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References (94)
-
G. Roncador, P. Brown, L. Maestre, S. Hue, J. Martínez-Torrecuadrada, K. Ling, S. Pratap, C. Toms, B. Fox, V. Cerundolo, F. Powrie, A. Banham (2005)
Analysis of FOXP3 protein expression in human CD4+CD25+ regulatory T cells at the single‐cell levelEuropean Journal of Immunology, 35
-
YuFeng Peng, Y. Laouar, Ming Li, E. Green, R. Flavell (2004)
TGF-beta regulates in vivo expansion of Foxp3-expressing CD4+CD25+ regulatory T cells responsible for protection against diabetes.Proceedings of the National Academy of Sciences of the United States of America, 101 13
-
E. Boden, Q. Tang, Hélène Bour-Jordan, J. Bluestone (2003)
The role of CD28 and CTLA4 in the function and homeostasis of CD4+CD25+ regulatory T cells.Novartis Foundation symposium, 252
-
Karin Loser, W. Hansen, Jenny Apelt, S. Balkow, Jan Buer, Stefan Beissert (2005)
In vitro-generated regulatory T cells induced by Foxp3-retrovirus infection control murine contact allergy and systemic autoimmunityGene Therapy, 12
-
B. Nelson, Timothy Martyak, L. Thompson, J. Moon, Tongwen Wang (2003)
Uncoupling of Promitogenic and Antiapoptotic Functions of IL-2 by Smad-Dependent TGF-β Signaling1The Journal of Immunology, 170
-
R. Khattri, Deborah Kasprowicz, T. Cox, M. Mortrud, M. Appleby, M. Brunkow, S. Ziegler, F. Ramsdell (2001)
The Amount of Scurfin Protein Determines Peripheral T Cell Number and Responsiveness1The Journal of Immunology, 167
-
L. Schubert, E. Jeffery, Yi Zhang, F. Ramsdell, S. Ziegler (2001)
Scurfin (FOXP3) Acts as a Repressor of Transcription and Regulates T Cell Activation*The Journal of Biological Chemistry, 276
-
Chuan Li, Philip Tucker (1993)
DNA-binding properties and secondary structural model of the hepatocyte nuclear factor 3/fork head domain.Proceedings of the National Academy of Sciences of the United States of America, 90 24
-
X. Tai, M. Cowan, L. Feigenbaum, A. Singer (2005)
CD28 costimulation of developing thymocytes induces Foxp3 expression and regulatory T cell differentiation independently of interleukin 2Nature Immunology, 6
-
D. Nieves, R. Phipps, S. Pollock, H. Ochs, Qili Zhu, G. Scott, C. Ryan, I. Kobayashi, T. Rossi, L. Goldsmith (2004)
Dermatologic and immunologic findings in the immune dysregulation, polyendocrinopathy, enteropathy, X-linked syndrome.Archives of dermatology, 140 4
-
R. Wildin, F. Ramsdell, J. Peake, F. Faravelli, J. Casanova, N. Buist, E. Levy-Lahad, M. Mazzella, O. Goulet, L. Perroni, F. Bricarelli, G. Byrne, M. Mceuen, S. Proll, M. Appleby, M. Brunkow (2001)
X-linked neonatal diabetes mellitus, enteropathy and endocrinopathy syndrome is the human equivalent of mouse scurfyNature Genetics, 27
-
M. Burchill, Christine Goetz, Martin Prlic, Jennifer O’Neil, Ian Harmon, S. Bensinger, L. Turka, P. Brennan, S. Jameson, M. Farrar (2003)
Distinct Effects of STAT5 Activation on CD4+ and CD8+ T Cell Homeostasis: Development of CD4+CD25+ Regulatory T Cells versus CD8+ Memory T Cells 1The Journal of Immunology, 171
-
B. Burgering, G. Kops (2002)
Cell cycle and death control: long live Forkheads.Trends in biochemical sciences, 27 7
-
C. Schramm, S. Huber, M. Protschka, P. Czochra, J. Burg, E. Schmitt, A. Lohse, P. Galle, M. Blessing (2004)
TGFbeta regulates the CD4+CD25+ T-cell pool and the expression of Foxp3 in vivo.International immunology, 16 9
-
Q. Tang, K. Henriksen, Mingying Bi, E. Finger, G. Szot, Jianqin Ye, E. Masteller, H. Mcdevitt, M. Bonyhadi, J. Bluestone (2004)
