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R. Negrin, D. Haeuber, A. Nagler, L. Olds, T. Donlon, L. Souza, P. Greenberg (1989)
Treatment of myelodysplastic syndromes with recombinant human granulocyte colony-stimulating factor. A phase I-II trial.Annals of internal medicine, 110 12
A. Gianni, M. Bregni, A. Stern, S. Siena, C. Tarella, A. Pileri, G. Bonadonna (1989)
GRANULOCYTE-MACROPHAGE COLONY-STIMULATING FACTOR TO HARVEST CIRCULATING HAEMOPOIETIC STEM CELLS FOR AUTOTRANSPLANTATIONThe Lancet, 334
W. Hammond, T. Price, L. Souza, D. Dale (1989)
Treatment of cyclic neutropenia with granulocyte colony-stimulating factor.The New England journal of medicine, 320 20
D. Gearing, J. King, N. Gough, Nicos A-Nicola (1989)
Expression cloning of a receptor for human granulocyte‐macrophage colony‐stimulating factor.The EMBO Journal, 8
John Thompson, Douglas Lee, P. Kidd, E. Rubin, Jenny Kaufmann, E. Bonnem, A. Fefer (1989)
Subcutaneous granulocyte-macrophage colony-stimulating factor in patients with myelodysplastic syndrome: toxicity, pharmacokinetics, and hematological effects.Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 7 5
C. Kelleher, Gary Wong, S. Clark, P. Schendel, Minden, E. McCulloch (1988)
Binding of iodinated recombinant human GM-CSF to the blast cells of acute myeloblastic leukemia.Leukemia, 2 4
Hans-Georg Fischer, S. Frosch, K. Reske, A. Reske-Kunz (1988)
Granulocyte-macrophage colony-stimulating factor activates macrophages derived from bone marrow cultures to synthesis of MHC class II molecules and to augmented antigen presentation function.Journal of immunology, 141 11
C. Begley, F. A., Lopez, A. N., Nicola, J. D., Warren, A. M., Vadas, J. C., Sanderson, D., Metcalf (1986)
Purified colony-stimulating factors enhance the survival of human neutrophils and eosinophils in vitro: a rapid and sensitive microassay for colony-stimulating factors.Blood, 68 1
G. Morstyn, G. Lieschke, J. Cebon, U. Dührsen, J. Villeval, W. Sheridan, K. McGrath, J. Layton (1989)
Early clinical trials with colony-stimulating factors.Cancer investigation, 7 5
M. Bronchud, A. Howell, D. Crowther, P. Hopwood, L. Souza, T. Dexter (1989)
The use of granulocyte colony-stimulating factor to increase the intensity of treatment with doxorubicin in patients with advanced breast and ovarian cancer.British Journal of Cancer, 60
S. Brandt, W. Peters, S. Atwater, J. Kurtzberg, Michael Borowitz, Roy Jones, E. Shpall, R. Bast, C. Gilbert, D. Oette (1988)
Effect of recombinant human granulocyte-macrophage colony-stimulating factor on hematopoietic reconstitution after high-dose chemotherapy and autologous bone marrow transplantation.The New England journal of medicine, 318 14
K. Welte, C. Zeidler, A. Reiter, W. Muller, E. Odenwald, L. Souza, H. Riehm (1990)
Differential effects of granulocyte-macrophage colony-stimulating factor and granulocyte colony-stimulating factor in children with severe congenital neutropenia.Blood, 75 5
A. Lindemann, F. Herrmann, W. Oster, G. Haffner, W. Meyenburg, L. Souza, R. Mertelsmann (1989)
Hematologic effects of recombinant human granulocyte colony-stimulating factor in patients with malignancy.Blood, 74 8
J. Antin, D. Weinberg, D. Rosenthal (1990)
Variable effect of recombinant human granulocyte-macrophage colony-stimulating factor on bone marrow fibrosis in patients with myelodysplasia.Experimental hematology, 18 4
C. Gattringer, J. Thaler, J. Drach, M. Micksche, H. Huber (1989)
GM-CSF treatment in aplasia after cytotoxic therapy.Onkologie, 12 1
M. Andreeff, A. Tafuri, S. Hegewisch-Becker (1990)
Colony-stimulating factors (rhG-CSF, rhGM-CSF, rhIL-3, and BCGF) recruit myeloblastic and lymphoblastic leukemic cells and enhance the cytotoxic effects of cytosine-arabinoside.Haematology and blood transfusion, 33
MH Bronchud, J. Scarffe, N. Thatcher, D. Crowther, L. Souza, N. Alton, N. Testa, T. Dexter (1987)
Phase I/II study of recombinant human granulocyte colony-stimulating factor in patients receiving intensive chemotherapy for small cell lung cancer.British Journal of Cancer, 56
M. Moore (1990)
Coordinate Actions of Hematopoietic Growth Factors in Stimulation of Bone Marrow Function
