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Noncoding RNAs in Cancer Development

Noncoding RNAs in Cancer Development It is becoming increasingly clear that a large repertoire of noncoding RNAs (ncRNAs) are actively transcribed from the mammalian genome, regulating diverse cellular processes in development and diseases through a variety of gene regulatory mechanisms. As the most extensively studied ncRNA species, microRNAs (miRNAs) are important components in the oncogene and tumor suppressor network, and have been employed as potential biomarkers, therapeutic reagents, and therapeutic targets for cancer treatment. Other ncRNAs, particularly long noncoding RNAs, also have a profound impact on cancer development, as demonstrated in both mouse and human tumor models. We are only starting to understand the realm of ncRNA biology, and the exact molecular mechanisms governing ncRNA functions remain largely unexplored. With numerous ncRNAs discovered through high-throughput approaches, understanding their functions in malignant transformation will be one of the most exciting challenges in cancer research. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Annual Review of Cancer Biology Annual Reviews

Noncoding RNAs in Cancer Development

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Publisher
Annual Reviews
Copyright
Copyright © 2017 by Annual Reviews. All rights reserved
ISSN
2472-3428
eISSN
2472-3428
DOI
10.1146/annurev-cancerbio-050216-034443
Publisher site
See Article on Publisher Site

Abstract

It is becoming increasingly clear that a large repertoire of noncoding RNAs (ncRNAs) are actively transcribed from the mammalian genome, regulating diverse cellular processes in development and diseases through a variety of gene regulatory mechanisms. As the most extensively studied ncRNA species, microRNAs (miRNAs) are important components in the oncogene and tumor suppressor network, and have been employed as potential biomarkers, therapeutic reagents, and therapeutic targets for cancer treatment. Other ncRNAs, particularly long noncoding RNAs, also have a profound impact on cancer development, as demonstrated in both mouse and human tumor models. We are only starting to understand the realm of ncRNA biology, and the exact molecular mechanisms governing ncRNA functions remain largely unexplored. With numerous ncRNAs discovered through high-throughput approaches, understanding their functions in malignant transformation will be one of the most exciting challenges in cancer research.

Journal

Annual Review of Cancer BiologyAnnual Reviews

Published: Mar 6, 2017

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