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Follicular Helper CD4 T Cells (T FH )

Follicular Helper CD4 T Cells (T FH ) T cell help to B cells is a fundamental aspect of adaptive immunity and the generation of immunological memory. Follicular helper CD4 T (T FH ) cells are the specialized providers of B cell help. T FH cells depend on expression of the master regulator transcription factor Bcl6. Distinguishing features of T FH cells are the expression of CXCR5, PD-1, SAP (SH2D1A), IL-21, and ICOS, among other molecules, and the absence of Blimp-1 ( prdm1 ). T FH cells are important for the formation of germinal centers. Once germinal centers are formed, T FH cells are needed to maintain them and to regulate germinal center B cell differentiation into plasma cells and memory B cells. This review covers T FH differentiation, T FH functions, and human T FH cells, discussing recent progress and areas of uncertainty or disagreement in the literature, and it debates the developmental relationship between T FH cells and other CD4 T cell subsets (Th1, Th2, Th17, iTreg). http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Annual Review of Immunology Annual Reviews

Follicular Helper CD4 T Cells (T FH )

Annual Review of Immunology , Volume 29 – Apr 23, 2011

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Publisher
Annual Reviews
Copyright
Copyright ©© 2011 by Annual Reviews. All rights reserved
ISSN
0732-0582
eISSN
1545-3278
DOI
10.1146/annurev-immunol-031210-101400
pmid
21314428
Publisher site
See Article on Publisher Site

Abstract

T cell help to B cells is a fundamental aspect of adaptive immunity and the generation of immunological memory. Follicular helper CD4 T (T FH ) cells are the specialized providers of B cell help. T FH cells depend on expression of the master regulator transcription factor Bcl6. Distinguishing features of T FH cells are the expression of CXCR5, PD-1, SAP (SH2D1A), IL-21, and ICOS, among other molecules, and the absence of Blimp-1 ( prdm1 ). T FH cells are important for the formation of germinal centers. Once germinal centers are formed, T FH cells are needed to maintain them and to regulate germinal center B cell differentiation into plasma cells and memory B cells. This review covers T FH differentiation, T FH functions, and human T FH cells, discussing recent progress and areas of uncertainty or disagreement in the literature, and it debates the developmental relationship between T FH cells and other CD4 T cell subsets (Th1, Th2, Th17, iTreg).

Journal

Annual Review of ImmunologyAnnual Reviews

Published: Apr 23, 2011

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