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Rong Li (1997)
Bee1, a Yeast Protein with Homology to Wiscott-Aldrich Syndrome Protein, Is Critical for the Assembly of Cortical Actin CytoskeletonThe Journal of Cell Biology, 136
Daniel Zicha, William Allen, Paul Brickell, C. Kinnon, Graham Dunn, Gareth Jones, A. Thrasher (1998)
Chemotaxis of macrophages is abolished in the Wiskott‐Aldrich syndromeBritish Journal of Haematology, 101
M. Gallego, M. Santamaría, J. Peña, I. Molina (1997)
Defective actin reorganization and polymerization of Wiskott-Aldrich T cells in response to CD3-mediated stimulationBlood, 90
Qili Zhu, C. Watanabe, Ting Liu, D. Hollenbaugh, R. Blaese, S. Kanner, A. Aruffo, H. Ochs (1997)
Wiskott-Aldrich syndrome/X-linked thrombocytopenia: WASP gene mutations, protein expression, and phenotype.Blood, 90 7
W. Krivit, E. Yunis, J. White (1966)
Platelet survival studies in Aldrich syndrome.Pediatrics, 37 2
L. MacCarthy-Morrogh, H. Gaspar, Yi-chien Wang, F. Katz, Lisa Thompson, M. Layton, A. Jones, C. Kinnon (1998)
Absence of expression of the Wiskott-Aldrich syndrome protein in peripheral blood cells of Wiskott-Aldrich syndrome patients.Clinical immunology and immunopathology, 88 1
H. Kupfer, Colin Monks, Abraham Kupfer (1994)
Small splenic B cells that bind to antigen-specific T helper (Th) cells and face the site of cytokine production in the Th cells selectively proliferate: immunofluorescence microscopic studies of Th-B antigen- presenting cell interactionsThe Journal of Experimental Medicine, 179
B. Geiger, D. Rosen, G. Berke (1982)
Spatial relationships of microtubule-organizing centers and the contact area of cytotoxic T lymphocytes and target cellsThe Journal of Cell Biology, 95
C. Ponting, C. Phillips (1997)
Identification of homer as a homologue of the Wiskott-Aldrich Syndrome protein suggests a receptor-binding function for WH1 domainsJournal of Molecular Medicine, 75
H. Miki, K. Miura, K. Matuoka, T. Nakata, N. Hirokawa, S. Orita, K. Kaibuchi, Y. Takai, T. Takenawa (1994)
Association of Ash/Grb-2 with dynamin through the Src homology 3 domain.The Journal of biological chemistry, 269 8
S. Snapper, F. Rosen, E. Mizoguchi, Philip Cohen, W. Khan, C. Liu, T. Hagemann, S. Kwan, R. Ferrini, L. Davidson, A. Bhan, F. Alt (1998)
Wiskott-Aldrich syndrome protein-deficient mice reveal a role for WASP in T but not B cell activation.Immunity, 9 1
W. Lu, Steve Katz, Ruchika Gupta, B. Mayer (1997)
Activation of Pak by membrane localization mediated by an SH3 domain from the adaptor protein NckCurrent Biology, 7
D. Stewart, S. Treiber‐Held, C. Kurman, F. Facchetti, L. Notarangelo, D. Nelson (1996)
Studies of the expression of the Wiskott-Aldrich syndrome protein.The Journal of clinical investigation, 97 11
T. Zoladek, G. Vaduva, Leslie Hunter, M. Boguta, GO B.DENNIS, Nancy Martin, Anita Hopper (1995)
Mutations altering the mitochondrial-cytoplasmic distribution of Mod5p implicate the actin cytoskeleton and mRNA 3' ends and/or protein synthesis in mitochondrial deliveryMolecular and Cellular Biology, 15
A. Silva, Z. Li, C. Vera, E. Canto, P. Findell, C. Rudd (1997)
Cloning of a novel T-cell protein FYB that binds FYN and SH2-domain-containing leukocyte protein 76 and modulates interleukin 2 production.Proceedings of the National Academy of Sciences of the United States of America, 94 14
M. Rudolph, P. Bayer, A. Abo, J. Kuhlmann, I. Vetter, A. Wittinghofer (1998)
The Cdc42/Rac Interactive Binding Region Motif of the Wiskott Aldrich Syndrome Protein (WASP) Is Necessary but Not Sufficient for Tight Binding to Cdc42 and Structure Formation*The Journal of Biological Chemistry, 273
R. Pardi, L. Inverardi, C. Rugarli, J. Bender (1992)
Antigen-receptor complex stimulation triggers protein kinase C- dependent CD11a/CD18-cytoskeleton association in T lymphocytesThe Journal of Cell Biology, 116
G. Kammer, J. Smith, R. Mitchell (1983)
Capping of human T cell specific determinants: kinetics of capping and receptor re-expression and regulation by the cytoskeleton.Journal of immunology, 130 1
M. Baldini (1972)
NATURE OF THE PLATELET DEFECT IN THE WISKOTT‐ALDRICH SYNDROME *Annals of the New York Academy of Sciences, 201
Aldrich Ra, Steinberg Ag, Campbell Dc (1954)
Pedigree demonstrating a sex-linked recessive condition characterized by draining ears, eczematoid dermatitis and bloody diarrhea.Pediatrics, 13
SAU-PING, Kwan, Tracy Hagemann, Brian Radtke, R. Michael, BLAESEt, Fred Rosen (1995)