J. Gabrilove, A. Jakubowski, Katherine Fain, J. Grous, H. Scher, C. Sternberg, A. Yagoda, B. Clarkson, M. Bonilla, H. Oettgen, K. Alton, T. Boone, B. Altrock, K. Welte, Lawrence SouLat (1988)
Phase I study of granulocyte colony-stimulating factor in patients with transitional cell carcinoma of the urothelium.The Journal of clinical investigation, 82 4
R. Simmers, L. Webber, M. Shannon, M. Garson, G. Wong, M. Vadas, G. Sutherland (1987)
Localization of the G-CSF gene on chromosome 17 proximal to the breakpoint in the t(15;17) in acute promyelocytic leukemia.Blood, 70 1
G. Wong, JS Witek, P. Temple, KM Wilkens, AC Leary, DP Luxenberg, Jones Ss, E. Brown, Kay Rm, Orr Ec (1985)
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R. Fukunaga, Etsuko Ishizaka-Ikeda, Y. Seto, S. Nagata (1990)
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J. Layton, H. Hockman, W. Sheridan, G. Morstyn (1989)
Evidence for a novel in vivo control mechanism of granulopoiesis: mature cell-related control of a regulatory growth factorBlood, 74
H. Koeffler, J. Gasson, Andreas Tobler (1988)
Transcriptional and posttranscriptional modulation of myeloid colony-stimulating factor expression by tumor necrosis factor and other agentsMolecular and Cellular Biology, 8
Stephen Devereux, H. Bull, D. Ccmpos‐Costa, R. Saib, Dc Linch (1989)
Granulocyte macrophage colony stimulating factor induced changes in cellular adhesion molecule expression and adhesion to endothelium: in‐vitro and in‐vivo studies in manBritish Journal of Haematology, 71
François Herrmann, A. Lindemann, H. Klein, Michael Lübbert, G. Schulz, R. Mertelsmann (1989)
Effect of recombinant human granulocyte-macrophage colony-stimulating factor in patients with myelodysplastic syndrome with excess blasts.Leukemia, 3 5
J. Cebon, G. Morstyn (1990)
The potential role of granulocyte-macrophage colony stimulating factor (GM-CSF) in cancer chemotherapy.Cancer surveys, 9 1
K. Ikebuchi, J. Ihle, Y. Hirai, G. Wong, S. Clark, M. Ogawa (1988)
Synergistic factors for stem cell proliferation: further studies of the target stem cells and the mechanism of stimulation by interleukin-1, interleukin-6, and granulocyte colony-stimulating factor.Blood, 72 6
G. Lieschke, J. Cebon, G. Morstyn (1989)
Characterization of the clinical effects after the first dose of bacterially synthesized recombinant human granulocyte-macrophage colony-stimulating factor.Blood, 74 8
H. Teshima, Jun Ishikawa, Hitoshi Kitayama, Tamotsu Yamagami, A. Hiraoka, Hiroyuki Nakamura, Hirotoshi Shibata, T. Masaoka, F. Takaku (1989)
Clinical effects of recombinant human granulocyte colony-stimulating factor in leukemia patients: a phase I/II study.Experimental hematology, 17 8
Salvatore Siena, M. Bregni, B. Brando, F. Ravagnani, G. Bonadonna, Gianni Am (1989)
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W. Seelentag, J. Mermod, R. Montesano, P. Vassalli (1987)
Additive effects of interleukin 1 and tumour necrosis factor‐alpha on the accumulation of the three granulocyte and macrophage colony‐stimulating factor mRNAs in human endothelial cells.The EMBO Journal, 6
S. Vadhan-Raj, M. Keating, M. Keating, A. Lemaistre, A. Lemaistre, W. Hittelman, W. Hittelman, K. McCredie, K. McCredie, J. Trujillo, J. Trujillo, H. Broxmeyer, H. Broxmeyer, C. Henney, C. Henney, J. Gutterman, J. Gutterman (1987)
Effects of recombinant human granulocyte-macrophage colony-stimulating factor in patients with myelodysplastic syndromes.The New England journal of medicine, 317 25
W. Oster, A. Lindemann, R. Mertelsmann, F. Herrmann (1989)
Granulocyte-macrophage colony-stimulating factor (CSF) and multilineage CSF recruit human monocytes to express granulocyte CSF.Blood, 73 1
Kerry Taylor, S. Jagannath, G. Spitzer, J. Spinolo, S Tucker, Beverly Fogel, Fernando Cabanillas, F. Hagemeister, Lawrence Souza (1989)
Recombinant human granulocyte colony-stimulating factor hastens granulocyte recovery after high-dose chemotherapy and autologous bone marrow transplantation in Hodgkin's disease.Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 7 12
By Ulrich, J. Villeval, Janis Boyd, G. Kannourakis, George Morstyn, D. Metcalf (1988)
Effects of recombinant human granulocyte colony-stimulating factor on hematopoietic progenitor cells in cancer patients.Blood, 72 6
