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Isolated Growth Hormone Deficiency and Related Disorders

Isolated Growth Hormone Deficiency and Related Disorders Thomas J. Merimee, MD. Department of Medicine, Boston University School of Medicine, Boston, Massachusetts -:·7102 This brief discussion wm consider those forms of dwarfism characterized either by a mono tropic deficiency of human growth hormone (HGH) (a defect in synthesis and/or release), a defect in the ability of HGH to generate sulfation factor, or end organ subresponsiveness to exogenous or endogenous HGH. Although there is controversy over what term should be used to describe such dwarfs, the term ateliosis is historically correct, and a somewhat neutral term is useful if it is rigor­ ously defined as in the preceding sentence. Although interest in dwarfism has existed for centuries, it was not until 1902 that Guilford (1) proposed the first systematic classification based upon the simple observation that dwarfs appear to be of two major types: those with and those without obvious physical abnormalities. For the latter group, now known more popularly as midgets, Guilford used the term ateliosis (ateliosis not arriving at perfection), since he considered this form of dwarfism a disorder in which growth and development were not arrested but in which both were retarded. He recognized, likewise, that some of these patients attained sexual maturity whereas http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Annual Review of Medicine Annual Reviews

Isolated Growth Hormone Deficiency and Related Disorders

Merimee, T J
Annual Review of Medicine , Volume 25 (1) – Feb 1, 1974
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Publisher
Annual Reviews
Copyright
Copyright 1974 Annual Reviews. All rights reserved
Subject
Review Articles
ISSN
0066-4219
eISSN
1545-326X
DOI
10.1146/annurev.me.25.020174.001033
pmid
4596227
Publisher site
See Article on Publisher Site

Abstract

Thomas J. Merimee, MD. Department of Medicine, Boston University School of Medicine, Boston, Massachusetts -:·7102 This brief discussion wm consider those forms of dwarfism characterized either by a mono tropic deficiency of human growth hormone (HGH) (a defect in synthesis and/or release), a defect in the ability of HGH to generate sulfation factor, or end organ subresponsiveness to exogenous or endogenous HGH. Although there is controversy over what term should be used to describe such dwarfs, the term ateliosis is historically correct, and a somewhat neutral term is useful if it is rigor­ ously defined as in the preceding sentence. Although interest in dwarfism has existed for centuries, it was not until 1902 that Guilford (1) proposed the first systematic classification based upon the simple observation that dwarfs appear to be of two major types: those with and those without obvious physical abnormalities. For the latter group, now known more popularly as midgets, Guilford used the term ateliosis (ateliosis not arriving at perfection), since he considered this form of dwarfism a disorder in which growth and development were not arrested but in which both were retarded. He recognized, likewise, that some of these patients attained sexual maturity whereas

Journal

Annual Review of Medicine – Annual Reviews

Published: Feb 1, 1974

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