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J. Digby, E. McNeill, O. Dyar, V. Lâm, D. Greaves, R. Choudhury (2010)
Anti-inflammatory effects of nicotinic acid in adipocytes demonstrated by suppression of fractalkine, RANTES, and MCP-1 and upregulation of adiponectinAtherosclerosis, 209
Y. Itoh, Y. Kawamata, M. Harada, Makoto Kobayashi, Ryo Fujii, S. Fukusumi, K. Ogi, M. Hosoya, Yasuhiro Tanaka, H. Uejima, Hideyuki Tanaka, M. Maruyama, Rie Satoh, Shoichi Okubo, H. Kizawa, H. Komatsu, Fumika Matsumura, Yuko Noguchi, T. Shinohara, S. Hinuma, Y. Fujisawa, M. Fujino (2003)
Free fatty acids regulate insulin secretion from pancreatic β cells through GPR40Nature, 422
Jonathan Brestoff, D. Artis (2013)
Commensal bacteria at the interface of host metabolism and the immune systemNature Immunology, 14
Y. Konno, S. Ueki, M. Takeda, Yoshiki Kobayashi, Mami Tamaki, Y. Moritoki, H. Oyamada, M. Itoga, H. Kayaba, A. Omokawa, M. Hirokawa (2015)
Functional Analysis of Free Fatty Acid Receptor GPR120 in Human Eosinophils: Implications in Metabolic HomeostasisPLoS ONE, 10
Jian Tan, Craig McKenzie, M. Potamitis, A. Thorburn, C. Mackay, L. Macia (2014)
The role of short-chain fatty acids in health and disease.Advances in immunology, 121
Hyeon Kim, V. Jadhav, D. Jeong, W. Park, J. Song, Sunkyung Lee, Heeyeong Cho (2015)
Discovery of 4-(phenyl)thio-1H-pyrazole derivatives as agonists of GPR109A, a high affinity niacin receptorArchives of Pharmacal Research, 38
Geun-Shik Lee, N. Subramanian, A. Kim, I. Aksentijevich, R. Goldbach-Mansky, D. Sacks, R. Germain, D. Kastner, J. Chae (2012)
The calcium-sensing receptor regulates the NLRP3 inflammasome through Ca2+ and cAMPNature, 492
Jang-Won Choi, Soo-Young Lee, Yong-Sun Choi (1996)
Identification of a putative G protein-coupled receptor induced during activation-induced apoptosis of T cells.Cellular immunology, 168 1
P. Sapieha, M. Sirinyan, David Hamel, Karine Zaniolo, Jean-Sébastien Joyal, Jang‐Hyeon Cho, J. Honoré, E. Kermorvant-Duchemin, D. Varma, S. Tremblay, M. Leduc, L. Řiháková, P. Hardy, W. Klein, X. Mu, O. Mamer, P. Lachapelle, A. Polo, C. Beauséjour, G. Andelfinger, G. Mitchell, F. Sennlaub, S. Chemtob (2008)
The succinate receptor GPR91 in neurons has a major role in retinal angiogenesisNature Medicine, 14
M. Kamp, Raymond Shim, Alyce Nicholls, A. Oliveira, L. Mason, Lauren Binge, C. Mackay, Connie Wong (2016)
G Protein-Coupled Receptor 43 Modulates Neutrophil Recruitment during Acute InflammationPLoS ONE, 11
A. Rosko, Karen McColl, F. Zhong, Christopher Ryder, Ming-jin Chang, A. Sattar, P. Caimi, B. Hill, Sayer Al-harbi, A. Almasan, C. Distelhorst (2014)
Acidosis Sensing Receptor GPR65 Correlates with Anti-Apoptotic Bcl-2 Family Member Expression in CLL Cells: Potential Implications for the CLL MicroenvironmentJournal of leukemia (Los Angeles, Calif.), 2
E. Elinav, T. Strowig, A. Kau, Jorge Henao-Mejia, Christoph Thaiss, C. Booth, D. Peaper, J. Bertin, S. Eisenbarth, J. Gordon, R. Flavell (2011)
NLRP6 Inflammasome Regulates Colonic Microbial Ecology and Risk for ColitisCell, 145
Takeshi Hosoi, Y. Koguchi, E. Sugikawa, Aiko Chikada, K. Ogawa, Naoki Tsuda, N. Suto, S. Tsunoda, T. Taniguchi, T. Ohnuki (2002)
Identification of a Novel Human Eicosanoid Receptor Coupled to Gi/o *The Journal of Biological Chemistry, 277
Tina Rubic, G. Lametschwandtner, S. Jost, S. Hinteregger, Julian Kund, N. Carballido‐Perrig, C. Schwärzler, T. Junt, H. Voshol, J. Meingassner, Xiaohong Mao, G. Werner, A. Rot, J. Carballido (2008)
Triggering the succinate receptor GPR91 on dendritic cells enhances immunityNature Immunology, 9
Huayun Deng, Haibei Hu, Ye Fang (2012)
Multiple tyrosine metabolites are GPR35 agonistsScientific Reports, 2
T. Hubbard, I. Murray, G. Perdew (2015)
Indole and Tryptophan Metabolism: Endogenous and Dietary Routes to Ah Receptor ActivationDrug Metabolism and Disposition, 43
J. Ou, Franck Carbonero, E. Zoetendal, J. DeLany, Mei Wang, K. Newton, H. Gaskins, S. O’Keefe (2013)
Diet, microbiota, and microbial metabolites in colon cancer risk in rural Africans and African Americans.The American journal of clinical nutrition, 98 1
A. Perino, T. Pols, Mitsunori Nomura, S. Stein, R. Pellicciari, K. Schoonjans (2014)
TGR5 reduces macrophage migration through mTOR-induced C/EBPβ differential translation.The Journal of clinical investigation, 124 12
Qiong Wu, Hui Wang, Xiaoping Zhao, Yufang Shi, Min Jin, B. Wan, Hua-Zhou Xu, Yi-fan Cheng, H. Ge, Yanyun Zhang (2013)
Identification of G-protein-coupled receptor 120 as a tumor-promoting receptor that induces angiogenesis and migration in human colorectal carcinomaOncogene, 32
Kanako Iwasaki, N. Harada, K. Sasaki, S. Yamane, Keiko Iida, Kazuyo Suzuki, A. Hamasaki, Daniela Nasteska, Kimitaka Shibue, Erina Joo, Takanari Harada, T. Hashimoto, Y. Asakawa, A. Hirasawa, N. Inagaki (2015)
Free fatty acid receptor GPR120 is highly expressed in enteroendocrine K cells of the upper small intestine and has a critical role in GIP secretion after fat ingestion.Endocrinology, 156 3
J. Maravillas-Montero, A. Burkhardt, P. Hevezi, Christina Carnevale, M. Smit, A. Zlotnik (2015)
