Access the full text.
Sign up today, get DeepDyve free for 14 days.
A. Shukla, K. Lounsbury, Trisha Barrett, J. Gell, M. Rincón, K. Butnor, D. Taatjes, G. Davis, P. Vacek, K. Nakayama, Kei-ichi Nakayama, C. Steele, B. Mossman (2007)
Asbestos-induced peribronchiolar cell proliferation and cytokine production are attenuated in lungs of protein kinase C-delta knockout mice.The American journal of pathology, 170 1
K. Rasbach, R. Schnellmann (2007)
Signaling of Mitochondrial Biogenesis following Oxidant Injury*Journal of Biological Chemistry, 282
L. Aguilera-Aguirre, A. Bácsi, A. Saavedra-Molina, A. Kurosky, S. Sur, I. Boldogh (2009)
Mitochondrial Dysfunction Increases Allergic Airway Inflammation1The Journal of Immunology, 183
Aditi Chatterjee, E. Mambo, D. Sidransky (2006)
Mitochondrial DNA mutations in human cancerOncogene, 25
A. Sureshbabu, V. Bhandari (2013)
Targeting mitochondrial dysfunction in lung diseases: emphasis on mitophagyFrontiers in Physiology, 4
F. Antigny, N. Girardin, D. Raveau, M. Frieden, F. Becq, C. Vandebrouck (2009)
Dysfunction of mitochondria Ca2+ uptake in cystic fibrosis airway epithelial cells.Mitochondrion, 9 4
L. Collins, S. Hajizadeh, E. Holme, I. Jonsson, A. Tarkowski (2004)
Endogenously oxidized mitochondrial DNA induces in vivo and in vitro inflammatory responsesJournal of Leukocyte Biology, 75
T. Ago, J. Kuroda, J. Pain, Cexiong Fu, Hong Li, J. Sadoshima (2010)
Upregulation of Nox4 by Hypertrophic Stimuli Promotes Apoptosis and Mitochondrial Dysfunction in Cardiac MyocytesCirculation Research, 106
R. Scarpulla (2008)
Transcriptional paradigms in mammalian mitochondrial biogenesis and function.Physiological reviews, 88 2
F. Jornayvaz, G. Shulman (2010)
Regulation of mitochondrial biogenesis.Essays in biochemistry, 47
H. Lam, S. Cloonan, A. Bhashyam, J. Haspel, Anju Singh, J. Sathirapongsasuti, Morgan Cervo, H. Yao, Anna Chung, Kenji Mizumura, C. An, B. Shan, Jonathan Franks, K. Haley, C. Owen, Y. Tesfaigzi, G. Washko, John Quackenbush, E. Silverman, I. Rahman, Hong-pyo Kim, Ashfaq Mahmood, S. Biswal, S. Ryter, A. Choi (2013)
Histone deacetylase 6-mediated selective autophagy regulates COPD-associated cilia dysfunction.The Journal of clinical investigation, 123 12
Shiqin Sun, T. Sursal, Y. Adibnia, Cong Zhao, Yi Zheng, Haipeng Li, L. Otterbein, C. Hauser, K. Itagaki (2013)
Mitochondrial DAMPs Increase Endothelial Permeability through Neutrophil Dependent and Independent PathwaysPLoS ONE, 8
J. Barbi, D. Pardoll, F. Pan (2013)
Metabolic control of the Treg/Th17 axisImmunological Reviews, 252
Lei Liu, Du Feng, Guo Chen, Ming Chen, Q. Zheng, Pingping Song, Q. Ma, Chongzhuo Zhu, Rui Wang, Wanjun Qi, Lei Huang, P. Xue, Bao-wei Li, Xiao-hui Wang, Haijing Jin, Jun Wang, Fuquan Yang, Pingsheng Liu, Yushan Zhu, Senfang Sui, Quan Chen (2012)
Mitochondrial outer-membrane protein FUNDC1 mediates hypoxia-induced mitophagy in mammalian cellsNature Cell Biology, 14
Christian Metallo, M. Heiden (2010)
Metabolism strikes back: metabolic flux regulates cell signaling.Genes & development, 24 24
A. West, I. Brodsky, C. Rahner, D. Woo, H. Erdjument-Bromage, P. Tempst, M. Walsh, Yongwon Choi, G. Shadel, S. Ghosh (2011)
TLR signaling augments macrophage bactericidal activity through mitochondrial ROSNature, 472
C. Piantadosi, H. Suliman (2012)
Transcriptional control of mitochondrial biogenesis and its interface with inflammatory processes.Biochimica et biophysica acta, 1820 4
K. Moriguchi, N. Higashi, S. Kitagawa, K. Takase, N. Ohya, T. Uyeda, K. Hirai (1984)
Differentiation of human pulmonary alveolar epithelial cells revealed by peroxisome changes in pulmonary proteinosis.Experimental and molecular pathology, 40 2
Ji Zhang, P. Ney (2009)
Role of BNIP3 and NIX in cell death, autophagy, and mitophagyCell Death and Differentiation, 16
K. Lounsbury, M. Stern, D. Taatjes, S. Jaken, B. Mossman (2002)
Increased localization and substrate activation of protein kinase C delta in lung epithelial cells following exposure to asbestos.The American journal of pathology, 160 6