In Vitro–expanded Antigen-specific Regulatory T Cells Suppress Autoimmune DiabetesThe Journal of Experimental Medicine, 199
-
T. Malek, B. Porter, E. Codias, P. Scibelli, Aixin Yu (2000)
Normal Lymphoid Homeostasis and Lack of Lethal Autoimmunity in Mice Containing Mature T Cells with Severely Impaired IL-2 Receptors1The Journal of Immunology, 164
-
H. Yagi, T. Nomura, Kyoko Nakamura, S. Yamazaki, T. Kitawaki, S. Hori, M. Maeda, M. Onodera, T. Uchiyama, S. Fujii, S. Sakaguchi (2004)
Crucial role of FOXP3 in the development and function of human CD25+CD4+ regulatory T cells.International immunology, 16 11
-
C. Owen, C. Jennings, H. Imrie, A. Lachaux, N. Bridges, T. Cheetham, S. Pearce (2003)
Mutational analysis of the FOXP3 gene and evidence for genetic heterogeneity in the immunodysregulation, polyendocrinopathy, enteropathy syndrome.The Journal of clinical endocrinology and metabolism, 88 12
-
C. Piccirillo, J. Letterio, A. Thornton, R. McHugh, M. Mamura, H. Mizuhara, E. Shevach (2002)
CD4+CD25+ Regulatory T Cells Can Mediate Suppressor Function in the Absence of Transforming Growth Factor β1 Production and ResponsivenessThe Journal of Experimental Medicine, 196
-
D. Lundsgaard, T. Holm, L. Hornum, H. Markholst (2005)
In vivo control of diabetogenic T-cells by regulatory CD4+CD25+ T-cells expressing Foxp3.Diabetes, 54 4
-
T. Malek, A. Bayer (2004)
Tolerance, not immunity, crucially depends on IL-2Nature Reviews Immunology, 4
-
S. Kanangat, P. Blair, R. Reddy, Massoud Deheshia, V. Godfrey, B. Rouse, Erby Wilkinson (1996)
Disease in the scurfy (sf) mouse is associated with overexpression of cytokine genesEuropean Journal of Immunology, 26
-
V. Trouet, Jan Esper, Nicholas Graham, Andy Baker, J. Scourse, David, C. Frank (2003)
Supporting Online Material -
R. Khattri, T. Cox, Sue-Ann Yasayko, F. Ramsdell (2003)
An essential role for Scurfin in CD4+CD25+ T regulatory cellsNature Immunology, 4
-
J. Amiel, V. Raclin, J. Jouannic, N. Morichon, Hélène Hoffman-Radvanyi, M. Dommergues, J. Feingold, A. Munnich, J. Bonnefont (2001)
Trinucleotide repeat contraction: a pitfall in prenatal diagnosis of myotonic dystrophyJournal of Medical Genetics, 38
-
K. Moore, R. Malefyt, R. Coffman, A. O’Garra (2001)
Interleukin-10 and the interleukin-10 receptor.Annual review of immunology, 19
-
R. Wildin, S. Smyk-Pearson, A. Filipovich (2002)
Clinical and molecular features of the immunodysregulation, polyendocrinopathy, enteropathy, X linked (IPEX) syndromeJournal of Medical Genetics, 39
-
Q. Tang, K. Henriksen, E. Boden, A. Tooley, Jianqin Ye, S. Subudhi, Xincheng Zheng, T. Strom, J. Bluestone (2003)
Cutting Edge: CD28 Controls Peripheral Homeostasis of CD4+CD25+ Regulatory T Cells 1The Journal of Immunology, 171
-
R. Mallone, S. Kochik, H. Reijonen, B. Carson, S. Ziegler, W. Kwok, G. Nepom (2005)
Functional avidity directs T-cell fate in autoreactive CD4+ T cells.Blood, 106 8
-
S. Sakaguchi, N. Sakaguchi, M. Asano, M. Itoh, M. Toda (1995)
Immunologic self-tolerance maintained by activated T cells expressing IL-2 receptor alpha-chains (CD25). Breakdown of a single mechanism of self-tolerance causes various autoimmune diseases.Journal of immunology, 155 3
-
Claudio Pignata, L. Gaetaniello, A. Masci, Jorge Frank, A. Christiano, Eliana Matrecano, Luigi Racioppi (2001)
Human equivalent of the mouse Nude/SCID phenotype: long-term evaluation of immunologic reconstitution after bone marrow transplantation.Blood, 97 4
