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Lambda Chains and Genes in Inbred Mice

Lambda Chains and Genes in Inbred Mice In inbred mice, immunoglobulins (Igs) with K light (L) chains outnumber those with A. L chains by about 20: 1 ( 1-3). A similar or even greater disproportion is found in mouse myeloma proteins (4). Therefore, amino acid sequence analyses of Ig L chains were initially carried out on K chains. Many VK sequences, but only a single CK sequence, were revealed, in accord with later evidence for many VK1 but only a single CK gene segment (5, 6). Amino acid sequences of A. chains made by myeloma tumors suggested a similar arrangement, except that these sequences could be accounted for by only a single VA. gene, as well as a single CA. gene (7). The extremely limited sequence variability of the A. chains [see (7)] suggested, moreover, that they were not significant contributors to the enormous structural and functional diversity that characterizes murine Igs as a whole. While this viewpoint has not been altered by the subsequent finding of additional A. chain isotypes2 (8-10), the overall theme of this review is that the very simplicity of the inbred mouse A. light-chain system offers special opportunities to learn about some fundamental properties of Igs, namely, structure-function relationships, Ig http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Annual Review of Immunology Annual Reviews

Lambda Chains and Genes in Inbred Mice

Eisen, H N; Reilly, E B
Annual Review of Immunology , Volume 3 (1) – Apr 1, 1985
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Publisher
Annual Reviews
Copyright
Copyright 1985 Annual Reviews. All rights reserved
Subject
Review Articles
ISSN
0732-0582
eISSN
1545-3278
DOI
10.1146/annurev.iy.03.040185.002005
pmid
3933530
Publisher site
See Article on Publisher Site

Abstract

In inbred mice, immunoglobulins (Igs) with K light (L) chains outnumber those with A. L chains by about 20: 1 ( 1-3). A similar or even greater disproportion is found in mouse myeloma proteins (4). Therefore, amino acid sequence analyses of Ig L chains were initially carried out on K chains. Many VK sequences, but only a single CK sequence, were revealed, in accord with later evidence for many VK1 but only a single CK gene segment (5, 6). Amino acid sequences of A. chains made by myeloma tumors suggested a similar arrangement, except that these sequences could be accounted for by only a single VA. gene, as well as a single CA. gene (7). The extremely limited sequence variability of the A. chains [see (7)] suggested, moreover, that they were not significant contributors to the enormous structural and functional diversity that characterizes murine Igs as a whole. While this viewpoint has not been altered by the subsequent finding of additional A. chain isotypes2 (8-10), the overall theme of this review is that the very simplicity of the inbred mouse A. light-chain system offers special opportunities to learn about some fundamental properties of Igs, namely, structure-function relationships, Ig

Journal

Annual Review of Immunology – Annual Reviews

Published: Apr 1, 1985

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