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Optic Atrophy and Neurosyphilis

Optic Atrophy and Neurosyphilis M.D. AND CHARLES W. ISRAEL, M.D. Department of Ophthalmology, University of Miami School of Medicine, Miami, Florida Two major recent advances in late syphilis of interest to every clinician have occurred in the past decade. These are: 1. the frequency of clinically progressive late seronegative syphilis; and 2. the presence of treponemes in patients with late syphilis despite penicillin therapy. The presence of trepo­ nemes in lymph nodes, despite penicillin therapy for syphilis, was first re­ ported in both animals and man by Coliart in 1962 (1-3). This observation was confirmed in rabbits by Del Carpio Of greater interest to the ophthalmologist was the discovery of treponemes in human aqueous humor, after administration of large doses of penicillin (4), and in man by BOl1cinelli (5). (6). This discovery was thereafter confirmed by Goldman (7), Jo ne s (8), and Christman (9). Furthermore, study of a control group confirmed the absence of spirochetes in the aqueous humor of patients with senile cata­ racts, also examined by the same fluorescent antibody technique (10). Fi­ nally, the persistence of treponemes in the lymph nodes of both man and rabbit, despite treatment and even retreatment with penicillin, has been con­ firmed by http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Annual Review of Medicine Annual Reviews

Optic Atrophy and Neurosyphilis

Annual Review of Medicine , Volume 22 (1) – Feb 1, 1971

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Publisher
Annual Reviews
Copyright
Copyright 1971 Annual Reviews. All rights reserved
Subject
Review Articles
ISSN
0066-4219
eISSN
1545-326X
DOI
10.1146/annurev.me.22.020171.000535
pmid
4944410
Publisher site
See Article on Publisher Site

Abstract

M.D. AND CHARLES W. ISRAEL, M.D. Department of Ophthalmology, University of Miami School of Medicine, Miami, Florida Two major recent advances in late syphilis of interest to every clinician have occurred in the past decade. These are: 1. the frequency of clinically progressive late seronegative syphilis; and 2. the presence of treponemes in patients with late syphilis despite penicillin therapy. The presence of trepo­ nemes in lymph nodes, despite penicillin therapy for syphilis, was first re­ ported in both animals and man by Coliart in 1962 (1-3). This observation was confirmed in rabbits by Del Carpio Of greater interest to the ophthalmologist was the discovery of treponemes in human aqueous humor, after administration of large doses of penicillin (4), and in man by BOl1cinelli (5). (6). This discovery was thereafter confirmed by Goldman (7), Jo ne s (8), and Christman (9). Furthermore, study of a control group confirmed the absence of spirochetes in the aqueous humor of patients with senile cata­ racts, also examined by the same fluorescent antibody technique (10). Fi­ nally, the persistence of treponemes in the lymph nodes of both man and rabbit, despite treatment and even retreatment with penicillin, has been con­ firmed by

Journal

Annual Review of MedicineAnnual Reviews

Published: Feb 1, 1971

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