Identification of mutations in the Wiskott-Aldrich syndrome gene and characterization of a polymorphic dinucleotide repeat at DXS6940, adjacent to the disease gene.Proceedings of the National Academy of Sciences of the United States of America, 92 10
Yan Wu, S. Spencer, L. Lasky (1998)
Tyrosine Phosphorylation Regulates the SH3-mediated Binding of the Wiskott-Aldrich Syndrome Protein to PSTPIP, a Cytoskeletal-associated Protein*The Journal of Biological Chemistry, 273
T. Geppert, P. Lipsky (1990)
Regulatory role of microfilaments in the induction of T4 cell proliferation and interleukin 2 production.Cellular immunology, 131 1
E. Nishida, S. Maekawa, H. Sakai (1984)
Cofilin, a protein in porcine brain that binds to actin filaments and inhibits their interactions with myosin and tropomyosin.Biochemistry, 23 22
H. Miki, K. Miura, T. Takenawa (1996)
N‐WASP, a novel actin‐depolymerizing protein, regulates the cortical cytoskeletal rearrangement in a PIP2‐dependent manner downstream of tyrosine kinases.The EMBO Journal, 15
J. Hartwig, G. Bokoch, C. Carpenter, P. Janmey, Lance Taylor, A. Toker, T. Stossel (1995)
Thrombin receptor ligation and activated rac uncap actin filament barbed ends through phosphoinositide synthesis in permeabilized human plateletsCell, 82
K. Schwarz (1996)
WASPbase: a database of WAS- and XLT-causing mutations.Immunology today, 17 11
T. Lechler, Rong Li (1997)
In Vitro Reconstitution of Cortical Actin Assembly Sites in Budding YeastThe Journal of Cell Biology, 138
O. Parolini, G. Ressmann, O. Haas, J. Pawlowsky, H. Gadner, W. Knapp, W. Holter (1998)
X-linked Wiskott-Aldrich syndrome in a girl.The New England journal of medicine, 338 5
G. Wengler, JB Gorlin, JM Williamson, Fs Rosen, DH Bing (1995)
Nonrandom inactivation of the X chromosome in early lineage hematopoietic cells in carriers of Wiskott-Aldrich syndrome.Blood, 85 9
J. Derry, P. Wiedemann, P. Blair, Y. Wang, J. Kerns, V. Lemahieu, V. Godfrey, J. Wilkinson, U. Francke (1995)
The mouse homolog of the Wiskott-Aldrich syndrome protein (WASP) gene is highly conserved and maps near the scurfy (sf) mutation on the X chromosome.Genomics, 29 2
E. Remold-O’Donnell, J. Brocklyn, D. Kenney (1992)
Effect of platelet calpain on normal T-lymphocyte CD43: hypothesis of events in the Wiskott-Aldrich syndrome.Blood, 79 7
A. Shaw, Michael Dustin (1997)
Making the T cell receptor go the distance: a topological view of T cell activation.Immunity, 6 4
R. Parkman, D. Kenney, E. Remold-O’Donnell, S. Perrine, F. Rosen (1981)
SURFACE PROTEIN ABNORMALITIES IN LYMPHOCYTES AND PLATELETS FROM PATIENTS WITH WISKOTT-ALDRICH SYNDROMEThe Lancet, 318
A. Kuramoto, M. Steiner, M. Baldini (1970)
Lack of platelet response to stimulation in the Wiskott-Aldrich syndrome.The New England journal of medicine, 282 9
P. Phatak, C. Packman (1994)
Engagement of the T‐cell antigen receptor by anti‐CD3 monoclonal antibody causes a rapid increase in lymphocyte F‐actinJournal of Cellular Physiology, 159
C. Monks, B. Freiberg, H. Kupfer, N. Sciaky, A. Kupfer (1998)
Three-dimensional segregation of supramolecular activation clusters in T cellsNature, 395
K. Prasad, O. Janssen, R. Kapeller, M. Raab, Lewis Cantleyi, C. Rudd (1993)
Src-homology 3 domain of protein kinase p59fyn mediates binding to phosphatidylinositol 3-kinase in T cells.Proceedings of the National Academy of Sciences of the United States of America, 90 15
K. Fischer, Y. Kong, H. Nishina, K. Tedford, L. Marengère, I. Kozieradzki, Takehiko Sasaki, M. Starr, G. Chan, S. Gardener, M. Nghiem, D. Bouchard, M. Barbacid, A. Bernstein, J. Penninger, J. Penninger (1998)
Vav is a regulator of cytoskeletal reorganization mediated by the T-cell receptorCurrent Biology, 8
L. Quilliam, Q. Lambert, Leigh Mickelson-Young, J. Westwick, A. Sparks, B. Kay, N. Jenkins, D. Gilbert, N. Copeland, C. Der (1996)
Isolation of a NCK-associated Kinase, PRK2, an SH3-binding Protein and Potential Effector of Rho Protein Signaling*The Journal of Biological Chemistry, 271
D. Kenney, R. Reid, D. Parent, F. Rosen, Eileen Remold-O'Donnell (1994)
Evidence implicating calpain (Ca2+ ‐dependent neutral protease) in the destructive thrombocytopenia of the Wiskott‐Aldrich syndromeBritish Journal of Haematology, 87
S. Donnelly, M. Pocklington, D. Pallotta, E. Orr (1993)
A proline‐rich protein, verprolin, involved in cytoskeletal organization and cellular growth in the yeast Saccharomyces cerevisiaeMolecular Microbiology, 10
Luis Canales, Alvin Mauer (1967)