A. Gazdhar, D. Lebrecht, M. Roth, M. Tamm, N. Venhoff, C. Foocharoen, T. Geiser, U. Walker (2014)
Time-dependent and somatically acquired mitochondrial DNA mutagenesis and respiratory chain dysfunction in a scleroderma model of lung fibrosisScientific Reports, 4
T. Liu, Vidula Vachharajani, P. Millet, M. Bharadwaj, A. Molina, C. McCall (2014)
Sequential Actions of SIRT1-RELB-SIRT3 Coordinate Nuclear-Mitochondrial Communication during Immunometabolic Adaptation to Acute Inflammation and Sepsis*The Journal of Biological Chemistry, 290
L. Berod, Christin Friedrich, A. Nandan, J. Freitag, S. Hagemann, Kirsten Harmrolfs, Aline Sandouk, C. Hesse, C. Castro, H. Bähre, S. Tschirner, Nataliya Gorinski, Melanie Gohmert, C. Mayer, J. Huehn, E. Ponimaskin, W. Abraham, R. Müller, M. Lochner, T. Sparwasser (2014)
De novo fatty acid synthesis controls the fate between regulatory T and T helper 17 cellsNature Medicine, 20
Michael Murphy, Robin Smith (2000)
Drug delivery to mitochondria: the key to mitochondrial medicine.Advanced drug delivery reviews, 41 2
V. Panduri, S. Surapureddi, S. Soberanes, S. Weitzman, N. Chandel, D. Kamp (2006)
P53 mediates amosite asbestos-induced alveolar epithelial cell mitochondria-regulated apoptosis.American journal of respiratory cell and molecular biology, 34 4
J. Santos, Ľ. Hunáková, Yiming Chen, C. Bortner, B. Houten (2003)
Cell Sorting Experiments Link Persistent Mitochondrial DNA Damage with Loss of Mitochondrial Membrane Potential and Apoptotic Cell Death*The Journal of Biological Chemistry, 278
W. Ding, Hong-Min Ni, Min Li, Y. Liao, Xiaoyun Chen, D. Stolz, G. Dorn, Xiao-Ming Yin (2010)
Nix Is Critical to Two Distinct Phases of Mitophagy, Reactive Oxygen Species-mediated Autophagy Induction and Parkin-Ubiquitin-p62-mediated Mitochondrial Priming*The Journal of Biological Chemistry, 285
E. Nisoli, E. Clementi, C. Paolucci, Valeria Cozzi, C. Tonello, C. Sciorati, R. Bracale, A. Valerio, M. Francolini, S. Moncada, M. Carruba (2003)
Mitochondrial Biogenesis in Mammals: The Role of Endogenous Nitric OxideScience, 299
K. Block, Y. Gorin, H. Abboud (2009)
Subcellular localization of Nox4 and regulation in diabetesProceedings of the National Academy of Sciences, 106
Rongbin Zhou, A. Yazdi, P. Menu, J. Tschopp (2011)
A role for mitochondria in NLRP3 inflammasome activationNature, 469
P. Mannam, Amanda Shinn, A. Srivastava, R. Neamu, Wendy Walker, M. Bohanon, J. Merkel, Min-Jong Kang, Charles Cruz, Amy Ahasic, Margaret Pisani, M. Trentalange, A. West, G. Shadel, Jack Elias, Patty Lee (2014)
MKK3 regulates mitochondrial biogenesis and mitophagy in sepsis-induced lung injury.American journal of physiology. Lung cellular and molecular physiology, 306 7
S. Murthy, A. Adamcakova-Dodd, Sarah Perry, L. Tephly, R. Keller, N. Metwali, D. Meyerholz, Yongqiang Wang, M. Glogauer, P. Thorne, A. Carter, A. Carter (2009)
Modulation of reactive oxygen species by Rac1 or catalase prevents asbestos-induced pulmonary fibrosis.American journal of physiology. Lung cellular and molecular physiology, 297 5
Saburo Ito, J. Araya, Yusuke Kurita, Kenji Kobayashi, Naoki Takasaka, Masahiro Yoshida, Hiromichi Hara, S. Minagawa, H. Wakui, S. Fujii, Jun Kojima, Kenichiro Shimizu, T. Numata, M. Kawaishi, M. Odaka, T. Morikawa, T. Harada, S. Nishimura, Y. Kaneko, K. Nakayama, K. Kuwano (2015)
PARK2-mediated mitophagy is involved in regulation of HBEC senescence in COPD pathogenesisAutophagy, 11
D. Vats, Lata Mukundan, J. Odegaard, Lina Zhang, Kristi Smith, Christine Morel, R. Wagner, D. Greaves, P. Murray, A. Chawla (2006)
Oxidative metabolism and PGC-1beta attenuate macrophage-mediated inflammation.Cell metabolism, 4 1
G. Massaro, D. Gail, D. Massaro (1975)
Lung oxygen consumption and mitochondria of alveolar epithelial and endothelial cells.Journal of applied physiology, 38 4
A. Cherry, H. Suliman, Raquel Bartz, C. Piantadosi (2013)
