel, M. Karin (1991)
The role of Jun, Fos and the AP-1 complex in cell-proliferation and transformation.Biochimica et biophysica acta, 1072 2-3
K. Carey, Tara Dillon, J. Schmitt, A. Baird, A. Holdorf, D. Straus, A. Shaw, P. Stork (2000)
CD28 and the Tyrosine Kinase Lck Stimulate Mitogen-Activated Protein Kinase Activity in T Cells via Inhibition of the Small G Protein Rap1Molecular and Cellular Biology, 20
N. Roy, Q. Deveraux, R. Takahashi, G. Salvesen, John Reed (1997)
The c‐IAP‐1 and c‐IAP‐2 proteins are direct inhibitors of specific caspasesThe EMBO Journal, 16
Q. Deveraux, John Reed (1999)
IAP family proteins--suppressors of apoptosis.Genes & development, 13 3
P. Lu, G. Wulf, Xiao Zhou, P. Davies, K. Lu (1999)
The prolyl isomerase Pin1 restores the function of Alzheimer-associated phosphorylated tau proteinNature, 399
Sylvia Schwarz, K. Matuschewski, D. Liakopoulos, M. Scheffner, S. Jentsch (1998)
The ubiquitin-like proteins SMT3 and SUMO-1 are conjugated by the UBC9 E2 enzyme.Proceedings of the National Academy of Sciences of the United States of America, 95 2
H. Lelouard, E. Gatti, F. Cappello, O. Gresser, Voahirana Camosseto, P. Pierre (2002)
Transient aggregation of ubiquitinated proteins during dendritic cell maturationNature, 417
Thomas Schmitt, J. Zúñiga-Pflücker (2002)
Induction of T cell development from hematopoietic progenitor cells by delta-like-1 in vitro.Immunity, 17 6
M. Ashcroft, K. Vousden (1999)
Regulation of p53 stabilityOncogene, 18
F. Macian, C. López-Rodríguez, A. Rao (2001)
Partners in transcription: NFAT and AP-1Oncogene, 20
A. Wodarz, R. Nusse (1998)
Mechanisms of Wnt signaling in development.Annual review of cell and developmental biology, 14
E. Sebzda, M. Bracke, T. Tugal, N. Hogg, D. Cantrell (2002)
Rap1A positively regulates T cells via integrin activation rather than inhibiting lymphocyte signalingNature Immunology, 3
S. Matsuzawa, John Reed (2001)
Siah-1, SIP, and Ebi collaborate in a novel pathway for beta-catenin degradation linked to p53 responses.Molecular cell, 7 5
M. Babst, G. Odorizzi, Eden Estepa, S. Emr (2000)
Mammalian Tumor Susceptibility Gene 101 (TSG101) and the Yeast Homologue, Vps23p, Both Function in Late Endosomal TraffickingTraffic, 1
A. Dahl, P. Beverley, H. Stauss (1996)
A synthetic peptide derived from the tumor-associated protein mdm2 can stimulate autoreactive, high avidity cytotoxic T lymphocytes that recognize naturally processed protein.Journal of immunology, 157 1
Jung-Hyun Min, Haifeng Yang, M. Ivan, F. Gertler, W. Kaelin, N. Pavletich (2002)
Structure of an HIF-1α-pVHL Complex: Hydroxyproline Recognition in SignalingScience, 296
E. Hewitt, Lidia Duncan, Din Mufti, J. Baker, P. Stevenson, P. Lehner (2002)
Ubiquitylation of MHC class I by the K3 viral protein signals internalization and TSG101‐dependent degradationThe EMBO Journal, 21
Camilla Öberg, Jinhe Li, A. Pauley, E. Wolf, M. Gurney, U. Lendahl (2001)
The Notch Intracellular Domain Is Ubiquitinated and Negatively Regulated by the Mammalian Sel-10 Homolog*The Journal of Biological Chemistry, 276
M. Deftos, M. Bevan (2000)
Notch signaling in T cell development.Current opinion in immunology, 12 2
S. Hatakeyama, M. Yada, M. Matsumoto, N. Ishida, K. Nakayama (2001)
