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The field of bacterial infection in the past two years can be characterized more by the problems it has presented than by.the progress which has been made. We seem to be in a lull after the period of turbulence which marked the first saturation of our population with antibiotiCs. No antibacterial drugs of exceptional and unique 'properties were developed and no great advances in the treatment of infection occurred. Diseases of greatest interest were those caused by staphylococci and Gram-negative bacilli, organisms which, under normal conditions, are benign inhabitants of the skin and mucous mem branes of man,· but which either naturally possess, or soon acquire, anti microbial resistance. The infections caused by these organisms, their fre quency, epidemic tendencies, pathogenesis, treatment, and explanations for their current prevalence, are the principal problems which are described in this review. We have formed the opinion that these problem infections are not going to be effectively controlled by presently available antimicrobial therapy, and that their alleviation must probably await the discovery of new approaches to treatment. Some encouragement for such developments may be found in several new concepts of infection and its treatment included in the following review. STAPHYLOCOCCAL DISEASE Apprehension
Annual Review of Medicine – Annual Reviews
Published: Feb 1, 1960
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