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Immunology and Experimental Dermatology

Immunology and Experimental Dermatology This account is only incidentally biographical. Its aim is to relate the successive steps that led to an understanding of contact-type reactions and certain other allergic responses of guinea pigs. This narrative reflects the chanciness with which important observations come to light, so often attributed to the "prepared mind" -whatever that phrase really signifies. The story starts in 1932, when, at age 27, I was hired by Simon Flexner to work with Karl Landsteiner, then ten years at The Rockefeller Institute for Medical Research. Landsteiner's work was three-fold. He continued, first of all, his work on human blood groups. Secondly, he was investigating hapten-protein complexes which induced antibodies in rabbits and ap­ peared to be hapten-specific; this led to his study of inhibition tests, in which p-amino-benzoyl-hapten would block precipitation of hapten­ carrier 2 by antibodies against hapten-carrier 1; the respective carriers were essentially non-cross-reacting. Third, he was starting work on synthesis of glycyl- and leucyl- peptides to provide di-, tri-, pentapeptides for antigenic specificity. Still only a gleam in Landsteiner's eye was the possibility of studying contact ant reactivity in the laboratory. In 1907, without any hard evidence, Wolff-Eisner (1) had voiced the concept that dermatological problems http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Annual Review of Immunology Annual Reviews

Immunology and Experimental Dermatology

Chase, Merrill W.
Annual Review of Immunology , Volume 3 (1) – Apr 1, 1985
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Publisher
Annual Reviews
Copyright
Copyright 1985 Annual Reviews. All rights reserved
Subject
Review Articles
ISSN
0732-0582
eISSN
1545-3278
DOI
10.1146/annurev.iy.03.040185.000245
pmid
3904768
Publisher site
See Article on Publisher Site

Abstract

This account is only incidentally biographical. Its aim is to relate the successive steps that led to an understanding of contact-type reactions and certain other allergic responses of guinea pigs. This narrative reflects the chanciness with which important observations come to light, so often attributed to the "prepared mind" -whatever that phrase really signifies. The story starts in 1932, when, at age 27, I was hired by Simon Flexner to work with Karl Landsteiner, then ten years at The Rockefeller Institute for Medical Research. Landsteiner's work was three-fold. He continued, first of all, his work on human blood groups. Secondly, he was investigating hapten-protein complexes which induced antibodies in rabbits and ap­ peared to be hapten-specific; this led to his study of inhibition tests, in which p-amino-benzoyl-hapten would block precipitation of hapten­ carrier 2 by antibodies against hapten-carrier 1; the respective carriers were essentially non-cross-reacting. Third, he was starting work on synthesis of glycyl- and leucyl- peptides to provide di-, tri-, pentapeptides for antigenic specificity. Still only a gleam in Landsteiner's eye was the possibility of studying contact ant reactivity in the laboratory. In 1907, without any hard evidence, Wolff-Eisner (1) had voiced the concept that dermatological problems

Journal

Annual Review of Immunology – Annual Reviews

Published: Apr 1, 1985

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