Peroxisome Proliferator-activated Receptor γ Co-activator 1-α as a Critical Co-activator of the Murine Hepatic Oxidative Stress Response and Mitochondrial Biogenesis in Staphylococcus aureus Sepsis*The Journal of Biological Chemistry, 289
D. Gail, C. Lenfant (1983)
Cells of the lung: biology and clinical implications.The American review of respiratory disease, 127 3
P. Sexton, P. Metcalf, J. Kolbe (2014)
Respiratory Effects of Insulin Sensitisation with Metformin: A Prospective Observational StudyCOPD: Journal of Chronic Obstructive Pulmonary Disease, 11
W. Kaelin, S. McKnight (2013)
Influence of Metabolism on Epigenetics and DiseaseCell, 153
D. Hood (2001)
Invited Review: contractile activity-induced mitochondrial biogenesis in skeletal muscle.Journal of applied physiology, 90 3
A. Agrawal, Y. Prakash (2014)
Obesity, metabolic syndrome, and airway disease: a bioenergetic problem?Immunology and allergy clinics of North America, 34 4
C. Piantadosi, C. Withers, Raquel Bartz, N. MacGarvey, P. Fu, T. Sweeney, K. Welty-Wolf, H. Suliman (2011)
Heme Oxygenase-1 Couples Activation of Mitochondrial Biogenesis to Anti-inflammatory Cytokine Expression*The Journal of Biological Chemistry, 286
E. Zifa, Z. Daniil, Eleutheria Skoumi, M. Stavrou, K. Papadimitriou, Marini Terzenidou, K. Kostikas, Vasileios Bagiatis, K. Gourgoulianis, Z. Mamuris (2012)
Mitochondrial genetic background plays a role in increasing risk to asthmaMolecular Biology Reports, 39
B. Shapiro (1988)
MITOCHONDRIAL DYSFUNCTION, ENERGY EXPENDITURE, AND CYSTIC FIBROSISThe Lancet, 332
Shih-Feng Liu, H. Kuo, ching-wan Tseng, Hung‐Tu Huang, Yung-Che Chen, Chia-Cheng Tseng, Meng-Chih Lin (2015)
Leukocyte Mitochondrial DNA Copy Number Is Associated with Chronic Obstructive Pulmonary DiseasePLoS ONE, 10
P. Kirkham, P. Barnes (2013)
Oxidative stress in COPD.Chest, 144 1
H. Galley (2011)
Oxidative stress and mitochondrial dysfunction in sepsis.British journal of anaesthesia, 107 1
R. Rizzuto, D. Stefani, A. Raffaello, C. Mammucari (2012)
Mitochondria as sensors and regulators of calcium signallingNature Reviews Molecular Cell Biology, 13
H. Suliman, M. Carraway, C. Piantadosi (2003)
Postlipopolysaccharide oxidative damage of mitochondrial DNA.American journal of respiratory and critical care medicine, 167 4
P. Schumacker, M. Gillespie, K. Nakahira, A. Choi, E. Crouser, C. Piantadosi, J. Bhattacharya (2014)
Mitochondria in lung biology and pathology: more than just a powerhouse.American journal of physiology. Lung cellular and molecular physiology, 306 11
A. Terman, T. Kurz, M. Navrátil, E. Arriaga, U. Brunk (2010)
Mitochondrial turnover and aging of long-lived postmitotic cells: the mitochondrial-lysosomal axis theory of aging.Antioxidants & redox signaling, 12 4
P. Dromparis, E. Michelakis (2013)
Mitochondria in vascular health and disease.Annual review of physiology, 75
D. Haden, H. Suliman, M. Carraway, K. Welty-Wolf, A. Ali, H. Shitara, H. Yonekawa, C. Piantadosi (2007)
Mitochondrial biogenesis restores oxidative metabolism during Staphylococcus aureus sepsis.American journal of respiratory and critical care medicine, 176 8
O. Kamdar, W. Le, Jingmei Zhang, Andrew Ghio, Glenn Rosen, D. Upadhyay (2008)
Air pollution induces enhanced mitochondrial oxidative stress in cystic fibrosis airway epitheliumFEBS Letters, 582
K. Hirai, K. Ogawa (1986)
Cytochemical quantitation of cytochrome oxidase activity in rat pulmonary alveolar epithelial cells and possible defect in type I cells.Journal of electron microscopy, 35 1
Heather Osborn-Heaford, Alan Ryan, S. Murthy, A-M. Racila, Chao He, J. Sieren, Douglas Spitz, A. Carter (2011)
Mitochondrial Rac1 GTPase Import and Electron Transfer from Cytochrome c Are Required for Pulmonary Fibrosis*The Journal of Biological Chemistry, 287
T. Ahmad, I. Sundar, C. Lerner, Janice Gerloff, A. Tormos, H. Yao, I. Rahman (2015)
Impaired mitophagy leads to cigarette smoke stress‐induced cellular senescence: implications for chronic obstructive pulmonary diseaseThe FASEB Journal, 29