U Box Proteins as a New Family of Ubiquitin-Protein Ligases*The Journal of Biological Chemistry, 276
C. Cenciarelli, Kenneth Wilhelm, A. Guo, A. Weissman (1996)
T Cell Antigen Receptor Ubiquitination Is a Consequence of Receptor-mediated Tyrosine Kinase Activation (*)The Journal of Biological Chemistry, 271
S. Salghetti, M. Muratani, H. Wijnen, B. Futcher, W. Tansey (2000)
Functional overlap of sequences that activate transcription and signal ubiquitin-mediated proteolysisProceedings of the National Academy of Sciences of the United States of America, 97
L. Aravind, E. Koonin (2000)
The U box is a modified RING finger — a common domain in ubiquitinationCurrent Biology, 10
S. Salghetti, A. Caudy, Joshua Chenoweth, W. Tansey (2001)
Regulation of Transcriptional Activation Domain Function by UbiquitinScience, 293
A. Melker, G. Horst, J. Calafat, H. Jansen, J. Borst (2001)
c-Cbl ubiquitinates the EGF receptor at the plasma membrane and remains receptor associated throughout the endocytic route.Journal of cell science, 114 Pt 11
U. Schubert, L. Antón, J. Gibbs, C. Norbury, J. Yewdell, J. Bennink (2000)
Rapid degradation of a large fraction of newly synthesized proteins by proteasomesNature, 404
Deyu Fang, C. Elly, Baixue Gao, N. Fang, Yoav Altman, C. Joazeiro, T. Hunter, N. Copeland, N. Jenkins, Yun-Cai Liu (2002)
Dysregulation of T lymphocyte function in itchy mice: a role for Itch in TH2 differentiationNature Immunology, 3
Y. Chiang, H. Kole, K. Brown, M. Naramura, S. Fukuhara, R. Hu, I. Jang, J. Gutkind, E. Shevach, Hua Gu (2000)
Cbl-b regulates the CD28 dependence of T-cell activationNature, 403
M. Scheffner, J. Huibregtse, R. Vierstra, P. Howley (1993)
The HPV-16 E6 and E6-AP complex functions as a ubiquitin-protein ligase in the ubiquitination of p53Cell, 75
T. Mosmann, R. Coffman (1989)
TH1 and TH2 cells: different patterns of lymphokine secretion lead to different functional properties.Annual review of immunology, 7
Jun Liu, J. Stevens, C. Rote, H. Yost, Yaoxiong Hu, K. Neufeld, Raymond White, N. Matsunami (2001)
Siah-1 mediates a novel beta-catenin degradation pathway linking p53 to the adenomatous polyposis coli protein.Molecular cell, 7 5
V. Boussiotis, G. Freeman, A. Berezovskaya, D. Barber, L. Nadler (1997)
Maintenance of human T cell anergy: blocking of IL-2 gene transcription by activated Rap1.Science, 278 5335
L. Deng, chen wang, E. Spencer, Liyong Yang, A. Braun, J. You, C. Slaughter, C. Pickart, Zhijian Chen (2000)
Activation of the IκB Kinase Complex by TRAF6 Requires a Dimeric Ubiquitin-Conjugating Enzyme Complex and a Unique Polyubiquitin ChainCell, 103
J. Pui, D. Allman, Lanwei Xu, S. Derocco, F. Karnell, S. Bakkour, Julia Lee, T. Kadesch, R. Hardy, J. Aster, W. Pear (1999)
Notch1 expression in early lymphopoiesis influences B versus T lineage determination.Immunity, 11 3
O. Pornillos, S. Alam, R. Rich, D. Myszka, D. Davis, W. Sundquist (2002)
Structure and functional interactions of the Tsg101 UEV domainThe EMBO Journal, 21
E. Yeh, Matt Dermer, C. Commisso, Lily Zhou, C. McGlade, G. Boulianne (2001)
Neuralized functions as an E3 ubiquitin ligase during Drosophila developmentCurrent Biology, 11
Tomasz Sosinowski, Nigel Killeen, Arthur Weiss (2001)
