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Warner C. Greene Metabolism Branch, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20205 Warren J. Leonard Cell Biology and Metabolism Branch, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland 20205 OVERVIEW OF INTERLEUKIN-2 (IL-2) AND IL-2 RECEPTORS In 1 976, Morgan et al first reported the presence of a T-cell growth promoting activity in the supernatants of activated T-cell cultures; they denoted this T-cell growth factor (TCGF) (1). In subsequent years, TCGF was characterized as a distinct biochemical entity and found to be a 15,500dalton glycoprotein (2). TCGF was purified to homogeneity (3), molecu larly cloned (4), and cDNAs expressed in eukaryotic cells. The entire gene has now been sequenced (5, 6) and localized to human chromosome 4 (7). TCGF, or interleukin-2 (IL-2) as it is now denoted, has played a key role in the study ofT-cell biology. This lymphokine has permitted both the long term growth and the cloning of hurnan and murine T-cell lines displaying helper and cytotoxic T-cell function (8). Furthermore, possible therapeutic effects of IL-2 in various malignancies and immunodeficiency states are now under study. IL-2 is not produced by resting T cells; however, following activation
Annual Review of Immunology – Annual Reviews
Published: Apr 1, 1986
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