-
S. Sakaguchi (2005)
Naturally arising Foxp3-expressing CD25+CD4+ regulatory T cells in immunological tolerance to self and non-selfNature Immunology, 6
-
S. Huber, C. Schramm, H. Lehr, A. Mann, S. Schmitt, C. Becker, M. Protschka, P. Galle, M. Neurath, M. Blessing (2004)
Cutting Edge: TGF-β Signaling Is Required for the In Vivo Expansion and Immunosuppressive Capacity of Regulatory CD4+CD25+ T Cells1The Journal of Immunology, 173
-
J. Chai, S. Xue, D. Coe, C. Addey, I. Bartok, D. Scott, E. Simpson, H. Stauss, S. Hori, S. Sakaguchi, J. Dyson (2005)
Regulatory T Cells, Derived from Naïve CD4+CD25− T Cells by In Vitro Foxp3 Gene Transfer, Can Induce Transplantation ToleranceTransplantation, 79
-
Wanjun Chen, W. Jin, N. Hardegen, K. Lei, Li Li, N. Marinos, G. McGrady, S. Wahl (2003)
Conversion of Peripheral CD4+CD25− Naive T Cells to CD4+CD25+ Regulatory T Cells by TGF-β Induction of Transcription Factor Foxp3The Journal of Experimental Medicine, 198
-
Deborah Kasprowicz, P. Smallwood, A. Tyznik, S. Ziegler (2003)
Scurfin (FoxP3) Controls T-Dependent Immune Responses In Vivo Through Regulation of CD4+ T Cell Effector Function 1The Journal of Immunology, 171
-
Y. Wan, R. Flavell (2005)
Identifying Foxp3-expressing suppressor T cells with a bicistronic reporter.Proceedings of the National Academy of Sciences of the United States of America, 102 14
-
C. Piccirillo, A. Thornton (2004)
Cornerstone of peripheral tolerance: naturally occurring CD4+CD25+ regulatory T cells.Trends in immunology, 25 7
-
Ruka Setoguchi, S. Hori, Takeshi Takahashi, S. Sakaguchi (2005)
Homeostatic maintenance of natural Foxp3 + CD25+ CD4+ regulatory T cells by interleukin (IL)-2 and induction of autoimmune disease by IL-2 neutralizationThe Journal of Experimental Medicine, 201
-
S. Miller, A. Kohm, P. Carpentier, H. Anger
EncephalomyelitisExperimental Autoimmune System Inflammation During Active Immune Responses and Central Nervous Cells Suppress Antigen-Specific Autoreactive Regulatory T + CD25+ Cutting Edge: CD4 -
E. Tivol, F. Borriello, A. Schweitzer, William Lynch, J. Bluestone, Arlene Sharpe (1995)
Loss of CTLA-4 leads to massive lymphoproliferation and fatal multiorgan tissue destruction, revealing a critical negative regulatory role of CTLA-4.Immunity, 3 5
-
T. Malek, Aixin Yu, V. Vincek, P. Scibelli, Lin Kong (2002)
CD4 regulatory T cells prevent lethal autoimmunity in IL-2Rbeta-deficient mice. Implications for the nonredundant function of IL-2.Immunity, 17 2
-
J. Marie, J. Letterio, M. Gavin, A. Rudensky (2005)
TGF-β1 maintains suppressor function and Foxp3 expression in CD4+CD25+ regulatory T cellsThe Journal of Experimental Medicine, 201
-
Shanru Li, Joel Weidenfeld, E. Morrisey (2004)
Transcriptional and DNA Binding Activity of the Foxp1/2/4 Family Is Modulated by Heterotypic and Homotypic Protein InteractionsMolecular and Cellular Biology, 24
-
P. Waterhouse, J. Penninger, E. Timms, A. Wakeham, A. Shahinian, Kelvin Lee, C. Thompson, H. Griesser, T. Mak (1995)
Lymphoproliferative Disorders with Early Lethality in Mice Deficient in Ctla-4Science, 270
-
B. Nelson (2004)
IL-2, Regulatory T Cells, and ToleranceThe Journal of Immunology, 172
-
C. Baecher-Allan, Julia Brown, G. Freeman, D. Hafler (2001)
CD4+CD25high Regulatory Cells in Human Peripheral Blood1The Journal of Immunology, 167
-
M. Levings, R. Sangregorio, M. Roncarolo (2001)