The Src-like adaptor protein downregulates the T cell receptor on CD4+CD8+ thymocytes and regulates positive selection.Immunity, 15 3
J. Bos (1998)
All in the family? New insights and questions regarding interconnectivity of Ras, Rap1 and RalThe EMBO Journal, 17
E. Latres, D. Chiaur, M. Pagano (1999)
The human F box protein β-Trcp associates with the Cul1/Skp1 complex and regulates the stability of β-cateninOncogene, 18
N. Kotaja, U. Karvonen, O. Jänne, J. Palvimo (2002)
PIAS Proteins Modulate Transcription Factors by Functioning as SUMO-1 LigasesMolecular and Cellular Biology, 22
Wei Li, C. Whaley, A. Mondino, D. Mueller (1996)
Blocked Signal Transduction to the ERK and JNK Protein Kinases in Anergic CD4+ T CellsScience, 271
C. Krawczyk, C. Krawczyk, K. Bachmaier, K. Bachmaier, Takehiko Sasaki, Takehiko Sasaki, Russell Jones, S. Snapper, D. Bouchard, I. Kozieradzki, I. Kozieradzki, P. Ohashi, F. Alt, J. Penninger, J. Penninger (2000)
Cbl-b is a negative regulator of receptor clustering and raft aggregation in T cells.Immunity, 13 4
M. Shull, I. Ormsby, A. Kier, S. Pawlowski, R. Diebold, M. Yin, Ruth Allen, C. Sidman, G. Proetzel, D. Calvin, Nikki Annunziata, T. Doetschman (1992)
Targeted disruption of the mouse transforming growth factor-β1 gene results in multifocal inflammatory diseaseNature, 359
P. Jaakkola, D. Mole, Ya-min Tian, Michael Wilson, J. Gielbert, S. Gaskell, A. Kriegsheim, H. Hebestreit, Mridul Mukherji, C. Schofield, P. Maxwell, C. Pugh, P. Ratcliffe (2001)
Targeting of HIF-α to the von Hippel-Lindau Ubiquitylation Complex by O2-Regulated Prolyl HydroxylationScience, 292
G. Pantaleo, D. Olive, A. Poggi, T. Pozzan, L. Moretta, A. Moretta (1987)
Antibody-induced modulation of the CD3/T cell receptor complex causes T cell refractoriness by inhibiting the early metabolic steps involved in T cell activationThe Journal of Experimental Medicine, 166
W. Perry, C. Hustad, D. Swing, T. O'Sullivan, N. Jenkins, N. Copeland (1998)
The itchy locus encodes a novel ubiquitin protein ligase that is disrupted in a18H miceNature Genetics, 18
E. Wong, C. Fong, Jormay Lim, P. Yusoff, B. Low, W. Langdon, G. Guy (2002)
Sprouty2 attenuates epidermal growth factor receptor ubiquitylation and endocytosis, and consequently enhances Ras/ERK signallingThe EMBO Journal, 21
J. Villadangos, H. Ploegh (2000)
Proteolysis in MHC class II antigen presentation: who's in charge?Immunity, 12 3
L. Coscoy, D. Sanchez, D. Ganem (2001)
A novel class of herpesvirus-encoded membrane-bound E3 ubiquitin ligases regulates endocytosis of proteins involved in immune recognitionThe Journal of Cell Biology, 155
S. Ishido, Joong-Kook Choi, Bok-Soo Lee, Chunyang Wang, M. Demaria, R. Johnson, G. Cohen, Jae Jung (2000)
Inhibition of natural killer cell-mediated cytotoxicity by Kaposi's sarcoma-associated herpesvirus K5 protein.Immunity, 13 3
G. Semenza (2001)
HIF-1 and mechanisms of hypoxia sensing.Current opinion in cell biology, 13 2
S. Bonni, Hong-Rui Wang, Carrie Causing, Peter Kavsak, S. Stroschein, K. Luo, J. Wrana (2001)
TGF-β induces assembly of a Smad2–Smurf2 ubiquitin ligase complex that targets SnoN for degradationNature Cell Biology, 3
D. Allman, J. Punt, D. Izon, J. Aster, W. Pear (2002)
