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Regulation of B-Cell Growth and Differentiation by Soluble Factors

Regulation of B-Cell Growth and Differentiation by Soluble Factors Interleukins are a family of molecules that transmit growth and differentia­ tion signals between various types of leukocytes and thus presumably are major effectors of immune regulation. Cell biologists and immunologists have directed much attention to the nature of interleukins that operate on T lymphocytes (84,85) and macrophages (15,106). Recently, it has become clear that such antigen-nonspecific cofactors also operate on B lymphocytes (5,27,49,51,52,56,63,73,97,99,104,110,129,135,141,142). However, as is common in an emerging field, an overall understanding of the involve­ ment of soluble factors in B-cell responses has been hampered by competing nomenclatures and by the use of differing operational criteria to identify, describe, enumerate, and characterize the various B cell-specific interleu­ kins. Here we review a variety of observations derived from both single and multicellular in vitro assays, using both mouse and human lymphocytes and numerous sources of interleukins, in an effort to derive a unified concept of factor-mediated B-cell development. Such an understanding will require an appreciation of the substantial functional heterogeneity of B cells, e.g. sub­ sets, lineages, differentiation stages, and individual specificity. Thus, it is desirable to preface our review with a brief description of the physiology of this system. Splenic B lymphocytes of the mouse http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Annual Review of Immunology Annual Reviews

Regulation of B-Cell Growth and Differentiation by Soluble Factors

Howard, M; Paul, W E
Annual Review of Immunology , Volume 1 (1) – Apr 1, 1983
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Publisher
Annual Reviews
Copyright
Copyright 1983 Annual Reviews. All rights reserved
Subject
Review Articles
ISSN
0732-0582
eISSN
1545-3278
DOI
10.1146/annurev.iy.01.040183.001515
pmid
6242466
Publisher site
See Article on Publisher Site

Abstract

Interleukins are a family of molecules that transmit growth and differentia­ tion signals between various types of leukocytes and thus presumably are major effectors of immune regulation. Cell biologists and immunologists have directed much attention to the nature of interleukins that operate on T lymphocytes (84,85) and macrophages (15,106). Recently, it has become clear that such antigen-nonspecific cofactors also operate on B lymphocytes (5,27,49,51,52,56,63,73,97,99,104,110,129,135,141,142). However, as is common in an emerging field, an overall understanding of the involve­ ment of soluble factors in B-cell responses has been hampered by competing nomenclatures and by the use of differing operational criteria to identify, describe, enumerate, and characterize the various B cell-specific interleu­ kins. Here we review a variety of observations derived from both single and multicellular in vitro assays, using both mouse and human lymphocytes and numerous sources of interleukins, in an effort to derive a unified concept of factor-mediated B-cell development. Such an understanding will require an appreciation of the substantial functional heterogeneity of B cells, e.g. sub­ sets, lineages, differentiation stages, and individual specificity. Thus, it is desirable to preface our review with a brief description of the physiology of this system. Splenic B lymphocytes of the mouse

Journal

Annual Review of Immunology – Annual Reviews

Published: Apr 1, 1983

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