Human Cd25+Cd4+ T Regulatory Cells Suppress Naive and Memory T Cell Proliferation and Can Be Expanded in Vitro without Loss of FunctionThe Journal of Experimental Medicine, 193
-
Virginia Godfrey, B. Rouse, J. Wilkinsont (1994)
Transplantation of T cell-mediated, lymphoreticular disease from the scurfy (sf) mouse.The American journal of pathology, 145 2
-
A. Bayer, Aixin Yu, D. Adeegbe, T. Malek (2005)
Essential role for interleukin-2 for CD4+CD25+ T regulatory cell development during the neonatal periodThe Journal of Experimental Medicine, 201
-
C. Bennett, H. Ochs (2001)
IPEX is a unique X-linked syndrome characterized by immune dysfunction, polyendocrinopathy, enteropathy, and a variety of autoimmune phenomenaCurrent Opinion in Pediatrics, 13
-
J. Snow, N. Abraham, M. Ma, B. Herndier, A. Pastuszak, M. Goldsmith (2003)
Loss of Tolerance and Autoimmunity Affecting Multiple Organs in STAT5A/5B-Deficient Mice 1The Journal of Immunology, 171
-
E. Shevach (2002)
CD4+CD25+ suppressor T cells: more questions than answersNature Reviews Immunology, 2
-
K. Kaestner, W. Knöchel, D. Martinez (2000)
Unified nomenclature for the winged helix/forkhead transcription factors.Genes & development, 14 2
-
H. Ochs, S. Ziegler, T. Torgerson (2005)
FOXP3 acts as a rheostat of the immune responseImmunological Reviews, 203
-
J. Buckner, U. Holzer, E. Novak, H. Reijonen, W. Kwok, G. Nepom (2002)
Defining antigen-specific responses with human MHC class II tetramers.The Journal of allergy and clinical immunology, 110 2
-
H. Jonuleit, E. Schmitt, M. Stassen, A. Tuettenberg, J. Knop, A. Enk (2001)
Identification and Functional Characterization of Human Cd4+Cd25+ T Cells with Regulatory Properties Isolated from Peripheral BloodThe Journal of Experimental Medicine, 193
-
G. Nepom, J. Buckner, E. Novak, S. Reichstetter, H. Reijonen, J. Gebe, Rongfang Wang, E. Swanson, W. Kwok (2002)
HLA class II tetramers: tools for direct analysis of antigen-specific CD4+ T cells.Arthritis and rheumatism, 46 1
-
Ling-Yun Lin, Jonathan Hron, S. Peng (2004)
Regulation of NF-kappaB, Th activation, and autoinflammation by the forkhead transcription factor Foxo3a.Immunity, 21 2
-
Bin Wang, Danjuan Lin, Chuan Li, P. Tucker (2003)
Multiple Domains Define the Expression and Regulatory Properties of Foxp1 Forkhead Transcriptional Repressors*Journal of Biological Chemistry, 278
-
J. Fontenot, M. Gavin, A. Rudensky (2003)
Foxp3 programs the development and function of CD4+CD25+ regulatory T cellsNature Immunology, 4
-
A. Mehling, K. Loser, G. Varga, D. Metze, T. Luger, T. Schwarz, S. Grabbe, S. Beissert (2001)
Overexpression of Cd40 Ligand in Murine Epidermis Results in Chronic Skin Inflammation and Systemic AutoimmunityThe Journal of Experimental Medicine, 194
-
E. Kaufmann, Dorothee Müller, Walter Knöchel (1995)
DNA recognition site analysis of Xenopus winged helix proteins.Journal of molecular biology, 248 2
-
Clark Lb, M. Appleby, M. Brunkow, J. Wilkinson, S. Ziegler, F. Ramsdell (1999)
Cellular and molecular characterization of the scurfy mouse mutant.Journal of immunology, 162 5
-
J. Bluestone, A. Abbas (2003)
Opinion-regulatory lymphocytes: Natural versus adaptive regulatory T cellsNature Reviews Immunology, 3
-
S. Fu, N. Zhang, A. Yopp, Dongmei Chen, Minwei Mao, Dang-Xiao Chen, Haojiang Zhang, Yaozhong Ding, J. Bromberg (2004)
TGF‐β Induces Foxp3 + T‐Regulatory Cells from CD4 + CD25 − PrecursorsAmerican Journal of Transplantation, 4
-
M. Walker, Deborah Kasprowicz, V. Gersuk, Angèle Bénard, Megan Landeghen, J. Buckner, S. Ziegler (2003)