An Invitation to T and More Notch Signaling in LymphopoiesisCell, 109
A. Germani, H. Bruzzoni-Giovanelli, A. Fellous, S. Gisselbrecht, N. Varin‐Blank, F. Calvo (2000)
SIAH-1 interacts with α-tubulin and degrades the kinesin Kid by the proteasome pathway during mitosisOncogene, 19
I. Frew, R. Dickins, A. Cuddihy, Merci Rosario, C. Reinhard, M. O’Connell, D. Bowtell (2002)
Normal p53 Function in Primary Cells Deficient for Siah GenesMolecular and Cellular Biology, 22
C. Joazeiro, A. Weissman (2000)
RING Finger Proteins Mediators of Ubiquitin Ligase ActivityCell, 102
V. Heissmeyer, D. Krappmann, E. Hatada, C. Scheidereit (2001)
Shared Pathways of IκB Kinase-Induced SCFβTrCP-Mediated Ubiquitination and Degradation for the NF-κB Precursor p105 and IκBαMolecular and Cellular Biology, 21
A. Fong, Shao-Cong Sun (2002)
Genetic Evidence for the Essential Role of β-Transducin Repeat-containing Protein in the Inducible Processing of NF-κB2/p100*The Journal of Biological Chemistry, 277
C. Hustad, W. Perry, L. Siracusa, C. Rasberry, L. Cobb, B. Cattanach, R. Kovatch, N. Copeland, N. Jenkins (1995)
Molecular genetic characterization of six recessive viable alleles of the mouse agouti locus.Genetics, 140 1
C. Stebbins, W. Kaelin, N. Pavletich (1999)
Structure of the VHL-ElonginC-ElonginB complex: implications for VHL tumor suppressor function.Science, 284 5413
T. Unger, T. Juven-Gershon, E. Moallem, M. Berger, Ronit Sionov, G. Lozano, M. Oren, Y. Haupt (1999)
Critical role for Ser20 of human p53 in the negative regulation of p53 by Mdm2The EMBO Journal, 18
C. Rubin, V. Litvak, Helena Medvedovsky, Yaara Zwang, S. Lev, Y. Yarden (2003)
Sprouty Fine-Tunes EGF Signaling through Interlinked Positive and Negative Feedback LoopsCurrent Biology, 13
N. Niederberger, K. Holmberg, S. Alam, W. Sakati, M. Naramura, Hua Gu, N. Gascoigne (2003)
Allelic Exclusion of the TCR α-Chain Is an Active Process Requiring TCR-Mediated Signaling and c-Cbl1The Journal of Immunology, 170
N. Anandasabapathy, G. Ford, D. Bloom, C. Holness, V. Paragas, C. Seroogy, H. Skrenta, Marie Hollenhorst, C. Fathman, L. Soares (2003)
GRAIL: an E3 ubiquitin ligase that inhibits cytokine gene transcription is expressed in anergic CD4+ T cells.Immunity, 18 4
Jason Grayson, J. Lanier, J. Altman, R. Ahmed (2001)
The Role of p53 in Regulating Antiviral T Cell Responses1The Journal of Immunology, 167
U. Schubert, D. Ott, E. Chertova, R. Welker, U. Tessmer, M. Princiotta, J. Bennink, H. Kräusslich, J. Yewdell (2000)
Proteasome inhibition interferes with gag polyprotein processing, release, and maturation of HIV-1 and HIV-2.Proceedings of the National Academy of Sciences of the United States of America, 97 24
Michael Loreto, D. Berry, C. McGlade (2002)
Functional Cooperation between c-Cbl and Src-Like Adaptor Protein 2 in the Negative Regulation of T-Cell Receptor SignalingMolecular and Cellular Biology, 22
M. Furman, H. Ploegh (2002)
Lessons from viral manipulation of protein disposal pathways.The Journal of clinical investigation, 110 7
M. Itoh, Cheol‐Hee Kim, Gregory Palardy, T. Oda, Yun-Jin Jiang, Donovan Maust, Sang-Yeob Yeo, K. Lorick, Gavin Wright, L. Ariza-McNaughton, A. Weissman, Julian Lewis, S. Chandrasekharappa, A. Chitnis (2003)