Sex-linked hereditary thrombocytopenia as a variant of Wiskott-Aldrich syndrome.The New England journal of medicine, 277 17
D. Kenney (1990)
Wiskott‐Aldrich syndrome and related X‐linked thrombocytopeniaCurrent Opinion in Pediatrics, 2
Antonello Petrella, I. Doti, V. Agosti, P. Giarrusso, D. Vitale, H. Bond, C. Cuomo, P. Tassone, Brunella Franco, Andrea Ballabio, Salvatore Venuta, Giovanni Morrone (1998)
A 5' regulatory sequence containing two Ets motifs controls the expression of the Wiskott-Aldrich syndrome protein (WASP) gene in human hematopoietic cells.Blood, 91 12
L. Lum, D. Tubergen, L. Corash, R. Blaese (1980)
Splenectomy in the management of the thrombocytopenia of the Wiskott-Aldrich syndrome.The New England journal of medicine, 302 16
I. Melamed, G. Downey, K. Aktories, C. Roifman (1991)
Microfilament assembly is required for antigen-receptor-mediated activation of human B lymphocytes.Journal of immunology, 147 4
Rikki Kolluri, K. Tolias, Christopher Carpenter, Fred Rosen, Tomas Kirchhausen (1996)
Direct interaction of the Wiskott-Aldrich syndrome protein with the GTPase Cdc42.Proceedings of the National Academy of Sciences of the United States of America, 93 11
Maiko Fukuoka, Hiroaki Miki, Tadaomi Takenawa (1997)
Identification of N-WASP homologs in human and rat brain.Gene, 196 1-2
O. Parolini, S. Berardelli, E. Riedl, C. Bello‐Fernandez, H. Strobl, O. Majdic, W. Knapp (1997)
Expression of Wiskott-Aldrich syndrome protein (WASP) gene during hematopoietic differentiation.Blood, 90 1
F. Facchetti, L. Blanzuoli, W. Vermi, L. Notarangelo, S. Giliani, M. Fiorini, A. Fasth, D. Stewart, D. Nelson (1998)
Defective actin polymerization in EBV‐transformed B‐cell lines from patients with the Wiskott–Aldrich syndromeThe Journal of Pathology, 185
H. Will, S. Atkinson, G. Butler, Bryan Smith, G. Murphy (1996)
The Soluble Catalytic Domain of Membrane Type 1 Matrix Metalloproteinase Cleaves the Propeptide of Progelatinase A and Initiates Autoproteolytic ActivationThe Journal of Biological Chemistry, 271
Yi-Chi Su, Jiahuai Han, Shuichan Xu, M. Cobb, E. Skolnik (1997)
NIK is a new Ste20‐related kinase that binds NCK and MEKK1 and activates the SAPK/JNK cascade via a conserved regulatory domainThe EMBO Journal, 16
M. Cooper, H. Chase, J. Lowman, W. Krivit, R. Good (1968)
Wiskott-Aldrich syndrome. An immunologic deficiency disease involving the afferent limb of immunity.The American journal of medicine, 44 4
D. Kenney, L. Cairns, E. Remold-O’Donnell, J. Peterson, F. Rosen, R. Parkman (1986)
Morphological abnormalities in the lymphocytes of patients with the Wiskott-Aldrich syndrome.Blood, 68 6
G. Downey, J. Butler, J. Brumell, N. Borregaard, L. Kjeldsen, A. Sue-A-Quan, S. Grinstein (1996)
Chemotactic Peptide-induced Activation of MEK-2, the Predominant Isoform in Human NeutrophilsThe Journal of Biological Chemistry, 271
A. Oda, H. Ochs, B. Druker, K. Ozaki, C. Watanabe, M. Handa, Y. Miyakawa, Yasuo Ikeda (1998)
Collagen induces tyrosine phosphorylation of Wiskott-Aldrich syndrome protein in human platelets.Blood, 92 6
T. Geppert, P. Lipsky (1991)
Association of various T cell-surface molecules with the cytoskeleton. Effect of cross-linking and activation.Journal of immunology, 146 10
Bianca Rocca, A. Bellacosa, R. Cristofaro, Giovanni Neri, M. Ventura, Nicola Maggiano, Carlo Rumi, Raffaele Landolfi (1996)
Wiskott-Aldrich syndrome: report of an autosomal dominant variant.Blood, 87 11
Steve Caplan, Shlomit Zeliger, Lynn Wang, Michal Baniyash (1995)
Cell-surface-expressed T-cell antigen-receptor zeta chain is associated with the cytoskeleton.Proceedings of the National Academy of Sciences of the United States of America, 92 11
Eileen Remold-O'Donnell, F. Rosen, D. Kenney (1996)
Defects in Wiskott-Aldrich syndrome blood cells.Blood, 87 7
M. Sells, U. Knaus, S. Bagrodia, D. Ambrose, G. Bokoch, J. Chernoff (1997)
Human p21-activated kinase (Pak1) regulates actin organization in mammalian cellsCurrent Biology, 7
O. Rivero-Lezcano, A. Marcilla, J. Sameshima, K. Robbins (1995)
Wiskott-Aldrich syndrome protein physically associates with Nck through Src homology 3 domainsMolecular and Cellular Biology, 15
Sau-Plng Kwan, Tracy Hagemann, R.Michael Blaese, A. Knutsen, Fred Rosen (1995)
Scanning of the Wiskott-Aldrich syndrome (WAS) gene: identification of 18 novel alterations including a possible mutation hotspot at Arg86 resulting in thrombocytopenia, a mild WAS phenotype.Human molecular genetics, 4 10
Wenda Greer, Pak Kwong, Monica Peacocke, Peter Ip, Laurence Rubin, Katherine Siminovitch (1989)
