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Receptor-Mediated Antigen Uptake and its Effect on Antigen Presentation to Class II-Restricted T Lymphocytes

Receptor-Mediated Antigen Uptake and its Effect on Antigen Presentation to Class II-Restricted T... While the antigen-antibody interaction can be described by the con­ centration and affinity of the two reactants, the recognition of exogenous protein antigens by class II-restricted T cells follows more complex rules. T lymphocytes recognize complexes of antigen bound to major histo­ compatibility complex (MHC) molecules on the surface of antigen pre­ senting cells (APC). Since most soluble protein antigens do not bind in their native form to class-II molecules, the APC have to capture these antigens, then internalize and process them, usually by proteolysis, into a form able to bind to class-II molecules. These complexes are reexposed on the cell surface where they must reach a critical threshold for T-cell triggering (1). Thus, the concentration of the antigen-MHC class-II complexes that accumulate on an APC exposed to antigen is dependent on several factors: (a) the concentration of free antigen, (b) the efficiency of antigen capture by APC, (c) the efficiency of processing, (d) the concentration of class-II molecules with available binding sites and, (e) the stability of the complex. 773 0732--0582/90/0410--0773$02.00 LANZAVECCHIA Each of these factors may become limiting under particular conditions and can be in principle compensated by increasing any of the others. Class-II expression and http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Annual Review of Immunology Annual Reviews

Receptor-Mediated Antigen Uptake and its Effect on Antigen Presentation to Class II-Restricted T Lymphocytes

Annual Review of Immunology , Volume 8 (1) – Apr 1, 1990

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Publisher
Annual Reviews
Copyright
Copyright 1990 Annual Reviews. All rights reserved
Subject
Review Articles
ISSN
0732-0582
eISSN
1545-3278
DOI
10.1146/annurev.iy.08.040190.004013
pmid
2188679
Publisher site
See Article on Publisher Site

Abstract

While the antigen-antibody interaction can be described by the con­ centration and affinity of the two reactants, the recognition of exogenous protein antigens by class II-restricted T cells follows more complex rules. T lymphocytes recognize complexes of antigen bound to major histo­ compatibility complex (MHC) molecules on the surface of antigen pre­ senting cells (APC). Since most soluble protein antigens do not bind in their native form to class-II molecules, the APC have to capture these antigens, then internalize and process them, usually by proteolysis, into a form able to bind to class-II molecules. These complexes are reexposed on the cell surface where they must reach a critical threshold for T-cell triggering (1). Thus, the concentration of the antigen-MHC class-II complexes that accumulate on an APC exposed to antigen is dependent on several factors: (a) the concentration of free antigen, (b) the efficiency of antigen capture by APC, (c) the efficiency of processing, (d) the concentration of class-II molecules with available binding sites and, (e) the stability of the complex. 773 0732--0582/90/0410--0773$02.00 LANZAVECCHIA Each of these factors may become limiting under particular conditions and can be in principle compensated by increasing any of the others. Class-II expression and

Journal

Annual Review of ImmunologyAnnual Reviews

Published: Apr 1, 1990

There are no references for this article.