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Infectious Diseases The Effects of Cortisone and Adrenocorticotropic Hormone on Infection

Infectious Diseases The Effects of Cortisone and Adrenocorticotropic Hormone on Infection by Hench and his co-workers (4) of the use of cortisone and ACTH in rheumatoid arthritis, and the subsequent application by others to numerous, wholly unrelated disease states ranging from severe burns to gout, clinical trials of the materials in infectious diseases were inevitable. The first reports of their usc in pneumonia, by Finland and his collaborators (5), aroused widespread interest. These workers described the effects of ACTH on the course of acute pneumococcal pneu­ monia and primary atypical pneumonia; in each case there occurred a rapid and apparently beneficial response, with defervescence of fever and clear cut improvement in the symptoms and signs of the disease. In each instance, The survey of the literature pertaining to this review was concluded in Septem­ ber, Professor of Pediatrics and Medicine, American Legion Memorial Research Professor. THOMAS however, there was a conspicuous discrepancy; the patient with pneumococ­ cal pneumonia was found to have bacteremia during a two day period after ACTH had apparently improved his state, and the patient with primary atypical pneumonia resumed the typical course of her disease as ·soon as ACTH was stopped. The therapeutic effect of cortisone in typhoid fever was studied by Smadel (6), Woodward http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Annual Review of Medicine Annual Reviews

Infectious Diseases The Effects of Cortisone and Adrenocorticotropic Hormone on Infection

Thomas, L
Annual Review of Medicine , Volume 3 (1) – Feb 1, 1952
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Publisher
Annual Reviews
Copyright
Copyright 1952 Annual Reviews. All rights reserved
Subject
Review Articles
ISSN
0066-4219
eISSN
1545-326X
DOI
10.1146/annurev.me.03.020152.000245
pmid
13092826
Publisher site
See Article on Publisher Site

Abstract

by Hench and his co-workers (4) of the use of cortisone and ACTH in rheumatoid arthritis, and the subsequent application by others to numerous, wholly unrelated disease states ranging from severe burns to gout, clinical trials of the materials in infectious diseases were inevitable. The first reports of their usc in pneumonia, by Finland and his collaborators (5), aroused widespread interest. These workers described the effects of ACTH on the course of acute pneumococcal pneu­ monia and primary atypical pneumonia; in each case there occurred a rapid and apparently beneficial response, with defervescence of fever and clear cut improvement in the symptoms and signs of the disease. In each instance, The survey of the literature pertaining to this review was concluded in Septem­ ber, Professor of Pediatrics and Medicine, American Legion Memorial Research Professor. THOMAS however, there was a conspicuous discrepancy; the patient with pneumococ­ cal pneumonia was found to have bacteremia during a two day period after ACTH had apparently improved his state, and the patient with primary atypical pneumonia resumed the typical course of her disease as ·soon as ACTH was stopped. The therapeutic effect of cortisone in typhoid fever was studied by Smadel (6), Woodward

Journal

Annual Review of Medicine – Annual Reviews

Published: Feb 1, 1952

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