Cutting Edge: GPR35/CXCR8 Is the Receptor of the Mucosal Chemokine CXCL17The Journal of Immunology, 194
O. Osborn, D. Oh, Joanne McNelis, M. Sanchez-Alavez, Saswata Talukdar, Min Lu, Pingping Li, Lucinda Thiede, H. Morinaga, Jane Kim, J. Heinrichsdorff, Sarah Nalbandian, Jachelle Ofrecio, M. Scadeng, S. Schenk, J. Hadcock, T. Bártfai, J. Olefsky (2012)
G protein-coupled receptor 21 deletion improves insulin sensitivity in diet-induced obese mice.The Journal of clinical investigation, 122 7
S. Cipriani, A. Mencarelli, M. Chini, E. Distrutti, B. Renga, G. Bifulco, F. Baldelli, A. Donini, S. Fiorucci (2011)
The Bile Acid Receptor GPBAR-1 (TGR5) Modulates Integrity of Intestinal Barrier and Immune Response to Experimental ColitisPLoS ONE, 6
K. Maslowski, A. Vieira, Aylwin Ng, J. Kranich, F. Sierro, Di Yu, H. Schilter, M. Rolph, F. Mackay, D. Artis, R. Xavier, M. Teixeira, C. Mackay (2009)
Regulation of inflammatory responses by gut microbiota and chemoattractant receptor GPR43Nature, 461
J. Markle, D. Frank, Steven Mortin-Toth, C. Robertson, Leah Feazel, U. Rolle-Kampczyk, M. Bergen, K. McCoy, A. Macpherson, J. Danska (2013)
Sex Differences in the Gut Microbiome Drive Hormone-Dependent Regulation of AutoimmunityScience, 339
N. Huda-Faujan, A. Abdulamir, A. Fatimah, O. Anas, M. Shuhaimi, A. Yazid, Y. Loong (2010)
The Impact of the Level of the Intestinal Short Chain Fatty Acids in Inflammatory Bowel Disease Patients Versus Healthy SubjectsThe Open Biochemistry Journal, 4
Nicholas Arpaia, Clarissa Campbell, Xiying Fan, Stanislav Dikiy, J. Veeken, P. Deroos, Hui Liu, J. Cross, K. Pfeffer, P. Coffer, A. Rudensky (2013)
Metabolites produced by commensal bacteria promote peripheral regulatory T cell generationNature, 504
Y. Irukayama-tomobe, Hirokazu Tanaka, T. Yokomizo, T. Hashidate‐Yoshida, M. Yanagisawa, T. Sakurai (2009)
Aromatic D-amino acids act as chemoattractant factors for human leukocytes through a G protein-coupled receptor, GPR109BProceedings of the National Academy of Sciences, 106
Deeksha Gambhir, S. Ananth, Rajalakshmi Veeranan-Karmegam, Selvakumar Elangovan, S. Hester, Eric Jennings, S. Offermanns, Julian Nussbaum, Sylvia Smith, M. Thangaraju, V. Ganapathy, Pamela Martin (2012)
GPR109A as an anti-inflammatory receptor in retinal pigment epithelial cells and its relevance to diabetic retinopathy.Investigative ophthalmology & visual science, 53 4
Christopher Ryder, Karen McColl, F. Zhong, C. Distelhorst (2012)
Acidosis Promotes Bcl-2 Family-mediated Evasion of ApoptosisThe Journal of Biological Chemistry, 287
A. Ziegler, M. Rewers, O. Simell, T. Simell, J. Lempainen, A. Steck, C. Winkler, J. Ilonen, R. Veijola, M. Knip, E. Bonifacio, G. Eisenbarth (2013)
Seroconversion to multiple islet autoantibodies and risk of progression to diabetes in children.JAMA, 309 23
Y. Hakak, K. Lehmann‐Bruinsma, S. Phillips, Thuy Le, C. Liaw, D. Connolly, D. Behan (2009)
The role of the GPR91 ligand succinate in hematopoiesisJournal of Leukocyte Biology, 85
A. Thorburn, Craig McKenzie, S. Shen, D. Stanley, L. Macia, L. Mason, Laura Roberts, Connie Wong, Raymond Shim, R. Robert, N. Chevalier, Jian Tan, Eliana Mariño, R. Moore, Lee Wong, M. McConville, D. Tull, L. Wood, V. Murphy, J. Mattes, P. Gibson, C. Mackay (2015)
Evidence that asthma is a developmental origin disease influenced by maternal diet and bacterial metabolitesNature Communications, 6
R. Perry, Liang Peng, N. Barry, G. Cline, Dongyan Zhang, Rebecca Cardone, K. Petersen, R. Kibbey, A. Goodman, G. Shulman (2016)
Acetate mediates a microbiome-brain-β cell axis promoting metabolic syndromeNature, 534
J. Harig, K. Soergel, R. Komorowski, C. Wood (1989)
Treatment of diversion colitis with short-chain-fatty acid irrigation.The New England journal of medicine, 320 1
Changlu Liu, Jiejun Wu, Jessica Zhu, Chester Kuei, Jingxue Yu, Jonathan Shelton, S. Sutton, Xiaorong Li, S. Yun, T. Mirzadegan, C. Mazur, F. Kamme, T. Lovenberg (2009)
Lactate Inhibits Lipolysis in Fat Cells through Activation of an Orphan G-protein-coupled Receptor, GPR81*Journal of Biological Chemistry, 284
Yong Tang, Yakun Chen, Hongmei Jiang, G. Robbins, D. Nie (2011)
G‐protein‐coupled receptor for short‐chain fatty acids suppresses colon cancerInternational Journal of Cancer, 128
L. Macia, Jian Tan, A. Vieira, K. Leach, D. Stanley, S. Luong, M. Maruya, Craig McKenzie, A. Hijikata, Connie Wong, Lauren Binge, A. Thorburn, N. Chevalier, C. Ang, Eliana Mariño, R. Robert, S. Offermanns, Mauro Teixeira, R. Moore, R. Flavell, S. Fagarasan, C. Mackay (2015)
Metabolite-sensing receptors GPR43 and GPR109A facilitate dietary fibre-induced gut homeostasis through regulation of the inflammasomeNature Communications, 6
Myunghoo Kim, S. Kang, Jeongho Park, M. Yanagisawa, Chang Kim (2014)
The commensal bacteria metabolites short chain fatty acids positively regulate epithelial innate immune responses in the gut (MUC4P.847)The Journal of Immunology
Hua Gao, Yue Sun, Yalan Wu, B. Luan, Yaya Wang, B. Qu, G. Pei (2004)
Identification of β-Arrestin2 as a G Protein-Coupled Receptor-Stimulated Regulator of NF-κB PathwaysMolecular Cell, 14
