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of dimenhydrinate ( Dramamine) , Tyler (14) called attention to the need for controlled tests employing hysocine as well as a placebo. The tests of Strickland & Hahn (is) and Simon & Seyler (16) , representative of this type of study, indicated that dimenhydrinate reduced motion sickness about 50 per cent or to about the same degree as hyoscine. In passengers, the drowsiness produced by dimenhydrinate may be desirable; in military personnel, this effect on about 10 to 25 per cent of individuals is of course undesirable. Shaw (17), reviewing tests conducted in the U. S. Navy, concluded that dimenhydrinate was prophylactic against motion sickness in 50 mg. doses and that it was effective as a therapeutic agent in 100 mg. doses. The larger dosage produced drowsiness in 25 per cent of individuals. In the excellent report by Boland & Grinsted (18), it was concluded that scopolamine and .- BEHNKE dimenhydrinate were equally effective in the prevention and ultimate cure of air sickness. Side effects reported were few, mild, and similar for both types of medication. One of the many valuable contributions of Wendt (19) in the field of motion sickness is his evaluation of the psychological factors
Annual Review of Medicine – Annual Reviews
Published: Feb 1, 1951
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