Mind bomb is a ubiquitin ligase that is essential for efficient activation of Notch signaling by Delta.Developmental cell, 4 1
S. Mendrysa, M. McElwee, J. Michalowski, K. O'Leary, K. Young, M. Perry (2003)
mdm2 Is Critical for Inhibition of p53 during Lymphopoiesis and the Response to Ionizing IrradiationMolecular and Cellular Biology, 23
Han-kuei Huang, C. Joazeiro, Emanuela Bonfoco, S. Kamada, J. Leverson, T. Hunter (2000)
The inhibitor of apoptosis, cIAP2, functions as a ubiquitin-protein ligase and promotes in vitro monoubiquitination of caspases 3 and 7.The Journal of biological chemistry, 275 35
R. Amir, K. Iwai, A. Ciechanover (2002)
The NEDD8 Pathway Is Essential for SCFβ-TrCP-mediated Ubiquitination and Processing of the NF-κB Precursor p105*The Journal of Biological Chemistry, 277
L. Hicke (2001)
Ubiquitin and proteasomes: Protein regulation by monoubiquitinNature Reviews Molecular Cell Biology, 2
J. Cox, P. Galardy, J. Bennink, J. Yewdell (1995)
Presentation of endogenous and exogenous antigens is not affected by inactivation of E1 ubiquitin-activating enzyme in temperature-sensitive cell lines.Journal of immunology, 154 2
H. Oda, Santhosh Kumar, P. Howley (1999)
Regulation of the Src family tyrosine kinase Blk through E6AP-mediated ubiquitination.Proceedings of the National Academy of Sciences of the United States of America, 96 17
Michael Karin, Y. Ben-Neriah (2000)
Phosphorylation meets ubiquitination: the control of NF-[kappa]B activity.Annual review of immunology, 18
S. Verbeek, D. Izon, F. Hofhuis, E. Robanus-Maandag, H. Riele, M. Watering, M. Oosterwegel, Anne Wilson, H. Macdonald, H. Clevers (1995)
An HMG-box-containing T-cell factor required for thymocyte differentiationNature, 374
Tracy Washburn, E. Schweighoffer, T. Gridley, David Chang, B. Fowlkes, D. Cado, E. Robey (1997)
Notch Activity Influences the αβ versus γδ T Cell Lineage DecisionCell, 88
P. Freemont (2000)
Ubiquitination: RING for destruction?Current Biology, 10
Keane Mm, O. Rivero-Lezcano, Mitchell Ja, Keith Robbins, S. Lipkowitz (1995)
Cloning and characterization of cbl-b: a SH3 binding protein with homology to the c-cbl proto-oncogene.Oncogene, 10 12
Lan Huang, E. Kinnucan, Guangli Wang, S. Beaudenon, P. Howley, J. Huibregtse, N. Pavletich (1999)
Structure of an E6AP-UbcH7 complex: insights into ubiquitination by the E2-E3 enzyme cascade.Science, 286 5443
L. Coscoy, D. Ganem (2003)
PHD domains and E3 ubiquitin ligases: viruses make the connection.Trends in cell biology, 13 1
C. Shi, J. Kehrl (2003)
Tumor Necrosis Factor (TNF)-induced Germinal Center Kinase-related (GCKR) and Stress-activated Protein Kinase (SAPK) Activation Depends upon the E2/E3 Complex Ubc13-Uev1A/TNF Receptor-associated Factor 2 (TRAF2)*The Journal of Biological Chemistry, 278
B. Jehn, I. Dittert, S. Beyer, K. Mark, W. Bielke (2002)
c-Cbl Binding and Ubiquitin-dependent Lysosomal Degradation of Membrane-associated Notch1*The Journal of Biological Chemistry, 277
S. Stroschein, S. Bonni, J. Wrana, K. Luo (2001)
Smad3 recruits the anaphase-promoting complex for ubiquitination and degradation of SnoN.Genes & development, 15 21