M. Bonilla, A. Gillio, Mary Ruggeiro, N. Kernan, J. Brochstein, Miguel Abboud, Luca Fumagalli, M. Vincent, Janice Gabrilove, Karl Welte, Lawrence Souza, Richard O'Reilly (1989)
Effects of recombinant human granulocyte colony-stimulating factor on neutropenia in patients with congenital agranulocytosis.The New England journal of medicine, 320 24
S. Vadhan-Raj, W. Hittelman, H. Broxmeyer, M. Keating, D. Urdal, J. Gutterman (1989)
In Vivo Biologic Activities of Recombinant Human Granulocyte‐Macrophage Colony‐Stimulating FactorAnnals of the New York Academy of Sciences, 554
S. Kaplan, RE Basford, Edward Wing, Rk Shadduck (1989)
The effect of recombinant human granulocyte macrophage colony-stimulating factor on neutrophil activation in patients with refractory carcinoma.Blood, 73 3
D. Coleman, J. Chodakewitz, A. Bartiss, J. Mellors (1988)
Granulocyte-macrophage colony-stimulating factor enhances selective effector functions of tissue-derived macrophagesBlood, 72
J. Gabrilove, A. Jakubowski, H. Scher, C. Sternberg, G. Wong, J. Grous, A. Yagoda, Katherine Fain, M. Moore, B. Clarkson, H. Oettgen, K. Alton, K. Welte, L. Souza (1988)
Effect of granulocyte colony-stimulating factor on neutropenia and associated morbidity due to chemotherapy for transitional-cell carcinoma of the urothelium.The New England journal of medicine, 318 22
Yu-Chung Yang, A. Ciarletta, P. Temple, M. Chung, S. Clark (1986)
Human IL-3 (multi-CSF): Identification by expression cloning of a novel hematopoietic growth factor related to murine IL-3Cell, 47
Edward Wing, Dewey Magee, Theresa Whiteside, S. Kaplan, R. Shadduck (1989)
Recombinant human granulocyte/macrophage colony-stimulating factor enhances monocyte cytotoxicity and secretion of tumor necrosis factor alpha and interferon in cancer patients.Blood, 73 3
W. Steward, J. Scarffe, R. Austin, E. Bonnem, N. Thatcher, G. Morgenstern, D. Crowther (1989)
Recombinant human granulocyte macrophage colony stimulating factor (rhGM-CSF) given as daily short infusions--a phase I dose-toxicity study.British Journal of Cancer, 59
K. Welte, E. Platzer, L. Lu, J. Gabrilove, E. Levi, R. Mertelsmann, M. Moore (1985)
Purification and biochemical characterization of human pluripotent hematopoietic colony-stimulating factor.Proceedings of the National Academy of Sciences of the United States of America, 82 5
A. Ohsaka, S. Kitagawa, S. Sakamoto, Yasuo Miura, N. Takanashi, Fumimaro Takaku, M. Saito (1989)
In vivo activation of human neutrophil functions by administration of recombinant human granulocyte colony-stimulating factor in patients with malignant lymphoma.Blood, 74 8
Colony stimulating factors and interleukins regulate proliferation, differ entiation, and functional activation of hematopoietic cells of multiple lineages. These hematopoietic growth factors are proving effective in vivo in stimulation of granulopoiesis in clinical situations associated with myelosuppression. G-CSF and GM-CSF promote accelerated granulocyte recovery following chemotherapy, or allogeneic or autologous bone mar row transplantation, in patients with cancer. In congenital defects of granulocyte production or in acquired disorders such as idiopathic neutro penia or aplastic anemia, CSF administration can lead to recovery of functioning granulocytes. This has resulted in a reduction in the morbidity and mortality associated with these diseases and now permits both a dose and a schedule intensification of chemotherapy. In myeloid leukemia and mye10dysplastic syndromes, CSF treatment, particularly G-CSF, has proved effective for certain patients in improving neutrophil, platelet, and occasionally red cell production while reducing blast cells. The recombinant growth factors are generally well tolerated with few limiting toxicities at dose levels that effectively stimulate hematopoiesis. INTRODUCTION Colony stimulating factors (CSF) belong to an ever expanding family of hematopoietic growth factors that includes ten interleukins (IL-I-IO) and 1 59 0732-0582/91/0410-0159 $02.00 MOORE erythropoietin. Initially defined and identified by their ability to stimulate colony formation
Annual Review of Immunology – Annual Reviews
Published: Apr 1, 1991
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