D. Oh, Saswata Talukdar, E. Bae, T. Imamura, H. Morinaga, WuQiang Fan, Pingping Li, Wendell Lu, S. Watkins, J. Olefsky (2010)
GPR120 Is an Omega-3 Fatty Acid Receptor Mediating Potent Anti-inflammatory and Insulin-Sensitizing EffectsCell, 142
K. Zandi‐Nejad, A. Takakura, Mollie Jurewicz, A. Chandraker, S. Offermanns, D. Mount, R. Abdi (2013)
The role of HCA2 (GPR109A) in regulating macrophage functionThe FASEB Journal, 27
Kaia Mobraten, T. Haug, C. Kleiveland, T. Lea (2013)
Omega-3 and omega-6 PUFAs induce the same GPR120-mediated signalling events, but with different kinetics and intensity in Caco-2 cellsLipids in Health and Disease, 12
M. Sawzdargo, S. George, Tuan Nguyen, Shijie Xu, L. Kolakowski, B. O'dowd (1997)
A cluster of four novel human G protein-coupled receptor genes occurring in close proximity to CD22 gene on chromosome 19q13.1.Biochemical and biophysical research communications, 239 2
Torsten Olszak, Dingding An, S. Zeissig, M. Vera, J. Richter, A. Franke, J. Glickman, R. Siebert, R. Baron, Dennis Kasper, R. Blumberg (2012)
Microbial Exposure During Early Life Has Persistent Effects on Natural Killer T Cell FunctionScience, 336
D. Im, C. Heise, Tuan Nguyen, B. O'dowd, K. Lynch (2001)
Identification of a Molecular Target of Psychosine and Its Role in Globoid Cell FormationThe Journal of Cell Biology, 153
A. Stefka, Taylor Feehley, P. Tripathi, J. Qiu, K. McCoy, S. Mazmanian, Melissa Tjota, Goo-Young Seo, Severine Cao, B. Theriault, D. Antonopoulos, Liang Zhou, E. Chang, Yangbo Fu, C. Nagler (2014)
Commensal bacteria protect against food allergen sensitizationProceedings of the National Academy of Sciences, 111
Vignir Ísberg, Kirsten Andersen, C. Bisig, G. Dietz, H. Bräuner‐Osborne, D. Gloriam (2014)
Computer-Aided Discovery of Aromatic l-α-Amino Acids as Agonists of the Orphan G Protein-Coupled Receptor GPR139Journal of chemical information and modeling, 54 6
Patrick Smith, Michael Howitt, N. Panikov, M. Michaud, C. Gallini, M. Bohlooly-y, J. Glickman, W. Garrett (2013)
The Microbial Metabolites, Short-Chain Fatty Acids, Regulate Colonic Treg Cell HomeostasisScience, 341
L. Jostins, S. Ripke, R. Weersma, R. Duerr, D. McGovern, Ken Hui, James Lee, L. Schumm, Y. Sharma, Carl Anderson, J. Essers, M. Mitrovič, Kaida Ning, I. Cleynen, E. Théâtre, Sarah Spain, Soumya Raychaudhuri, P. Goyette, Zhi Wei, Clara Abraham, J. Achkar, Tariq Ahmad, L. Amininejad, Ashwin Ananthakrishnan, Vibeke Andersen, Jane Andrews, L. Baidoo, T. Balschun, P. Bampton, Alain Bitton, G. Boucher, S. Brand, Carsten Büning, A. Cohain, Sven Cichon, Mauro D’Amato, Dirk Jong, Kathy Devaney, Marla Dubinsky, C. Edwards, D. Ellinghaus, Lynnette Ferguson, Denis Franchimont, K. Fransén, R. Gearry, Michel Georges, C. Gieger, J. Glas, T. Haritunians, A. Hart, C. Hawkey, M. Hedl, Xinli Hu, Tom Karlsen, L. Kupčinskas, S. Kugathasan, A. Latiano, D. Laukens, I. Lawrance, Charlie Lees, É. Louis, G. Mahy, John Mansfield, Angharad Morgan, C. Mowat, W. Newman, O. Palmieri, C. Ponsioen, U. Potocnik, N. Prescott, Miguel Regueiro, Jerome Rotter, Richard Russell, J. Sanderson, Miquel Sans, J. Satsangi, Stefan Schreiber, L. Simms, Jurgita Šventoraitytė, S. Targan, Kent Taylor, M. Tremelling, H Verspaget, M. Vos, C. Wijmenga, D. Wilson, J. Winkelmann, R. Xavier, Sebastian Zeissig, Bin Zhang, Clarence Zhang, Hongyu Zhao, M. Silverberg, V. Annese, H. Hakonarson, S. Brant, G. Radford-Smith, Christopher Mathew, J. Rioux, Eric Schadt, M. Daly, A. Franke, M. Parkes, S. Vermeire, J. Barrett, Judy Cho (2012)
Host-microbe interactions have shaped the genetic architecture of inflammatory bowel diseaseNature, 491
X. Ke (2012)
Presence of multiple independent effects in risk loci of common complex human diseases.American journal of human genetics, 91 1
Mark Nøhr, M. Pedersen, A. Gille, Kristoffer Egerod, M. Engelstoft, A. Husted, R. Sichlau, K. Grunddal, S. Poulsen, Sangdon Han, Robert Jones, S. Offermanns, T. Schwartz (2013)
GPR41/FFAR3 and GPR43/FFAR2 as cosensors for short-chain fatty acids in enteroendocrine cells vs FFAR3 in enteric neurons and FFAR2 in enteric leukocytes.Endocrinology, 154 10
A. Franke, D. McGovern, J. Barrett, Kai Wang, L. Graham, Radford-Smith, T. Ahmad, C. Lees, T. Balschun, James Lee, Rebecca, D Roberts, C. Anderson, J. Bis, S. Bumpstead, D. Ellinghaus, Eleonora Festen, M. Georges, T. Haritunians, L. Jostins, Anna, Latiano, C. Mathew, G. Montgomery, N. Prescott, Jérôme, I. Rotter, P. Schumm, Y. Sharma, L. Simms, K. Taylor, David, Whiteman, C. Wijmenga, R. Baldassano, M. Barclay, M. Theodore, Bayless, S. Brand, Carsten Buning, A. Cohen, Jean-Frederick, Colombel, M. Cottone, L. Stronati, T. Denson, M. Vos, Renata, D’Inca, M. Dubinsky, C. Edwards, T. Florin, D. Franchimont, R. Gearry, J. Glas, A. Gossum, S. Guthery, Jonas, Halfvarson, D. Hommes, J. Hugot, D. Laukens, I. Lawrance, M. Lémann, A. Levine, C. Libioulle, E. Louis, C. Mowat, William, Newman, J. Panés, A. Phillips, D. Proctor, M. Regueiro, Paul, Rutgeerts, J. Sanderson, M. Sans, F. Seibold, A. Steinhart, P. Stokkers, L. Torkvist, Gerd Ublick, S. Raychaudhuri, Todd Green, T. Walters, S. Targan, S. Brant, J. Rioux, M. D’Amato, R. Weersma, S. Kugathasan, A. Griffiths, C. John, Mansfield, S. Vermeire, R. Duerr, M. Silverberg, Jack, Satsangi, S. Schreiber, Judy Cho, V. Annese, H. Hakonarson, M. Daly, M. Parkes (2010)
