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D. Presky, H. Yang, L. Minetti, A. Chua, N. Nabavi, Chang‐you Wu, M. Gately, U. Gubler (1996)
A functional interleukin 12 receptor complex is composed of two beta-type cytokine receptor subunits.Proceedings of the National Academy of Sciences of the United States of America, 93 24
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Endogenously produced IL-12 is required for the induction of protective T cells during Mycobacterium avium infections in mice.Journal of immunology, 155 4
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▪ Abstract Interleukin-12 (IL-12) is a heterodimeric cytokine that plays a central role in promoting type 1 T helper cell (Th1) responses and, hence, cell-mediated immunity. Its activities are mediated through a high-affinity receptor composed of two subunits, designated β1 and β2. Of these two subunits, β2 is more restricted in its distribution, and regulation of its expression is likely a central mechanism by which IL-12 responsiveness is controlled. Studies with neutralizing anti-IL-12 antibodies and IL-12-deficient mice have suggested that endogenous IL-12 plays an important role in the normal host defense against infection by a variety of intracellular pathogens. However, IL-12 appears also to play a central role in the genesis of some forms of immunopathology. Inhibition of IL-12 synthesis or activity may be beneficial in diseases associated with pathologic Th1 responses, such as multiple sclerosis or Crohn's disease. On the other hand, administration of recombinant IL-12 may have utility in the treatment of diseases associated with pathologic Th2 responses such as allergic disorders and asthma.
Annual Review of Immunology – Annual Reviews
Published: Apr 1, 1998
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