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and Historical Background Over a century ago Metchnikoffformulated the phagocytic theory of host defenses. In experiments with marine invertebrates, Metchnikoff noted that certain strains of the invading fungus were ingested and destroyed by phagocytes. Other strains were not attacked, and a disseminated fatal disease then developed ( 1). Metchnikoff predicted that abnormalities of phagocytic cells would compromise host defenses. A century later this concept was commonly demonstrated by the development of over whelming bacterial and fungal infection in conditions resulting in severe quantitative or functional deficiencies of circulating neutrophils. Beginning with Janeway's description in 1954, of a "fatal granulomatous disease of childhood" (2), several intrinsic disorders of phagocytic cells have been characterized. In the past 15 years, application of new techniques and intense interest in the biology of phagocytic cells have greatly promoted knowledge of factors regulating leukocyte function. The present discussion is not intended to be an exhaustive review of phagocyte defects but is focused on well-characterized and historically important disorders and emphasizes recent advances in our knowledge of the underlying defects. For a detailed discussion of the evaluation and management of patients with phagocyte defects, the reader is referred to several recent reviews (3-6). Adherence Related
Annual Review of Immunology – Annual Reviews
Published: Apr 1, 1987
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