Peter Jackson, A. Eldridge, E. Freed, Laura Furstenthal, Jerry Hsu, Brett Kaiser, J. Reimann (2000)
The lore of the RINGs: substrate recognition and catalysis by ubiquitin ligases.Trends in cell biology, 10 10
Yuan Shao, C. Elly, Yun-Cai Liu (2003)
Negative regulation of Rap1 activation by the Cbl E3 ubiquitin ligaseEMBO reports, 4
F. Macian, F. García-Cózar, S. Im, H. Horton, M. Byrne, A. Rao (2002)
Transcriptional Mechanisms Underlying Lymphocyte ToleranceCell, 109
S. Fuchs, V. Fried, Z. Ronai (1998)
Stress-activated kinases regulate protein stabilityOncogene, 17
P. Fields, T. Gajewski, F. Fitch (1996)
Blocked Ras Activation in Anergic CD4+ T CellsScience, 271
K. Bachmaier, C. Krawczyk, I. Kozieradzki, Y. Kong, Takehiko Sasaki, A. Oliveira-dos-Santos, S. Mariathasan, D. Bouchard, A. Wakeham, A. Itié, J. Le, P. Ohashi, I. Sarosi, H. Nishina, S. Lipkowitz, J. Penninger (2000)
Negative regulation of lymphocyte activation and autoimmunity by the molecular adaptor Cbl-bNature, 403
H. Coope, P. Atkinson, B. Huhse, M. Belich, J. Janzen, M. Holman, G. Klaus, Leland Johnston, Steven Ley (2002)
CD40 regulates the processing of NF‐κB2 p100 to p52The EMBO Journal, 21
K. Miyazono (2000)
TGF-β signaling by Smad proteinsCytokine & Growth Factor Reviews, 11
J. Maranchie, J. Vasselli, J. Riss, J. Bonifacino, W. Linehan, R. Klausner (2002)
The contribution of VHL substrate binding and HIF1-alpha to the phenotype of VHL loss in renal cell carcinoma.Cancer cell, 1 3
S. Artavanis-Tsakonas, M. Rand, Robert Lake (1999)
Notch signaling: cell fate control and signal integration in development.Science, 284 5415
F. Margottin, S. Bour, H. Durand, L. Selig, S. Bénichou, Virginie Richard, Dominique Thomas, K. Strebel, R. Benarous (1998)
A novel human WD protein, h-beta TrCp, that interacts with HIV-1 Vpu connects CD4 to the ER degradation pathway through an F-box motif.Molecular cell, 1 4
Ubiquitin (Ub)-protein conjugation represents a novel means of posttranscriptional modification in a proteolysis-dependent or -independent manner. E3 Ub ligases play a key role in governing the cascade of Ub transfer reactions by recognizing and catalyzing Ub conjugation to specific protein substrates. The E3s, which can be generally classified into HECT-type and RING-type families, are involved in the regulation of many aspects of the immune system, including the development, activation, and differentiation of lymphocytes, T cell–tolerance induction, antigen presentation, immune evasion, and virus budding. E3-promoted ubiquitination affects a wide array of biological processes, such as receptor downmodulation, signal transduction, protein processing or translocation, protein-protein interaction, and gene transcription, in addition to proteasome-mediated degradation. Deficiency or mutation of some of the E3s like Cbl, Cbl-b, or Itch, causes abnormal immune responses such as autoimmunity, malignancy, and inflammation. This review discusses our current understanding of E3 Ub ligases in both innate and adaptive immunity. Such knowledge may facilitate the development of novel therapeutic approaches for immunological diseases.
Annual Review of Immunology – Annual Reviews
Published: Apr 23, 2004
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