T. Ichinohe, Tatsuya Yamazaki, T. Koshiba, Y. Yanagi (2013)
Mitochondrial protein mitofusin 2 is required for NLRP3 inflammasome activation after RNA virus infectionProceedings of the National Academy of Sciences, 110
B. Aravamudan, Alexander Kiel, Michelle Freeman, P. Delmotte, M. Thompson, R. Vassallo, G. Sieck, C. Pabelick, Y. Prakash (2014)
Cigarette smoke-induced mitochondrial fragmentation and dysfunction in human airway smooth muscle.American journal of physiology. Lung cellular and molecular physiology, 306 9
A. Meyer, J. Zoll, A. Charles, A. Charloux, F. Blay, P. Diemunsch, J. Sibilia, F. Piquard, B. Gény (2013)
Skeletal muscle mitochondrial dysfunction during chronic obstructive pulmonary disease: central actor and therapeutic targetExperimental Physiology, 98
Sven Geisler, Kira Holmström, Diana Skujat, F. Fiesel, Oliver Rothfuss, P. Kahle, W. Springer (2010)
PINK1/Parkin-mediated mitophagy is dependent on VDAC1 and p62/SQSTM1Nature Cell Biology, 12
Corina Waveren, Yubo Sun, H. Cheung, C. Moraes (2006)
Oxidative phosphorylation dysfunction modulates expression of extracellular matrix--remodeling genes and invasion.Carcinogenesis, 27 3
G. Shadel, T. Horvath (2015)
Mitochondrial ROS Signaling in Organismal HomeostasisCell, 163
Kenji Mizumura, S. Cloonan, K. Nakahira, A. Bhashyam, Morgan Cervo, T. Kitada, K. Glass, C. Owen, Ashfaq Mahmood, G. Washko, S. Hashimoto, S. Ryter, A. Choi (2014)
Mitophagy-dependent necroptosis contributes to the pathogenesis of COPD.The Journal of clinical investigation, 124 9
T. Finkel, S. Menazza, Kira Holmström, Randi Parks, Julia Liu, Junhui Sun, Jie Liu, Xin Pan, E. Murphy (2015)
The ins and outs of mitochondrial calcium.Circulation research, 116 11
Chikara Otsubo, Sivakama Bharathi, R. Uppala, O. Ilkayeva, Dongning Wang, Kevin McHugh, Ye Zou, Jieru Wang, J. Alcorn, Y. Zuo, M. Hirschey, E. Goetzman (2015)
Long-chain Acylcarnitines Reduce Lung Function by Inhibiting Pulmonary Surfactant*The Journal of Biological Chemistry, 290
M. Cha, Dong Kim, I. Mook-Jung (2015)
The role of mitochondrial DNA mutation on neurodegenerative diseasesExperimental & Molecular Medicine, 47
J. Lloreta, M. Orozco, J. Gea, J. Corominas, S. Serrano (1996)
Selective diaphragmatic mitochondrial abnormalities in a patient with marked air flow obstruction.Ultrastructural pathology, 20 1
N. Chandel (2014)
Mitochondria as signaling organellesBMC Biology, 12
Erika Pearce, M. Poffenberger, Chih-Hao Chang, Russell Jones (2013)
Fueling Immunity: Insights into Metabolism and Lymphocyte FunctionScience, 342
J. Athale, Allison Ulrich, N. MacGarvey, Raquel Bartz, K. Welty-Wolf, H. Suliman, C. Piantadosi (2012)
Nrf2 promotes alveolar mitochondrial biogenesis and resolution of lung injury in Staphylococcus aureus pneumonia in mice.Free radical biology & medicine, 53 8
Avignat Patel, J. Song, S. Chu, Kenji Mizumura, J. Osorio, Ying Shi, S. El-Chemaly, C. Lee, I. Rosas, J. Elias, A. Choi, D. Morse (2015)
Epithelial Cell Mitochondrial Dysfunction and PINK1 Are Induced by Transforming Growth Factor- Beta1 in Pulmonary FibrosisPLoS ONE, 10
D. Green, F. Llambi (2015)
Cell Death Signaling.Cold Spring Harbor perspectives in biology, 7 12
B. Aravamudan, M. Thompson, C. Pabelick, Y. Prakash (2013)
Mitochondria in lung diseasesExpert Review of Respiratory Medicine, 7
K. Nakahira, J. Haspel, V. Rathinam, Seon-Jin Lee, T. Dolinay, H. Lam, J. Englert, M. Rabinovitch, M. Cernadas, Hong-pyo Kim, K. Fitzgerald, S. Ryter, A. Choi (2011)
Autophagy proteins regulate innate immune responses by inhibiting the release of mitochondrial DNA mediated by the NALP3 inflammasome.Nature immunology, 12 3
Cole Haynes, D. Ron (2010)
The mitochondrial UPR – protecting organelle protein homeostasisJournal of Cell Science, 123
Derek Narendra, Atsushi Tanaka, D. Suen, R. Youle (2008)
Parkin is recruited selectively to impaired mitochondria and promotes their autophagyThe Journal of Cell Biology, 183