X-chromosome inactivation in the Wiskott-Aldrich syndrome: a marker for detection of the carrier state and identification of cell lineages expressing the gene defect.Genomics, 4 1
G. Wengler, L. Notarangelo, S. Giliani, M. Pirastru, A. Ugazio, O. Parolini (1995)
Mutation analysis in Wiskott Aldrich syndrome on chorionic villus DNAThe Lancet, 346
H. Miki, S. Nonoyama, Qili Zhu, A. Aruffo, H. Ochs, T. Takenawa (1997)
Tyrosine kinase signaling regulates Wiskott-Aldrich syndrome protein function, which is essential for megakaryocyte differentiation.Cell growth & differentiation : the molecular biology journal of the American Association for Cancer Research, 8 2
N. Selliah, M. Bartik, S. Carlson, W. Brooks, T. Roszman (1995)
cAMP accumulation in T-cells inhibits anti-CD3 monoclonal antibody-induced actin polymerizationJournal of Neuroimmunology, 56
Adam Pallant, Allen Eskenazi, Marie-Geneviève Mattei, R. Fournier, S. Carlsson, Minoru Fukuda, J. Frelinger (1989)
Characterization of cDNAs encoding human leukosialin and localization of the leukosialin gene to chromosome 16.Proceedings of the National Academy of Sciences of the United States of America, 86 4
K. Debell, A. Conti, María Alava, Thomas Hoffman, Ezio Bonvini (1992)
Microfilament assembly modulates phospholipase C-mediated signal transduction by the TCR/CD3 in murine T helper lymphocytes.Journal of immunology, 149 7
J. Chiaro, A. Dharmkrong-at, G. Bloom (1972)
X-linked thrombocytopenic purpura. I. Clinical and genetic studies of a kindred.American journal of diseases of children, 123 6
M. Symons, J. Derry, Brian Karlak, Sharon Jiang, V. Lemahieu, F. McCormick, U. Francke, A. Abo (1996)
Wiskott–Aldrich Syndrome Protein, a Novel Effector for the GTPase CDC42Hs, Is Implicated in Actin PolymerizationCell, 84
K. Hsieh, M. Chang, C. Lee, C. Wang (1988)
Wiskott-Aldrich syndrome and inflammatory bowel disease.Annals of allergy, 60 5
N. Henriquez, G. Rijkers, B. Zegers (1994)
Antigen receptor-mediated transmembrane signaling in Wiskott-Aldrich syndrome.Journal of immunology, 153 1
Sau-Ping Kwan, Thomas Lehner, Tracy Hagemann, Bing Lu, Michael Blaese, Hans Ochs, Ralph Wedgwood, Jurg Ott, Ian Craig, Fred Rosen (1991)
Localization of the gene for the Wiskott-Aldrich syndrome between two flanking markers, TIMP and DXS255, on Xp11.22-Xp11.3.Genomics, 10 1
A. Gilmore, K. Burridge (1996)
Regulation of vinculin binding to talin and actin by phosphatidyl-inositol-4-5-bisphosphateNature, 381
D. Pantaloni, M. Carlier (1993)
How profilin promotes actin filament assembly in the presence of thymosin β4Cell, 75
A. Villa, L. Notarangelo, P. Macchi, E. Mantuano, G. Cavagni, D. Brugnoni, D. Strina, M. Patrosso, U. Ramenghi, M. Sacco, A. Ugazio, P. Vezzoni (1995)
X–linked thrombocytopenia and Wiskott–Aldrich syndrome are allelic diseases with mutations in the WASP geneNature Genetics, 9
K. Matuoka, F. Shibasaki, M. Shibata, T. Takenawa (1993)
Ash/Grb‐2, a SH2/SH3‐containing protein, couples to signaling for mitogenesis and cytoskeletal reorganization by EGF and PDGF.The EMBO Journal, 12
Tom Joneson, Michele McDonough, D. Bar-Sagi, L. Aelst (1996)
RAC Regulation of Actin Polymerization and Proliferation by a Pathway Distinct from Jun KinaseScience, 274
S. Yonemura, A. Nagafuchi, N. Sato, Shoichiro (1993)
Concentration of an integral membrane protein, CD43 (leukosialin, sialophorin), in the cleavage furrow through the interaction of its cytoplasmic domain with actin-based cytoskeletonsThe Journal of Cell Biology, 120
Sheila Thomas, Philippe Soriano, A. Imamoto (1995)
Specific and redundant roles of Src and Fyn in organizing the cytoskeletonNature, 376
Lisa Stowers, Deborah Yelon, Leslie Berg, John Chant (1995)
Regulation of the polarization of T cells toward antigen-presenting cells by Ras-related GTPase CDC42.Proceedings of the National Academy of Sciences of the United States of America, 92 11
M. Parsey, George Lewis (1993)
Actin polymerization and pseudopod reorganization accompany anti-CD3-induced growth arrest in Jurkat T cells.Journal of immunology, 151 4
R. Taylor, W. Duffus, M. Raff, S. Petris (1971)
Redistribution and pinocytosis of lymphocyte surface immunoglobulin molecules induced by anti-immunoglobulin antibody.Nature: New biology, 233 42
J. Lehmann, G. Riethmuller, Judith Johnson (1990)
Nck, a melanoma cDNA encoding a cytoplasmic protein consisting of the src homology units SH2 and SH3.Nucleic acids research, 18 4
