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Epidemiological, Neurobiological, and Genetic Clues to the Mechanisms Linking Cannabis Use to Risk for Nonaffective Psychosis

Epidemiological, Neurobiological, and Genetic Clues to the Mechanisms Linking Cannabis Use to... Epidemiological studies have shown that the association between cannabis and psychosis is robust and consistent across different samples, with compelling evidence for a dose-response relationship. Because longitudinal work indicates that cannabis use precedes psychotic symptoms, it seems reasonable to assume a causal relationship. However, more work is needed to address the possibility of gene-environment correlation (for example, genetic risk for psychosis causing onset of cannabis use). Moreover, knowledge about underlying biological mechanisms linking cannabis use and psychosis is still relatively limited. In order to understand how cannabis use may lead to an increased risk for psychosis, in the present article we ( a ) review the epidemiological, neurobiological, and genetic evidence linking cannabinoids and psychosis, ( b ) assess the quality of the evidence, and finally ( c ) try to integrate the most robust findings into a neurodevelopmental model of cannabis-induced psychosis and identify the gaps in knowledge that are in need of further investigation. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Annual Review of Clinical Psychology Annual Reviews

Epidemiological, Neurobiological, and Genetic Clues to the Mechanisms Linking Cannabis Use to Risk for Nonaffective Psychosis

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References (143)

Publisher
Annual Reviews
Copyright
Copyright © 2014 by Annual Reviews. All rights reserved
ISSN
1548-5943
eISSN
1548-5951
DOI
10.1146/annurev-clinpsy-032813-153631
pmid
24471373
Publisher site
See Article on Publisher Site

Abstract

Epidemiological studies have shown that the association between cannabis and psychosis is robust and consistent across different samples, with compelling evidence for a dose-response relationship. Because longitudinal work indicates that cannabis use precedes psychotic symptoms, it seems reasonable to assume a causal relationship. However, more work is needed to address the possibility of gene-environment correlation (for example, genetic risk for psychosis causing onset of cannabis use). Moreover, knowledge about underlying biological mechanisms linking cannabis use and psychosis is still relatively limited. In order to understand how cannabis use may lead to an increased risk for psychosis, in the present article we ( a ) review the epidemiological, neurobiological, and genetic evidence linking cannabinoids and psychosis, ( b ) assess the quality of the evidence, and finally ( c ) try to integrate the most robust findings into a neurodevelopmental model of cannabis-induced psychosis and identify the gaps in knowledge that are in need of further investigation.

Journal

Annual Review of Clinical Psychology – Annual Reviews

Published: Mar 28, 2014

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