C. Barkauskas, Michael Cronce, C. Rackley, Emily Bowie, D. Keene, B. Stripp, S. Randell, P. Noble, B. Hogan (2013)
Type 2 alveolar cells are stem cells in adult lung.The Journal of clinical investigation, 123 7
F. Verhamme, K. Bracke, G. Joos, G. Brusselle (2015)
Transforming growth factor-β superfamily in obstructive lung diseases. more suspects than TGF-β alone.American journal of respiratory cell and molecular biology, 52 6
M. Carraway, H. Suliman, C. Kliment, K. Welty-Wolf, T. Oury, C. Piantadosi (2008)
Mitochondrial biogenesis in the pulmonary vasculature during inhalational lung injury and fibrosis.Antioxidants & redox signaling, 10 2
M. Calixto, L. Lintomen, D. André, L. Leiria, Danilo Ferreira, Camilo Lellis-Santos, G. Anhê, S. Bordin, R. Landgraf, E. Antunes (2013)
Metformin Attenuates the Exacerbation of the Allergic Eosinophilic Inflammation in High Fat-Diet-Induced Obesity in MicePLoS ONE, 8
T. Kleine, D. Leister (2016)
Retrograde signaling: Organelles go networking.Biochimica et biophysica acta, 1857 8
N. Chan, Anna Salazar, A. Pham, Michael Sweredoski, Natalie Kolawa, R. Graham, S. Hess, D. Chan (2011)
Broad activation of the ubiquitin–proteasome system by Parkin is critical for mitophagyHuman Molecular Genetics, 20
R. Hotchkiss, I. Karl (2003)
The pathophysiology and treatment of sepsis.The New England journal of medicine, 348 2
B. Dranka, B. Hill, V. Darley-Usmar (2010)
Mitochondrial reserve capacity in endothelial cells: The impact of nitric oxide and reactive oxygen species.Free radical biology & medicine, 48 7
Hong Zhu, Z. Jia, J. Strobl, M. Ehrich, H. Misra, Yunbo Li (2008)
Potent Induction of Total Cellular and Mitochondrial Antioxidants and Phase 2 Enzymes by Cruciferous Sulforaphane in Rat Aortic Smooth Muscle Cells: Cytoprotection Against Oxidative and Electrophilic StressCardiovascular Toxicology, 8
H. Suliman, C. Piantadosi (2016)
Mitochondrial Quality Control as a Therapeutic TargetPharmacological Reviews, 68
H. Suliman, M. Carraway, L. Tatro, C. Piantadosi (2007)
A new activating role for CO in cardiac mitochondrial biogenesisJournal of Cell Science, 120
D. Postma, K. Rabe (2015)
The Asthma-COPD Overlap Syndrome.The New England journal of medicine, 373 13
N. Subramanian, K. Natarajan, M. Clatworthy, Ze Wang, R. Germain (2013)
The Adaptor MAVS Promotes NLRP3 Mitochondrial Localization and Inflammasome ActivationCell, 153
T. Ahmad, Shravani Mukherjee, B. Pattnaik, M. Kumar, Suchita Singh, Rakhshinda Rehman, B. Tiwari, K. Jha, Amruta Barhanpurkar, M. Wani, S. Roy, U. Mabalirajan, B. Ghosh, A. Agrawal (2014)
Miro1 regulates intercellular mitochondrial transport & enhances mesenchymal stem cell rescue efficacyThe EMBO Journal, 33
M. Singer (2013)
The role of mitochondrial dysfunction in sepsis-induced multi-organ failureVirulence, 5
H. Suliman, C. Piantadosi (2014)
Mitochondrial biogenesis: regulation by endogenous gases during inflammation and organ stress.Current pharmaceutical design, 20 35
T. Cash, Yi Pan, M. Simon (2007)
Reactive oxygen species and cellular oxygen sensing.Free radical biology & medicine, 43 9
A. Alsuwaidi, S. Benedict, J. Kochiyil, F. Mustafa, Stacey Hartwig, S. Almarzooqi, A. Albawardi, T. Rizvi, S. Varga, A. Souid (2013)
Bioenergetics of murine lungs infected with respiratory syncytial virusVirology Journal, 10
Jisun Lee, S. Giordano, Jianhua Zhang (2011)
Autophagy, mitochondria and oxidative stress: cross-talk and redox signallingBiochemical Journal, 441
H. Suliman, K. Welty-Wolf, M. Carraway, L. Tatro, C. Piantadosi (2004)
Lipopolysaccharide induces oxidative cardiac mitochondrial damage and biogenesis.Cardiovascular research, 64 2
G. Twig, Brigham Hyde, O. Shirihai (2008)
Mitochondrial fusion, fission and autophagy as a quality control axis: the bioenergetic view.Biochimica et biophysica acta, 1777 9
U. Mabalirajan, A. Dinda, Sarvesh Kumar, R. Roshan, Pooja Gupta, Surendra Sharma, B. Ghosh (2008)
Mitochondrial Structural Changes and Dysfunction Are Associated with Experimental Allergic Asthma1The Journal of Immunology, 181
