Access the full text.
Sign up today, get DeepDyve free for 14 days.
P. Stuart, G. Cassell, J. Woodward (1989)
Induction of class II MHC antigen expression in macrophages by Mycoplasma species.Journal of immunology, 142 10
R. Steinman, Nadia Nogueira, M. Witmer, J. Tydings, Ira Ii (1980)
Lymphokine enhances the expression and synthesis of Ia antigens on cultured mouse peritoneal macrophagesThe Journal of Experimental Medicine, 152
I. Amaldi, W. Reith, C. Berte, B. Mach (1989)
Induction of HLA class II genes by IFN-gamma is transcriptional and requires a trans-acting protein.Journal of immunology, 142 3
M. Boothby, H. Liou, L. Glimcher (1989)
Differences in DNA sequence specificity among MHC class II X box binding proteins.Journal of immunology, 142 3
D. Mathis, C. Benoist, V. Williams, M. Kanter, H. Mcdevitt (1983)
The murine Eα immune response geneCell, 32
R. Salter, J. Alexander, F. Levine, D. Pious, P. Cresswell (1985)
Evidence for two trans-acting genes regulating HLA class II antigen expression.Journal of immunology, 135 6
Berish Rubin, Sylvia Anderson, Ruth Lunn, N. Richardson, Gary Hellermann, Larry Smith, Lloyd Old (1988)
Tumor necrosis factor and IFN induce a common set of proteins.Journal of immunology, 141 4
L. Falk, L. Wahl, S. Vogel (1988)
Analysis of Ia antigen expression in macrophages derived from bone marrow cells cultured in granulocyte-macrophage colony-stimulating factor or macrophage colony-stimulating factor.Journal of immunology, 140 8
A. Marcadet, D. Cohen, J. Dausset, A. Fischer, A. Durandy, C. Griscelli (1985)
Genotyping with DNA probes in combined immunodeficiency syndrome with defective expression of HLA.The New England journal of medicine, 312 20
T. Collins, L. Lapierre, W. Fiers, J. Strominger, J. Pober (1986)
Recombinant human tumor necrosis factor increases mRNA levels and surface expression of HLA-A,B antigens in vascular endothelial cells and dermal fibroblasts in vitro.Proceedings of the National Academy of Sciences of the United States of America, 83 2
Jose ALVARO-GRACIA, N. Zvaifler, G. Firestein (1989)
Cytokines in chronic inflammatory arthritis. IV. Granulocyte/macrophage colony-stimulating factor-mediated induction of class II MHC antigen on human monocytes: a possible role in rheumatoid arthritisThe Journal of Experimental Medicine, 170
J. Mckearn, C. Baum, J. Davie (1984)
Cell surface antigens expressed by subsets of pre-B cells and B cells.Journal of immunology, 132 1
M. Boothby, E. Gravallese, H. Liou, L. Glimcher (1988)
A DNA binding protein regulated by IL-4 and by differentiation in B cells.Science, 242 4885
N. Jones, P. Rigby, E. Ziff (1988)
Trans-acting protein factors and the regulation of eukaryotic transcription: lessons from studies on DNA tumor viruses.Genes & development, 2 3
A. Calman, B. Peterlin (1988)
Evidence for a trans-acting factor that regulates the transcription of class II major histocompatibility complex genes: genetic and functional analysis.Proceedings of the National Academy of Sciences of the United States of America, 85 23
J. Monroe, J. Cambier (1983)
Level of mIa expression on mitogen-stimulated murine B lymphocytes is dependent on position in cell cycle.Journal of immunology, 130 2
D. Paulnock-King, K. Sizer, Y. Freund, P. Jones, J. Parnes (1985)
Coordinate induction of Ia alpha, beta, and Ii mRNA in a macrophage cell line.Journal of immunology, 135 1
P. Halloran, J. Jephthah-Ochola, J. Urmson, S. Farkas (1985)
Systemic immunologic stimuli increase class I and II antigen expression in mouse kidney.Journal of immunology, 135 2
Clifford Hume, Janet Lee (1989)
Congenital immunodeficiencies associated with absence of HLA class II antigens on lymphocytes result from distinct mutations in trans-acting factors.Human immunology, 26 4
W. Koch, C. Benoist, D. Mathis (1989)
Anatomy of a new B-cell-specific enhancerMolecular and Cellular Biology, 9