A. Marie-Cardine, E. Bruyns, C. Eckerskorn, H. Kirchgessner, S. Meuer, B. Schraven (1997)
Molecular Cloning of SKAP55, a Novel Protein That Associates with the Protein Tyrosine Kinase p59 fyn in Human T-lymphocytes*The Journal of Biological Chemistry, 272
E. Fearon, D. Kohn, J. Winkelstein, B. Vogelstein, R. Blaese (1988)
Carrier detection in the Wiskott Aldrich syndromeBlood, 72
Howard Pearson, Howard Pearson, N. Shulman, N. Shulman, F. Oski, F. Oski, Donald Eitzman, Donald Eitzman (1966)
Platelet survival in Wiskott-Aldrich syndrome.The Journal of pediatrics, 68 5
A. Hall (1998)
Rho GTPases and the actin cytoskeleton.Science, 279 5350
N. Lamarche, N. Tapon, L. Stowers, P. Burbelo, P. Aspenström, Tina Bridges, J. Chant, A. Hall (1996)
Rac and Cdc42 Induce Actin Polymerization and G1 Cell Cycle Progression Independently of p65PAK and the JNK/SAPK MAP Kinase CascadeCell, 87
Ochs, S., J., Slichter, L., A., Harker, W., E. Von, Behrens, R., Clark, Wedgwood (1980)
The Wiskott-Aldrich syndrome: studies of lymphocytes, granulocytes, and platelets.Blood, 55 2
(1997)
Variable expression of WASP in B cell lines of Wiskott-Aldrich syndrome patients.Journal of immunology, 158 9
S. Valitutti, M. Dessing, K. Aktories, H. Gallati, A. Lanzavecchia (1995)
Sustained signaling leading to T cell activation results from prolonged T cell receptor occupancy. Role of T cell actin cytoskeletonThe Journal of Experimental Medicine, 181
Giles Cory, L. MacCarthy-Morrogh, S. Banin, I. Gout, Paul Brickell, Roland Levinsky, Christine Kinnon, Ruth Lovering (1996)
Evidence that the Wiskott-Aldrich syndrome protein may be involved in lymphoid cell signaling pathways.Journal of immunology, 157 9
J. Prchal, A. Carroll, Prchal Jf, W. Crist, H. Skalka, W. Gealy, J. Harley, A. Malluh (1980)
Wiskott-Aldrich syndrome: cellular impairments and their implication for carrier detectionBlood, 56
B. Lowin-Kropf, V. Shapiro, A. Weiss (1998)
Cytoskeletal Polarization of T Cells Is Regulated by an Immunoreceptor Tyrosine-based Activation Motif–dependent MechanismThe Journal of Cell Biology, 140
T. Pawson (1995)
Protein modules and signalling networksNature, 373
I. Antón, W. Lu, B. Mayer, N. Ramesh, R. Geha (1998)
The Wiskott-Aldrich Syndrome Protein-interacting Protein (WIP) Binds to the Adaptor Protein Nck*The Journal of Biological Chemistry, 273
M. Galisteo, J. Chernoff, Yi-Chi Su, E. Skolnik, J. Schlessinger (1996)
The adaptor protein Nck links receptor tyrosine kinases with the serine-threonine kinase Pak1The Journal of Biological Chemistry, 271
H. Simon, G. Mills, S. Hashimoto, S. Hashimoto, K. Siminovitch (1992)
Evidence for defective transmembrane signaling in B cells from patients with Wiskott-Aldrich syndrome.The Journal of clinical investigation, 90 4
J. Puck, K. Siminovitch, M. Poncz, C. Greenberg, M. Rottem, M. Conley (1990)
Atypical presentation of Wiskott-Aldrich syndrome: diagnosis in two unrelated males based on studies of maternal T cell X chromosome inactivation.Blood, 75 12
P. Phatak, C. Packman, M. Lichtman (1988)
Protein kinase C modulates actin conformation in human T lymphocytes.Journal of immunology, 141 9
M. Olson, N. Pasteris, J. Gorski, A. Hall (1996)
Faciogenital dysplasia protein (FGD1) and Vav, two related proteins required for normal embryonic development, are upstream regulators of Rho GTPasesCurrent Biology, 6
Sau-Ping Kwan, Tracy Hagemann, R.Michael Blaese, Fred Rosen (1995)
A high-resolution map of genes, microsatellite markers, and new dinucleotide repeats from UBE1 to the GATA locus in the region Xp11.23.Genomics, 29 1
J. Derry, J. Kerns, K. Weinberg, H. Ochs, V. Volpini, X. Estivill, A. Walker, U. Francke, U. Francke (1995)
WASP gene mutations in Wiskott-Aldrich syndrome and X-linked thrombocytopenia.Human molecular genetics, 4 7
C. Monks, H. Kupfer, I. Tamir, A. Barlow, A. Kupfer (1997)
Selective modulation of protein kinase C-Θ during T-cell activationNature, 385
N. Selliah, William Brooks, T. Roszman (1996)
Proteolytic cleavage of alpha-actinin by calpain in T cells stimulated with anti-CD3 monoclonal antibody.Journal of immunology, 156 9
T. Kondoh, K. Hayashi, Tadashi Matsumoto, Masaaki Yoshimoto, Tomohiro Morio, J. Yata, Y. Tsuji (1995)
Two sisters with clinical diagnosis of Wiskott-Aldrich syndrome: is the condition in the family autosomal recessive?American journal of medical genetics, 60 5
K. Fischer, A. Zmuidzinas, S. Gardner, M. Barbacid, A. Bernstein, C. Guidos (1995)
Defective T-cell receptor signalling and positive selection of Vav-deficient CD4+CDS+thymocytesNature, 374
