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For many years immunologists have been well served by the viewpoint that the immune system's primary goal is to discriminate between self and non-self. I believe that it is time to change viewpoints and, in this essay, I discuss the possibility that the immune system does not care about self and non-self, that its primary driving force is the need to detect and protect against danger, and that it does not do the job alone, but receives positive and negative communications from an extended network of other bodily tissues. INTRODUCTION Among the fundamental questions in immunology, there are three that lie at the heart of the regulation of immunity. They are: 1) How is self tolerance induced and maintained? 2) How is memory induced and main tained? and 3) How is the class of response determined? This essay is about the first one, tolerance (actually T cell tolerance), but it is also about something deeper, something that affects the way we think about every aspect of immunity. It is about the belief that the immune system's primary driving force is the need to discriminate between self and non-self. I have abandoned this belief. Over the years that I
Annual Review of Immunology – Annual Reviews
Published: Apr 1, 1994
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