P. Massa, A. Schimpl, E. Wecker, V. meulen (1987)
Tumor necrosis factor amplifies measles virus-mediated Ia induction on astrocytes.Proceedings of the National Academy of Sciences of the United States of America, 84 20
Paula Sherman, Patricia BASTAt, J. Ting
Upstream DNA sequences required for tissue-specific expression of the HLA-DRa gene
R. Accolla, L. Scarpellino, G. Carra, J. Guardiola (1985)
Trans-acting element(s) operating across species barriers positively regulate expression of major histocompatibility complex class II genesThe Journal of Experimental Medicine, 162
R. Chang, S. Lee (1986)
Effects of interferon-gamma and tumor necrosis factor-alpha on the expression of an Ia antigen on a murine macrophage cell line.Journal of immunology, 137 9
H. Saito, R. Maki, L. Clayton, S. Tonegawa (1983)
Complete primary structures of the E beta chain and gene of the mouse major histocompatibility complex.Proceedings of the National Academy of Sciences of the United States of America, 80 18
A. Houghton, T. Thomson, D. Gross, H. Oettgen, L. Old (1984)
Surface antigens of melanoma and melanocytes. Specificity of induction of Ia antigens by human gamma-interferonThe Journal of Experimental Medicine, 160
R. Schöpfer, F. Figueroa, D. Nižetić, E. Nevo, J. Klein (1987)
Evolutionary diversification of class II P loci in the Mhc of the mole-rat Spalax ehrenbergi.Molecular biology and evolution, 4 3
Y. Wang, A. Larsen, B. Peterlin (1987)
A tissue-specific transcriptional enhancer is found in the body of the HLA-DR alpha geneThe Journal of Experimental Medicine, 166
S. Squinto, J. Doucet, A. Block, S. Morrow, W. Davenport (1989)
Induction of macrophage-like differentiation of HL-60 leukemia cells by tumor necrosis factor-alpha: potential role of fos expression.Molecular endocrinology, 3 2
W. Landschulz, P. Johnson, S. McKnight (1988)
The leucine zipper: a hypothetical structure common to a new class of DNA binding proteins.Science, 240 4860
M. Klemsz, L. Justement, E. Palmer, J. Cambier (1989)
Induction of c-fos and c-myc expression during B cell activation by IL-4 and immunoglobulin binding ligands.Journal of immunology, 143 3
A. Zlotnik, M. Fischer, N. Roehm, D. Zipori (1987)
Evidence for effects of interleukin 4 (B cell stimulatory factor 1) on macrophages: enhancement of antigen presenting ability of bone marrow-derived macrophages.Journal of immunology, 138 12
Nopporn Sittisombut (1988)
Two distinct nuclear factors bind the conserved regulatory sequences of a rabbit major histocompatibility complex class II geneMolecular and Cellular Biology, 8
E. Stimac, S. Lyons, D. Pious (1988)
Transcription of HLA class II genes in the absence of B-cell-specific octamer-binding factorMolecular and Cellular Biology, 8
G. Trinchieri, M. Kobayashi, M. Rosen, R. Loudon, M. Murphy, B. Perussia (1986)
Tumor necrosis factor and lymphotoxin induce differentiation of human myeloid cell lines in synergy with immune interferonThe Journal of Experimental Medicine, 164
T. Godal, C. Davies, E. Smeland, R. Heikkilä, S. Funderud, H. Steen, K. Hildrum (1985)
Antibodies to surface IgM and IgD increase the expression of various class II antigens on human B cellsEuropean Journal of Immunology, 15
P. Sherman, P. Basta, T. Moore, A. Brown, J. Ting (1989)
Class II box consensus sequences in the HLA-DR alpha gene: transcriptional function and interaction with nuclear proteinsMolecular and Cellular Biology, 9
G. Dennis, J. Mizuguchi, V. McMillan, F. Finkelman, J. Ohara, J. Mond (1987)
Comparison of the calcium requirement for the induction and maintenance of B cell class II molecule expression and for B cell proliferation stimulated by mitogens and purified growth factors.Journal of immunology, 138 12
C. Préval, B. Lisowska‐Grospierre, M. Loche, C. Griscelli, B. Mach (1985)
