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Factors Controlling the B-Cell Cycle

Factors Controlling the B-Cell Cycle The basis of a humoral response of the immune system to antigen is the proliferation of antigen-specific B lymphocytes and their maturation to antibody(immunoglobulin, Ig)-secreting cells (1). Antigen selects from the repertoire of resting B cells, each expressing one of the diverse sets of variable regions of heavy and light chains of Ig on their surface (2-5). Upon stimulation, in vivo or in vitro, cells will divide every 20 hr at 37°C, in vitro B for 5-15 divisions (6). A singleB-cell clone retains remarkable synchrony for several divisions (6,7). WhenB cells mature they not only increase their rate of Ig synthesis and begin actively to secrete Ig,they also switch the class of heavy chains that carry the variable regions involved in antigen recog­ nition. A single dividing clone of B cells may switch at any division (8). Switching occurs in individual cells of the clone. Furthermore,a high rate of somatic mutations occurs in Ig genes during the process of clonal B-cell expansion that may alter the specificity of antigen recognition (9-12). Within an expanding clone of B cells, some cells may return to rest and remain in the immune system as long-lived memory cells (13). In vitro such http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Annual Review of Immunology Annual Reviews

Factors Controlling the B-Cell Cycle

Melchers, F; Andersson, J
Annual Review of Immunology , Volume 4 (1) – Apr 1, 1986
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References (123)

Publisher
Annual Reviews
Copyright
Copyright 1986 Annual Reviews. All rights reserved
Subject
Review Articles
ISSN
0732-0582
eISSN
1545-3278
DOI
10.1146/annurev.iy.04.040186.000305
pmid
2939855
Publisher site
See Article on Publisher Site

Abstract

The basis of a humoral response of the immune system to antigen is the proliferation of antigen-specific B lymphocytes and their maturation to antibody(immunoglobulin, Ig)-secreting cells (1). Antigen selects from the repertoire of resting B cells, each expressing one of the diverse sets of variable regions of heavy and light chains of Ig on their surface (2-5). Upon stimulation, in vivo or in vitro, cells will divide every 20 hr at 37°C, in vitro B for 5-15 divisions (6). A singleB-cell clone retains remarkable synchrony for several divisions (6,7). WhenB cells mature they not only increase their rate of Ig synthesis and begin actively to secrete Ig,they also switch the class of heavy chains that carry the variable regions involved in antigen recog­ nition. A single dividing clone of B cells may switch at any division (8). Switching occurs in individual cells of the clone. Furthermore,a high rate of somatic mutations occurs in Ig genes during the process of clonal B-cell expansion that may alter the specificity of antigen recognition (9-12). Within an expanding clone of B cells, some cells may return to rest and remain in the immune system as long-lived memory cells (13). In vitro such

Journal

Annual Review of Immunology – Annual Reviews

Published: Apr 1, 1986

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