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Pathogenesis and Pathology of Mastocytosis

Pathogenesis and Pathology of Mastocytosis Systemic mastocytosis is a clonal disorder of mast cells that may variably present with characteristic skin lesions, episodes of mast cell mediator release, and disturbances of hematopoiesis. No curative therapy presently exists. Conventional management has relied on agents that antagonize mediators released by mast cells, inhibit mediator secretion, or modulate mast cell proliferation. Recent advances in the molecular understanding of the pathophysiology of systemic mastocytosis have provided new therapeutic considerations, including new and novel tyrosine kinase inhibitors. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Annual Review of Pathology: Mechanisms of Disease Annual Reviews

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References (124)

Publisher
Annual Reviews
Copyright
Copyright © 2017 by Annual Reviews. All rights reserved
ISSN
1553-4006
eISSN
1553-4014
DOI
10.1146/annurev-pathol-052016-100312
pmid
28135563
Publisher site
See Article on Publisher Site

Abstract

Systemic mastocytosis is a clonal disorder of mast cells that may variably present with characteristic skin lesions, episodes of mast cell mediator release, and disturbances of hematopoiesis. No curative therapy presently exists. Conventional management has relied on agents that antagonize mediators released by mast cells, inhibit mediator secretion, or modulate mast cell proliferation. Recent advances in the molecular understanding of the pathophysiology of systemic mastocytosis have provided new therapeutic considerations, including new and novel tyrosine kinase inhibitors.

Journal

Annual Review of Pathology: Mechanisms of DiseaseAnnual Reviews

Published: Jan 24, 2017

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