Genome-wide meta-analysis increases to 71 the number of confirmed Crohn's disease susceptibility lociNature Genetics, 42
A. Anbazhagan, S. Priyamvada, Tarunmeet Gujral, S. Bhattacharyya, W. Alrefai, P. Dudeja, A. Borthakur (2016)
A novel anti-inflammatory role of GPR120 in intestinal epithelial cells.American journal of physiology. Cell physiology, 310 7
Louis Cohen, Hahk-Soo Kang, J. Chu, Yun-Han Huang, Emma Gordon, Boojala Reddy, Melinda Ternei, J. Craig, S. Brady (2015)
Functional metagenomic discovery of bacterial effectors in the human microbiome and isolation of commendamide, a GPCR G2A/132 agonistProceedings of the National Academy of Sciences, 112
Yande Guo, Wenlian Zhang, C. Giroux, Yinlong Cai, P. Ekambaram, A. Dilly, Andrew Hsu, Senlin Zhou, K. Maddipati, Jingjing Liu, Sangeeta Joshi, S. Tucker, M. Lee, K. Honn (2011)
Identification of the Orphan G Protein-coupled Receptor GPR31 as a Receptor for 12-(S)-Hydroxyeicosatetraenoic Acid*The Journal of Biological Chemistry, 286
Yikyung Park, A. Subar, A. Hollenbeck, A. Schatzkin (2011)
Dietary fiber intake and mortality in the NIH-AARP diet and health study.Archives of internal medicine, 171 12
K. Lassen, Craig McKenzie, M. Mari, T. Murano, J. Begun, Leigh Baxt, G. Goel, E. Villablanca, Szu-Yu Kuo, Hailiang Huang, L. Macia, A. Bhan, M. Batten, M. Daly, F. Reggiori, C. Mackay, R. Xavier (2016)
Genetic Coding Variant in GPR65 Alters Lysosomal pH and Links Lysosomal Dysfunction with Colitis Risk.Immunity, 44 6
S. Ishii, Y. Kihara, Takao Shimizu (2005)
Identification of T Cell Death-associated Gene 8 (TDAG8) as a Novel Acid Sensing G-protein-coupled Receptor*Journal of Biological Chemistry, 280
Xiaojin Xu, L. Ye, K. Araki, R. Ahmed (2012)
mTOR, linking metabolism and immunity.Seminars in immunology, 24 6
Joanne McNelis, Y. Lee, R. Mayoral, Rik Kant, Andrew Johnson, Joshua Wollam, J. Olefsky (2015)
GPR43 Potentiates β-Cell Function in ObesityDiabetes, 64
Veroushka Ballester, Xiuqing Guo, R. Vendrell, T. Haritunians, Alexandra Klomhaus, Dalin Li, D. McGovern, J. Rotter, E. Torres, K. Taylor (2014)
Association of NOD2 and IL23R with Inflammatory Bowel Disease in Puerto RicoPLoS ONE, 9
Aurélien Trompette, E. Gollwitzer, K. Yadava, A. Sichelstiel, N. Sprenger, C. Ngom-Bru, C. Blanchard, T. Junt, L. Nicod, N. Harris, B. Marsland (2014)
Gut microbiota metabolism of dietary fiber influences allergic airway disease and hematopoiesisNature Medicine, 20
T. Zelante, R. Iannitti, C. Cunha, A. Luca, Gloria Giovannini, G. Pieraccini, R. Zecchi, C. D’Angelo, Cristina Massi-Benedetti, F. Fallarino, A. Carvalho, P. Puccetti, L. Romani (2013)
Tryptophan catabolites from microbiota engage aryl hydrocarbon receptor and balance mucosal reactivity via interleukin-22.Immunity, 39 2
Saori Oka, R. Ota, M. Shima, A. Yamashita, T. Sugiura (2010)
GPR35 is a novel lysophosphatidic acid receptor.Biochemical and biophysical research communications, 395 2
H. Luhrs, T. Gerke, F. Boxberger, Kerstin Backhaus, R. Melcher, W. Scheppach, T. Menzel (2001)
Butyrate Inhibits Interleukin-1-Mediated Nuclear Factor-Kappa B Activation in Human Epithelial CellsDigestive Diseases and Sciences, 46
Weihai He, F. Miao, Daniel Lin, R. Schwandner, Zhulun Wang, Jinhai Gao, Jin-Long Chen, H. Tian, L. Ling (2004)
Citric acid cycle intermediates as ligands for orphan G-protein-coupled receptorsNature, 429
Lili Ding, Li Yang, Zhengtao Wang, Wendong Huang (2015)
Bile acid nuclear receptor FXR and digestive system diseasesActa Pharmaceutica Sinica. B, 5
S. Fukuda, Hidehiro Toh, K. Hase, K. Oshima, Yumiko Nakanishi, Kazutoshi Yoshimura, T. Tobe, J. Clarke, D. Topping, Tohru Suzuki, T. Taylor, K. Itoh, J. Kikuchi, H. Morita, M. Hattori, H. Ohno (2011)
Bifidobacteria can protect from enteropathogenic infection through production of acetateNature, 469
L. Ignarro, M. Balestrieri, C. Napoli (2007)
Nutrition, physical activity, and cardiovascular disease: an update.Cardiovascular research, 73 2
A. Hirasawa, K. Tsumaya, T. Awaji, S. Katsuma, T. Adachi, M. Yamada, Y. Sugimoto, S. Miyazaki, G. Tsujimoto (2005)
Free fatty acids regulate gut incretin glucagon-like peptide-1 secretion through GPR120Nature Medicine, 11
C. Venkataraman, Frederick Kuo (2005)
The G-protein coupled receptor, GPR84 regulates IL-4 production by T lymphocytes in response to CD3 crosslinking.Immunology letters, 101 2
Kashan Ahmed, S. Tunaru, C. Langhans, J. Hanson, C. Michalski, S. Kölker, Patricia Jones, J. Okun, S. Offermanns (2009)
Deorphanization of GPR109B as a Receptor for the β-Oxidation Intermediate 3-OH-octanoic Acid and Its Role in the Regulation of Lipolysis*The Journal of Biological Chemistry, 284
M. Thangaraju, G. Cresci, Kebin Liu, S. Ananth, Jaya Gnanaprakasam, D. Browning, J. Mellinger, Sylvia Smith, Gregory Digby, N. Lambert, P. Prasad, V. Ganapathy (2009)
GPR109A is a G-protein-coupled receptor for the bacterial fermentation product butyrate and functions as a tumor suppressor in colon.Cancer research, 69 7