K. Fortner, J. Russell, R. Budd (1998)
Down‐modulation of CD2 delays deletion of superantigen‐responsive T cellsEuropean Journal of Immunology, 28
M. Raab, Yun-Cai Cai, S. Bunnell, S. Heyeck, L. Berg, C. Rudd (1995)
p56Lck and p59Fyn regulate CD28 binding to phosphatidylinositol 3-kinase, growth factor receptor-bound protein GRB-2, and T cell-specific protein-tyrosine kinase ITK: implications for T-cell costimulation.Proceedings of the National Academy of Sciences of the United States of America, 92 19
H. Miki, Takuya Sasaki, Y. Takai, T. Takenawa (1998)
Induction of filopodium formation by a WASP-related actin-depolymerizing protein N-WASPNature, 391
A. Rhoads, F. Friedberg (1997)
Sequence motifs for calmodulin recognitionThe FASEB Journal, 11
S. Valitutti, S. Müller, M. Cella, E. Padovan, A. Lanzavecchia (1995)
Serial triggering of many T-cell receptors by a few peptideMHC complexesNature, 375
E. Atkinson, H. Ostergaard, K. Kane, M. Pinkoski, A. Caputo, M. Olszowy, R. Bleackley (1996)
A Physical Interaction between the Cell Death Protein Fas and the Tyrosine Kinase p59(*)The Journal of Biological Chemistry, 271
G. Pedraza-Alva, Lilia Mérida, S. Burakoff, Y. Rosenstein (1996)
CD43-specific Activation of T Cells Induces Association of CD43 to Fyn Kinase*The Journal of Biological Chemistry, 271
N. Gerwin, C. Friedrich, Antonio Perez-Atayde, F. Rosen, J. Gutiérrez-Ramos (1996)
Multiple antigens are altered on T and B lymphocytes from peripheral blood and spleen of patients with Wiskott–Aldrich syndromeClinical & Experimental Immunology, 106
C. Nobes, A. Hall (1995)
Rho, Rac, and Cdc42 GTPases regulate the assembly of multimolecular focal complexes associated with actin stress fibers, lamellipodia, and filopodiaCell, 81
J. Derry, H. Ochs, U. Francke (1994)
Isolation of a novel gene mutated in Wiskott-Aldrich syndromeCell, 78
G. Wengler, Luigi Notarangelo, S. Berardelli, G. Pollonni, P. Mella, Anders Fasth, Alberto Ugazio, O. Parolini (1995)
High prevalence of nonsense, frame shift, and splice-site mutations in 16 patients with full-blown Wiskott-Aldrich syndrome.Blood, 86 10
Qili Zhu, Michael Zhang, R. Blaese, J. Derry, A. Junker, U. Francke, S.-H. Chen, H. Ochs (1995)
The Wiskott-Aldrich syndrome and X-linked congenital thrombocytopenia are caused by mutations of the same gene.Blood, 86 10
W.James Gealy, J. Dwyer, J. Harley (1980)
ALLELIC EXCLUSION OF GLUCOSE-6-PHOSPHATE DEHYDROGENASE IN PLATELETS AND T LYMPHOCYTES FROM A WISKOTT-ALDRICH SYNDROME CARRIERThe Lancet, 315
N. Fusaki, A. Iwamatsu, M. Iwashima, J. Fujisawa (1997)
Interaction between Sam68 and Src Family Tyrosine Kinases, Fyn and Lck, in T Cell Receptor Signaling*The Journal of Biological Chemistry, 272
E. Remold-O’Donnell, D. Kenney, R. Parkman, L. Cairns, B. Savage, F. Rosen (1984)
Characterization of a human lymphocyte surface sialoglycoprotein that is defective in Wiskott-Aldrich syndromeThe Journal of Experimental Medicine, 159
I. Molina, D. Kenney, Fred Rosen, Eileen Remold-O'Donnell (1992)
T cell lines characterize events in the pathogenesis of the Wiskott- Aldrich syndromeThe Journal of Experimental Medicine, 176
G. Basile, Rémi Lagelouse, Nathalie Lambert, Klaus Schwarz, Bernard Mareck, Sylvie Odent, Nicole Schlegel, Alain Fischer (1996)
Isolated X-linked thrombocytopenia in two unrelated families is associated with point mutations in the Wiskott-Aldrich syndrome protein gene.The Journal of pediatrics, 129 1
G. Taylor (1971)
Aeronautics before 1919Nature, 233
K. Gröttum, T. Hovig, H. Holmsen, A. Abrahamsen, M. Jeremić, M. Seip (1969)
Wiskott—Aldrich Syndrome: Qualitative Platelet Defects and Short Platelet SurvivalBritish Journal of Haematology, 17
R. Parkman, J. Rappeport, R. Geha, J. Belli, R. Cassady, R. Levey, D. Nathan, F. Rosen (1978)
Complete correction of the Wiskott-Aldrich syndrome by allogeneic bone-marrow transplantation.The New England journal of medicine, 298 17
S. Petris (1974)
Inhibition and reversal of capping by cytochalasin B, yinblastine and colchicineNature, 250
P. Aspenström, U. Lindberg, A. Hall (1996)
Two GTPases, Cdc42 and Rac, bind directly to a protein implicated in the immunodeficiency disorder Wiskott–Aldrich syndromeCurrent Biology, 6
M. Rozdzial, Bernard Malissen, Terri Finkel (1995)
Tyrosine-phosphorylated T cell receptor zeta chain associates with the actin cytoskeleton upon activation of mature T lymphocytes.Immunity, 3 5
D. Cox, P. Chang, T. Kurosaki, S. Greenberg (1996)
