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Specific Cell-Adhesion Mechanisms Determining Migration Pathways of Recirculating Lymphocytes

Specific Cell-Adhesion Mechanisms Determining Migration Pathways of Recirculating Lymphocytes Recirculating lymphocytes traffic continuously between blood and lymph moving by a route that takes them through various lymphoid organs in the body. Though the cells circulate freely in the bloodstream and have opportunity for interaction elsewhere, they are not promiscuous but faith­ fully seek out those blood vessels that provide entry into these tissues (1-15). Lymphocytes gain access to lymph nodes and mucosal-associated lymphoid tissues, e.g. Peyer's patches, via a system of specialized mic­ rovascular structures, the high endothelial cell venules (HEV) (4). Such interactions are crucial for recirculation and reassortment of lymphocytes because the vascular endothelium is the first barrier these cells must nego­ tiate as they move from blood into tissue. Prime .importance is therefore attached to the understanding of lymphocyte-high endothelial cell inter­ actions. This review thus focuses on properties of lymphocytes and high endothelium that play a role in their affinity and specificity for each other. 201 0732--0582/87/0410--0201$02.00 WOODRUFF, CLARKE & CHIN Other aspects of lymphocyte recirculation have ben reviewed elsewhere (8, 10-15) and are only briefly considered here. PHYSIOLOGIC CHARACTERISTICS OF LYMPHOCYTE RECIRCULATION The lymphoid system is composed of fixed, distinct organs widely dis­ tributed throughout the body and circulating lymphocytes moving through http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Annual Review of Immunology Annual Reviews

Specific Cell-Adhesion Mechanisms Determining Migration Pathways of Recirculating Lymphocytes

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References (48)

Publisher
Annual Reviews
Copyright
Copyright 1987 Annual Reviews. All rights reserved
Subject
Review Articles
ISSN
0732-0582
eISSN
1545-3278
DOI
10.1146/annurev.iy.05.040187.001221
pmid
3297104
Publisher site
See Article on Publisher Site

Abstract

Recirculating lymphocytes traffic continuously between blood and lymph moving by a route that takes them through various lymphoid organs in the body. Though the cells circulate freely in the bloodstream and have opportunity for interaction elsewhere, they are not promiscuous but faith­ fully seek out those blood vessels that provide entry into these tissues (1-15). Lymphocytes gain access to lymph nodes and mucosal-associated lymphoid tissues, e.g. Peyer's patches, via a system of specialized mic­ rovascular structures, the high endothelial cell venules (HEV) (4). Such interactions are crucial for recirculation and reassortment of lymphocytes because the vascular endothelium is the first barrier these cells must nego­ tiate as they move from blood into tissue. Prime .importance is therefore attached to the understanding of lymphocyte-high endothelial cell inter­ actions. This review thus focuses on properties of lymphocytes and high endothelium that play a role in their affinity and specificity for each other. 201 0732--0582/87/0410--0201$02.00 WOODRUFF, CLARKE & CHIN Other aspects of lymphocyte recirculation have ben reviewed elsewhere (8, 10-15) and are only briefly considered here. PHYSIOLOGIC CHARACTERISTICS OF LYMPHOCYTE RECIRCULATION The lymphoid system is composed of fixed, distinct organs widely dis­ tributed throughout the body and circulating lymphocytes moving through

Journal

Annual Review of Immunology – Annual Reviews

Published: Apr 1, 1987

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