Robert Walters, Arun Shukla, Jeffrey Kovacs, Jonathan Violin, S. Dewire, Christopher Lam, J. Chen, Michael Muehlbauer, E. Whalen, Robert Lefkowitz (2009)
beta-Arrestin1 mediates nicotinic acid-induced flushing, but not its antilipolytic effect, in mice.The Journal of clinical investigation, 119 5
Tina Herbst, A. Sichelstiel, Corinne Schär, K. Yadava, K. Bürki, J. Cahenzli, K. McCoy, B. Marsland, N. Harris (2011)
Dysregulation of allergic airway inflammation in the absence of microbial colonization.American journal of respiratory and critical care medicine, 184 2
E. Poul, Cécile Loison, S. Struyf, J. Springael, V. Lannoy, Marie-Eve Decobecq, S. Brézillon, V. Dupriez, G. Vassart, J. Damme, M. Parmentier, M. Detheux (2003)
Functional Characterization of Human Receptors for Short Chain Fatty Acids and Their Role in Polymorphonuclear Cell Activation*Journal of Biological Chemistry, 278
Jinghong Wang, Xiaosu Wu, Nicole Simonavicius, H. Tian, L. Ling (2006)
Medium-chain Fatty Acids as Ligands for Orphan G Protein-coupled Receptor GPR84*Journal of Biological Chemistry, 281
Wolfgang Scheppach, Wolfgang Scheppach, H. Sommer, H. Sommer, T. Kirchner, T. Kirchner, G. Paganelli, G. Paganelli, P. Bartram, P. Bartram, S. Christl, S. Christl, F. Richter, F. Richter, G. Dusel, G. Dusel, H. Kasper, H. Kasper (1992)
Effect of butyrate enemas on the colonic mucosa in distal ulcerative colitis.Gastroenterology, 103 1
A. Wahlström, Sama Sayin, H. Marschall, F. Bäckhed (2016)
Intestinal Crosstalk between Bile Acids and Microbiota and Its Impact on Host Metabolism.Cell metabolism, 24 1
Yumei Xiong, N. Miyamoto, K. Shibata, M. Valasek, T. Motoike, R. Kedzierski, M. Yanagisawa (2004)
Short-chain fatty acids stimulate leptin production in adipocytes through the G protein-coupled receptor GPR41.Proceedings of the National Academy of Sciences of the United States of America, 101 4
G. Godlewski, László Offertáler, J. Wagner, G. Kunos (2009)
Receptors for acylethanolamides-GPR55 and GPR119.Prostaglandins & other lipid mediators, 89 3-4
Jian Tan, Craig McKenzie, P. Vuillermin, G. Goverse, C. Vinuesa, R. Mebius, L. Macia, C. Mackay (2016)
Dietary Fiber and Bacterial SCFA Enhance Oral Tolerance and Protect against Food Allergy through Diverse Cellular Pathways.Cell reports, 15 12
R. Estruch, E. Ros, J. Salas‐Salvadó, M. Covas, D. Corella, F. Arós, E. Gómez-Gracia, V. Ruíz-Gutiérrez, M. Fiol, J. Lapetra, R. Lamuela-Raventós, L. Serra-Majem, X. Pintó, J. Basora, M. Muñoz, J. Sorlí, J. Martínez, M. Martínez-González (2013)
Primary prevention of cardiovascular disease with a Mediterranean diet.The New England journal of medicine, 368 14
L. Yin, G. Laevsky, C. Giardina (2001)
Butyrate Suppression of Colonocyte NF-κB Activation and Cellular Proteasome Activity*The Journal of Biological Chemistry, 276
J. Butzner, R. Parmar, C. Bell, V. Dalal (1996)
Butyrate enema therapy stimulates mucosal repair in experimental colitis in the rat.Gut, 38
Xiang Zhu, Eucabeth Mose, S. Hogan, N. Zimmermann (2014)
Differential eosinophil and mast cell regulation: mast cell viability and accumulation in inflammatory tissue are independent of proton-sensing receptor GPR65.American journal of physiology. Gastrointestinal and liver physiology, 306 11
I. Kimura, K. Ozawa, D. Inoue, Takeshi Imamura, K. Kimura, Takeshi Maeda, Kazuya Terasawa, Daiji Kashihara, Kanako Hirano, T. Tani, Tomoyuki Takahashi, Satoshi Miyauchi, G. Shioi, H. Inoue, G. Tsujimoto (2013)
The gut microbiota suppresses insulin-mediated fat accumulation via the short-chain fatty acid receptor GPR43Nature Communications, 4
J. Chai, J. Digby, R. Choudhury (2013)
GPR109A and Vascular InflammationCurrent Atherosclerosis Reports, 15
Sangwon Kim, W. Xiang, C. Kwak, Yi Yang, X. Lin, M. Ota, U. Sarpel, D. Rifkin, R. Xu, D. Littman (2013)
GPR15-Mediated Homing Controls Immune Homeostasis in the Large Intestine MucosaScience, 340
Tomoko Fujita, T. Matsuoka, T. Honda, K. Kabashima, T. Hirata, S. Narumiya (2011)
A GPR40 agonist GW9508 suppresses CCL5, CCL17, and CXCL10 induction in keratinocytes and attenuates cutaneous immune inflammation.The Journal of investigative dermatology, 131 8
L. Kottyan, A. Collier, K. Cao, Kathryn Niese, M. Hedgebeth, C. Radu, O. Witte, G. Hershey, M. Rothenberg, N. Zimmermann (2009)
Eosinophil viability is increased by acidic pH in a cAMP- and GPR65-dependent manner.Blood, 114 13
Jeongho Park, Myunghoo Kim, S. Kang, A. Jannasch, B. Cooper, J. Patterson, Chang Kim (2014)
Short chain fatty acids induce both effector and regulatory T cells by suppression of histone deacetylases and regulation of the mTOR-S6K pathwayMucosal immunology, 8
H. Duboc, Y. Taché, A. Hofmann (2014)
The bile acid TGR5 membrane receptor: from basic research to clinical application.Digestive and liver disease : official journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver, 46 4
S. Lee, Hyun In, M. Kwon, Bi-Oh Park, Minmi Jo, Mun-Ock Kim, Sungchan Cho, Sangku Lee, Hyun-Jun Lee, Y. Kwak, Sunhong Kim (2013)
β-Arrestin 2 mediates G protein-coupled receptor 43 signals to nuclear factor-κB.Biological & pharmaceutical bulletin, 36 11
