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ALTON I. SUTNICK, M.D., IRVING MILLMAN, PH.D., W. THOMAS LONDON, M.D., BARUCH S. BLUMBERG, M.D., PH.D. The Institute for Cancer Research, Fox Chase, Philadelphia, Pennsylvania Australia antigen [Au(l)] is an infectious agent which can cause hepatitis in man. The data supporting the infectious hypothesis as well as the genetic, clinical, epidemiologic, and other studies have been reviewed elsewhere (1-4). Other current studies will be reviewed in this paper. CHEMISTRY et The presence of genetic material in Au(1) was first reported by Jozwiak al (5) in January, 1971. In their studies, nucleic acids were found in small (Juantities (5 percent) in purified Au(1), and colorimetric tests were negative for DNA. They concluded that Au(1) contains RNA; thi s has been con firmed by Millman and colleagues. In an earlier study, Millman et al (6) reported that if RNA were p resen t in Au(1) it would constitute less than 10 percent of the total weight of protein. Australia antigen has been isolated fro m plasma by pretreatment with a variety of proteolytic and other enzymes, followed by gel filtration and densi ty centrifugation . The isolated particles of Au(1) (free of normal serum constituents) have an electron microscopic appearance
Annual Review of Medicine – Annual Reviews
Published: Feb 1, 1972
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