Induction of FoxP3 and acquisition of T regulatory activity by stimulated human CD4+CD25- T cells.The Journal of clinical investigation, 112 9
-
M. Brunkow, E. Jeffery, K. Hjerrild, B. Paeper, L. Clark, Sue-Ann Yasayko, J. Wilkinson, D. Galas, S. Ziegler, F. Ramsdell (2001)
Disruption of a new forkhead/winged-helix protein, scurfin, results in the fatal lymphoproliferative disorder of the scurfy mouseNature Genetics, 27
-
Ling-Yun Lin, Melanie Spoor, Andrea Gerth, S. Brody, S. Peng (2004)
Modulation of Th1 Activation and Inflammation by the NF-κB Repressor Foxj1Science, 303
-
M. Fantini, C. Becker, G. Monteleone, F. Pallone, P. Galle, M. Neurath (2004)
Cutting Edge: TGF-β Induces a Regulatory Phenotype in CD4+CD25− T Cells through Foxp3 Induction and Down-Regulation of Smad7The Journal of Immunology, 172
-
J. Fontenot, A. Rudensky (2005)
A well adapted regulatory contrivance: regulatory T cell development and the forkhead family transcription factor Foxp3Nature Immunology, 6
-
M. Morgan, J. Bilsen, A. Bakker, B. Heemskerk, M. Schilham, F. Hartgers, B. Elferink, L. Zanden, R. Vries, T. Huizinga, T. Ottenhoff, R. Toes (2005)
Expression of FOXP3 mRNA is not confined to CD4+CD25+ T regulatory cells in humans.Human immunology, 66 1
-
D. Wraith, K. Nicolson, N. Whitley (2004)
Regulatory CD4+ T cells and the control of autoimmune disease.Current opinion in immunology, 16 6
-
E. Novak, S. Masewicz, A. Liu, Å. Lernmark, W. Kwok, G. Nepom (2001)
Activated human epitope-specific T cells identified by class II tetramers reside within a CD4high, proliferating subset.International immunology, 13 6
-
J. Fontenot, J. Rasmussen, L. Williams, James Dooley, A. Farr, A. Rudensky (2005)
Regulatory T cell lineage specification by the forkhead transcription factor foxp3.Immunity, 22 3
-
T. Torgerson, H. Ochs (2002)
Immune dysregulation, polyendocrinopathy, enteropathy, X-linked syndrome: a model of immune dysregulationCurrent Opinion in Allergy and Clinical Immunology, 2
-
D. Dieckmann, Heidi Plottner, S. Berchtold, T. Berger, G. Schuler (2001)
Ex Vivo Isolation and Characterization of Cd4+Cd25+ T Cells with Regulatory Properties from Human BloodThe Journal of Experimental Medicine, 193
-
T. Chatila, F. Blaeser, N. Ho, H. Lederman, Constantine Voulgaropoulos, C. Helms, A. Bowcock (2000)
JM2, encoding a fork head-related protein, is mutated in X-linked autoimmunity-allergic disregulation syndrome.The Journal of clinical investigation, 106 12
-
B. Nelson (2002)
Interleukin-2 signaling and the maintenance of self-tolerance.Current directions in autoimmunity, 5
-
E. Suri‐Payer, Anna Amar, A. Thornton, E. Shevach (1998)
CD4+CD25+ T cells inhibit both the induction and effector function of autoreactive T cells and represent a unique lineage of immunoregulatory cells.Journal of immunology, 160 3
-
B. Powell, N. Buist, P. Stenzel (1982)
An X-linked syndrome of diarrhea, polyendocrinopathy, and fatal infection in infancy.The Journal of pediatrics, 100 5
-
Kyra Oswald-Richter, S. Grill, N. Shariat, M. Leelawong, Mark Sundrud, D. Haas, D. Unutmaz (2004)
HIV Infection of Naturally Occurring and Genetically Reprogrammed Human Regulatory T-cellsPLoS Biology, 2
-
L. Fahlén, S. Read, L. Gorelik, S. Hurst, R. Coffman, R. Flavell, F. Powrie (2005)
T cells that cannot respond to TGF-β escape control by CD4+CD25+ regulatory T cellsThe Journal of Experimental Medicine, 201
-
