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Regulation of Major Histocompatibility Complex Class-II Genes: X,Y and Other Letters of the Alphabet

Regulation of Major Histocompatibility Complex Class-II Genes: X,Y and Other Letters of the Alphabet Class-II genes of the major histocompatibility complex (MHC) play a key role in regulating and restricting the immune response (1). They control the acquisition of the mature T cell repertoire by positive and negative selection events in the thymus (2), and they provide the molecular support for antigen presentation to T cells (3), thus conditioning the initiating events of the immune response as well as intercellular collaboration between the various actors (3). Probably as a reflection of their regulatory role, class-II gene products (also called Ia molecules) show a specific and limited cell-type distribution. This specific expression is further modulated by a variety of positive and negative effectors. The study of MHC class­ II gene regulation is thus of interest for two reasons: because of the importance of class-II genes in the immune system, and because they present a challenge to the student of eukaryotic gene regulation. We limit the scope of this review to the regulation of those genes that encode the "classical" Ia molecules: the A and E complexes in Mus and the HLA-DR, DQ, and DP complexes in Homo. Each of these is a heterodimeric membrane glycoprotein comprised of an alpha and a beta 681 http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Annual Review of Immunology Annual Reviews

Regulation of Major Histocompatibility Complex Class-II Genes: X,Y and Other Letters of the Alphabet

Annual Review of Immunology , Volume 8 (1) – Apr 1, 1990

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References (88)

Publisher
Annual Reviews
Copyright
Copyright 1990 Annual Reviews. All rights reserved
Subject
Review Articles
ISSN
0732-0582
eISSN
1545-3278
DOI
10.1146/annurev.iy.08.040190.003341
pmid
2111709
Publisher site
See Article on Publisher Site

Abstract

Class-II genes of the major histocompatibility complex (MHC) play a key role in regulating and restricting the immune response (1). They control the acquisition of the mature T cell repertoire by positive and negative selection events in the thymus (2), and they provide the molecular support for antigen presentation to T cells (3), thus conditioning the initiating events of the immune response as well as intercellular collaboration between the various actors (3). Probably as a reflection of their regulatory role, class-II gene products (also called Ia molecules) show a specific and limited cell-type distribution. This specific expression is further modulated by a variety of positive and negative effectors. The study of MHC class­ II gene regulation is thus of interest for two reasons: because of the importance of class-II genes in the immune system, and because they present a challenge to the student of eukaryotic gene regulation. We limit the scope of this review to the regulation of those genes that encode the "classical" Ia molecules: the A and E complexes in Mus and the HLA-DR, DQ, and DP complexes in Homo. Each of these is a heterodimeric membrane glycoprotein comprised of an alpha and a beta 681

Journal

Annual Review of ImmunologyAnnual Reviews

Published: Apr 1, 1990

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