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Protein Tyrosine Phosphatases in Autoimmunity

Protein Tyrosine Phosphatases in Autoimmunity Protein tyrosine phosphatases (PTPs) are important regulators of many cellular functions and a growing number of PTPs have been implicated in human disease conditions, such as developmental defects, neoplastic disorders, and immunodeficiency. Here, we review the involvement of PTPs in human autoimmunity. The leading examples include the allelic variant of the lymphoid tyrosine phosphatase ( PTPN22 ), which is associated with multiple autoimmune diseases, and mutations that affect the exon-intron splicing of CD45 ( PTPRC ). We also find it likely that additional PTPs are involved in susceptibility to autoimmune and inflammatory diseases. Finally, we discuss the possibility that PTPs regulating the immune system may serve as therapeutic targets. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Annual Review of Immunology Annual Reviews

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Publisher
Annual Reviews
Copyright
Copyright © 2008 by Annual Reviews. All rights reserved
ISSN
0732-0582
eISSN
1545-3278
DOI
10.1146/annurev.immunol.26.021607.090418
pmid
18303998
Publisher site
See Article on Publisher Site

Abstract

Protein tyrosine phosphatases (PTPs) are important regulators of many cellular functions and a growing number of PTPs have been implicated in human disease conditions, such as developmental defects, neoplastic disorders, and immunodeficiency. Here, we review the involvement of PTPs in human autoimmunity. The leading examples include the allelic variant of the lymphoid tyrosine phosphatase ( PTPN22 ), which is associated with multiple autoimmune diseases, and mutations that affect the exon-intron splicing of CD45 ( PTPRC ). We also find it likely that additional PTPs are involved in susceptibility to autoimmune and inflammatory diseases. Finally, we discuss the possibility that PTPs regulating the immune system may serve as therapeutic targets.

Journal

Annual Review of ImmunologyAnnual Reviews

Published: Apr 23, 2008

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