A. Vieira, L. Macia, I. Galvão, F. Martins, M. Canesso, F. Amaral, Cristiana Garcia, K. Maslowski, E. Leon, Doris Shim, J. Nicoli, J. Harper, M. Teixeira, C. Mackay (2015)
A Role for Gut Microbiota and the Metabolite‐Sensing Receptor GPR43 in a Murine Model of GoutArthritis & Rheumatology, 67
M. Vinolo, G. Ferguson, S. Kulkarni, G. Damoulakis, K. Anderson, M. Bohlooly-y, L. Stephens, P. Hawkins, R. Curi, B. Ko, H. Kong (2011)
SCFAs Induce Mouse Neutrophil Chemotaxis through the GPR43 ReceptorPLoS ONE, 6
J. Swann, E. Want, F. Geier, K. Spagou, I. Wilson, J. Sidaway, J. Nicholson, E. Holmes (2010)
Systemic gut microbial modulation of bile acid metabolism in host tissue compartmentsProceedings of the National Academy of Sciences, 108
M. Barth, N. Ahluwalia, T. Anderson, Gregory Hardy, Sumita Sinha, Jose Alvarez-Cardona, Ivy Pruitt, E. Rhee, R. Colvin, R. Gerszten (2009)
Kynurenic Acid Triggers Firm Arrest of Leukocytes to Vascular Endothelium under Flow Conditions*The Journal of Biological Chemistry, 284
L. Bindels, P. Porporato, E. Dewulf, J. Verrax, A. Neyrinck, J. Martin, K. Scott, P. Calderon, O. Féron, G. Muccioli, P. Sonveaux, Patrice Cani, N. Delzenne (2012)
Gut microbiota-derived propionate reduces cancer cell proliferation in the liverBritish Journal of Cancer, 107
R. Place, E. Noonan, C. Giardina (2005)
HDAC inhibition prevents NF-κB activation by suppressing proteasome activity: Down-regulation of proteasome subunit expression stabilizes IκBαBiochemical Pharmacology, 70
K. Maslowski, C. Mackay (2010)
Diet, gut microbiota and immune responsesNature Immunology, 12
A. Littlewood-Evans, Sophie Sarret, Verena Apfel, Perrine Loesle, J. Dawson, Juan Zhang, Alban Muller, B. Tigani, R. Kneuer, S. Patel, Stephanie Valeaux, N. Gommermann, T. Rubic-Schneider, T. Junt, J. Carballido (2016)
GPR91 senses extracellular succinate released from inflammatory macrophages and exacerbates rheumatoid arthritisThe Journal of Experimental Medicine, 213
Masakatsu Suzuki, S. Takaishi, Miyuki Nagasaki, Yoshiko Onozawa, Ikue Iino, Hiroaki Maeda, T. Komai, T. Oda (2013)
Medium-chain Fatty Acid-sensing Receptor, GPR84, Is a Proinflammatory ReceptorThe Journal of Biological Chemistry, 288
R. Hinterleitner, B. Jabri (2016)
A dendritic cell subset designed for oral toleranceNature Immunology, 17
M. Cox, J. Jackson, Michaela Stanton, A. Rojas-Triana, L. Bober, M. Laverty, Xiaoxin Yang, Feng Zhu, Jianjun Liu, Suke Wang, F. Monsma, G. Vassileva, M. Maguire, E. Gustafson, M. Bayne, C. Chou, D. Lundell, C. Jenh (2009)
Short-chain fatty acids act as antiinflammatory mediators by regulating prostaglandin E2 and cytokines.World Journal of Gastroenterology, 15
Jinghong Wang, Nicole Simonavicius, Xiaosu Wu, G. Swaminath, J. Reagan, H. Tian, L. Ling (2006)
Kynurenic Acid as a Ligand for Orphan G Protein-coupled Receptor GPR35*Journal of Biological Chemistry, 281
P. Calder (2005)
Polyunsaturated fatty acids and inflammation.Biochemical Society transactions, 33 Pt 2
L. Wen, R. Ley, R. Ley, P. Volchkov, P. Stranges, L. Avanesyan, Austin Stonebraker, Changyun Hu, F. Wong, G. Szot, J. Bluestone, J. Gordon, A. Chervonsky (2008)
Innate immunity and intestinal microbiota in the development of Type 1 diabetesNature, 455
N. Tosa, M. Murakami, W. Jia, M. Yokoyama, T. Masunaga, C. Iwabuchi, M. Inobe, K. Iwabuchi, T. Miyazaki, K. Onoé, M. Iwata, T. Uede (2003)
Critical function of T cell death-associated gene 8 in glucocorticoid-induced thymocyte apoptosis.International immunology, 15 6
T. Senga, S. Iwamoto, Tsunehiko Yoshida, T. Yokota, K. Adachi, E. Azuma, M. Hamaguchi, T. Iwamoto (2003)
LSSIG is a novel murine leukocyte-specific GPCR that is induced by the activation of STAT3.Blood, 101 3
Shin-Ichiro Karaki, Hideaki Tazoe, H. Hayashi, H. Kashiwabara, Kazunari Tooyama, Yuichi Suzuki, A. Kuwahara (2008)
Expression of the short-chain fatty acid receptor, GPR43, in the human colonJournal of Molecular Histology, 39
C. Bouchard, J. Pagé, Andréanne Bédard, Pierrot Tremblay, L. Vallières (2007)
G protein‐coupled receptor 84, a microglia‐associated protein expressed in neuroinflammatory conditionsGlia, 55
Yukihiro Furusawa, Yuuki Obata, S. Fukuda, T. Endo, G. Nakato, D. Takahashi, Yumiko Nakanishi, Chikako Uetake, Keiko Kato, Tamotsu Kato, Masumi Takahashi, Noriko Fukuda, S. Murakami, E. Miyauchi, S. Hino, K. Atarashi, Satoshi Onawa, Yumiko Fujimura, T. Lockett, J. Clarke, D. Topping, M. Tomita, S. Hori, O. Ohara, T. Morita, H. Koseki, J. Kikuchi, K. Honda, K. Hase, H. Ohno (2013)
Commensal microbe-derived butyrate induces the differentiation of colonic regulatory T cellsNature, 504
Andrew Brown, S. Goldsworthy, Ashley Barnes, Michelle Eilert, Lili Tcheang, D. Daniels, A. Muir, M. Wigglesworth, I. Kinghorn, N. Fraser, N. Pike, J. Strum, K. Steplewski, P. Murdock, J. Holder, F. Marshall, P. Szekeres, Shelagh Wilson, D. Ignar, S. Foord, A. Wise, S. Dowell (2003)
The Orphan G Protein-coupled Receptors GPR41 and GPR43 Are Activated by Propionate and Other Short Chain Carboxylic Acids*The Journal of Biological Chemistry, 278
