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The T Cell Receptor as a Multicomponent Signalling Machine: CD4/CD8 Coreceptors and CD45 in T Cell Activation

The T Cell Receptor as a Multicomponent Signalling Machine: CD4/CD8 Coreceptors and CD45 in T... The T cell receptor is a multicomponent signalling machine. The three main components are the hypervariable (l(: f3 heterodimer that confers specificity and its attendant invariant chains CD3 y, 6, and s and the (: ( or,: 1'/, the CD4 or CDS coreceptor, and CD45. Each of these components is required for efficient signal transduction, and each has relevant enzy­ matic activity associated with it. The invariant part of the T cell receptor is associated with the tyrosine kinase p59!yn, the coreceptors are associated with the tyrosine kinase p561c\ and the cytoplasmic domain of CD45 has tyrosine-specific phosphatase activity. Moreover, there is strong evidence that these components interact in the plane of the membrane, and that these interactions are relevant for signal transduction. Finally, changes in the structure of CD45 that occur during differentiation of T cells alter the interactions of these three components of the signal transducing machin­ ery, perhaps accounting for changes in signal transduction that accompany T-cell development in the thymus and the development of immunological memory cells. 645 0732-0582/92/041 0--0645$02.00 JANEWAY INTRODUCTION The activation of T cells is required for virtually all immune responses. Activation can be assessed in many different ways, each illustrating http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Annual Review of Immunology Annual Reviews

The T Cell Receptor as a Multicomponent Signalling Machine: CD4/CD8 Coreceptors and CD45 in T Cell Activation

Annual Review of Immunology , Volume 10 (1) – Apr 1, 1992

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Publisher
Annual Reviews
Copyright
Copyright 1992 Annual Reviews. All rights reserved
Subject
Review Articles
ISSN
0732-0582
eISSN
1545-3278
DOI
10.1146/annurev.iy.10.040192.003241
pmid
1534242
Publisher site
See Article on Publisher Site

Abstract

The T cell receptor is a multicomponent signalling machine. The three main components are the hypervariable (l(: f3 heterodimer that confers specificity and its attendant invariant chains CD3 y, 6, and s and the (: ( or,: 1'/, the CD4 or CDS coreceptor, and CD45. Each of these components is required for efficient signal transduction, and each has relevant enzy­ matic activity associated with it. The invariant part of the T cell receptor is associated with the tyrosine kinase p59!yn, the coreceptors are associated with the tyrosine kinase p561c\ and the cytoplasmic domain of CD45 has tyrosine-specific phosphatase activity. Moreover, there is strong evidence that these components interact in the plane of the membrane, and that these interactions are relevant for signal transduction. Finally, changes in the structure of CD45 that occur during differentiation of T cells alter the interactions of these three components of the signal transducing machin­ ery, perhaps accounting for changes in signal transduction that accompany T-cell development in the thymus and the development of immunological memory cells. 645 0732-0582/92/041 0--0645$02.00 JANEWAY INTRODUCTION The activation of T cells is required for virtually all immune responses. Activation can be assessed in many different ways, each illustrating

Journal

Annual Review of ImmunologyAnnual Reviews

Published: Apr 1, 1992

There are no references for this article.