Syk Tyrosine Kinase Is Required for Immunoreceptor Tyrosine Activation Motif-dependent Actin Assembly*The Journal of Biological Chemistry, 271
Hongtao Yu, James Chen, S. Feng, D. Dalgarno, A. Brauer, Stuart Schrelber (1994)
Structural basis for the binding of proline-rich peptides to SH3 domainsCell, 76
R. Blaese, W. Strober, R. Brown, T. Waldmann (1968)
The Wiskott-Aldrich syndrome. A disorder with a possible defect in antigen processing or recognition.Lancet, 1 7551
D. Schindelhauer, M. Weiss, H. Hellebrand, A. Golla, M. Hergersberg, R. Seger, B. Belohradsky, A. Meindl (1996)
Wiskott-Aldrich syndrome: no strict genotype-phenotype correlations but clustering of missense mutations in the amino-terminal part of the WASP gene productHuman Genetics, 98
C. Shelley, Eileen Remold-O'Donnell, Alvin Davis, Gail Bruns, F. Rosen, Michael Carroll, Alexander Whitehead (1989)
Molecular characterization of sialophorin (CD43), the lymphocyte surface sialoglycoprotein defective in Wiskott-Aldrich syndrome.Proceedings of the National Academy of Sciences of the United States of America, 86 8
S. Spencer, D. Dowbenko, Jill Cheng, Wenlu Li, J. Brush, S. Utzig, V. Simanis, L. Lasky (1997)
PSTPIP: A Tyrosine Phosphorylated Cleavage Furrow–associated Protein that Is a Substrate for a PEST Tyrosine PhosphataseThe Journal of Cell Biology, 138
J. Bear, J. Rawls, C. Saxe (1998)
SCAR, a WASP-related Protein, Isolated as a Suppressor of Receptor Defects in Late Dictyostelium DevelopmentThe Journal of Cell Biology, 142
Rikki Kolluri, Amro Shehabeldin, Monica Peacocke, A. Lamhonwah, Krystyna Teichert-Kuliszewska, Sherman Weissman, Katherine Siminovitch (1995)
Identification of WASP mutations in patients with Wiskott-Aldrich syndrome and isolated thrombocytopenia reveals allelic heterogeneity at the WAS locus.Human molecular genetics, 4 7
K. Reif, D. Cantrell (1998)
Networking Rho family GTPases in lymphocytes.Immunity, 8 4
N. Ramesh, I. Antón, J. Hartwig, R. Geha (1997)
WIP, a protein associated with wiskott-aldrich syndrome protein, induces actin polymerization and redistribution in lymphoid cells.Proceedings of the National Academy of Sciences of the United States of America, 94 26
K. Sullivan, C. Mullen, R. Blaese, J. Winkelstein (1994)
A multiinstitutional survey of the Wiskott-Aldrich syndrome.The Journal of pediatrics, 125 6 Pt 1
P. Burbelo, D. Drechsel, A. Hall (1995)
A Conserved Binding Motif Defines Numerous Candidate Target Proteins for Both Cdc42 and Rac GTPases (*)The Journal of Biological Chemistry, 270
A. Tarakhovsky, M. Turner, S. Schaal, P. Mee, L. Duddy, K. Rajewsky, V. Tybulewicz (1995)
Defective antigen receptor-mediated proliferation of B and T cells in the absence of VavNature, 374
S. Zigmond (1998)
Actin cytoskeleton: The Arp2/3 complex gets to the pointCurrent Biology, 8
R. Badolato, Silvano Sozzani, Fabio Malacarne, Susanna Bresciani, M. Fiorini, A. Borsatti, Alberto Albertini, Alberto Mantovani, A. Ugazio, Luigi Notarangelo (1998)
Monocytes from Wiskott-Aldrich patients display reduced chemotaxis and lack of cell polarization in response to monocyte chemoattractant protein-1 and formyl-methionyl-leucyl-phenylalanine.Journal of immunology, 161 2
P. Finan, Candida Soames, L. Wilson, D. Nelson, D. Stewart, O. Truong, J. Hsuan, S. Kellie (1996)
Identification of Regions of the Wiskott-Aldrich Syndrome Protein Responsible for Association with Selected Src Homology 3 Domains*The Journal of Biological Chemistry, 271
S. Banin, O. Truong, D. Katz, M. Waterfield, P. Brickell, I. Gout (1996)
Wiskott–Aldrich syndrome protein (WASp) is a binding partner for c-Src family protein-tyrosine kinasesCurrent Biology, 6
W. Greer, Amro Shehabeldin, J. Schulman, A. Junker, Katherine Siminovitch (1996)
Identification of WASP mutations, mutation hotspots and genotype-phenotype disparities in 24 patients with the Wiskott-Aldrich syndromeHuman Genetics, 98
C. Amaya, S. Dorantes, A. Toro, A. Bello, J. Cuëllar (1973)
Attenuated form of Wiskott-Aldrich syndrome.The Journal of pediatrics, 82 1
Michael Dustin, M. Olszowy, A. Holdorf, Jun Li, S. Bromley, N. Desai, Patricia Widder, F. Rosenberger, P. Merwe, P. Allen, A. Shaw (1998)
A Novel Adaptor Protein Orchestrates Receptor Patterning and Cytoskeletal Polarity in T-Cell ContactsCell, 94
S. Bunnell, P. Henry, Rikki Kolluri, T. Kirchhausen, R. Rickles, L. Berg (1996)
Identification of Itk/Tsk Src Homology 3 Domain Ligands*The Journal of Biological Chemistry, 271
M. Peacocke, K. Siminovitch (1987)