E. Bettelli, Maryam Dastrange, M. Oukka (2005)
Foxp3 interacts with nuclear factor of activated T cells and NF-kappa B to repress cytokine gene expression and effector functions of T helper cells.Proceedings of the National Academy of Sciences of the United States of America, 102 14
-
E. Gambineri, T. Torgerson, H. Ochs (2003)
Immune dysregulation, polyendocrinopathy, enteropathy, and X-linked inheritance (IPEX), a syndrome of systemic autoimmunity caused by mutations of FOXP3, a critical regulator of T-cell homeostasisCurrent Opinion in Rheumatology, 15
-
E. Jaeckel, H. Boehmer, M. Manns (2005)
Antigen-specific FoxP3-transduced T-cells can control established type 1 diabetes.Diabetes, 54 2
-
P. Coffer, B. Burgering (2004)
Forkhead-box transcription factors and their role in the immune systemNature Reviews Immunology, 4
-
A. Scheffold, J. Hühn, T. Höfer (2005)
Regulation of CD4+CD25+ regulatory T cell activity: it takes (IL‐)two to tangoEuropean Journal of Immunology, 35
-
A. Schimpl, I. Berberich, B. Kneitz, S. Krämer, B. Santner‐Nanan, S. Wagner, M. Wolf, T. Hünig (2002)
IL-2 and autoimmune disease.Cytokine & growth factor reviews, 13 4-5
-
M. Walker, B. Carson, G. Nepom, S. Ziegler, J. Buckner (2005)
De novo generation of antigen-specific CD4+CD25+ regulatory T cells from human CD4+CD25- cells.Proceedings of the National Academy of Sciences of the United States of America, 102 11
-
C. Baecher-Allan, V. Viglietta, D. Hafler (2004)
Human CD4+CD25+ regulatory T cells.Seminars in immunology, 16 2
-
M. Nehls, D. Pfeifer, M. Schorpp, H. Hedrich, T. Boehm (1994)
New member of the winged-helix protein family disrupted in mouse and rat nude mutationsNature, 372
-
E. Kaufmann, W. Knöchel (1996)
Five years on the wings of fork headMechanisms of Development, 57
-
C. Bennett, J. Christie, F. Ramsdell, M. Brunkow, P. Ferguson, L. Whitesell, T. Kelly, F. Saulsbury, P. Chance, H. Ochs (2001)
The immune dysregulation, polyendocrinopathy, enteropathy, X-linked syndrome (IPEX) is caused by mutations of FOXP3Nature Genetics, 27
- Publisher
- Annual Reviews
- Copyright
- Copyright © 2006 by Annual Reviews. All rights reserved
- ISSN
- 0732-0582
- eISSN
- 1545-3278
- DOI
- 10.1146/annurev.immunol.24.021605.090547
- pmid
- 16551248
- Publisher site
- See Article on Publisher Site
Abstract
Abstract The immune system has evolved mechanisms to recognize and eliminate threats, as well as to protect against self-destruction. Tolerance to self-antigens is generated through two fundamental mechanisms: ( a ) elimination of self-reactive cells in the thymus during selection and ( b ) generation of a variety of peripheral regulatory cells to control self-reactive cells that escape the thymus. It is becoming increasing apparent that a population of thymically derived CD4 + regulatory T cells, exemplified by the expression of the IL-2Rα chain, is essential for the maintenance of peripheral tolerance. Recent work has shown that the forkhead family transcription factor Foxp3 is critically important for the development and function of the regulatory T cells. Lack of Foxp3 leads to development of fatal autoimmune lymphoproliferative disease; furthermore, ectopic Foxp3 expression can phenotypically convert effector T cells to regulatory T cells. This review focuses on Foxp3 expression and function and highlights differences between humans and mice regarding Foxp3 regulation.
Journal
Annual Review of Immunology – Annual Reviews
Published: Apr 23, 2006