Chounghun Kang, Li Ji (2012)
Role of PGC-1α signaling in skeletal muscle health and diseaseAnnals of the New York Academy of Sciences, 1271
N. Soulitzis, E. Neofytou, M. Psarrou, Aristotelis Anagnostis, Nektarios Tavernarakis, N. Siafakas, E. Tzortzaki (2012)
Downregulation of lung mitochondrial prohibitin in COPD.Respiratory medicine, 106 7
Qin Zhang, M. Raoof, Yu Chen, Y. Sumi, T. Sursal, W. Junger, K. Brohi, K. Itagaki, C. Hauser (2009)
Circulating Mitochondrial DAMPs Cause Inflammatory Responses to InjuryNature, 464
Daniel Egan, Joungmok Kim, R. Shaw, K. Guan (2011)
The autophagy initiating kinase ULK1 is regulated via opposing phosphorylation by AMPK and mTORAutophagy, 7
J. Nunnari, A. Suomalainen (2012)
Mitochondria: In Sickness and in HealthCell, 148
Yuanyuan Zhao, Xiaofeng Sun, Xuanli Nie, Liwei Sun, T. Tang, Dahua Chen, Qinmiao Sun (2012)
COX5B Regulates MAVS-mediated Antiviral Signaling through Interaction with ATG5 and Repressing ROS ProductionPLoS Pathogens, 8
R. Medzhitov (2007)
Recognition of microorganisms and activation of the immune responseNature, 449
S. Buder-Hoffmann, A. Shukla, Trisha Barrett, M. MacPherson, K. Lounsbury, B. Mossman (2009)
A protein kinase Cdelta-dependent protein kinase D pathway modulates ERK1/2 and JNK1/2 phosphorylation and Bim-associated apoptosis by asbestos.The American journal of pathology, 174 2
Alan Chang, Allison Ulrich, H. Suliman, C. Piantadosi (2015)
Redox regulation of mitophagy in the lung during murine Staphylococcus aureus sepsis.Free radical biology & medicine, 78
J. Williamson, B. Corkey (1979)
Assay of citric acid cycle intermediates and related compounds--update with tissue metabolite levels and intracellular distribution.Methods in enzymology, 55
K. Garber (2012)
Biochemistry: A radical treatmentNature, 489
M. Hüttemann, Icksoo Lee, Xiufeng Gao, P. Pecina, A. Pecinová, Jenney Liu, S. Aras, N. Sommer, T. Sanderson, Monica Tost, F. Neff, J. Aguilar-Pimentel, L. Becker, B. Naton, B. Rathkolb, J. Rozman, J. Favor, W. Hans, C. Prehn, O. Puk, A. Schrewe, Minxuan Sun, H. Höfler, J. Adamski, R. Bekeredjian, J. Graw, T. Adler, D. Busch, M. Klingenspor, T. Klopstock, M. Ollert, E. Wolf, H. Fuchs, V. Gailus-Durner, M. Angelis, N. Weissmann, Jeffrey Doan, D. Bassett, L. Grossman (2012)
Cytochrome c oxidase subunit 4 isoform 2‐knockout mice show reduced enzyme activity, airway hyporeactivity, and lung pathologyThe FASEB Journal, 26
S. Kongara, V. Karantza (2012)
The interplay between autophagy and ROS in tumorigenesisFrontiers in Oncology, 2
Chih-Hao Chang, Jonathan Curtis, Leonard Maggi, B. Faubert, A. Villarino, David O’Sullivan, S. Huang, G. Windt, J. Blagih, J. Qiu, J. Weber, E. Pearce, Russell Jones, Erika Pearce (2013)
Posttranscriptional Control of T Cell Effector Function by Aerobic GlycolysisCell, 153
Bill Chen, T. Coon, Jennifer Glasser, C. Zou, Bryon Ellis, T. Das, A. McKelvey, Shristi Rajbhandari, T. Lear, Christelle Kamga, S. Shiva, Chenjian Li, J. Pilewski, J. Callio, C. Chu, A. Ray, P. Ray, Y. Tyurina, V. Kagan, R. Mallampalli (2014)
E3 Ligase Subunit Fbxo15 and PINK1 Kinase Regulate Cardiolipin Synthase 1 Stability and Mitochondrial Function in PneumoniaCell reports, 7
G. Szabadkai, A. Simoni, K. Bianchi, D. Stefani, S. Leo, M. Wieckowski, R. Rizzuto (2006)
Mitochondrial dynamics and Ca2+ signaling.Biochimica et biophysica acta, 1763 5-6
C. Harvey, R. Thimmulappa, S. Sethi, X. Kong, L. Yarmus, Robert Brown, D. Feller-Kopman, R. Wise, S. Biswal (2011)
Targeting Nrf2 Signaling Improves Bacterial Clearance by Alveolar Macrophages in Patients with COPD and in a Mouse ModelScience Translational Medicine, 3
I. Novak, V. Kirkin, David McEwan, Ji Zhang, P. Wild, Alexis Rozenknop, V. Rogov, F. Löhr, Doris Popovic, A. Occhipinti, A. Reichert, J. Terzic, V. Dötsch, P. Ney, I. Dikič (2010)
Nix is a selective autophagy receptor for mitochondrial clearanceEMBO reports, 11
K. Ikeda, Sachiko Shiba, Kuniko Horie-Inoue, K. Shimokata, S. Inoue (2013)