A trans-acting class II regulatory gene unlinked to the MHC controls expression of HLA class II genesNature, 318
P. Sarthou, Evelyne Jouvain‐Marche, P. Cazenave, Christian Guern (1987)
Phorbol ester induces class II gene expression in pre‐B cell linesEuropean Journal of Immunology, 17
T. Cotner, J. Williams, L. Christenson, H. Shapiro, T. Strom, J. Strominger (1983)
Simultaneous flow cytometric analysis of human T cell activation antigen expression and DNA contentThe Journal of Experimental Medicine, 157
F. Momburg, N. Koch, P. Möller, G. Moldenhauer, G. Butcher, G. Hämmerling (1986)
Differential expression of Ia and Ia-associated invariant chain in mouse tissues after in vivo treatment with IFN-gamma.Journal of immunology, 136 3
F. Latron, M. Jotterand-Bellomo, A. Maffei, L. Scarpellino, M. Bernard, J. Strominger, R. Accolla (1988)
Active suppression of major histocompatibility complex class II gene expression during differentiation from B cells to plasma cells.Proceedings of the National Academy of Sciences of the United States of America, 85 7
M. Diedrichs, D. Schendel (1989)
Differential surface expression of class II isotypes on activated CD4 and CD8 cells correlates with levels of locus-specific mRNA.Journal of immunology, 142 9
R. Pujol-Borrell, I. Todd, M. Doshi, G. Bottazzo, R. Sutton, D. Gary, G. Adolf, M. Feldmann (1987)
HLA class II induction in human islet cells by interferon-γ plus tumour necrosis factor or lymphotoxinNature, 326
P. Marrack, J. Kappler (1988)
The T-cell repertoire for antigen and MHC.Immunology today, 9 10
M. Takiguchi, J. Frelinger (1986)
Induction of antigen presentation ability in purified cultures of astroglia by interferon-gamma.The Journal of molecular and cellular immunology : JMCI, 2 5
Masataka Nakamura, T. Manser, G. Pearson, M. Daley, M. Gefter (1984)
Effect of IFN-γ on the immune response in vivo and on gene expression in vitroNature, 307
L. Mengle-Gaw, H. Mcdevitt (1985)
Genetics and expression of mouse Ia antigens.Annual review of immunology, 3
Y. Noma, P. Sideras, T. Naito, Susanne Bergstedt-Lindquist, C. Azuma, E. Severinson, T. Tanabe, T. Kinashi, F. Matsuda, Y. Yaoita, T. Honjo (1986)
Cloning of cDNA encoding the murine IgG1 induction factor by a novel strategy using SP6 promoterNature, 319
L. Leclercq, J. Cambier, Z. Mishal, M. Julius, J. Thèze (1986)
Supernatant from a cloned helper T cell stimulates most small resting B cells to undergo increased I-A expression, blastogenesis, and progression through cell cycle.Journal of immunology, 136 2
Patricia Steeg, Robert Moore, Joost Oppenheim (1980)
Regulation of murine macrophage Ia-antigen expression by products of activated spleen cellsThe Journal of Experimental Medicine, 152
R. Schwartz (1986)
Immune response (Ir) genes of the murine major histocompatibility complex.Advances in immunology, 38
B. Aggarwal, T. Eessalu, P. Hass (1985)
Characterization of receptors for human tumour necrosis factor and their regulation by γ-interferonNature, 318
A. Dorn, B. Durand, Corinne Marfing, M. Meur, C. Benoist, D. Mathis (1987)
Conserved major histocompatibility complex class II boxes--X and Y--are transcriptional control elements and specifically bind nuclear proteins.Proceedings of the National Academy of Sciences of the United States of America, 84 17
T. Lindsten, C. Thompson, F. Finkelman, B. Andersson, I. Scher (1984)
Changes in the expression of B cell surface markers on complement receptor-positive and complement receptor-negative B cells induced by phorbol myristate acetate.Journal of immunology, 132 1
P. Stuart, A. Zlotnik, J. Woodward (1988)
Induction of class I and class II MHC antigen expression on murine bone marrow-derived macrophages by IL-4 (B cell stimulatory factor 1).Journal of immunology, 140 5
R. Huijsduijnen, J. Bollekens, A. Dorn, C. Benoist, D. Mathis (1987)
