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S IGNAL T RANSDUCTION M EDIATED BY THE T C ELL A NTIGEN R ECEPTOR : The Role of Adapter Proteins*

S IGNAL T RANSDUCTION M EDIATED BY THE T C ELL A NTIGEN R ECEPTOR : The Role of Adapter Proteins* ▪ Abstract Engagement of the T cell antigen receptor (TCR) leads to a complex series of molecular changes at the plasma membrane, in the cytoplasm, and at the nucleus that lead ultimately to T cell effector function. Activation at the TCR of a set of protein tyrosine kinases (PTKs) is an early event in this process. This chapter reviews some of the critical substrates of these PTKs, the adapter proteins that, following phosphorylation on tyrosine residues, serve as binding sites for many of the critical effector enzymes and other adapter proteins required for T cell activation. The role of these adapters in binding various proteins, the interaction of adapters with plasma membrane microdomains, and the function of adapter proteins in control of the cytoskeleton are discussed. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Annual Review of Immunology Annual Reviews

S IGNAL T RANSDUCTION M EDIATED BY THE T C ELL A NTIGEN R ECEPTOR : The Role of Adapter Proteins*

Annual Review of Immunology , Volume 20 (1) – Apr 1, 2002

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Publisher
Annual Reviews
Copyright
Copyright 2002 Annual Reviews. All rights reserved
Subject
Review Articles
ISSN
0732-0582
eISSN
1545-3278
DOI
10.1146/annurev.immunol.20.092601.111357
pmid
11861607
Publisher site
See Article on Publisher Site

Abstract

▪ Abstract Engagement of the T cell antigen receptor (TCR) leads to a complex series of molecular changes at the plasma membrane, in the cytoplasm, and at the nucleus that lead ultimately to T cell effector function. Activation at the TCR of a set of protein tyrosine kinases (PTKs) is an early event in this process. This chapter reviews some of the critical substrates of these PTKs, the adapter proteins that, following phosphorylation on tyrosine residues, serve as binding sites for many of the critical effector enzymes and other adapter proteins required for T cell activation. The role of these adapters in binding various proteins, the interaction of adapters with plasma membrane microdomains, and the function of adapter proteins in control of the cytoskeleton are discussed.

Journal

Annual Review of ImmunologyAnnual Reviews

Published: Apr 1, 2002

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