A stabilizing factor for mitochondrial respiratory supercomplex assembly regulates energy metabolism in muscleNature Communications, 4
Laura Sena, N. Chandel (2012)
Physiological roles of mitochondrial reactive oxygen species.Molecular cell, 48 2
F. Cero, V. Hillestad, I. Sjaastad, A. Yndestad, P. Aukrust, T. Ranheim, I. Lunde, M. Olsen, E. Lien, Lili Zhang, S. Haugstad, E. Løberg, G. Christensen, K. Larsen, O. Skjønsberg (2015)
Absence of the inflammasome adaptor ASC reduces hypoxia-induced pulmonary hypertension in mice.American journal of physiology. Lung cellular and molecular physiology, 309 4
Saori Yoshii, C. Kishi, Naotada Ishihara, N. Mizushima (2011)
Parkin Mediates Proteasome-dependent Protein Degradation and Rupture of the Outer Mitochondrial Membrane*♦The Journal of Biological Chemistry, 286
M. Mustafa, C. Cross (1974)
Effects of short-term ozone exposure on lung mitochondrial oxidative and energy metabolism.Archives of biochemistry and biophysics, 162 2
U. Mabalirajan, T. Ahmad, G. Leishangthem, A. Dinda, A. Agrawal, B. Ghosh (2010)
L-arginine reduces mitochondrial dysfunction and airway injury in murine allergic airway inflammation.International immunopharmacology, 10 12
A. West, G. Shadel, S. Ghosh (2011)
Mitochondria in innate immune responsesNature Reviews Immunology, 11
M. Bueno, Y. Lai, Y. Romero, J. Brands, C. Croix, Christelle Kamga, Catherine Corey, J. Herazo-Maya, J. Sembrat, Janet Lee, S. Duncan, M. Rojas, S. Shiva, C. Chu, A. Mora (2015)
PINK1 deficiency impairs mitochondrial homeostasis and promotes lung fibrosis.The Journal of clinical investigation, 125 2
A. Chomyn (2001)
Mitochondrial Genetic Control of Assembly and Function of Complex I in Mammalian CellsJournal of Bioenergetics and Biomembranes, 33
Sylvia Ai, Kenneth Hsu, C. Herbert, Z. Cheng, J. Hunt, C. Lewis, P. Thomas (2013)
Mitochondrial DNA mutations in exhaled breath condensate of patients with lung cancer.Respiratory medicine, 107 6
M. Toorn, D. Slebos, H. Bruin, H. Leuvenink, S. Bakker, R. Gans, G. Köeter, A. Oosterhout, H. Kauffman (2007)
Cigarette smoke-induced blockade of the mitochondrial respiratory chain switches lung epithelial cell apoptosis into necrosis.American journal of physiology. Lung cellular and molecular physiology, 292 5
Michelle Goritzka, S. Makris, Fahima Kausar, L. Durant, C. Pereira, Y. Kumagai, F. Culley, M. Mack, S. Akira, C. Johansson (2015)
Alveolar macrophage–derived type I interferons orchestrate innate immunity to RSV through recruitment of antiviral monocytesThe Journal of Experimental Medicine, 212
M. Islam, Shonita Das, M. Emin, M. Wei, L. Sun, Kristin Westphalen, D. Rowlands, S. Quadri, S. Bhattacharya, J. Bhattacharya (2012)
Mitochondrial transfer from bone-marrow–derived stromal cells to pulmonary alveoli protects against acute lung injuryNature Medicine, 18
V. Bocci, G. Valacchi (2015)
Nrf2 activation as target to implement therapeutic treatmentsFrontiers in Chemistry, 3
S. Berkelhamer, Gina Kim, J. Radder, S. Wedgwood, Lyubov Czech, R. Steinhorn, P. Schumacker (2013)
Developmental differences in hyperoxia-induced oxidative stress and cellular responses in the murine lung.Free radical biology & medicine, 61
S. Dasgupta, E. Soudry, N. Mukhopadhyay, Chunbo Shao, J. Yee, S. Lam, W. Lam, Wei Zhang, A. Gazdar, P. Fisher, D. Sidransky (2012)
Mitochondrial DNA mutations in respiratory complex‐I in never‐smoker lung cancer patients contribute to lung cancer progression and associated with EGFR gene mutationJournal of Cellular Physiology, 227
R. Vartak, C. Porras, Yidong Bai (2013)
Respiratory supercomplexes: structure, function and assemblyProtein & Cell, 4
D. Kamp, E. Shacter, S. Weitzman (2011)
Chronic inflammation and cancer: the role of the mitochondria.Oncology, 25 5
X. Gu, Guannan Wu, Yan-wen Yao, Junli Zeng, Donghong Shi, T. Lv, L. Luo, Yong Song (2015)
Intratracheal administration of mitochondrial DNA directly provokes lung inflammation through the TLR9-p38 MAPK pathway.Free radical biology & medicine, 83