Properties of a CCAAT box-binding protein.Nucleic acids research, 15 18
R. Germain (1986)
Immunology: The ins and outs of antigen processing and presentationsNature, 322
W. Reith, S. Satola, C. Sanchez, I. Amaldi, B. Lisowska‐Grospierre, C. Griscelli, M. Hadam, B. Mach (1988)
Congenital immunodeficiency with a regulatory defect in MHC class II gene expression lacks a specific HLA-DR promoter binding protein, RF-XCell, 53
P. Mitchell, R. Tjian (1989)
Transcriptional regulation in mammalian cells by sequence-specific DNA binding proteins.Science, 245 4916
S. Singh, E. Abramson, C. Krco, C. David (1984)
Endogenous synthesis of Ia antigens by a cloned T cell line.The Journal of molecular and cellular immunology : JMCI, 1 3
Clifford Hume, L. Shookster, Nancy Collins, R. O'Reilly, Janet Lee (1989)
Bare lymphocyte syndrome: altered HLA class II expression in B cell lines derived from two patients.Human immunology, 25 1
S. Berrih, F. Arenzana‐Seisdedos, S. Cohen, R. Devos, D. Charron, J. Virelizier (1985)
Interferon-gamma modulates HLA class II antigen expression on cultured human thymic epithelial cells.Journal of immunology, 135 2
M. Scher, D. Beller, E. Unanue (1980)
Demonstration of a soluble mediator that induces exudates rich in Ia- positive macrophagesThe Journal of Experimental Medicine, 152
G. Bancroft, K. Sheehan, Robert Schreiber, Emil Unanue (1989)
Tumor necrosis factor is involved in the T cell-independent pathway of macrophage activation in scid mice.Journal of immunology, 143 1
F. Rousset, R. Malefijt, B. Slierendregt, J. Aubry, J. Bonnefoy, T. Defrance, J. Banchereau, J. Vries (1988)
Regulation of Fc receptor for IgE (CD23) and class II MHC antigen expression on Burkitt's lymphoma cell lines by human IL-4 and IFN-gamma.Journal of immunology, 140 8
D. Didier, J. Schiffenbauer, S. Woulfe, M. Zacheis, B. Schwartz (1988)
Characterization of the cDNA encoding a protein binding to the major histocompatibility complex class II Y box.Proceedings of the National Academy of Sciences of the United States of America, 85 19
J. Mckearn, N. Rosenberg (1985)
Mapping cell surface antigens on mouse pre‐B cell linesEuropean Journal of Immunology, 15
P. Dellabona, F. Latron, A. Maffei, L. Scarpellino, R. Accolla (1989)
Transcriptional control of MHC class II gene expression during differentiation from B cells to plasma cells.Journal of immunology, 142 8
S. Smale, D. Baltimore (1989)
The “initiator” as a transcription control elementCell, 57
D. Niederwieser, J. Auböck, J. Troppmair, M. Herold, G. Schuler, G. Boeck, J. Lotz, P. Fritsch, C. Huber (1988)
IFN-mediated induction of MHC antigen expression on human keratinocytes and its influence on in vitro alloimmune responses.Journal of immunology, 140 8
P. Gladstone, D. Pious (1978)
Stable variants affecting B cell alloantigens in human lymphoid cellsNature, 271
M. Lenardo, D. Baltimore (1989)
NF-κB: A pleiotropic mediator of inducible and tissue-specific gene controlCell, 58
J. Pober, T. Collins, M. Gimbrone, R. Cotran, J. Gitlin, W. Fiers, C. Clayberger, A. Krensky, S. Burakoff, C. Reiss (1983)
Lymphocytes recognize human vascular endothelial and dermal fibroblast Ia antigens induced by recombinant immune interferonNature, 305
M. Schuermann, M. Neuberg, J. Hunter, T. Jenuwein, R. Ryseck, R. Bravo, R. Müller (1989)
The leucine repeat motif in Fos protein mediates complex formation with Jun/AP-1 and is required for transformationCell, 56
A. Dorn, H. Fehling, W. Koch, M. Meur, P. Gerlinger, C. Benoist, D. Mathis (1988)
B-cell control region at the 5' end of a major histocompatibility complex class II gene: sequences and factorsMolecular and Cellular Biology, 8
M. Sakurai, J. Strominger (1988)
B-cell-specific enhancer activity of conserved upstream elements of the class II major histocompatibility complex DQB gene.Proceedings of the National Academy of Sciences of the United States of America, 85 18