Nagendra Singh, Ashish Gurav, Sathish Sivaprakasam, E. Brady, Ravi Padia, Huidong Shi, M. Thangaraju, P. Prasad, S. Manicassamy, D. Munn, J. Lee, S. Offermanns, V. Ganapathy (2014)
Activation of Gpr109a, receptor for niacin and the commensal metabolite butyrate, suppresses colonic inflammation and carcinogenesis.Immunity, 40 1
Cong Tang, Kashan Ahmed, A. Gille, Shun Lu, H. Gröne, S. Tunaru, S. Offermanns (2015)
Loss of FFA2 and FFA3 increases insulin secretion and improves glucose tolerance in type 2 diabetesNature Medicine, 21
Jianing Li, Yu Wang, Lihua Tang, W. Villiers, D. Cohen, J. Woodward, F. Finkelman, E. Eckhardt (2013)
Dietary medium-chain triglycerides promote oral allergic sensitization and orally induced anaphylaxis to peanut protein in mice.The Journal of allergy and clinical immunology, 131 2
J. Segain, D. Blétière, A. Bourreille, V. Leray, N. Gervois, C. Rosales, L. Ferrier, C. Bonnet, H. Blottière, J. Galmiche (2000)
Butyrate inhibits inflammatory responses through NFkappaB inhibition: implications for Crohn's disease.Gut, 47 3
C. Vallière, Yu Wang, J. Eloranta, Solange Vidal, I. Clay, M. Spalinger, I. Tcymbarevich, A. Terhalle, Marie-Gabrielle Ludwig, T. Suply, M. Fried, G. Kullak-Ublick, I. Frey-Wagner, M. Scharl, K. Seuwen, C. Wagner, G. Rogler (2015)
G Protein-coupled pH-sensing Receptor OGR1 Is a Regulator of Intestinal InflammationInflammatory Bowel Diseases, 21
Tomohiko Murakami, Johan Ockinger, Jiujiu Yu, Vanessa Byles, A. McColl, A. Hofer, T. Horng (2012)
Critical role for calcium mobilization in activation of the NLRP3 inflammasomeProceedings of the National Academy of Sciences, 109
K. Halpern, A. Veprik, N. Rubins, Orly Naaman, M. Walker (2012)
GPR41 Gene Expression Is Mediated by Internal Ribosome Entry Site (IRES)-dependent Translation of Bicistronic mRNA Encoding GPR40 and GPR41 Proteins*The Journal of Biological Chemistry, 287
Carlos Pérez, Aline Dumas, L. Vallières, J. Guénet, F. Benavides (2013)
Several classical mouse inbred strains, including DBA/2, NOD/Lt, FVB/N, and SJL/J, carry a putative loss-of-function allele of Gpr84.The Journal of heredity, 104 4
B. Khor, A. Gardet, R. Xavier (2011)
Genetics and pathogenesis of inflammatory bowel diseaseNature, 474
Raúl Muñoz-Planillo, Peter Kuffa, G. Martínez-Colón, B. Smith, Thekkelnaycke Rajendiran, G. Núñez (2013)
K⁺ efflux is the common trigger of NLRP3 inflammasome activation by bacterial toxins and particulate matter.Immunity, 38 6
I. Niot, H. Poirier, T. Tran, P. Besnard (2009)
Intestinal absorption of long-chain fatty acids: evidence and uncertainties.Progress in lipid research, 48 2
S. Krishnamoorthy, A. Recchiuti, Chia Nan, S. Yacoubian, Chih‐Hao Lee, Rong Yang, N. Petasis, C. Serhan (2010)
Resolvin D1 binds human phagocytes with evidence for proresolving receptorsProceedings of the National Academy of Sciences, 107
C. Briscoe, M. Tadayyon, J. Andrews, William Benson, J. Chambers, Michelle Eilert, C. Ellis, N. Elshourbagy, A. Goetz, D. Minnick, P. Murdock, H. Sauls, U. Shabon, Lisa Spinage, J. Strum, P. Szekeres, K. Tan, J. Way, D. Ignar, Shelagh Wilson, A. Muir (2003)
The Orphan G Protein-coupled Receptor GPR40 Is Activated by Medium and Long Chain Fatty Acids*The Journal of Biological Chemistry, 278
H. Kyaw, Zhizhen Zeng, K. Su, Ping Fan, B. Shell, K. Carter, Yi Li (1998)
Cloning, characterization, and mapping of human homolog of mouse T-cell death-associated gene.DNA and cell biology, 17 6
Meng Li, Xiangyu Meng, Jie Xu, Xiuqing Huang, Hong-xia Li, Guoping Li, Shu Wang, Yong Man, Weiqing Tang, Jian Li (2016)
GPR40 agonist ameliorates liver X receptor-induced lipid accumulation in liver by activating AMPK pathwayScientific Reports, 6
A. Thorburn, L. Macia, C. Mackay (2014)
Diet, metabolites, and "western-lifestyle" inflammatory diseases.Immunity, 40 6
H. Nagasaki, T. Kondo, Masahiro Fuchigami, H. Hashimoto, Y. Sugimura, N. Ozaki, H. Arima, A. Ota, Y. Oiso, Y. Hamada (2012)
Inflammatory changes in adipose tissue enhance expression of GPR84, a medium‐chain fatty acid receptorFEBS Letters, 586
K. Page, A. Williamson, Namyi Yu, E. McNay, J. Dzuira, R. McCrimmon, R. Sherwin (2009)
Medium-Chain Fatty Acids Improve Cognitive Function in Intensively Treated Type 1 Diabetic Patients and Support In Vitro Synaptic Transmission During Acute HypoglycemiaDiabetes, 58
Polina Mamontov, E. Neiman, Tinghua Cao, J. Perrigoue, Joshua Friedman, Anuk Das, J. Mora (2015)
Effects of short chain fatty acids and GPR43 stimulation on human Treg function (IRC5P.631)The Journal of Immunology
Craig McKenzie, C. Mackay, L. Macia (2015)
GPR43 – A Prototypic Metabolite Sensor Linking Metabolic and Inflammatory DiseasesTrends in Endocrinology & Metabolism, 26
M. St-Onge, Peter Jones (2002)
Physiological effects of medium-chain triglycerides: potential agents in the prevention of obesity.The Journal of nutrition, 132 3
M. Lukasova, C. Malaval, A. Gille, J. Kero, S. Offermanns (2011)
Nicotinic acid inhibits progression of atherosclerosis in mice through its receptor GPR109A expressed by immune cells.The Journal of clinical investigation, 121 3