Linkage of the Wiskott-Aldrich syndrome with polymorphic DNA sequences from the human X chromosome.Proceedings of the National Academy of Sciences of the United States of America, 84 10
S. Helmke, K. Pfenninger, K. Pfenninger (1995)
Growth cone enrichment and cytoskeletal association of non-receptor tyrosine kinases.Cell motility and the cytoskeleton, 30 3
L. Holsinger, I. Graef, W. Swat, T. Chi, D. Bautista, L. Davidson, R. Lewis, F. Alt, G. Crabtree (1998)
Defects in actin-cap formation in Vav-deficient mice implicate an actin requirement for lymphocyte signal transductionCurrent Biology, 8
E. Calautti, C. Missero, P. Stein, R. Ezzell, G. Dotto (1995)
fyn tyrosine kinase is involved in keratinocyte differentiation control.Genes & development, 9 18
G. Vaduva, N. Martin, A. Hopper (1997)
Actin-binding Verprolin Is a Polarity Development Protein Required for the Morphogenesis and Function of the Yeast Actin CytoskeletonThe Journal of Cell Biology, 139
Rong Zhang, F. Alt, L. Davidson, S. Orkin, W. Swat (1995)
Defective signalling through the T- and B-cell antigen receptors in lymphoid cells lacking the vav proto-oncogeneNature, 374
I. Molina, J. Sancho, C. Terhorst, F. Rosen, E. Remold-O’Donnell (1993)
T cells of patients with the Wiskott-Aldrich syndrome have a restricted defect in proliferative responses.Journal of immunology, 151 8
T. Stossel (1993)
On the crawling of animal cells.Science, 260 5111
H. Miki, T. Takenawa (1998)
Direct binding of the verprolin-homology domain in N-WASP to actin is essential for cytoskeletal reorganization.Biochemical and biophysical research communications, 243 1
Verhoeven Aj, Vanags Ie, H. vanHaarlem, Akkerman Jw (1989)
Impaired energy metabolism in platelets from patients with Wiskott-Aldrich syndrome.Thrombosis and Haemostasis, 61
V. Morales, S. Snapper, R. Blumberg (1996)
Probing the gastrointestinal immune function using transgenic and knockout technologyCurrent Opinion in Gastroenterology, 12
L. Altman, R. Snyderman, R. Blaese (1974)
Abnormalities of chemotactic lymphokine synthesis and mononuclear leukocyte chemotaxis in Wiskott-Aldrich syndrome.The Journal of clinical investigation, 54 2
Hong She, S. Rockow, Jiping Tang, Riko Nishimura, E. Skolnik, Mei Chen, Ben Margolis, Wei Li (1997)
Wiskott-Aldrich syndrome protein is associated with the adapter protein Grb2 and the epidermal growth factor receptor in living cells.Molecular biology of the cell, 8 9
P. Garrity, Y. Rao, I. Salecker, J. Mcglade, T. Pawson, S. Zipursky (1996)
Drosophila Photoreceptor Axon Guidance and Targeting Requires the Dreadlocks SH2/SH3 Adapter ProteinCell, 85
T. Pawson (1995)
Getting down to specificsNature, 373
A. Kupfer, S. Swain, C. Janeway, S. Singer (1986)
The specific direct interaction of helper T cells and antigen-presenting B cells.Proceedings of the National Academy of Sciences of the United States of America, 83 16
H. Stormorken, B. Hellum, T. Egeland, T. Abrahamsen, T. Hovig (1991)
X-Linked Thrombocytopenia and Thrombocytopathia: Attenuated Wiskott-Aldrich SyndromeThrombosis and Haemostasis, 65
G. Marone, F. Albini, L. Martino, S. Quattrin, S. Poto, M. Condorelli (1986)
The Wiskott‐Aldrich syndrome: studies of platelets, basophils and polymorphonuclear leucocytesBritish Journal of Haematology, 62
Sawping Kwan, Lodewijk SANrxuyL, Michael Blaese, Louis Kunkel, Gail Bruns, Robin Parmley, Shannon Skarshaug, David Page, Jurg On, Fred Rosen (1988)
Genetic mapping of the Wiskott-Aldrich syndrome with two highly-linked polymorphic DNA markers.Genomics, 3 1
▪ Abstract The Wiskott-Aldrich Syndrome (WAS) is a rare X-linked primary immunodeficiency that is characterized by recurrent infections, hematopoietic malignancies, eczema, and thrombocytopenia. A variety of hematopoietic cells are affected by the genetic defect, including lymphocytes, neutrophils, monocytes, and platelets. Early studies noted both signaling and cytoskeletal abnormalities in lymphocytes from WAS patients. Following the identification of WASP , the gene mutated in patients with this syndrome, and the more generally expressed WASP homologue N-WASP , studies have demonstrated that WASP-family molecules associate with numerous signaling molecules known to alter the actin cytoskeleton. WASP/N-WASP may depolymerize actin directly and/or serve as an adaptor or scaffold for these signaling molecules in a complex cascade that regulates the cytoskeleton.
Annual Review of Immunology – Annual Reviews
Published: Apr 1, 1999
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