G. Gibson, R. Loddenkemper, B. Lundbäck, Y. Sibille (2013)
Respiratory health and disease in Europe: the new European Lung White BookEuropean Respiratory Journal, 42
C. Zou, M. Synan, Jin Li, Sheng Xiong, M. Manni, Yuan Liu, Bill Chen, Yutong Zhao, S. Shiva, Y. Tyurina, Jianfei Jiang, Janet Lee, Sudipta Das, A. Ray, P. Ray, V. Kagan, R. Mallampalli (2016)
LPS impairs oxygen utilization in epithelia by triggering degradation of the mitochondrial enzyme Alcat1Journal of Cell Science, 129
Ke Wang, D. Klionsky (2011)
Mitochondria removal by autophagyAutophagy, 7
Kai Mao, Ke Wang, Xu Liu, D. Klionsky (2013)
The scaffold protein Atg11 recruits fission machinery to drive selective mitochondria degradation by autophagy.Developmental cell, 26 1
J. Aich, U. Mabalirajan, T. Ahmad, K. Khanna, R. Rehman, A. Agrawal, B. Ghosh (2012)
Resveratrol attenuates experimental allergic asthma in mice by restoring inositol polyphosphate 4 phosphatase (INPP4A).International immunopharmacology, 14 4
A. Evans, D. Hardie, C. Peers, A. Mahmoud (2011)
Hypoxic pulmonary vasoconstriction: mechanisms of oxygen-sensing.Current opinion in anaesthesiology, 24 1
J. Eberle, A. Hossini (2008)
Expression and Function of Bcl-2 Proteins in MelanomaCurrent Genomics, 9
M. Aichler, Mareike Elsner, N. Ludyga, A. Feuchtinger, Verena Zangen, Stefan Maier, B. Balluff, Cédrik Schöne, Ludwig Hierber, H. Braselmann, S. Meding, S. Rauser, H. Zischka, M. Aubele, M. Schmitt, M. Feith, S. Hauck, M. Ueffing, R. Langer, B. Kuster, H. Zitzelsberger, H. Höfler, A. Walch (2013)
Clinical response to chemotherapy in oesophageal adenocarcinoma patients is linked to defects in mitochondriaThe Journal of Pathology, 230
A. Fisher, H. Steinberg, D. Bassett (1974)
Energy utilization by the lung.The American journal of medicine, 57 3
Q. Hou, Junfei Jin, Hui Zhou, S. Novgorodov, A. Bielawska, Z. Szulc, Y. Hannun, L. Obeid, Y. Hsu (2011)
Mitochondrially targeted ceramides preferentially promote autophagy, retard cell growth, and induce apoptosisJournal of Lipid Research, 52
Remarkable new roles for mitochondria in calcium handling, apoptosis, heme turnover, inflammation, and oxygen and nutrient sensing have been discovered for organelles that were once thought to be simple energy converters. Although deficits in mitochondrial function are often associated with energy failure and apoptosis, working cells maintain a mitochondrial reserve that affords the organelles distinct homeostatic sensing and regulatory abilities in lung cells. As primary intracellular sources of oxidants, mitochondria serve as critical monitors and modulators of vital oxidation-reduction processes, including mitochondrial biogenesis, mitophagy, inflammasome activation, cell proliferation, and prevention of fibrosis. These processes participate in disease pathogenesis in all lung regions mainly when interference with mitochondrial quality control mechanisms impedes their roles in maintenance of lung health. Sharper identification of mitochondrial-driven signaling mechanisms in specific lung cell types will better refine our understanding of respiratory disease pathogenesis and lead to new diagnostic and therapeutic measures to support mitochondrial quality.
Annual Review of Physiology – Annual Reviews
Published: Feb 10, 2017
Read and print from thousands of top scholarly journals.
Already have an account? Log in
Bookmark this article. You can see your Bookmarks on your DeepDyve Library.
To save an article, log in first, or sign up for a DeepDyve account if you don’t already have one.
Copy and paste the desired citation format or use the link below to download a file formatted for EndNote
Access the full text.
Sign up today, get DeepDyve free for 14 days.
All DeepDyve websites use cookies to improve your online experience. They were placed on your computer when you launched this website. You can change your cookie settings through your browser.