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Dynamics of Bone Metabolism

Dynamics of Bone Metabolism For many years metabolism of calcium and bone was investigated with metabolic balance and histologic techniques alone. More recently the advent of radioactive isotopes has made possible the determination of rates of calcium movement within the individual (1-3), Methods have been devised for the study of bone metabolism in vivo (4, 5). Urinary hydroxyproline has proved to be a useful index of collagen turnover (6-8). Studies with these procedures have greatly increased our understanding of normal processes as well as those involved in clinical diseases of bone. The ultimate goal, how­ ever, is to define clearly metabolic alterations at the cellular and molecular level and to correlate these changes with clinical aberrations. In this review will be presented an outline of the methods for kinetic studies of calcium metabolism in vivo, results of some of the studies with these methods, findings in some of the studies of bone metabolism in vitro, and a brief discussion of hydroxyproline metabolism. Because of its relevance to bone metabolism and because it is the subject of widespread current interest and intensive investigation, the most recent information concerning thyro­ calcitonin will also be presented. STUDIES OF SKELETAL DYNAMICS The radioactive isotopes which have http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Annual Review of Medicine Annual Reviews

Dynamics of Bone Metabolism

Bell, N H
Annual Review of Medicine , Volume 18 (1) – Feb 1, 1967
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Publisher
Annual Reviews
Copyright
Copyright 1967 Annual Reviews. All rights reserved
Subject
Review Articles
ISSN
0066-4219
eISSN
1545-326X
DOI
10.1146/annurev.me.18.020167.001503
pmid
5337528
Publisher site
See Article on Publisher Site

Abstract

For many years metabolism of calcium and bone was investigated with metabolic balance and histologic techniques alone. More recently the advent of radioactive isotopes has made possible the determination of rates of calcium movement within the individual (1-3), Methods have been devised for the study of bone metabolism in vivo (4, 5). Urinary hydroxyproline has proved to be a useful index of collagen turnover (6-8). Studies with these procedures have greatly increased our understanding of normal processes as well as those involved in clinical diseases of bone. The ultimate goal, how­ ever, is to define clearly metabolic alterations at the cellular and molecular level and to correlate these changes with clinical aberrations. In this review will be presented an outline of the methods for kinetic studies of calcium metabolism in vivo, results of some of the studies with these methods, findings in some of the studies of bone metabolism in vitro, and a brief discussion of hydroxyproline metabolism. Because of its relevance to bone metabolism and because it is the subject of widespread current interest and intensive investigation, the most recent information concerning thyro­ calcitonin will also be presented. STUDIES OF SKELETAL DYNAMICS The radioactive isotopes which have

Journal

Annual Review of Medicine – Annual Reviews

Published: Feb 1, 1967

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