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J. Hollander, E. Brown, R. Jessar, L. Udell, N. Smukler, M. Bowie (1954)
Local Anti-Rheumatic Effectiveness of Higher Esters and Analogues of Hydrocortisone *†Annals of the Rheumatic Diseases, 13
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J. Thomson, C. Ferciot, W. Bartels, F. Webster (1953)
The light bulb type of prosthesis for the femoral head.Surgery, gynecology & obstetrics, 96 3
J. Connolly (1967)
Congenital dislocation of the hipBritish Medical Journal, 4
By ROBERT M. STECHER Department of Medicine, Western Reserve University; School of Medicine at City Hospital, Cleveland Ohio CORTISONE AND ACTH2 Any discussion of rheumatoid arthritis always brings up for consideration cortisone and its derivatives. After nearly six years of experience the drug is recognized as a substance with effective therapeutic activities as well as a potent agent for control of pain. Despite all the dire promises formerly made, cortisone properly used does not ablate adrenal activity or produce complete diabetes. If prescribed with reasonable caution psychoses, compression frac tures, rounded facies, buffalo hump, hirsutism, and high blood pressure usually can be avoided. It has been shown that these drugs can be given un interruptedly for long periods with reasonable safety. The original recommendation of starting with 300, 200 and 100 mg. of cortisone a day has been modified. Most physicians start now with 100 mg. a day, reducing the dose as improvement occurs until a maintenance level is reached. Since cortisone is not curative but must be continued for long pe riods the least effective dose is desirable. It is thought by some to be better to begin with 50 mg. a day, increasing in increments of
Annual Review of Medicine – Annual Reviews
Published: Feb 1, 1955
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