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More than Meets the Eye: Hidden Structures in the Proteome

More than Meets the Eye: Hidden Structures in the Proteome A central dogma of molecular biology is that the sequence of a protein dictates its particular fold and the fold dictates its function. Indeed, the sequence structure function hypothesis has been a guiding principle by which scientists approach molecular biology. Every student knows that the genome encodes information for the progression from primary sequence to secondary, tertiary, and ultimately quaternary structure. Yet with a growing number of proteins, a fifth level has been identified: rearrangement of existing structures into distinct forms. Recent observations indicate that replication of Ebola virus depends on this fifth level. We believe other viruses with compact genomes and rapid evolution under selective pressure will be a rich source of examples of polypeptides that rearrange to gain added functions. In this review, we describe mechanisms by which viral, prokaryotic, and eukaryotic polypeptides have adopted alternate structures to control or gain function. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Annual review of virology Annual Reviews

More than Meets the Eye: Hidden Structures in the Proteome

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References (78)

Publisher
Annual Reviews
Copyright
Copyright 2016 by Annual Reviews. All rights reserved
ISSN
2327-056x
eISSN
2327-0578
DOI
10.1146/annurev-virology-100114-054923
pmid
27482901
Publisher site
See Article on Publisher Site

Abstract

A central dogma of molecular biology is that the sequence of a protein dictates its particular fold and the fold dictates its function. Indeed, the sequence structure function hypothesis has been a guiding principle by which scientists approach molecular biology. Every student knows that the genome encodes information for the progression from primary sequence to secondary, tertiary, and ultimately quaternary structure. Yet with a growing number of proteins, a fifth level has been identified: rearrangement of existing structures into distinct forms. Recent observations indicate that replication of Ebola virus depends on this fifth level. We believe other viruses with compact genomes and rapid evolution under selective pressure will be a rich source of examples of polypeptides that rearrange to gain added functions. In this review, we describe mechanisms by which viral, prokaryotic, and eukaryotic polypeptides have adopted alternate structures to control or gain function.

Journal

Annual review of virologyAnnual Reviews

Published: Sep 29, 2016

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