M. Blanar, L. Burkly, R. Flavell (1989)
NF-kappa B binds within a region required for B-cell-specific expression of major histocompatibility complex class II gene E alpha dMolecular and Cellular Biology, 9
R. Noelle, W. Kuziel, C. Maliszewski, E. McAdams, E. Vitetta, P. Tucker (1986)
Regulation of the expression of multiple class II genes in murine B cells by B cell stimulatory factor-1 (BSF-1).Journal of immunology, 137 5
J. Greenstein, E. Lord, P. Horan, J. Kappler, P. Marrack (1981)
Functional subsets of B cells defined by quantitative differences in surface I-A.Journal of immunology, 126 6
K. Sullivan, B. Peterlin (1987)
Transcriptional enhancers in the HLA-DQ subregionMolecular and Cellular Biology, 7
W. Reith, E. Barras, S. Satola, M. Kobr, D. Reinhart, Candelaria Sánchez, B. Mach (1989)
Cloning of the major histocompatibility complex class II promoter binding protein affected in a hereditary defect in class II gene regulation.Proceedings of the National Academy of Sciences of the United States of America, 86 11
S. Gillies, V. Folsom, S. Tonegawa (1984)
Cell type-specific enhancer element associated with a mouse MHC gene, EβNature, 310
F. Levine, D. Pious (1984)
Revertants from the HLA class II regulatory mutant 6.1.6: implications for the regulation of Ia gene expression.Journal of immunology, 132 2
N. Roehm, H. Leibson, Albert Zlotnik, J. Kappler, P. Marrack, J. Cambier, Damon Winchell (1984)
Interleukin-induced increase in Ia expression by normal mouse B cellsThe Journal of Experimental Medicine, 160
B. Servenius, L. Rask, P. Peterson (1987)
Class II genes of the human major histocompatibility complex. The DO beta gene is a divergent member of the class II beta gene family.The Journal of biological chemistry, 262 18
H. Liou, Mark Boothby, Laurie Glimcher (1988)
Distinct cloned class II MHC DNA binding proteins recognize the X box transcription element.Science, 242 4875
Class-II genes of the major histocompatibility complex (MHC) play a key role in regulating and restricting the immune response (1). They control the acquisition of the mature T cell repertoire by positive and negative selection events in the thymus (2), and they provide the molecular support for antigen presentation to T cells (3), thus conditioning the initiating events of the immune response as well as intercellular collaboration between the various actors (3). Probably as a reflection of their regulatory role, class-II gene products (also called Ia molecules) show a specific and limited cell-type distribution. This specific expression is further modulated by a variety of positive and negative effectors. The study of MHC class II gene regulation is thus of interest for two reasons: because of the importance of class-II genes in the immune system, and because they present a challenge to the student of eukaryotic gene regulation. We limit the scope of this review to the regulation of those genes that encode the "classical" Ia molecules: the A and E complexes in Mus and the HLA-DR, DQ, and DP complexes in Homo. Each of these is a heterodimeric membrane glycoprotein comprised of an alpha and a beta 681
Annual Review of Immunology – Annual Reviews
Published: Apr 1, 1990
Read and print from thousands of top scholarly journals.
Already have an account? Log in
Bookmark this article. You can see your Bookmarks on your DeepDyve Library.
To save an article, log in first, or sign up for a DeepDyve account if you don’t already have one.
Copy and paste the desired citation format or use the link below to download a file formatted for EndNote
Access the full text.
Sign up today, get DeepDyve free for 14 days.
All DeepDyve websites use cookies to improve your online experience. They were placed on your computer when you launched this website. You can change your cookie settings through your browser.