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By ERNEST JAWETZ University of California Medical Center, San Francisco ZZ, California Many physicians associate the word "infection" with the term "anti biotic." In the short span of a few years the impact of antimicrobial therapy has greatly altered the practice of medicine. Sulfonamides and antibiotics have saved innumerable lives and have made possible technical procedures in medicine and surgery not feasible previously. However, they have not eliminated the role of microorganisms in the causation of disease and they have introduced new problems in medical management. The microbial world has responded to the i ntroduction of antimicrobial substances into i ts ecological balance with derangement of normal bacterial flora, develop ment of resistance, and disturbances in host-parasite relationship. It has become increasingly apparent that the indiscriminate use of antimicrobial d rugs by physicians everywhere has vitiated their benefits. The action of an antimicrobial drug in man is quite different from the effect of that same drug on a specific microorganism in a test tube. The interplay between drug, host, and microbial world is being re-emphasized by recent events. This review attempts to summarize certain developments in the realm of antimicrobial therapy. Only very few of these can be
Annual Review of Medicine – Annual Reviews
Published: Feb 1, 1954
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