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P OTENTIAL N EW T HERAPIES FOR THE T REATMENT OF HIV-1 I NFECTION

P OTENTIAL N EW T HERAPIES FOR THE T REATMENT OF HIV-1 I NFECTION ▪ Abstract The development and clinical use of chemotherapeutic agents for the treatment of persistent HIV-1 infection over the past decade has profoundly and favorably affected the course of HIV-1 disease for many infected individuals. Unfortunately, the long-term use of these therapies is complicated by unwanted metabolic side effects, by issues of adherence, and by the selection of viral variants with reduced susceptibility. These complications have spurred the search for new anti-HIV-1 agents having improved pharmacological properties and expressing activity against viral variants resistant to the currently available agents. This brief review describes the current state of this search as well as potentially novel viral targets for chemotherapeutic intervention. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Annual Review of Medicine Annual Reviews

P OTENTIAL N EW T HERAPIES FOR THE T REATMENT OF HIV-1 I NFECTION

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Publisher
Annual Reviews
Copyright
Copyright © 2002 by Annual Reviews. All rights reserved
Subject
Review Articles
ISSN
0066-4219
eISSN
1545-326X
DOI
10.1146/annurev.med.53.082901.104110
pmid
11818489
Publisher site
See Article on Publisher Site

Abstract

▪ Abstract The development and clinical use of chemotherapeutic agents for the treatment of persistent HIV-1 infection over the past decade has profoundly and favorably affected the course of HIV-1 disease for many infected individuals. Unfortunately, the long-term use of these therapies is complicated by unwanted metabolic side effects, by issues of adherence, and by the selection of viral variants with reduced susceptibility. These complications have spurred the search for new anti-HIV-1 agents having improved pharmacological properties and expressing activity against viral variants resistant to the currently available agents. This brief review describes the current state of this search as well as potentially novel viral targets for chemotherapeutic intervention.

Journal

Annual Review of Medicine – Annual Reviews

Published: Feb 1, 2002

There are no references for this article.