Jonitha Gardner, Sue Wu, L. Ling, Jean Danao, Yang Li, W. Yeh, H. Tian, H. Baribault (2012)
G-protein-coupled receptor GPR21 knockout mice display improved glucose tolerance and increased insulin response.Biochemical and biophysical research communications, 418 1
Henry III, Y. Won, V. Lu, S. Ikeda (2015)
Human GPR42 is a transcribed multisite variant that exhibits copy number polymorphism and is functional when heterologously expressedScientific Reports, 5
Shin-Ichiro Karaki, R. Mitsui, H. Hayashi, I. Kato, H. Sugiya, T. Iwanaga, J. Furness, A. Kuwahara (2006)
Short-chain fatty acid receptor, GPR43, is expressed by enteroendocrine cells and mucosal mast cells in rat intestineCell and Tissue Research, 324
Christopher Henstidge, Nariman Balenga, L. Ford, R. Ross, M. Waldhoer, A. Irving (2009)
The GPR55 ligand L‐α‐lysophosphatidylinositol promotes RhoA‐dependent Ca2+ signaling and NFAT activationThe FASEB Journal, 23
J. Digby, F. Martínez, A. Jefferson, N. Ruparelia, J. Chai, M. Wamil, D. Greaves, R. Choudhury (2012)
Anti-Inflammatory Effects of Nicotinic Acid in Human Monocytes Are Mediated by GPR109A Dependent MechanismsArteriosclerosis, Thrombosis, and Vascular Biology, 32
V. Kamanna, S. Ganji, M. Kashyap (2009)
The mechanism and mitigation of niacin-induced flushingInternational Journal of Clinical Practice, 63
M. Schmid, Claudio Gemperle, Nicole Rimann, M. Hersberger (2016)
Resolvin D1 Polarizes Primary Human Macrophages toward a Proresolution Phenotype through GPR32The Journal of Immunology, 196
F. Vadder, P. Kovatcheva-Datchary, Daisy Goncalves, J. Vinera, C. Zitoun, A. Duchampt, F. Bäckhed, G. Mithieux (2014)
Microbiota-Generated Metabolites Promote Metabolic Benefits via Gut-Brain Neural CircuitsCell, 156
G. Tannahill, A. Curtis, Juraj Adamik, E. Palsson-McDermott, A. McGettrick, G. Goel, C. Frezza, N. Bernard, B. Kelly, N. Foley, Liang Zheng, A. Gardet, Z. Tong, S. Jany, S. Corr, M. Haneklaus, Brian Caffrey, K. Pierce, S. Walmsley, F. Beasley, E. Cummins, V. Nizet, M. Whyte, C. Taylor, Hening Lin, S. Masters, E. Gottlieb, V. Kelly, C. Clish, P. Auron, R. Xavier, R. Xavier, L. O’Neill (2013)
Succinate is an inflammatory signal that induces IL-1β through HIF-1αNature, 496
S. Tedelind, Fredrik Westberg, M. Kjerrulf, A. Vidal (2007)
Anti-inflammatory properties of the short-chain fatty acids acetate and propionate: a study with relevance to inflammatory bowel disease.World journal of gastroenterology, 13 20
A. Ljungh, T. Wadström (2006)
Lactic acid bacteria as probiotics.Current issues in intestinal microbiology, 7 2
Jonathan Violin, R. Lefkowitz (2007)
β-Arrestin-biased ligands at seven-transmembrane receptorsTrends in Pharmacological Sciences, 28
Hideru Obinata, Tomoyasu Hattori, S. Nakane, K. Tatei, T. Izumi (2005)
Identification of 9-Hydroxyoctadecadienoic Acid and Other Oxidized Free Fatty Acids as Ligands of the G Protein-coupled Receptor G2A*Journal of Biological Chemistry, 280
G. Frost, M. Sleeth, M. Sahuri-Arisoylu, B. Lizarbe, S. Cerdán, L. Brody, J. Anastasovska, Samar Ghourab, M. Hankir, Shuai Zhang, D. Carling, J. Swann, G. Gibson, A. Viardot, D. Morrison, Elizabeth Thomas, Jimmy Bell (2014)
The short-chain fatty acid acetate reduces appetite via a central homeostatic mechanismNature Communications, 5
J. Kahlenberg, G. Dubyak, J. Kahlenberg, George Michelle, Dubyak, Mechanisms (2004)
Mechanisms of caspase-1 activation by P2X7 receptor-mediated K+ release.American journal of physiology. Cell physiology, 286 5
Steinhart Ah, A. Brzezinski, J. Baker (1994)
Treatment of refractory ulcerative proctosigmoiditis with butyrate enemas.The American journal of gastroenterology, 89 2
A. Simopoulos (2002)
Omega-3 Fatty Acids in Inflammation and Autoimmune DiseasesJournal of the American College of Nutrition, 21
Nutrition and the gut microbiome regulate many systems, including the immune, metabolic, and nervous systems. We propose that the host responds to deficiency (or sufficiency) of dietary and bacterial metabolites in a dynamic way, to optimize responses and survival. A family of G protein–coupled receptors (GPCRs) termed the metabolite-sensing GPCRs bind to various metabolites and transmit signals that are important for proper immune and metabolic functions. Members of this family include GPR43, GPR41, GPR109A, GPR120, GPR40, GPR84, GPR35, and GPR91. In addition, bile acid receptors such as GPR131 (TGR5) and proton-sensing receptors such as GPR65 show similar features. A consistent feature of this family of GPCRs is that they provide anti-inflammatory signals; many also regulate metabolism and gut homeostasis. These receptors represent one of the main mechanisms whereby the gut microbiome affects vertebrate physiology, and they also provide a link between the immune and metabolic systems. Insufficient signaling through one or more of these metabolite-sensing GPCRs likely contributes to human diseases such as asthma, food allergies, type 1 and type 2 diabetes, hepatic steatosis, cardiovascular disease, and inflammatory bowel diseases.
Annual Review of Immunology – Annual Reviews
Published: Apr 26, 2017
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