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Mechanism of Lymphocyte-Mediated Cytotoxicity

Mechanism of Lymphocyte-Mediated Cytotoxicity Studies in many laboratories over the past 20 years have revealed that there are two well-characterized classes of lymphocytes that have cytotoxic activity: the cytotoxic T lymphocytes (CTL) and the large granular lymphocytes (LGL), which are responsible for antibody-dependent cell­ mediated cytotoxicity (ADCC) and for natural killer (NK). Most studies of cytotoxic mechanisms have focused on one or the other of these distinct cell types, which have clear differences in the way they recognize target cells. In my judgment, however, the results of studies of both types of lymphocyte­ mediated cytotoxicity indicate that they share basic features, which will be described in this review. In particular, three recent developments have helped stimulate the view that LGL and CTL share a basically similar lytic mechanism: (a) Various lines of evidence indicate that after target-cell binding is complete, the NK lytic process is similar to that previously demonstrated for CTL. (b) Researchers, in several laboratories, have found that cloned CTL can develop an NK-like pattern of target recognition after culture. (c) Isolated cytoplasmic granules from LGL and from CTL, which appear to be plausible mediators of the lytic effects of the cells, have generally similar cytolytic properties. In this review http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Annual Review of Immunology Annual Reviews

Mechanism of Lymphocyte-Mediated Cytotoxicity

Henkart, P A
Annual Review of Immunology , Volume 3 (1) – Apr 1, 1985
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Publisher
Annual Reviews
Copyright
Copyright 1985 Annual Reviews. All rights reserved
Subject
Review Articles
ISSN
0732-0582
eISSN
1545-3278
DOI
10.1146/annurev.iy.03.040185.000335
pmid
3904772
Publisher site
See Article on Publisher Site

Abstract

Studies in many laboratories over the past 20 years have revealed that there are two well-characterized classes of lymphocytes that have cytotoxic activity: the cytotoxic T lymphocytes (CTL) and the large granular lymphocytes (LGL), which are responsible for antibody-dependent cell­ mediated cytotoxicity (ADCC) and for natural killer (NK). Most studies of cytotoxic mechanisms have focused on one or the other of these distinct cell types, which have clear differences in the way they recognize target cells. In my judgment, however, the results of studies of both types of lymphocyte­ mediated cytotoxicity indicate that they share basic features, which will be described in this review. In particular, three recent developments have helped stimulate the view that LGL and CTL share a basically similar lytic mechanism: (a) Various lines of evidence indicate that after target-cell binding is complete, the NK lytic process is similar to that previously demonstrated for CTL. (b) Researchers, in several laboratories, have found that cloned CTL can develop an NK-like pattern of target recognition after culture. (c) Isolated cytoplasmic granules from LGL and from CTL, which appear to be plausible mediators of the lytic effects of the cells, have generally similar cytolytic properties. In this review

Journal

Annual Review of Immunology – Annual Reviews

Published: Apr 1, 1985

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